Enhances gene expression by forming a complex that interacts with nuclear receptors. This interaction stimulates transcriptional activities in a hormone-dependent manner, playing a crucial role in regulating gene expression and cellular responses.
Regulates actin dynamics by promoting the nucleation and formation of branched actin filaments. This complex is essential for various cellular processes, including cell motility, endocytosis, and the maintenance of cell shape.
Activates the immunoproteasome, a specialized form of the proteasome responsible for degrading proteins involved in antigen presentation. This activation contributes to immune responses by influencing the degradation of specific proteins.
Acts as the regulatory particle of the 26S proteasome, participating in the ATP-dependent degradation of ubiquitinated proteins. This process is crucial for maintaining cellular homeostasis by eliminating damaged or unwanted proteins.
Mediates vesicle trafficking by assembling clathrin-coated vesicles. This process is vital for intracellular transport, allowing cells to regulate the movement of proteins and other molecules between cellular compartments.
The Mi2/NuRD complex remodels chromatin and regulates gene expression through enzymes like histone deacetylases, maintaining genomic stability. It is crucial for fundamental cellular processes, including DNA repair and development.
The MeCP1 complex recognizes and binds to methylated CpG sites, contributing to gene silencing and maintaining DNA methylation patterns. Comprising MeCP2 and associated proteins, it is vital for epigenetic control and implicated in neurodevelopmental disorders.
The TRAP complex regulates transcription by influencing RNA polymerase II, impacting RNA synthesis and cellular processes like development and stress responses.
The NUMAC complex regulates gene expression through histone methylation, influencing chromatin structure. Comprising various subunits, it participates in cellular processes like differentiation and environmental responses.
The Nup 107-160 subcomplex is integral to the nuclear pore complex, governing nucleocytoplasmic transport by forming a scaffold. Composed of multiple nucleoporins, it regulates molecule passage, contributing to diverse cellular functions. It plays a crucial role in genetic information exchange within the cell.
The Anaphase-promoting Complex (APC) regulates cell cycle progression by ensuring the timely degradation of key proteins during mitosis and cytokinesis. It safeguards genomic stability and prevents uncontrolled cell division.
The p300-MDM2-p53 protein complex responds to stress and DNA damage by modulating the activity of the tumor suppressor protein p53. This intricate network helps maintain genomic integrity and regulates cell growth.
The hNURF complex remodels chromatin architecture, influencing gene expression and contributing to cellular processes like development and differentiation.
The RNA Polymerase II Holoenzyme Complex facilitates mRNA synthesis by providing the necessary machinery for transcription initiation and elongation. It is crucial for the accurate flow of genetic information.
The RNA Polymerase II Core Complex is essential for transcription, synthesizing mRNA from DNA templates during initiation and elongation. It ensures controlled and accurate gene expression.
The Prefoldin Complex aids in proper protein folding, acting as a chaperone to prevent misfolding and aggregation. It helps maintain protein homeostasis within the cell.
The Polycomb Repressive Complex 1 (PRC1) regulates gene expression through histone modifications, contributing to gene silencing and cellular identity maintenance. It plays a crucial role in development and cellular differentiation.
The Lymphotoxin Beta Receptor Complex is vital for immune system regulation, influencing inflammation, immune response, and lymphoid tissue development. It coordinates cellular interactions within the immune system to defend against pathogens.
The CCT complex, also known as the chaperonin-containing TCP1 complex, is involved in protein folding by assisting in the proper folding of nascent polypeptides. It provides a protected environment for protein maturation, ensuring correct three-dimensional structures. This complex is essential for cellular homeostasis and prevents the aggregation of misfolded proteins.
The PIDDsome complex plays a role in apoptosis regulation by facilitating the activation of caspase-2. It serves as a platform for assembling apoptotic signaling components, contributing to programmed cell death. This complex is crucial for maintaining cellular integrity and responding to various cellular stresses.
The Telomere-Associated Protein Complex is involved in telomere maintenance, ensuring the protection and regulation of chromosome ends. It participates in processes like DNA replication and repair, contributing to genomic stability and cellular longevity.
The APP695-APBB1-LRP1 complex is associated with Alzheimer's disease and is involved in the processing and clearance of amyloid-beta peptides. It modulates the trafficking and signaling of amyloid precursor protein (APP), impacting neurodegenerative processes.
The Gamma-BAR-AP1 complex is crucial for vesicle trafficking and sorting within the cell. It regulates the formation and function of transport vesicles, facilitating the precise delivery of cargo to specific cellular compartments. This complex plays a vital role in maintaining cellular organization and function.
The PBAF complex is a chromatin remodeling complex that regulates gene expression by altering the structure of chromatin. Comprising Polybromo and BAF components, it influences transcription and cellular differentiation, contributing to various biological processes.
The TFIID complex is essential for transcription initiation in eukaryotes. It recognizes and binds to the promoter region of genes, facilitating the assembly of the pre-initiation complex. TFIID is a key player in the regulation of gene expression and the initiation of mRNA synthesis.
The Condensin I-PARP-1-XRCC1 complex is involved in DNA repair and chromosome condensation. It participates in maintaining genomic stability by facilitating DNA repair processes and ensuring proper chromosome organization during cell division.
The Respiratory Chain Complex I, also known as the holoenzyme, is a component of the mitochondrial electron transport chain. It plays a crucial role in oxidative phosphorylation, generating ATP and facilitating energy transfer within the cell. This complex is essential for cellular respiration and energy production.
The 26S proteasome is a protein complex responsible for degrading ubiquitinated proteins. It plays a central role in cellular protein quality control, removing damaged or unwanted proteins and regulating various cellular processes, including cell cycle progression and signaling.
The BAF complex is a chromatin remodeling complex that regulates gene expression by altering the structure of chromatin. It participates in diverse cellular processes, including development and differentiation, contributing to the overall cellular identity.
The PA28-20S proteasome complex is involved in the regulation of protein degradation. It enhances the activity of the 20S proteasome, contributing to the efficient breakdown of proteins and maintaining cellular homeostasis.
The PA700-20S-PA28 complex is associated with proteasomal protein degradation. It enhances the activity of the 20S proteasome, facilitating the breakdown of ubiquitinated proteins. This complex plays a role in maintaining cellular protein quality and turnover.
The PA28gamma-20S proteasome complex is involved in regulating protein degradation. It associates with the 20S proteasome, enhancing its activity and contributing to the efficient breakdown of ubiquitinated proteins within the cell.
The CAND1-CUL1-RBX1 complex is involved in the regulation of protein ubiquitination and degradation. It modulates the activity of the CUL1-based ubiquitin ligase, contributing to the targeted degradation of specific proteins within the cell.
The CAND1-CUL3-RBX1 complex participates in the regulation of protein ubiquitination and degradation. It modulates the activity of the CUL3-based ubiquitin ligase, playing a role in targeted protein turnover and cellular homeostasis.
The CAND1-CUL4B-RBX1 complex is involved in the regulation of protein ubiquitination and degradation. It modulates the activity of the CUL4B-based ubiquitin ligase, contributing to targeted protein turnover and maintaining cellular homeostasis.
The Ubiquitin E3 Ligase (SKP1A) is involved in protein ubiquitination, marking proteins for degradation by the 26S proteasome. It plays a crucial role in the regulation of cellular processes by controlling the abundance of specific proteins within the cell.
The Mediator complex is essential for transcriptional regulation by facilitating communication between transcription factors and RNA polymerase II. It acts as a bridge, coordinating the assembly of the transcription machinery and influencing gene expression.
The ARC complex is associated with activity-regulated cytoskeleton-associated protein (Arc), playing a role in synaptic plasticity and memory formation. It modulates the strength and structure of synapses, contributing to neuronal communication and learning processes.
The SWI-SNF Chromatin Remodeling-Related-BRCA1 complex is involved in chromatin remodeling and DNA repair processes. It influences gene expression by altering chromatin structure and plays a role in maintaining genomic stability, particularly in association with the BRCA1 protein.
The BRAFT complex is associated with transcriptional regulation and cellular response to environmental signals. It plays a role in coordinating cellular processes by modulating gene expression and contributing to adaptive cellular responses.
The FA Core Complex, associated with Fanconi anemia, is involved in DNA repair and maintenance of genomic stability. It plays a crucial role in resolving DNA interstrand crosslinks, contributing to the prevention of chromosomal instability and cancer development.
The HMGB1-HMGB2-HSC70-ERP60-GAPDH complex is associated with various cellular processes, including chromatin organization, protein folding, and energy metabolism. It brings together different proteins with diverse functions, contributing to the coordination of cellular activities.
The SNF2h-Cohesin-NuRD complex is involved in chromatin remodeling and gene regulation. It influences gene expression by altering chromatin structure and plays a role in cellular processes such as development and differentiation.
The SIN3 complex is a transcriptional corepressor involved in gene regulation. It plays a role in the repression of specific genes by modifying chromatin structure, contributing to the control of cellular processes.
The PCNA-MSH2-MSH6 complex is involved in DNA repair processes, particularly in the recognition and correction of mismatched DNA bases. It plays a crucial role in maintaining genomic integrity and preventing the accumulation of mutations.
The MSH2-MLH1-PMS2-PCNA complex is crucial for DNA repair initiation, specifically in the mismatch repair pathway. It coordinates the recognition and correction of mismatched DNA bases, contributing to genomic stability and preventing the occurrence of mutations.
The MSH2-MLH1-PMS2 complex is pivotal in DNA repair initiation, particularly in the mismatch repair pathway. It coordinates the recognition and correction of mismatched DNA bases, contributing to genomic stability and preventing mutations.
The PCNA-DNA Polymerase Delta complex plays a key role in DNA replication. PCNA, in conjunction with DNA Polymerase Delta, ensures accurate and efficient synthesis of DNA strands during replication. This complex is essential for maintaining genomic integrity during cell division.
The VEGF Transcriptional Complex is involved in the regulation of vascular endothelial growth factor (VEGF) expression. It coordinates the transcriptional machinery to control the expression of genes involved in angiogenesis, contributing to the formation of blood vessels.
The CBP-IRF3 complex is associated with the regulation of immune responses. It involves the interaction between CREB-binding protein (CBP) and interferon regulatory factor 3 (IRF3), modulating the transcription of genes involved in antiviral defense and immune activation.
The SRCAP complex is a chromatin remodeling complex that plays a role in histone exchange. It replaces histone variants, contributing to the regulation of chromatin structure and gene expression. This complex is involved in various cellular processes, including development and differentiation.
The 40S ribosomal subunit is a component of the eukaryotic ribosome involved in protein synthesis. It associates with the 60S subunit to form the complete ribosome, facilitating the translation of mRNA into functional proteins.
The Ribosome is the cellular machinery responsible for protein synthesis. Comprising both the 40S and 60S subunits, it translates the genetic code carried by mRNA into polypeptide chains, playing a fundamental role in cellular function and protein production.
The 60S ribosomal subunit, in conjunction with the 40S subunit, forms the eukaryotic ribosome. It participates in protein synthesis by catalyzing the formation of peptide bonds between amino acids, contributing to the translation of mRNA into functional proteins.
The Cell Cycle Kinase Complex CDC2, also known as cyclin-dependent kinase 1 (CDK1), is a key regulator of the cell cycle. It controls cell division by phosphorylating target proteins, orchestrating the progression through various phases of the cell cycle.
The Cell Cycle Kinase Complex CDK2 is a cyclin-dependent kinase that regulates the cell cycle. It plays a crucial role in coordinating DNA synthesis and cell division, contributing to the orderly progression through the cell cycle.
The Cell Cycle Kinase Complex CDK4, in association with cyclin D, regulates the cell cycle by controlling the G1 to S phase transition. It phosphorylates target proteins, influencing the progression of cells through the cell cycle.
The Cell Cycle Kinase Complex CDK5 is a cyclin-dependent kinase involved in cell cycle regulation, particularly in post-mitotic neurons. It plays a role in neuronal development, migration, and synaptic function, contributing to the maintenance of neuronal integrity.
The PCNA-p21 complex is involved in cell cycle regulation, specifically in the control of DNA replication. p21 binds to PCNA, inhibiting the activity of DNA polymerases and preventing excessive DNA synthesis. This complex contributes to the orderly progression of the cell cycle.
The 55S ribosome is found in mitochondria and is involved in mitochondrial protein synthesis. Comprising both small and large subunits, it translates the genetic information carried by mitochondrial mRNA into functional proteins within the mitochondria.
The 39S ribosomal subunit, in conjunction with the 28S subunit, forms the large ribosomal subunit in prokaryotes. It participates in protein synthesis by catalyzing the formation of peptide bonds between amino acids, contributing to the translation of mRNA into functional proteins.
The 40S ribosomal subunit is a component of the eukaryotic ribosome involved in protein synthesis. It associates with the 60S subunit to form the complete ribosome, facilitating the translation of mRNA into functional proteins.
The DNA Ligase IV-XRCC4-PNK complex is involved in DNA repair, particularly in the non-homologous end-joining (NHEJ) pathway. It participates in the sealing of DNA double-strand breaks, ensuring genomic stability and integrity.
The DNA Ligase IV-XRCC4-XLF complex is crucial for DNA repair, specifically in the non-homologous end-joining (NHEJ) pathway. It plays a role in rejoining broken DNA ends, contributing to the maintenance of genomic stability.
The DNA Ligase III-XRCC1-PNK-DNA-Pol III complex is involved in various aspects of DNA metabolism, including base excision repair and DNA replication. It participates in sealing nicks in DNA strands and ensuring accurate DNA synthesis.
The ERCC1-ERCC4-MSH2 complex is involved in DNA repair processes, participating in nucleotide excision repair and mismatch repair. It plays a role in removing damaged DNA bases and maintaining genomic integrity.
The MSH2-MSH6-PMS2-MLH1 complex is crucial for DNA mismatch repair. It recognizes and corrects errors in DNA base pairing, contributing to the prevention of mutations and the maintenance of genomic stability.
The PCNA-MutS-alpha-MutL-alpha-DNA complex is involved in DNA mismatch repair. It coordinates the recognition and correction of mismatched DNA bases, ensuring genomic integrity and preventing mutations.
The Ubiquitin E3 Ligase (SKP1A) is involved in protein ubiquitination, marking proteins for degradation by the 26S proteasome. It plays a crucial role in the regulation of cellular processes by controlling the abundance of specific proteins within the cell.
The CAV3-DAG1 complex is associated with caveolae formation and signal transduction. It involves the interaction between caveolin-3 (CAV3) and dystroglycan (DAG1), contributing to cellular membrane organization and communication.
The 18S U11/U12 snRNP is involved in pre-mRNA splicing, specifically recognizing and processing U11/U12-type introns. It contributes to the precision of spliceosomal machinery, ensuring accurate mRNA splicing and gene expression.
The N-NOS-CHIP-HSP70-1 complex is associated with the regulation of neuronal nitric oxide synthase (N-NOS). It involves the interaction between CHIP, HSP70-1, and N-NOS, contributing to the maintenance of protein homeostasis and cellular function.
The GCN5-TRRAP histone acetyltransferase complex is involved in chromatin remodeling and gene regulation. It acetylates histone proteins, influencing chromatin structure and contributing to the control of gene expression.
The TFTC-type histone acetyl transferase complex is involved in chromatin modification and gene regulation. It acetylates histone proteins, influencing chromatin structure and playing a role in the control of gene expression.
The BP-SMAD complex is associated with the TGF-beta signaling pathway. It involves the interaction between bone morphogenetic protein (BMP) receptors and SMAD proteins, contributing to the regulation of cellular responses to TGF-beta family signals.
The TFTC complex is involved in transcriptional regulation by influencing the assembly of the transcription machinery. Comprising TATA-binding protein-free TAF-II-containing components, it participates in the control of gene expression and cellular processes.
The TFIID complex is essential for transcription initiation in eukaryotes. It recognizes and binds to the promoter region of genes, facilitating the assembly of the pre-initiation complex. TFIID is a key player in the regulation of gene expression and the initiation of mRNA synthesis.
The TFIID-beta complex is a variant of the TFIID complex involved in transcription initiation. It plays a role in recognizing and binding to specific promoters, contributing to the regulation of gene expression.
The TFTC complex is involved in transcriptional regulation by influencing the assembly of the transcription machinery. Comprising TATA-binding protein-free TAF-II-containing components, it participates in the control of gene expression and cellular processes.
The PCAF complex is a histone acetyltransferase complex involved in chromatin remodeling and gene regulation. It acetylates histone proteins, influencing chromatin structure and playing a role in the control of gene expression.
Prolyl 4-hydroxylase (alpha(I)-type) is an enzyme complex involved in the post-translational modification of collagen. It catalyzes the hydroxylation of proline residues, contributing to the stability and structure of collagen in the extracellular matrix.
The STAGA complex is a histone acetyltransferase complex involved in chromatin remodeling and transcriptional regulation. It acetylates histone proteins, influencing chromatin structure and playing a role in the control of gene expression.
The DA Complex is involved in cellular processes related to dopamine receptor signaling. It participates in the modulation of neurotransmission and responses to dopamine, influencing various physiological and behavioral functions within the nervous system.
The DAB Complex is associated with cell adhesion and signaling. It mediates the interaction between specific proteins, contributing to cellular adhesion processes and intracellular signaling cascades, thereby influencing cellular responses and interactions.
The RYK-WNT3A Complex is involved in Wnt signaling pathways. It facilitates the interaction between the receptor-like tyrosine kinase RYK and the WNT3A ligand, influencing cellular responses and developmental processes governed by Wnt signaling.
The TFIID Complex is a key player in transcription initiation. It includes components essential for recognizing the TATA box in DNA, promoting the assembly of the preinitiation complex, and initiating RNA polymerase II-mediated transcription of genes.
The TFIID complex is essential for transcription initiation in eukaryotes. It recognizes and binds to the promoter region of genes, facilitating the assembly of the pre-initiation complex. TFIID is a key player in the regulation of gene expression and the initiation of mRNA synthesis.
The TFTC Complex, also known as the TATA-Binding Protein-Free TAF-II-Containing Complex, is involved in transcriptional regulation. It includes components that participate in the modulation of gene expression by interacting with transcription factors and the basal transcription machinery.
The TFIID-beta Complex is a variant of the canonical TFIID complex involved in transcription initiation. It exhibits distinct functions or regulation compared to the standard TFIID complex, contributing to the diversity of transcriptional responses in different cellular contexts.
The AKAP250-PKA-PDE4D complex is involved in cellular signaling and cAMP regulation. It brings together AKAP250, PKA, and PDE4D, contributing to the spatial and temporal control of cAMP signaling pathways. The complex plays a role in cellular responses to various stimuli and regulatory processes.
The KCNQ1 macromolecular complex is integral in ion channel regulation and cardiac function. It involves KCNQ1 and associated proteins, contributing to the modulation of potassium channels. The complex plays a crucial role in controlling membrane potential and cellular excitability in cardiac tissues.
The Polycystin-1-E-Cadherin-Beta-Catenin complex is associated with cell adhesion and signaling. It brings together Polycystin-1, E-Cadherin, and Beta-Catenin, playing a role in cellular adhesion, signal transduction, and regulation of the cytoskeleton. The complex is essential for cellular interactions and tissue integrity.
The Polycystin-1-E-Cadherin-Beta-Catenin-Flotillin-2 complex is involved in membrane dynamics and signaling. It includes Polycystin-1, E-Cadherin, Beta-Catenin, and Flotillin-2, contributing to cellular adhesion, signal transduction, and membrane organization. The complex plays a role in various cellular processes.
The NuA4/Tip60-HAT complex is associated with histone acetylation and transcriptional regulation. It involves NuA4/Tip60 histone acetyltransferase, influencing chromatin structure and gene expression. The complex plays a crucial role in the modulation of gene transcription and cellular responses.
The XPA-ERCC1-ERCC4 complex is involved in nucleotide excision repair, recognizing and repairing DNA lesions caused by UV radiation and chemical agents. It coordinates the removal of damaged DNA segments, contributing to genomic stability and integrity.
The TRAP complex is associated with transcriptional regulation and RNA polymerase II activity. It facilitates the assembly of the transcription pre-initiation complex, influencing gene expression and contributing to mRNA synthesis.
The IGF1-IGFBP3-ALS complex is involved in insulin-like growth factor (IGF) signaling and regulation. It includes components that modulate the activity and transport of IGF1, influencing cellular growth and metabolic processes.
The SMCC complex, or Mediator complex, serves as a bridge between transcription factors and RNA polymerase II during transcription. It facilitates the communication between regulatory elements and the transcriptional machinery, influencing gene expression.
The DRIP complex, or Vitamin D receptor-interacting protein complex, is involved in the regulation of gene expression in response to vitamin D. It interacts with the vitamin D receptor, modulating transcription and cellular responses to vitamin D.
The IFNAR1-IFNAR2-IFNB1 complex is associated with interferon signaling, particularly in response to interferon-beta (IFNB1). It includes components that mediate the cellular response to interferon, influencing antiviral and immune processes.
The PBAF complex, or Polybromo- and BAF-containing complex, is a chromatin remodeling complex that regulates gene expression by altering chromatin structure. It participates in diverse cellular processes, including development and differentiation.
The BAF complex is a chromatin remodeling complex that regulates gene expression by altering chromatin structure. It participates in diverse cellular processes, including development and differentiation, contributing to the overall cellular identity.
The Decapping complex is involved in mRNA degradation by removing the 5' cap structure from mRNA molecules. It plays a role in the regulation of mRNA stability and turnover, influencing gene expression and cellular responses.
The LSm1-7 complex is associated with mRNA processing and degradation. It participates in the assembly of the mRNA decay machinery, influencing the degradation of specific mRNA transcripts and contributing to cellular homeostasis.
The BAF complex is a chromatin remodeling complex that regulates gene expression by altering chromatin structure. It participates in diverse cellular processes, including development and differentiation, contributing to the overall cellular identity.
The PBAF complex is a chromatin remodeling complex that regulates gene expression by altering chromatin structure. Comprising Polybromo and BAF components, it influences transcription and cellular differentiation, contributing to various biological processes.
The BAF complex is a chromatin remodeling complex that regulates gene expression by altering chromatin structure. It participates in diverse cellular processes, including development and differentiation, contributing to the overall cellular identity.
The p300-CBP-p270-SWI/SNF complex is involved in chromatin remodeling and transcriptional regulation. It includes components that modify chromatin structure, influencing gene expression and contributing to diverse cellular processes.
The p300-CBP-p270 complex is associated with chromatin modification and transcriptional regulation. It includes components that modify chromatin structure, influencing gene expression and contributing to diverse cellular processes.
The FHL2-p53-HIPK2 complex is associated with the regulation of p53, a tumor suppressor protein. It includes components that modulate p53 activity, influencing cellular responses to stress, DNA damage, and apoptosis.
The NuRD.1 complex, or Nucleosome remodeling and deacetylation complex, is involved in chromatin remodeling and gene regulation. It includes components that modify histone acetylation and influence chromatin structure, contributing to gene expression control.
The SAP complex, or Sin3-associated protein complex, is a transcriptional corepressor complex involved in gene regulation. It modulates chromatin structure and inhibits transcription, contributing to the repression of specific genes and cellular processes.
The mSin3A corepressor complex is associated with transcriptional regulation and chromatin modification. It functions as a corepressor, influencing gene expression by modifying chromatin structure and contributing to the control of cellular processes.
The NRD complex, or Nucleosome Remodeling and Deacetylation Complex, is involved in chromatin remodeling and gene regulation. It modulates histone acetylation and influences chromatin structure, contributing to the control of gene expression.
The CASK-LIN7C-APBA1 complex is associated with synaptic function and protein-protein interactions. It includes components that regulate the assembly of synaptic proteins, contributing to neuronal communication and function.
The CoREST-HDAC complex is involved in transcriptional regulation and chromatin modification. It acts as a corepressor by recruiting histone deacetylases (HDACs), influencing chromatin structure and gene expression control.
The LSD1 complex is a histone demethylase complex involved in chromatin modification and gene regulation. It participates in the removal of methyl groups from histone proteins, influencing chromatin structure and gene expression.
The Anti-HDAC2 complex is associated with the regulation of histone deacetylase 2 (HDAC2) activity. It includes components that modulate HDAC2 function, influencing chromatin structure and gene expression control.
The Anti-BHC110 complex is associated with the regulation of the BHC110 corepressor. It includes components that modulate BHC110 function, influencing chromatin structure and gene expression control.
The XFIM complex is associated with X-chromosome inactivation. It includes components that participate in the silencing of one of the X chromosomes in female cells, contributing to dosage compensation and gene regulation.
The BHC complex, or Brain-Enriched Corepressor (BHC) complex, is involved in transcriptional regulation and chromatin modification. It acts as a corepressor, influencing chromatin structure and gene expression control in neuronal cells.
The CtBP complex is associated with transcriptional regulation and chromatin modification. It acts as a corepressor by recruiting histone-modifying enzymes, influencing chromatin structure and gene expression control.
The CtBP core complex is involved in transcriptional regulation and chromatin modification. It acts as a corepressor by recruiting histone-modifying enzymes, influencing chromatin structure and gene expression control.
The HDAC2-Associated Core Complex is involved in histone deacetylation and transcriptional regulation. It includes histone deacetylase 2 (HDAC2) and associated proteins, contributing to the modification of chromatin structure and control of gene expression.
The VPS35-VPS29-VPS26A complex is associated with the retromer, a cellular machinery involved in endosomal sorting and vesicle trafficking. It plays a role in the recycling of membrane proteins, contributing to cellular homeostasis and membrane dynamics.
The Retromer Complex, including SNX1, SNX2, VPS35, VPS29, and VPS26A, is involved in endosomal trafficking and recycling of membrane proteins. It facilitates the sorting of proteins within endosomes, contributing to cellular membrane organization and protein homeostasis.
The RANBMP-CD39 complex is associated with nucleotide metabolism and signal transduction. It includes CD39, influencing the hydrolysis of nucleotides and participating in purinergic signaling pathways.
The C-CFTR-NHERF-Ezrin complex is associated with the regulation of CFTR (Cystic Fibrosis Transmembrane Conductance Regulator) activity. It includes components that modulate CFTR function, contributing to ion transport and cellular homeostasis.
The MeCP1 complex is involved in the recognition and binding of methylated DNA. It includes proteins like MeCP2, contributing to the regulation of gene expression by influencing chromatin structure and epigenetic modifications.
The SIN3-SAP25 complex is associated with transcriptional regulation and chromatin modification. It includes components involved in histone deacetylation and transcriptional repression, contributing to the control of gene expression.
The SIN3-HDAC-SAP30-ARID4 complex is involved in transcriptional regulation and chromatin modification. It participates in histone deacetylation and transcriptional repression, influencing gene expression control.
The BRMS1-mSin3A Corepressor Complex is associated with transcriptional regulation and chromatin modification. It includes components that modulate gene expression by interacting with the mSin3A corepressor complex.
The SNARE Complex, including HGS, SNAP25, and STX13, is involved in membrane fusion during vesicle trafficking. It facilitates the fusion of vesicles with target membranes, contributing to intracellular transport and cellular membrane dynamics.
The SNARE Complex, including SNAP25, STX13, and VAMP2, is involved in membrane fusion during vesicle trafficking. It facilitates the fusion of vesicles with target membranes, contributing to intracellular transport and cellular membrane dynamics.
The Brg1-Associated Complex I is involved in chromatin remodeling and gene regulation. It includes the Brg1 ATPase, contributing to the modification of chromatin structure and the control of gene expression.
The Brm-Associated Complex is involved in chromatin remodeling and gene regulation. It includes the Brm ATPase, contributing to the modification of chromatin structure and the control of gene expression.
The BRG1-SIN3A Complex is associated with transcriptional regulation and chromatin modification. It includes the BRG1 ATPase and mSin3A, contributing to the modification of chromatin structure and the control of gene expression.
The BRM-SIN3A Complex is associated with transcriptional regulation and chromatin modification. It includes the BRM ATPase and mSin3A, contributing to the modification of chromatin structure and the control of gene expression.
The MORF4L1-MRFAP1-RB1 Complex is involved in transcriptional regulation and chromatin modification. It includes components that modulate gene expression and interact with the retinoblastoma protein (RB1).
The P2X7 Receptor Signaling Complex is associated with P2X7 receptors and signal transduction. It includes components involved in P2X7 receptor-mediated cellular responses, contributing to purinergic signaling pathways.
The Ubiquitin E3 Ligase (FBXO31, SKP1A, CUL1, RBX1) is involved in protein ubiquitination and degradation. It marks specific proteins for degradation by the 26S proteasome, contributing to the regulation of cellular processes by controlling protein abundance.
The SNARE Complex, including SNAP23, STX4, and VAMP1, is involved in membrane fusion during vesicle trafficking. It facilitates the fusion of vesicles with target membranes, contributing to intracellular transport and cellular membrane dynamics.
The SNARE Complex, including SNAP23, STX4, and VAMP2, is involved in membrane fusion during vesicle trafficking. It facilitates the fusion of vesicles with target membranes, contributing to intracellular transport and cellular membrane dynamics.
The SNARE Complex, including STX4, VAMP1, and VAMP7, is involved in membrane fusion during vesicle trafficking. It facilitates the fusion of vesicles with target membranes, contributing to intracellular transport and cellular membrane dynamics.
The SIN3-ING1b Complex I is associated with transcriptional regulation and chromatin modification. It includes components involved in histone deacetylation and transcriptional repression, contributing to the control of gene expression.
The SIN3-ING1b Complex II is associated with transcriptional regulation and chromatin modification. It includes components involved in histone deacetylation and transcriptional repression, contributing to the control of gene expression.
The eIF3 Complex is involved in protein translation initiation. It includes multiple subunits, such as EIF3S6, EIF3S5, EIF3S4, EIF3S3, EIF3S6IP, EIF3S2, EIF3S9, EIF3S12, EIF3S10, EIF3S8, EIF3S1, and EIF3S7, contributing to the assembly of the translation initiation complex and protein synthesis.
The MeCP2-SIN3A-HDAC complex is involved in transcriptional regulation and chromatin modification. It includes components that modulate gene expression by interacting with MeCP2, SIN3A, and histone deacetylases (HDACs).
The Prune-Gelsolin complex is associated with actin dynamics and cellular morphology. It includes components that regulate the activity of gelsolin, contributing to actin filament remodeling and cellular processes such as cell motility.
The TREX complex is involved in mRNA export from the nucleus to the cytoplasm. It includes components that facilitate the coupling of mRNA processing and export, contributing to the efficient transport of mRNA transcripts.
The LARC complex, or LCR-Associated Remodeling Complex, is involved in chromatin remodeling and gene regulation. It includes components that contribute to the modification of chromatin structure, influencing gene expression and cellular processes.
The URI complex is associated with transcriptional regulation and RNA polymerase II activity. It includes components that interact with the RNA polymerase II subunit RPB5, contributing to the regulation of gene expression.
The Exon Junction Complex is involved in mRNA processing and surveillance. It is associated with spliced mRNA transcripts and contributes to mRNA quality control and nuclear-cytoplasmic transport.
The NuA4/Tip60-HAT Complex B is involved in histone acetylation and transcriptional regulation. It includes components that modify histone acetylation, influencing chromatin structure and the control of gene expression.
The Exosome is a cellular complex involved in RNA degradation and processing. It functions as a ribonuclease, contributing to the degradation of various RNA species, including mRNA and non-coding RNAs.
The SNARE Complex, including CPLX1, SNAP25, STX1A, and VAMP2, is involved in membrane fusion during vesicle trafficking. It facilitates the fusion of vesicles with target membranes, contributing to intracellular transport and cellular membrane dynamics.
The SNARE Complex, including CPLX2, SNAP25, STX1A, and VAMP2, is involved in membrane fusion during vesicle trafficking. It facilitates the fusion of vesicles with target membranes, contributing to intracellular transport and cellular membrane dynamics.
The NuA4/Tip60-HAT Complex A is involved in histone acetylation and transcriptional regulation. It includes components that modify histone acetylation, influencing chromatin structure and the control of gene expression.
The BRG1-SIN3A-HDAC Containing SWI/SNF Remodeling Complex I is involved in chromatin remodeling and gene regulation. It includes components that contribute to the modification of chromatin structure and the control of gene expression.
The BRM-SIN3A-HDAC Complex is associated with transcriptional regulation and chromatin modification. It includes the BRM ATPase, SIN3A, and histone deacetylases (HDACs), contributing to the modification of chromatin structure and the control of gene expression.
The BRG1-Associated Complex is involved in chromatin remodeling and gene regulation. It includes the BRG1 ATPase, contributing to the modification of chromatin structure and the control of gene expression.
The BRM-Associated Complex is involved in chromatin remodeling and gene regulation. It includes the BRM ATPase, contributing to the modification of chromatin structure and the control of gene expression.
The PAR-3-VE-Cadherin-Beta-Catenin Complex is associated with cell adhesion and polarity. It includes components that contribute to the formation of adherens junctions, regulating cell-cell adhesion and establishing cellular polarity.
The TRPC1-STIM1-ORAI1 complex is involved in calcium signaling and store-operated calcium entry (SOCE). It includes components that mediate the activation of calcium channels, contributing to intracellular calcium homeostasis.
The 20S Methylosome and RG-Containing Sm Protein Complex is associated with small nuclear ribonucleoprotein (snRNP) assembly and methylation. It includes components that participate in the modification of snRNPs, contributing to pre-mRNA splicing.
The 6S Methyltransferase and RG-Containing Sm Proteins Complex is associated with small nuclear ribonucleoprotein (snRNP) assembly and methylation. It includes components that participate in the modification of snRNPs, contributing to pre-mRNA splicing.
The PCI-PSA-SCG2 complex is involved in protein ubiquitination and degradation. It includes components that participate in the ubiquitin-proteasome system, contributing to the regulation of protein abundance and cellular processes.
The RICH1/AMOT Polarity Complex is associated with cellular polarity and cytoskeletal regulation. It includes components that contribute to the establishment of cell polarity, influencing cellular architecture and organization.
The DNMT1-EHMT2-PCNA complex is associated with DNA methylation and maintenance of chromatin structure. It includes components that participate in the regulation of DNA methylation and replication, contributing to genomic stability.
The TRAP-SMCC Mediator Complex is involved in transcriptional regulation and RNA polymerase II activity. It includes components that mediate the interaction between transcriptional activators and the RNA polymerase II machinery, contributing to gene expression control.
The BRAF53-BRCA2 complex is associated with DNA repair and genomic stability. It includes components that participate in the repair of DNA double-strand breaks, contributing to the maintenance of genomic integrity.
The SNARE Complex, including STX1A and SNAP29, is involved in membrane fusion during vesicle trafficking. It facilitates the fusion of vesicles with target membranes, contributing to intracellular transport and cellular membrane dynamics.
The SNARE Complex, including STX6, VAMP3, VAMP4, and VAMP8, is involved in membrane fusion during vesicle trafficking. It facilitates the fusion of vesicles with target membranes, contributing to intracellular transport and cellular membrane dynamics.
The SNARE Complex, including STX16, VAMP3, and VAMP4, is involved in membrane fusion during vesicle trafficking. It facilitates the fusion of vesicles with target membranes, contributing to intracellular transport and cellular membrane dynamics.
The SNARE Complex, including STX6, VAMP3, and VTI1A, is involved in membrane fusion during vesicle trafficking. It facilitates the fusion of vesicles with target membranes, contributing to intracellular transport and cellular membrane dynamics.
The SNARE Complex, including STX6, STX16, VAMP4, VTI1A, and VTI1B, is involved in membrane fusion during vesicle trafficking. It facilitates the fusion of vesicles with target membranes, contributing to intracellular transport and cellular membrane dynamics.
The MTA1 complex is associated with chromatin remodeling and gene regulation. It includes components that contribute to the modification of chromatin structure, influencing gene expression and cellular processes.
The MTA2 complex is associated with chromatin remodeling and gene regulation. It includes components that contribute to the modification of chromatin structure, influencing gene expression and cellular processes.
The MTA1-HDAC Core Complex is involved in histone deacetylation and transcriptional regulation. It includes components that modify histone acetylation, influencing chromatin structure and the control of gene expression.
The KIF3A/B-PAR-3-aPKC-PAR-6 Complex is associated with cellular polarity and cytoskeletal regulation. It includes components that contribute to the establishment of cell polarity and influence cytoskeletal dynamics.
The Toposome is associated with DNA topoisomerase function and DNA structure regulation. It includes components that participate in the regulation of DNA topology, contributing to processes such as DNA replication and transcription.
The CEN Complex is associated with centromere function and chromosome segregation. It includes components that contribute to the assembly and maintenance of the centromere, ensuring proper chromosome segregation during cell division.
The FACT Complex is involved in chromatin transcription and nucleosome disassembly. It includes components that facilitate the passage of RNA polymerase through nucleosomes, contributing to the regulation of gene expression.
The KIN17-PCNA-RPA70 complex is associated with DNA repair and replication. It includes components that participate in the coordination of DNA replication and repair processes, contributing to genomic stability.
The p23 Protein Complex is involved in chaperone-mediated protein folding and stability. It includes components that assist in the folding of newly synthesized proteins, contributing to protein conformation and cellular function.
The RC Complex, S-Phase-Specific, is associated with DNA replication and cell cycle progression. It includes components that participate in the initiation of DNA replication during the S phase of the cell cycle, ensuring accurate genome duplication.
The RC Complex during G2/M-Phase of the cell cycle is associated with DNA replication and cell cycle progression. It includes components that participate in the regulation of DNA replication during the G2/M phase, ensuring accurate genome duplication.
The HNF4A-SUB1 complex is associated with transcriptional regulation and chromatin modification. It includes components that contribute to the modification of chromatin structure, influencing gene expression and cellular processes.
The RAN-SNUPN-XPO1 complex is involved in nucleocytoplasmic transport and cargo export. It includes components that mediate the transport of proteins between the nucleus and cytoplasm, contributing to cellular compartmentalization.
The Ubiquitin E3 Ligase (SKP1A, SKP2, CUL1, RBX1) is involved in protein ubiquitination and degradation. It marks specific proteins for degradation by the 26S proteasome, contributing to the regulation of cellular processes by controlling protein abundance.
The Ubiquitin E3 Ligase (FBXW11, SKP1A, CUL1, RBX1) is involved in protein ubiquitination and degradation. It marks specific proteins for degradation by the 26S proteasome, contributing to the regulation of cellular processes by controlling protein abundance.
The SNX Complex, including SNX1 and SNX6, is involved in membrane trafficking and sorting. It includes components that participate in the sorting of proteins within endosomes, contributing to cellular membrane organization and protein transport.
The Retromer Complex, including SNX1, SNX2, VPS35, VPS29, and VPS26B, is involved in endosomal trafficking and recycling of membrane proteins. It plays a role in the recycling of membrane proteins, contributing to cellular homeostasis and membrane dynamics.
The BAR-BCL2-CASP8 complex is associated with apoptosis and cell death regulation. It includes components that participate in the regulation of apoptosis, influencing cell survival and programmed cell death pathways.
The CD8A-LCK complex is associated with T-cell receptor signaling and immune response. It includes components that mediate T-cell activation, contributing to the immune response against specific antigens.
The 12S U11 snRNP is associated with pre-mRNA splicing and spliceosome assembly. It includes components that participate in the recognition and processing of U11 snRNA, contributing to the formation of functional spliceosomes.
The PKD2-FPC complex is associated with ion channel regulation and cellular homeostasis. It includes components that contribute to the regulation of PKD2 (Polycystic Kidney Disease 2) channels, influencing ion transport and cellular function.
The DNA Repair Complex NEIL2-PNK-Pol(Beta)-LigIII(Alpha)-XRCC1 is associated with base excision repair and genomic stability. It includes components that participate in the repair of DNA damage, contributing to the maintenance of genomic integrity.
The DNA Repair Complex NEIL1-PNK-Pol(Beta)-LigIII(Alpha)-XRCC1 is associated with base excision repair and genomic stability. It includes components that participate in the repair of DNA damage, contributing to the maintenance of genomic integrity.
The BIRC5-AURKB-INCENP-EVI5 complex is associated with mitosis and chromosome segregation. It includes components that contribute to the regulation of mitotic processes, ensuring accurate chromosome segregation during cell division.
The PCNA-KU Antigen complex is associated with DNA repair and replication. It includes components that participate in the coordination of DNA replication and repair processes, contributing to genomic stability.
The Frataxin complex is associated with iron-sulfur cluster biogenesis and mitochondrial function. It includes components that contribute to the maturation of iron-sulfur proteins, influencing cellular energy metabolism and mitochondrial function.
The EGFR-SNX1 complex is associated with endocytosis and receptor trafficking. It includes components that participate in the internalization of the epidermal growth factor receptor (EGFR), regulating its cellular localization and downstream signaling.
The eIF3 complex is involved in protein translation initiation. It includes multiple subunits, such as EIF3S6, EIF3S5, EIF3S4, EIF3S3, EIF3S6IP, EIF3S2, EIF3S9, EIF3S12, EIF3S10, EIF3S8, EIF3S1, EIF3S7, and PCID1, contributing to the assembly of the translation initiation complex and protein synthesis.
The DNA synthesome complex with 13 subunits is associated with DNA replication and synthesis. It includes components that participate in the coordinated synthesis of DNA strands during DNA replication, ensuring accurate genome duplication.
The SNX1-TFRC complex is involved in endocytosis and receptor trafficking. It includes components that participate in the internalization of transferrin receptor (TFRC), regulating its cellular localization and recycling.
The TFIIIC containing-TOP1-SUB1 complex is associated with transcriptional regulation and chromatin modification. It includes components that mediate the interaction between transcriptional activators, DNA topoisomerase I (TOP1), and SUB1, contributing to gene expression control.
The DNA synthesome core complex is associated with DNA replication and synthesis. It includes core components that participate in the coordinated synthesis of DNA strands during DNA replication, ensuring accurate genome duplication.
The DNA synthesome complex with 15 subunits is associated with DNA replication and synthesis. It includes components that participate in the coordinated synthesis of DNA strands during DNA replication, ensuring accurate genome duplication.
The DNA synthesome complex with 17 subunits is associated with DNA replication and synthesis. It includes components that participate in the coordinated synthesis of DNA strands during DNA replication, ensuring accurate genome duplication.
The 5S-DNA-TFIIIA-TFIIIC2-TFIIIB subcomplex is associated with transcription initiation and RNA polymerase III activity. It includes components that contribute to the assembly of the RNA polymerase III preinitiation complex, ensuring the initiation of transcription for 5S ribosomal RNA.
The AURKB-BIRC5-XPO1 complex is associated with mitosis and chromosome segregation. It includes components that contribute to the regulation of mitotic processes, ensuring accurate chromosome segregation during cell division.
The Chromosomal Passenger Complex (CPC) with INCENP, CDCA8, BIRC5, and AURKB is associated with mitosis and chromosome segregation. It includes components that contribute to the regulation of mitotic processes, ensuring accurate chromosome segregation during cell division.
The CF IIAm complex is associated with pre-mRNA processing and cleavage during polyadenylation. It includes components that participate in the cleavage of pre-mRNA, contributing to the maturation of mRNA transcripts.
The SMN complex with 10 subunits is associated with spliceosome assembly and pre-mRNA splicing. It includes components that participate in the assembly of the spliceosome, ensuring the proper splicing of pre-mRNA transcripts.
The SMN complex with 16 subunits is associated with spliceosome assembly and pre-mRNA splicing. It includes components that participate in the assembly of the spliceosome, ensuring the proper splicing of pre-mRNA transcripts.
The Histone H3.1 complex is associated with chromatin structure and histone deposition. It includes components that contribute to the incorporation of histone H3.1 into nucleosomes, influencing chromatin organization and gene regulation.
The Histone H3.3 complex is associated with chromatin structure and histone deposition. It includes components that contribute to the incorporation of histone H3.3 into nucleosomes, influencing chromatin organization and gene regulation.
The FA complex, or Fanconi Anemia Complex, is associated with DNA repair and genomic stability. It includes components that participate in the repair of DNA damage, contributing to the maintenance of genomic integrity.
The ING1-p300-PCNA complex is associated with transcriptional regulation and DNA replication. It includes components that modulate gene expression by interacting with ING1, p300, and PCNA, contributing to chromatin modification and DNA replication processes.
The ING1-PCNA complex is associated with transcriptional regulation and DNA replication. It includes components that modulate gene expression by interacting with ING1 and PCNA, contributing to chromatin modification and DNA replication processes.
The SNARE Complex, including SNAP23, STX4, and VAMP3, is involved in membrane fusion during vesicle trafficking. It facilitates the fusion of vesicles with target membranes, contributing to intracellular transport and cellular membrane dynamics.
The c-MYC-ATPase-Helicase Complex is associated with transcriptional regulation and chromatin remodeling. It includes components that participate in the regulation of gene expression, influencing chromatin structure and cellular processes.
The BCOR complex is associated with transcriptional regulation and chromatin modification. It includes components that contribute to the modification of chromatin structure, influencing gene expression and cellular processes.
The C complex spliceosome is associated with pre-mRNA splicing and spliceosome assembly. It includes components that participate in the formation of the spliceosome, ensuring the proper splicing of pre-mRNA transcripts.
The CDC5L complex is associated with pre-mRNA splicing and spliceosome assembly. It includes components that participate in the formation of the spliceosome, ensuring the proper splicing of pre-mRNA transcripts.
The EGFR-containing signaling complex is associated with receptor tyrosine kinase signaling and cellular responses. It includes components that mediate intracellular signaling cascades in response to epidermal growth factor receptor (EGFR) activation.
The ESCRT-III complex is involved in membrane remodeling and vesicle scission. It includes components that participate in the endosomal sorting complex required for transport (ESCRT), contributing to membrane abscission and vesicle formation.
The DNA Double-Strand Break End-Joining Complex is associated with DNA repair and rejoining of broken DNA ends. It includes components that participate in the non-homologous end-joining pathway, contributing to the repair of double-strand DNA breaks.
The ESCRT-I complex is involved in membrane remodeling and vesicle formation. It includes components that participate in the endosomal sorting complex required for transport (ESCRT), contributing to membrane abscission and vesicle formation.
The Rap1 complex is associated with cell adhesion and signaling. It includes components that participate in the regulation of cellular adhesion and intracellular signaling, influencing cellular responses and communication.
The E2F-6 complex is associated with cell cycle regulation and transcriptional control. It includes components that participate in the modulation of E2F transcription factors, influencing cell cycle progression and gene expression.
The Oligosaccharyltransferase complex with the Stt3A variant is involved in protein glycosylation. It includes components that facilitate the transfer of oligosaccharides to nascent proteins, contributing to proper protein folding and function.
The Oligosaccharyltransferase complex with the Stt3B variant is involved in protein glycosylation. It includes components that facilitate the transfer of oligosaccharides to nascent proteins, contributing to proper protein folding and function.
The TRF1-TIN2 complex is associated with telomere maintenance and regulation. It includes components that participate in the protection and length regulation of telomeres, influencing cellular senescence and genomic stability.
The TRF1 telomere length regulation complex is associated with telomere maintenance and regulation. It includes components that participate in the protection and length regulation of telomeres, influencing cellular senescence and genomic stability.
The Rap1 complex is associated with telomere maintenance and regulation. It includes components that participate in the protection and regulation of telomeres, influencing cellular senescence and genomic stability.
The TRF-Rap1 complex I is associated with telomere maintenance and regulation. It includes components that participate in the protection and length regulation of telomeres, influencing cellular senescence and genomic stability.
The Ubiquitin E3 Ligase with FBXW7, CUL1, SKP1A, and RBX1 is involved in protein ubiquitination and degradation. It marks specific proteins for degradation by the 26S proteasome, contributing to the regulation of cellular processes by controlling protein abundance.
The Tankyrin 1-Tankyrin 2-TRF1 complex is associated with telomere maintenance and regulation. It includes components that participate in the protection and length regulation of telomeres, influencing cellular senescence and genomic stability.
The H2AX complex is associated with DNA damage response and repair. It includes components that participate in the recognition and repair of DNA double-strand breaks, contributing to genomic stability.
The Ubiquitin E3 Ligase with BMI1, SPOP, and CUL3 is involved in protein ubiquitination and degradation. It marks specific proteins for degradation by the 26S proteasome, contributing to the regulation of cellular processes by controlling protein abundance.
The Ubiquitin E3 Ligase with H2AFY, SPOP, and CUL3 is involved in protein ubiquitination and degradation. It marks specific proteins for degradation by the 26S proteasome, contributing to the regulation of cellular processes by controlling protein abundance.
The H2AX complex I is associated with DNA damage response and repair. It includes components that participate in the recognition and repair of DNA double-strand breaks, contributing to genomic stability.
The H2AX complex II is associated with DNA damage response and repair. It includes components that participate in the recognition and repair of DNA double-strand breaks, contributing to genomic stability.
The WINAC complex is associated with transcriptional regulation and chromatin modification. It includes components that contribute to the modulation of gene expression and chromatin structure, influencing cellular processes.
The FIB-associated protein complex is associated with transcriptional regulation and chromatin modification. It includes components that contribute to the modulation of gene expression and chromatin structure, influencing cellular processes.
The BAF complex is associated with chromatin remodeling and transcriptional regulation. It includes components that contribute to the alteration of chromatin structure, influencing gene expression and cellular processes.
The PBAF complex, or Polybromo- and BAF-containing complex, is associated with chromatin remodeling and transcriptional regulation. It includes components that contribute to the alteration of chromatin structure, influencing gene expression and cellular processes.
The Ubiquitin E3 Ligase with SPOP, DAXX, and CUL3 is involved in protein ubiquitination and degradation. It marks specific proteins for degradation by the 26S proteasome, contributing to the regulation of cellular processes by controlling protein abundance.
The Apoptosome is associated with apoptosis and programmed cell death. It includes components that participate in the activation of caspases, leading to the initiation of apoptosis and cellular dismantling.
The BAF complex is associated with chromatin remodeling and transcriptional regulation. It includes components that contribute to the alteration of chromatin structure, influencing gene expression and cellular processes.
The EBAFa complex is associated with transcriptional regulation and chromatin modification. It includes components that contribute to the modulation of gene expression and chromatin structure, influencing cellular processes.
The Menin-associated histone methyltransferase complex is associated with transcriptional regulation and chromatin modification. It includes components that contribute to the methylation of histones, influencing gene expression and cellular processes.
The Ubiquitin E3 Ligase with SIAH1, SIP, SKP1A, and TBL1X is involved in protein ubiquitination and degradation. It marks specific proteins for degradation by the 26S proteasome, contributing to the regulation of cellular processes by controlling protein abundance.
The MLL-HCF complex is associated with transcriptional regulation and chromatin modification. It includes components that contribute to the modulation of gene expression and chromatin structure, influencing cellular processes.
The ALL-1 supercomplex is associated with transcriptional regulation and chromatin modification. It includes components that contribute to the modulation of gene expression and chromatin structure, influencing cellular processes.
The Neddylin ligase with FBXO11, SKP1, CUL1, and RBX1 is involved in protein neddylation, a post-translational modification. It marks specific proteins for neddylation, contributing to the regulation of cellular processes and protein function.
The HNRPF-HNRPH1 complex is associated with pre-mRNA splicing and mRNA processing. It includes components that participate in the splicing of pre-mRNA transcripts, contributing to the maturation of mRNA and gene expression.
The DCS complex with PTBP1, PTBP2, HNRPH1, and HNRPF is associated with mRNA processing and splicing regulation. It includes components that participate in the splicing of pre-mRNA transcripts, influencing the maturation of mRNA and gene expression.
The MKK4-ARRB2-JNK3 complex is associated with signaling pathways and cellular responses. It includes components that mediate the activation of JNK3 through the MKK4-ARRB2 signaling axis, influencing cellular responses to extracellular stimuli.
The Multiprotein Bridging Complex involved in Translationally Coupled mRNA Turnover is associated with mRNA degradation and turnover. It includes components that facilitate the coordinated turnover of translationally coupled mRNAs, influencing post-transcriptional gene regulation and mRNA stability.
The EIF4G1-HSP70-HSPA8-HNRNPD-PABPC1 complex is associated with mRNA translation and stability. It includes components that participate in the regulation of translation initiation, mRNA stability, and protein synthesis, influencing cellular processes related to gene expression.
The Large Drosha Complex is associated with miRNA biogenesis and mRNA processing. It includes components that participate in the cleavage of primary miRNA transcripts, contributing to the generation of mature miRNAs and post-transcriptional gene regulation.
The SNW1 complex is associated with RNA splicing and transcriptional regulation. It includes components that participate in the regulation of pre-mRNA splicing and transcriptional processes, influencing gene expression and cellular responses.
The FOXO3-PCAF complex is associated with transcriptional regulation and chromatin modification. It includes components that participate in the acetylation of FOXO3 transcription factor, influencing gene expression and cellular processes.
The GALNS-Lysosomal Hydrolase 1.27 MDa complex is associated with lysosomal function and degradation. It includes components that participate in the activity of lysosomal hydrolases, contributing to the degradation of cellular substrates and maintenance of cellular homeostasis.
The WDR5-ASH2L-RBBP5-MLL2 complex is associated with histone methylation and transcriptional regulation. It includes components that participate in the methylation of histones, influencing chromatin structure and gene expression.
The ASCOM complex is associated with transcriptional regulation and chromatin modification. It includes components that contribute to the modulation of gene expression and chromatin structure, influencing cellular processes.
The MOF complex is associated with histone acetylation and transcriptional regulation. It includes components that participate in the acetylation of histones, influencing chromatin structure and gene expression.
The LIN2-LIN7-SAP97 complex is associated with cell adhesion and signaling. It includes components that mediate the interaction between LIN2, LIN7, and SAP97, influencing cellular adhesion and intracellular signaling.
The Mis12 centromere complex is associated with chromosome segregation and kinetochore function. It includes components that participate in the assembly of the kinetochore complex, ensuring proper chromosome alignment and segregation during cell division.
The SMAD3/4-E2F4/5-p107-DP1 complex is associated with signaling pathways and cell cycle regulation. It includes components that mediate the crosstalk between SMAD and E2F signaling, influencing cellular responses and progression through the cell cycle.
The BHC110 complex is associated with transcriptional regulation and chromatin modification. It includes components that contribute to the modulation of gene expression and chromatin structure, influencing cellular processes.
The NCOR2 complex is associated with transcriptional regulation and chromatin modification. It includes components that contribute to the modulation of gene expression and chromatin structure, influencing cellular processes.
The IL4-IL4R complex is associated with cytokine signaling and immune responses. It includes components that mediate the interaction between interleukin-4 (IL4) and its receptor (IL4R), influencing cellular responses and immune regulation.
The IL-2Rgamma/IL-4R receptor-IL-4 complex is associated with cytokine signaling and immune responses. It includes components that mediate the interaction between IL-2Rgamma, IL-4R, and IL-4, influencing cellular responses and immune regulation.
The IL6ST-PRKCD-STAT3 complex is associated with cytokine signaling and cellular responses. It includes components that mediate the activation of STAT3 through IL6ST and PRKCD, influencing cellular responses to interleukin-6 (IL6) signaling.
The p300-SMAD1-STAT3 complex is associated with transcriptional regulation and signaling. It includes components that participate in the activation of STAT3 through p300 and SMAD1, influencing gene expression and cellular responses.
The PPP2CA-PPP2R1A-PPP2R3A complex is associated with protein phosphatase activity and cellular regulation. It includes components that participate in the regulation of protein phosphatase 2A (PPP2A), influencing cellular processes and signaling.
The IPO13-RAN-EIF1AX complex is associated with nuclear transport and protein synthesis. It includes components that participate in the import of EIF1AX into the nucleus, influencing translation initiation and cellular processes.
The TNPO2-RAN-NXF1 complex is associated with nuclear transport and mRNA export. It includes components that participate in the export of mRNAs from the nucleus, influencing post-transcriptional gene regulation and cellular processes.
The KPNB1-RAN-RANBP1 complex is associated with nuclear transport and regulation. It includes components that participate in the import of proteins into the nucleus, influencing cellular processes related to nuclear transport.
The Vigilin-DNA-PK-Ku Antigen complex is associated with DNA repair and processing. It includes components that participate in the repair of DNA double-strand breaks, influencing genomic stability and cellular responses to DNA damage.
The FA Core Complex (Fanconi Anemia Core Complex) is associated with DNA repair and response to DNA damage. It includes components that participate in the repair of DNA interstrand crosslinks, influencing genomic stability and cellular responses to DNA damage.
The E2F4-p107-CyclinA complex is associated with cell cycle regulation and transcriptional control. It includes components that participate in the inhibition of E2F transcription factors, influencing cell cycle progression and gene expression.
The ABL2-HRAS-RIN1 complex is associated with signaling pathways and cellular responses. It includes components that mediate the crosstalk between ABL2, HRAS, and RIN1, influencing cellular responses to extracellular stimuli.
The IL2-IL2RA-IL2RB complex is associated with cytokine signaling and immune responses. It includes components that mediate the interaction between interleukin-2 (IL2), IL2RA, and IL2RB, influencing cellular responses and immune regulation.
The TICAM1-TICAM2-TLR4 complex is associated with Toll-like receptor (TLR) signaling and immune responses. It includes components that mediate the activation of TLR4 through TICAM1 and TICAM2, influencing cellular responses to microbial stimuli.
The CTCF-Nucleophosmin-PARP-HIS-KPNA-LMNA-TOP complex is associated with chromatin organization and gene regulation. It includes components that participate in the regulation of gene expression and chromatin structure, influencing cellular processes.
The TLE1 Corepressor Complex (MASH1 Promoter-Corepressor Complex) is associated with transcriptional regulation and chromatin modification. It includes components that contribute to the modulation of gene expression and chromatin structure, influencing cellular processes.
The (E.F.G) complex is associated with protein synthesis and translation. It includes components that participate in the binding and hydrolysis of GTP during the elongation phase of protein synthesis, influencing the accuracy and efficiency of translation.
The SMN complex is associated with mRNA splicing and RNA processing. It includes components that participate in the assembly of small nuclear ribonucleoproteins (snRNPs), influencing pre-mRNA splicing and gene expression.
The SMN-containing complex is associated with mRNA splicing and RNA processing. It includes components that participate in the assembly of snRNPs, contributing to the regulation of pre-mRNA splicing and gene expression.
The SMN-PolII-RHA complex is associated with transcriptional regulation and RNA metabolism. It includes components that interact with RNA polymerase II (PolII) and RNA helicase A (RHA), influencing transcription and RNA processing.
The CPSF6-EWSR1-ITCH-NUDT21-POLR2A-UBAP2L complex is associated with RNA processing and mRNA stability. It includes components that participate in the regulation of mRNA cleavage and polyadenylation, influencing post-transcriptional gene regulation.
The MICB-KLRK1-HCST Complex is associated with immune responses and cell activation. It influences cellular processes related to immune recognition and activation. The complex plays a role in modulating natural killer (NK) cell activity and immune surveillance against infected or stressed cells.
The ULBP3-KLRK1-HCST Complex is crucial for immune responses and cell activation, particularly in regulating natural killer (NK) cell activity. It plays a vital role in immune surveillance, helping identify and respond to infected or stressed cells. The complex is essential for coordinating effective immune responses, emphasizing its importance in the body's defense mechanisms.
The MICA-KLRK1-HCST Complex is intricately involved in immune responses and NK cell activation. It acts as a key player in immune surveillance, facilitating the detection and response to infected or stressed cells. This complex plays a crucial role in enhancing the body's defense mechanisms against potential threats.
Crucial for immune responses, the ULBP2-KLRK1-HCST Complex actively regulates NK cell activity and contributes significantly to immune surveillance. By modulating the detection and response to infected or stressed cells, this complex plays a vital role in bolstering the body's immune defenses.
The Ubiquitin E3 Ligase (SMURF2) is associated with protein ubiquitination and degradation. It includes components that participate in the ubiquitination of target proteins, marking them for degradation and influencing cellular processes related to protein turnover.
The RNF11-SMURF2-STAMBP complex is associated with endocytic processes and signal transduction. It includes components that participate in the regulation of ubiquitin-dependent endocytosis, influencing cellular responses to extracellular signals.
The LINGO1-RTN4R-NGFR Complex is intricately associated with cellular functions related to nerve growth and guidance. It influences processes that regulate neural development and communication, playing a pivotal role in shaping the nervous system. This complex contributes to the intricate network of signaling events essential for proper neural function.
The SORT1-NGFR Complex plays a crucial role in cellular processes related to nerve growth and signaling. It actively participates in the modulation of neural development and communication, contributing to the intricate network of events governing proper nervous system function. This complex is vital for orchestrating signaling pathways essential for neural development.
The SORT1-NGFR-NGFB Complex is intimately involved in cellular functions crucial for nerve growth and guidance. It actively influences processes related to neural development and communication, contributing to the intricate signaling network governing proper nervous system function. This complex plays a vital role in shaping and regulating neural processes essential for overall neural function.
The MAD1L1-MAD2L1 complex is associated with mitotic checkpoint regulation and cell cycle control. It includes components that participate in the spindle assembly checkpoint, influencing the fidelity of chromosome segregation during cell division.
The JUN-TCF4-CTNNB1 complex is associated with transcriptional regulation and Wnt signaling. It includes components that participate in the modulation of gene expression and cellular responses to Wnt signals, influencing developmental processes.
The SMAD3-HEF1-APC10-CDH1 complex is associated with cell cycle regulation and TGF-beta signaling. It includes components that mediate the crosstalk between SMAD3, HEF1, and the anaphase-promoting complex (APC), influencing cellular responses to TGF-beta signals.
The PML-SMAD2/3-SARA complex is associated with TGF-beta signaling and cellular responses. It includes components that participate in the regulation of SMAD2/3 activation by TGF-beta, influencing cellular processes related to growth and differentiation.
The PIAS3-SMAD3-P300 complex is associated with transcriptional regulation and TGF-beta signaling. It includes components that participate in the modulation of SMAD3 activity, influencing gene expression and cellular responses to TGF-beta signals.
The ITGAE-ITGB2-CD11 complex is associated with cell adhesion and immune responses. It includes components that mediate the interaction between integrins and CD11, influencing cellular adhesion and immune cell functions.
The TSG101-VPS37B-VPS28 complex is associated with endosomal sorting and vesicle trafficking. It includes components that participate in the formation of multivesicular bodies (MVBs), influencing the sorting and degradation of cellular proteins.
The PKD2-PACS1 Complex is intricately involved in cellular processes related to ion transport and signaling. It actively participates in modulating ion channel activities and cellular signaling events, contributing to overall cellular function. This complex plays a vital role in regulating ion homeostasis and cellular responses.
The BMP4-TWSG1 Complex plays a crucial role in cellular functions related to growth factor signaling. It actively influences processes such as cell differentiation and proliferation, contributing to the regulation of cellular growth and development. This complex is essential for orchestrating signaling pathways crucial for proper cellular responses.
The BMP4-BGN Complex is intimately involved in cellular processes crucial for growth factor signaling. It actively participates in the modulation of cellular events related to cell growth, differentiation, and development, contributing to the intricate signaling network governing proper cellular responses. This complex is vital for cellular growth regulation.
The IL12A-IL12B-IL12RB1 Complex is associated with immune responses and cytokine signaling. It influences cellular processes related to immune regulation and response to infections, playing a pivotal role in shaping immune system activities. This complex contributes to the intricate network of signaling events essential for proper immune function.
The IL12B-IL12RB1-IL12RB2 Complex is intricately involved in immune responses and cytokine signaling. It actively participates in the modulation of cellular events related to immune regulation, contributing to the intricate signaling network governing proper immune function. This complex plays a vital role in shaping immune system activities.
The IL12A-IL12B-IL12RB2 Complex is associated with immune responses and cytokine signaling. It influences cellular processes related to immune regulation and response to infections, playing a pivotal role in shaping immune system activities. This complex contributes to the intricate network of signaling events essential for proper immune function.
The IL-12RB1/B2 Receptor-IL-12 Complex is involved in immune responses and cytokine signaling. It modulates cellular processes related to immune regulation and response to infections, contributing to the intricate signaling network governing proper immune function. This complex is crucial for orchestrating immune system activities.
The JAK2-IL12RB2 Complex is intricately associated with immune responses and cytokine signaling. It actively participates in the modulation of cellular events related to immune regulation, contributing to the intricate signaling network governing proper immune function. This complex plays a vital role in shaping immune system activities.
The CASP8-FADD-MALT1-BCL10 complex is associated with apoptotic signaling and immune responses. It includes components that participate in the activation of caspase-8 and downstream signaling, influencing cellular responses to apoptotic stimuli.
The CASP8-CHUK-IKBKB-MALT1-BCL10 complex is associated with NF-kappaB signaling and immune responses. It includes components that participate in the regulation of NF-kappaB activation, influencing cellular responses to inflammatory signals.
The TNFRSF11A-TRAF6-SRC complex is associated with osteoclast differentiation and RANK signaling. It includes components that participate in the regulation of TNFRSF11A (RANK) signaling, influencing cellular responses related to bone homeostasis.
The NFKB1-NFKB2-REL-RELA-RELB complex is associated with NF-kappaB signaling and immune responses. It includes components that participate in the modulation of NF-kappaB activity, influencing cellular responses to inflammatory signals.
The NFKB1-NFKB2-RELA-RELB complex is associated with NF-kappaB signaling and immune responses. It includes components that participate in the regulation of NF-kappaB activity, influencing cellular responses to inflammatory signals.
The CDC37-HSP90AA1-HSP90AB1-MAP3K11 complex is associated with protein folding and kinase regulation. It includes components that participate in the chaperone activity of HSP90, influencing the stability and activity of MAP3K11 and other client kinases.
The DNAJB2-HSPA8-PSMA3 complex is associated with protein folding and proteasomal degradation. It includes components that participate in the chaperone activity of HSPA8 and the regulation of proteasomal degradation, influencing protein quality control.
The MAP2K5-PRKCI-SQSTM1 complex is associated with cellular signaling and autophagy. It includes components that participate in the regulation of MAP2K5 and PRKCI, influencing cellular responses to stress and autophagic processes.
The HSF1-YWHAE complex is associated with heat shock response and cellular stress. It includes components that participate in the regulation of heat shock factor 1 (HSF1) activity, influencing cellular responses to heat stress and proteotoxicity.
The ITGAM-ITGB2-CD11 Complex is intricately involved in cellular processes related to immune responses and cell adhesion. It actively participates in modulating immune cell activities and cellular adhesion events, contributing to overall immune system function. This complex plays a vital role in mediating immune cell interactions and responses to various stimuli.
The YBX1-AKT1 Complex is associated with cellular processes crucial for signaling and regulation. It actively influences processes such as cell growth, survival, and proliferation, contributing to the regulation of cellular activities. This complex is essential for orchestrating signaling pathways crucial for proper cellular responses.
The AR-AKT-APPL complex is associated with androgen receptor (AR) signaling, AKT activation, and APPL1-mediated processes. It participates in the regulation of cellular responses to androgens, Akt signaling, and APPL1-mediated cellular functions.
The Ubiquitin E3 Ligase (CDC34, CUL1, RBX1) complex is a key player in the cellular machinery responsible for protein ubiquitination and degradation. It facilitates the transfer of ubiquitin molecules to target proteins, marking them for degradation. The complex is involved in the ubiquitin-proteasome system, a fundamental mechanism for controlling protein turnover and maintaining proper cellular function.
The CNS-P53 complex is associated with central nervous system (CNS) function and p53-mediated processes. It includes components that participate in the regulation of p53 activity within the context of CNS-related cellular functions.
The Ubiquitin E3 Ligase (CDC34, NEDD8, BTRC, CUL1, SKP1A, RBX1) regulates protein levels, ensuring proper cellular function. It marks specific proteins for degradation, contributing to cellular balance and responsiveness to environmental cues.
The Ubiquitin E3 Ligase (SMAD3, BTRC, CUL1, SKP1A, RBX1) complex is associated with ubiquitination and degradation of SMAD3. It includes components that regulate the turnover of SMAD3, influencing TGF-beta signaling and cellular responses to growth factors.
The Ubiquitin E3 Ligase (FBXO18, SKP1A, CUL1, RBX1) complex is involved in protein ubiquitination and degradation. It includes components that mediate the ubiquitination of specific target proteins, marking them for degradation by the proteasome.
The Ubiquitin E3 Ligase (NIPA, SKP1A, CUL1, RBX1) complex is involved in protein ubiquitination and degradation. It includes components that mediate the ubiquitination of specific target proteins, marking them for degradation by the proteasome.
The 9-1-1-FEN1 complex is associated with DNA repair and replication. It includes components that participate in the recognition of DNA damage, checkpoint activation, and recruitment of FEN1 during DNA repair and replication processes.
The RAD52-ERCC4-ERCC1 complex is associated with DNA repair and homologous recombination. It includes components that participate in the processing of DNA double-strand breaks, contributing to the repair of damaged DNA through homologous recombination.
The MSH2/6-BLM-p53-RAD51 complex is associated with DNA repair and recombination. It includes components that participate in mismatch repair, DNA unwinding, p53-mediated responses, and the recruitment of RAD51 during homologous recombination.
The MutS-alpha-PK-zeta complex is associated with DNA repair and translesion synthesis. It includes components that participate in mismatch repair, DNA damage tolerance, and translesion DNA synthesis through the recruitment of DNA polymerase zeta (PK-zeta).
The ASF1-histone containing complex is associated with histone chaperone activity and chromatin assembly. It includes components that facilitate the deposition of histones onto DNA during chromatin assembly and histone exchange processes.
The Cofilin-Actin-CAP1 complex is associated with actin dynamics and cytoskeletal regulation. It includes components that participate in the regulation of actin filament turnover and actin cytoskeleton dynamics through the activity of cofilin and CAP1.
The ITGAV-ITGB8-MMP14-TGFB1 Complex is intricately involved in the signaling cascades initiated by transforming growth factor-beta 1 (TGF-beta1). It plays a crucial role in cellular responses associated with TGF-beta1 signaling, including extracellular matrix remodeling. This complex significantly influences cell adhesion, migration, and various cellular processes mediated by TGF-beta1.
The ITGAV-ITGB5-PLAUR Complex is a key player in regulating cell adhesion and migration. It actively participates in cellular interactions with the extracellular matrix, modulating processes related to cell motility and adhesion. This complex holds significance in cellular dynamics and responses to extracellular cues, contributing to the orchestration of cell behavior.
The ITGAV-ITGB5-ICAM4 Complex is instrumental in orchestrating cellular adhesion and immune responses. By influencing interactions between cells and modulating adhesion molecules, this complex actively shapes immune responses. Its role extends to the modulation of cellular processes related to immune recognition and adhesion-based immune responses.
The ITGAV-ITGB5-ADAM9 Complex is a central player in cell adhesion and signaling processes. It actively influences cellular interactions, signaling pathways, and processes related to cell adhesion and the dynamics of the extracellular matrix. This complex's activity is crucial for cellular behavior and the modulation of extracellular signaling cues.
The ITGAV-ITGB5-SPP1 Complex holds significance in cell adhesion and signaling pathways associated with osteopontin (SPP1). It actively participates in cellular interactions and signaling cascades related to osteopontin-mediated processes. This complex plays a vital role in cellular responses to osteopontin, contributing to various physiological and pathological processes.
The ITGB6-FYN-FN1 Complex is a key participant in cell adhesion and signaling processes. It influences cellular interactions, signaling pathways, and processes associated with cell adhesion and the dynamics of the extracellular matrix. This complex's activity is integral to cellular behavior and responses to extracellular cues.
The ITGAV-ITGB6-SPP1 Complex plays a crucial role in cell adhesion and signaling pathways related to osteopontin (SPP1). It actively participates in cellular interactions and signaling cascades associated with osteopontin-mediated processes. This complex is essential for cellular responses to osteopontin, contributing to various physiological and pathological processes.
The ITGAV-ITGB6-TGFB3 Complex is associated with signaling events initiated by transforming growth factor-beta 3 (TGF-beta3). It actively participates in cellular responses related to TGF-beta3 signaling, influencing cell adhesion, migration, and processes mediated by TGF-beta3. This complex holds significance in orchestrating cellular dynamics in response to TGF-beta3 cues.
The ITGAV-ITGB3-CD47-FCER2 Complex plays a crucial role in cell adhesion and immune responses. It actively influences interactions between cells and immune responses by modulating adhesion molecules and immune receptors. This complex is central to shaping immune recognition and adhesion-based immune responses.
The ITGAV-ITGB3-ADAM15 Complex is involved in cell adhesion and signaling processes. It actively influences cellular interactions, signaling pathways, and processes related to cell adhesion and the dynamics of the extracellular matrix. This complex's activity is integral to cellular behavior and responses to extracellular signaling cues.
The ITGAV-ITGB3-PXN-PTK2b Complex is associated with cell adhesion and focal adhesion signaling. It actively influences cellular interactions, signaling pathways, and processes related to focal adhesion dynamics and cell motility. This complex plays a vital role in cellular responses to extracellular cues and is crucial for orchestrating cell behavior.
The ITGAV-ITGB3-EGFR Complex is involved in cell adhesion and epidermal growth factor receptor (EGFR) signaling. It actively influences cellular interactions, signaling pathways, and processes related to cell adhesion and responses to growth factors. This complex is central to cellular dynamics and responses to extracellular cues.
The FN1-TGM2 Complex is associated with interactions between fibronectin (FN1) and transglutaminase 2 (TGM2). It actively influences cellular adhesion, extracellular matrix dynamics, and processes related to tissue repair and remodeling. This complex plays a crucial role in orchestrating cellular responses to extracellular cues and contributing to tissue homeostasis.
The ITGA2B-ITGB3-FN1-TGM2 Complex is associated with platelet adhesion and aggregation. It actively influences platelet function, adhesion, and aggregation processes during hemostasis and vascular responses. This complex is crucial for maintaining platelet homeostasis and orchestrating responses to vascular cues.
The ITGA2b-ITGB3-CD47-SRC Complex is involved in platelet activation and signaling. It actively influences platelet adhesion, activation, and signaling processes during hemostasis and vascular responses. This complex is central to maintaining platelet homeostasis and orchestrating responses to vascular cues.
The ITGA5-ITGB1-FN1-TGM2 Complex is associated with cell adhesion and signaling processes. It actively influences cellular interactions, signaling pathways, and processes related to cell adhesion and the dynamics of the extracellular matrix. This complex's activity is integral to cellular behavior and responses to extracellular cues.
The ITGA5-ITGB1-ADAM15 Complex is involved in cell adhesion and signaling processes. It actively influences cellular interactions, signaling pathways, and processes related to cell adhesion and the dynamics of the extracellular matrix. This complex's activity is integral to cellular behavior and responses to extracellular signaling cues.
The ITGA4-ITGB1-THBS2 Complex is involved in cell adhesion and signaling processes. It actively influences cellular interactions, signaling pathways, and processes related to cell adhesion and the dynamics of the extracellular matrix. This complex's activity is integral to cellular behavior and responses to extracellular cues.
The ITGA2-ITGB1-CD47 Complex is crucial for cell adhesion and signaling processes. It actively influences cellular interactions, signaling pathways, and processes related to cell adhesion and immune responses. This complex plays a central role in shaping immune recognition and adhesion-based immune responses.
The ITGA2-ITGB1-CHAD Complex is associated with cell adhesion and signaling processes. It actively influences cellular interactions, signaling pathways, and processes related to cell adhesion and the dynamics of the extracellular matrix. This complex's activity is integral to cellular behavior and responses to extracellular cues.
The ITGA2-ITGB1-COL6A3 Complex is involved in cell adhesion and signaling processes. It actively influences cellular interactions, signaling pathways, and processes related to cell adhesion and the dynamics of the extracellular matrix. This complex's activity is integral to cellular behavior and responses to extracellular cues.
The ITGA1-ITGB1-COL6A3 Complex is crucial for cell adhesion and signaling processes. It actively influences cellular interactions, signaling pathways, and processes related to cell adhesion and the dynamics of the extracellular matrix. This complex's activity is integral to cellular behavior and responses to extracellular cues.
The ITGA9-ITGB1-ADAM15 Complex is associated with cell adhesion and signaling processes. It actively influences cellular interactions, signaling pathways, and processes related to cell adhesion and the dynamics of the extracellular matrix. This complex's activity is integral to cellular behavior and responses to extracellular cues.
The Multiprotein Complex involving CBLB, EGFR, and SH3KBP1 is a critical regulator of signaling cascades. It modulates pathways associated with cell growth, proliferation, and survival. This complex plays a pivotal role in mediating cellular responses to various external stimuli, contributing to cellular homeostasis and dynamic signaling.
The CBL-EGFR-SH3GL2-SH3KBP1 Complex is involved in the regulation of epidermal growth factor receptor (EGFR) signaling. It modulates pathways associated with cell growth, proliferation, and survival. This complex plays a pivotal role in mediating cellular responses to EGFR activation, contributing to cellular homeostasis and dynamic signaling.
The MET-CIN85-SH3GL3-CBL Complex is associated with hepatocyte growth factor receptor (MET) signaling. It modulates pathways related to cell growth, survival, and migration. This complex plays a crucial role in mediating cellular responses to MET activation, contributing to cellular homeostasis and dynamic signaling.
The p130Cas-ER-alpha-cSrc-kinase-PI3-kinase p85-Subunit Complex is involved in estrogen receptor (ER-alpha) signaling. It modulates pathways related to cell proliferation, survival, and estrogen receptor responses. This complex plays a crucial role in mediating cellular responses to estrogen, contributing to cellular homeostasis and dynamic signaling.
The SRC-PRKCD-CDCP1 Complex is associated with signaling cascades involving Src kinase and protein kinase C delta (PRKCD). It modulates pathways related to cell survival, migration, and cellular responses to external stimuli. This complex plays a vital role in mediating cellular responses to Src kinase and PRKCD activation, contributing to cellular homeostasis and dynamic signaling.
The CRK-CRKL-PDGFRA-RAPGEF1 Complex is involved in platelet-derived growth factor receptor alpha (PDGFRA) signaling. It modulates pathways related to cell growth, proliferation, and migration. This complex plays a crucial role in mediating cellular responses to PDGFRA activation, contributing to cellular homeostasis and dynamic signaling.
Involved in various cellular processes, the CIN85 Complex serves as a central hub for signaling cascades and cellular responses. It plays roles in endocytosis, vesicle trafficking, cytoskeletal organization, integrin signaling, and protein degradation. The components, including CIN85, CRK, BCAR1, CBL, PIK3R1, GRB2, and SOS1, collectively impact cell adhesion, migration, and growth.
The GIPC1-LHCGR Complex is associated with luteinizing hormone/choriogonadotropin receptor (LHCGR) signaling. It modulates pathways related to hormone signaling and cellular responses to luteinizing hormone. This complex plays a crucial role in mediating cellular responses to LHCGR activation, contributing to cellular homeostasis and dynamic signaling.
The GIPC1-NTRK1-RGS19 Complex is involved in neurotrophic tyrosine kinase receptor type 1 (NTRK1) signaling. It modulates pathways related to neuronal growth, survival, and neurotrophic signaling. This complex plays a crucial role in mediating cellular responses to NTRK1 activation, contributing to cellular homeostasis and dynamic signaling.
The NCR3-CD247 Complex is associated with immune responses and natural cytotoxicity. It modulates pathways related to natural killer (NK) cell activation and immune surveillance. This complex plays a vital role in mediating cellular responses to immune activation, contributing to cellular homeostasis and dynamic signaling.
The CRKL-WAS-WIPF1-ZAP70 Complex is involved in immune signaling cascades. It modulates pathways related to immune cell activation, including the activation of T cells. This complex plays a crucial role in mediating cellular responses to immune activation, contributing to cellular homeostasis and dynamic signaling.
The ERBB2-MEMO-SHC Complex is associated with ERBB2 (HER2) signaling. It modulates pathways related to cell growth, survival, and responses to ERBB2 activation. This complex plays a crucial role in mediating cellular responses to ERBB2, contributing to cellular homeostasis and dynamic signaling.
The LAT-PLC-gamma-1-p85-GRB2-CBL-VAV-SLP-76 Signaling Complex is involved in T cell receptor signaling. It modulates pathways related to T cell activation, including activation of downstream signaling molecules. This complex plays a crucial role in mediating cellular responses to T cell activation, contributing to cellular homeostasis and dynamic signaling.
The Cbl-SLP-76-Grb2 Complex is associated with immune signaling cascades. It modulates pathways related to immune cell activation and downstream signaling events. This complex plays a vital role in mediating cellular responses to immune activation, contributing to cellular homeostasis and dynamic signaling.
The SLP-76-Cbl-Grb2-Shc Complex is involved in immune signaling cascades. It modulates pathways related to immune cell activation and downstream signaling events. This complex plays a crucial role in mediating cellular responses to immune activation, contributing to cellular homeostasis and dynamic signaling.
The PLC-gamma-2-SLP-76-Lyn-Grb2 Complex is associated with immune signaling cascades. It modulates pathways related to immune cell activation and downstream signaling events. This complex plays a vital role in mediating cellular responses to immune activation, contributing to cellular homeostasis and dynamic signaling.
The PKC-alpha-PLD1-PLC-gamma-2 Signaling Complex is involved in signaling cascades associated with protein kinase C alpha (PKC-alpha) and phospholipase D1 (PLD1). It modulates pathways related to cellular responses to PKC-alpha activation and downstream signaling events. This complex plays a crucial role in mediating cellular responses to PKC-alpha activation, contributing to cellular homeostasis and dynamic signaling.
The HGF-Met Complex is associated with hepatocyte growth factor (HGF) signaling. It modulates pathways related to cell growth, survival, and responses to HGF activation. This complex plays a crucial role in mediating cellular responses to HGF, contributing to cellular homeostasis and dynamic signaling.
The EGFR-CBL-GRB2 Complex is involved in epidermal growth factor receptor (EGFR) signaling. It modulates pathways related to cell growth, proliferation, and responses to EGFR activation. This complex plays a crucial role in mediating cellular responses to EGFR, contributing to cellular homeostasis and dynamic signaling.
The PLC-gamma-1-SLP-76-SOS1-LAT Complex is associated with T cell receptor signaling. It modulates pathways related to T cell activation, including activation of downstream signaling molecules. This complex plays a crucial role in mediating cellular responses to T cell activation, contributing to cellular homeostasis and dynamic signaling.
The PDGFRA-PLC-gamma-1-PI3K-SHP-2 Complex is involved in platelet-derived growth factor receptor alpha (PDGFRA) signaling. It modulates pathways related to cell growth, proliferation, and migration. This complex plays a crucial role in mediating cellular responses to PDGFRA activation, contributing to cellular homeostasis and dynamic signaling.
The p56(LCK)-CAML Complex is associated with T cell receptor signaling. It modulates pathways related to T cell activation and immune responses. This complex plays a vital role in mediating cellular responses to T cell activation, contributing to cellular homeostasis and dynamic signaling.
The FGFR2-c-Cbl-Lyn-Fyn Complex is involved in fibroblast growth factor receptor 2 (FGFR2) signaling. It modulates pathways related to cell growth, survival, and responses to FGFR2 activation. This complex plays a crucial role in mediating cellular responses to FGFR2, contributing to cellular homeostasis and dynamic signaling.
The p21(ras)GAP-Fyn-Lyn-Yes Complex is associated with signaling cascades involving p21(ras)GAP, Fyn, Lyn, and Yes kinases. It modulates pathways related to cell growth, survival, and responses to external stimuli. This complex plays a vital role in mediating cellular responses to various signaling inputs, contributing to cellular homeostasis and dynamic signaling.
The CD20-LCK-LYN-FYN-p75/80 Complex is integral to B-cell receptor signaling, playing a crucial role in the modulation of B-cell activation and subsequent antibody production. Its components, including CD20, LCK, LYN, FYN, and p75/80, collectively contribute to the orchestration of immune responses.
Facilitating early endosome fusion and regulating vesicle trafficking, the RAB5-EEA1 Complex, featuring RAB5 and EEA1, is essential for maintaining cellular dynamics. It governs endocytic processes and ensures the efficient transport of cargo molecules within the cell.
The Class C VPS/HOPS Complex, composed of various subunits, serves a pivotal role in vesicle trafficking and organelle dynamics. By regulating intracellular protein transport, this complex contributes to the maintenance of cellular homeostasis.
Critical for B-cell receptor signaling, the CD19-VAV1-PIK3R1 Complex, consisting of CD19, VAV1, and PIK3R1, is instrumental in influencing B-cell proliferation and differentiation. Its activities significantly contribute to the proper functioning of the immune system.
Involved in insulin receptor signaling, the Sam68-p85 PI3K-IRS-1-IR Signaling Complex, comprising Sam68, p85 PI3K, IRS-1, and the insulin receptor (IR), modulates glucose metabolism and cellular sensitivity to insulin. It plays a crucial role in cellular responses to insulin stimulation.
The Chromosomal Passenger Complex CPC (INCENP, BIRC5, AURKB) is pivotal for ensuring accurate chromosome segregation during cell division. Comprising INCENP, BIRC5, and AURKB, this complex coordinates various mitotic events, contributing to faithful genetic material distribution.
Regulating cell cycle progression and mitosis, the RasGAP-AURKA-Survivin Complex, featuring RasGAP, AURKA, and Survivin, plays a critical role in controlling cell division, spindle assembly, and maintaining chromosomal stability. Its activities impact the fidelity of cellular replication.
Pivotal for mitotic progression, the Chromosomal Passenger Complex CPC (CDCA8, AURKB, BIRC5) ensures accurate chromosome segregation during cell division. The coordinated activities of CDCA8, AURKB, and BIRC5 contribute to the precision of mitotic events.
This complex is involved in the regulation of pre-mRNA splicing, consisting of PGC-1, SRp40, SRp55, and SRp75, modulates alternative splicing patterns. It exerts influence on gene expression and RNA processing, contributing to cellular diversity in mRNA transcripts.
Engaged in transcriptional regulation and mRNA processing, the POLR2A-CCNT1-CDK9-NCL-LEM6-CPSF2 Complex, composed of various subunits, actively participates in RNA polymerase activity and mRNA maturation. Its functions are crucial for the proper regulation of gene expression.
The BRD4 Complex is involved in the regulation of gene expression by recognizing acetylated lysine residues on histones. It acts as a crucial mediator in chromatin remodeling and transcriptional activation, contributing to the modulation of various cellular processes.
The P-TEFb-BRD4-TRAP220 Complex plays a pivotal role in transcriptional elongation by facilitating the release of paused RNA polymerase II. It coordinates with various factors to regulate gene expression, influencing cellular responses and differentiation.
Engaged in transcriptional regulation, the CDK8-MED6-PARP1 Complex is involved in modulating RNA polymerase II activity. Its functions contribute to the fine-tuning of gene expression and cellular processes, including DNA repair and maintenance.
The HES1 Promoter-Notch Enhancer Complex is crucial for Notch signaling pathway activation and subsequent transcriptional regulation. It modulates the expression of HES1, a key downstream target, influencing cellular differentiation and development.
The CREBBP-KAT2B-MYOD1 Complex is involved in muscle-specific gene activation and myogenic differentiation. It coordinates the acetylation of histones and transcription factors, contributing to the regulation of muscle-related genes and cellular differentiation.
Playing a role in transcriptional regulation, the MYC-MAX-KAT2A-TRRAP Complex is associated with the activation of MYC target genes. It modulates gene expression patterns, influencing cellular proliferation, apoptosis, and other MYC-associated functions.
The ESR1-CDK7-CCNH-MNAT1-MTA1-HDAC2 Complex is involved in estrogen receptor signaling and transcriptional regulation. It modulates the activity of estrogen receptor alpha (ESR1) and contributes to the regulation of estrogen-responsive genes, impacting cellular responses.
The ER-alpha-p53-HDM2 Complex is associated with the interplay between estrogen receptor alpha (ER-alpha), p53, and HDM2. It plays a role in coordinating cellular responses to estrogen and p53-mediated signaling, contributing to cell fate decisions.
The FOXO3-TP53 Complex involves the interaction between FOXO3 and TP53, contributing to the modulation of cell cycle progression and apoptosis. It plays a role in coordinating cellular responses to stress and regulating genes involved in cell fate determination.
The p53-SP1 Complex represents the interaction between p53 and SP1 transcription factor. It is associated with the regulation of genes involved in cell cycle control, apoptosis, and DNA repair, influencing cellular responses to various stressors.
The p53 Homotetramer Complex is a tetrameric assembly of p53 proteins, forming a functional unit involved in transcriptional regulation. p53 is a crucial transcription factor that plays a pivotal role in cell cycle control, apoptosis, and DNA repair. This complex is a key player in cellular responses to stress, influencing the fate of the cell in various conditions.
The RNA Polymerase II (RNAPII) complex is responsible for transcribing protein-coding genes into messenger RNA (mRNA). It is essential for gene expression, ensuring accurate and regulated mRNA production, a fundamental step in protein synthesis.
The BRCA1-Core RNA Polymerase II Complex represents the interaction between BRCA1 and the core subunits of RNA Polymerase II. This complex is involved in regulating transcription, particularly in the DNA damage response, contributing to maintaining genomic stability.
The SMAD3-SMAD4-cJun-cFos Complex is a signaling assembly within the transforming growth factor-beta (TGF-beta) pathway. It plays a role in mediating cellular responses to TGF-beta signaling, impacting cell growth, differentiation, and other essential cellular processes.
The ETS2-FOS-JUN Complex is implicated in gene expression regulation and cellular responses. This complex involves the ETS2 transcription factor, along with the FOS and JUN transcription factors, forming a regulatory network that modulates the expression of target genes, influencing various cellular functions.
The SMAD3-SMAD4-CTCF Protein-DNA Complex is a regulatory complex involved in gene expression control. Comprising SMAD3, SMAD4, and the CCCTC-binding factor (CTCF), this complex contributes to the modulation of transcriptional programs, influencing the accessibility of genes within the genome.
The SMAD3-SMAD4-SP1 Complex is associated with TGF-beta signaling and gene regulation. This complex involves SMAD3, SMAD4, and the SP1 transcription factor, contributing to the control of gene expression and influencing cellular responses to TGF-beta signaling.
The complex integrates TGF-beta signaling with the FOXO3-FOXG1, regulating cell cycle, apoptosis, and differentiation. SMAD3 and SMAD4 mediate TGF-beta, while FOXO3 and FOXG1 impact FOXO3-responsive genes and development. It modulates cell survival, proliferation, and overall cellular function.
The SMAD3-SMAD4-cJUN Complex is implicated in TGF-beta signaling and transcriptional regulation. This complex involves SMAD3, SMAD4, and the cJUN transcription factor, contributing to the modulation of gene expression and influencing cell proliferation and differentiation.
The LRP1-MMP9-TIMP1 Complex is involved in the regulation of extracellular matrix remodeling and tissue homeostasis. It plays a crucial role in controlling processes such as cell migration and angiogenesis by balancing the activity of matrix metalloproteinases.
Crucial for cellular regulation, this complex ubiquitinates proteins like CHEK1, influencing cell cycle progression and DNA damage responses. It ensures genomic stability and proper responses to stressors by controlling regulatory protein levels. Dysregulation can lead to aberrant cell cycle and compromised DNA repair.
This multisubunit complex regulates protein stability through ubiquitination, impacting cell cycle control, signal transduction, and homeostasis. It involves cullin proteins, the COP9 signalosome, RING box protein, and Skp1-like proteins in ubiquitinating specific substrates. Dysregulation is implicated in various diseases, highlighting its significance in cellular physiology.
Involved in phosphorylation events, this complex modulates chromatin dynamics and cellular processes. It includes casein kinase II and HMG1, impacting gene expression and participating in various pathways through phosphorylation. Dysregulation may contribute to aberrant signaling and diseases.
Essential in cellular phosphorylation, this complex with beta-dimer and alpha subunits influences signal transduction, transcriptional regulation, and the cell cycle. The beta-dimer provides stability and substrate recognition, and the alpha subunits catalyze phosphorylation reactions. It plays a crucial role in regulating diverse cellular functions and diseases.
A multifunctional complex in transcriptional regulation, this assembly with HCF-1 influences gene expression, cell cycle, and DNA repair. HCF-1, a coactivator and chromatin modifier, modulates gene expression and contributes to genomic stability through DNA repair processes. Dysregulation may impact various cellular processes and diseases.
Instrumental in NF-kappa-B signaling, this complex ubiquitinates NFKBIA, activating NF-kappa-B and modulating immune responses. Comprising BTRC, CUL1, and SKP1A, dysregulation disrupts NF-kappa-B signaling, contributing to inflammatory diseases and cancer.
Involved in ubiquitin-mediated degradation of NFKBIA, this complex regulates NF-kappa-B signaling and cellular homeostasis. Comprising FBXW11, CUL1, and SKP1A, dysregulation contributes to conditions associated with aberrant NF-kappa-B signaling.
Crucial in cellular adhesion and signaling, this complex links the extracellular matrix to the cytoskeleton. ITGB5 associates with PTK2 and PXN, impacting adhesion, migration, and signal transduction. Dysregulation can affect cell motility and contribute to conditions, including cancer metastasis.
A coactivator in transcriptional regulation, SRC-3 modulates hormone signaling, cell cycle, and cellular differentiation. Interacting with nuclear receptors, it enhances transcriptional activity, playing a crucial role in development, metabolism, and immune responses. Dysregulation is implicated in cancer and diseases.
Acting as a coactivator for nuclear receptors, SRC-1 influences gene transcription in hormone signaling and cell growth. It enhances transcriptional activity, playing a crucial role in diverse physiological processes. Dysregulation is linked to various diseases, emphasizing its importance in cellular functions.
The Set1B complex is involved in histone methylation, contributing to chromatin modification and transcriptional regulation. It participates in the deposition of specific methyl marks on histone proteins, influencing gene expression and chromatin structure. Dysregulation can impact cellular processes and contribute to diseases.
The Set1A complex is associated with histone methylation and transcriptional regulation. It catalyzes the methylation of histones, impacting chromatin structure and gene expression. Its proper functioning is crucial for the regulation of cellular processes and maintenance of genomic stability. Dysregulation may contribute to various diseases.
The TROY-NGR-LINGO1 Complex is involved in regulating nerve growth factor (NGF) signaling and axon regeneration. It comprises TROY, NGR, and LINGO1, influencing neurite outgrowth and axon regeneration responses to NGF. This complex plays a crucial role in neuroplasticity and neuronal growth regulation.
BLM Complex II is involved in DNA repair and maintenance of genomic stability. It includes components that participate in resolving DNA structures and preventing genomic instability. Dysregulation may lead to impaired DNA repair and increased susceptibility to genetic abnormalities.
The FA Complex (Fanconi Anemia Complex) is crucial for DNA repair and response to DNA damage. It includes components that participate in the repair of DNA interstrand crosslinks, contributing to genomic stability and cellular responses to DNA damage. Dysregulation is associated with Fanconi anemia and cancer predisposition.
The JUND-FOSB-SMAD3-SMAD4 complex is associated with transcriptional regulation and signaling pathways. It includes components that mediate the crosstalk between JUND, FOSB, SMAD3, and SMAD4, influencing cellular responses and gene expression. Dysregulation can impact cell fate decisions and contribute to diseases.
The 17S U2 snRNP is involved in pre-mRNA splicing, contributing to mRNA processing and maturation. It includes components that participate in the splicing of introns, influencing gene expression and post-transcriptional regulation. Dysregulation can lead to aberrant splicing events and affect cellular functions.
This ubiquitin ligase complex, involving UBE2N and UBE2V2, is crucial for protein ubiquitination and degradation. It regulates the stability of target proteins, impacting cellular processes such as signal transduction and protein turnover. Dysregulation can contribute to various diseases by affecting protein homeostasis.
The SMN complex is associated with RNA metabolism and processing. It includes Survival of Motor Neuron (SMN) protein, contributing to the assembly of small nuclear ribonucleoproteins (snRNPs). Dysfunction of the SMN complex is linked to spinal muscular atrophy (SMA) and affects RNA processing.
The SMAD3-SMAD4-FOXO3 Complex plays a crucial role in the TGF-beta pathway, regulating cell growth, apoptosis, and differentiation. It controls FOXO3's transcriptional activity in response to TGF-beta signals, influencing the expression of genes involved in various cellular functions and maintaining homeostasis.
The SMAD3-SMAD4-FOXO1 Complex is a key player in the TGF-beta pathway, modulating cell growth, apoptosis, and differentiation. It regulates FOXO1's transcriptional activity in response to TGF-beta signals, impacting the expression of genes crucial for diverse cellular functions and homeostasis.
The SMAD3-SMAD4-FOXO4 Complex is integral to the TGF-beta pathway, orchestrating cellular processes like cell growth, apoptosis, and differentiation. It precisely regulates FOXO4's transcriptional activity in response to TGF-beta signals, influencing the expression of genes vital for maintaining cellular homeostasis.
The MBD1-Suv39h1-HP1 complex is associated with epigenetic regulation and chromatin modification. It includes components that participate in DNA methylation and histone modifications, influencing gene expression and chromatin structure. Dysregulation can impact cellular processes and contribute to diseases.
The TERF2-RAP1 complex is involved in telomere maintenance and protection. It includes components that contribute to the regulation of telomere length and chromatin structure, impacting cellular senescence and genomic stability. Dysregulation can lead to telomere-related disorders and affect cellular lifespan.
This E3 ubiquitin ligase complex, including CRY1, SKP1A, CUL1, and FBXL3, is involved in circadian rhythm regulation. It targets CRY1 for ubiquitination, influencing the circadian clock and cellular responses to daily cycles. Dysregulation can disrupt circadian rhythms and contribute to various health conditions.
This E3 ubiquitin ligase complex, including CRY2, SKP1A, CUL1, and FBXL3, is involved in circadian rhythm regulation. It targets CRY2 for ubiquitination, influencing the circadian clock and cellular responses to daily cycles. Dysregulation can disrupt circadian rhythms and contribute to various health conditions.
The BRCA1 B complex is associated with DNA repair and maintenance of genomic stability. It includes components that participate in homologous recombination and repair of DNA double-strand breaks, influencing cellular responses to DNA damage. Dysregulation is linked to breast and ovarian cancers.
The 9-1-1-APE1 complex is involved in DNA damage response and repair. It includes components that recognize and bind to DNA damage, activating repair processes. Dysregulation can lead to impaired DNA repair and genomic instability.
The BRCA1-BARD1-BACH1-DNA Damage Complex II is associated with DNA repair and cellular responses to DNA damage. It includes components that participate in the recognition and repair of DNA double-strand breaks, influencing genomic stability. Dysregulation is linked to breast and ovarian cancers.
The BRCA1-BARD1-BACH1-DNA Damage Complex I is associated with DNA repair and response to DNA damage. It includes components that participate in the repair of DNA double-strand breaks, influencing genomic stability and cellular responses to DNA damage.
The E3 Ubiquitin Ligase (BRCA1, BARD1) - UbcH5c complex is associated with protein ubiquitination and degradation. It includes components that participate in the ubiquitination of target proteins, marking them for degradation and influencing cellular processes such as cell cycle regulation and DNA repair.
The BRCA1-BARD1-UbcH7c complex is associated with protein ubiquitination and degradation. It includes components that participate in the ubiquitination of target proteins, marking them for degradation and influencing cellular processes such as cell cycle regulation and DNA repair.
The BRCA1-RNA Polymerase II complex is associated with transcriptional regulation and DNA repair. It includes components that participate in the modulation of RNA polymerase II activity, influencing gene expression and cellular responses to DNA damage.
The RSmad complex is associated with signaling pathways and cellular responses. It includes components that mediate the transmission of signals through receptor-regulated SMADs (RSmads), influencing cellular responses to TGF-beta and BMP signaling.
The TIF1gamma-SMAD2-SMAD3 complex is associated with transcriptional regulation and chromatin modification. It includes components that contribute to the modulation of gene expression and chromatin structure, influencing cellular responses to TGF-beta and BMP signaling.
The SMAD4-SMAD2-SMAD3 complex is associated with signaling pathways and cellular responses. It includes components that mediate the crosstalk between SMAD2, SMAD3, and SMAD4, influencing cellular responses to TGF-beta and BMP signaling.
The DAXX-Axin-p53-HIPK2 Complex plays a crucial role in regulating RNA biosynthesis and transcription. Additionally, it functions as an enzyme regulator within the nucleus and is involved in modulating various cellular responses and signaling pathways.
The Axin-p53-HIPK2 Complex is a molecular assembly involved in the regulation of RNA biosynthesis and transcription. It acts as an enzyme regulator within the nucleus and plays a pivotal role in modulating various cellular responses and signaling pathways.
The ITGA5-ITGB1-FN-1-NOV Complex is a multiprotein complex that actively participates in cellular processes related to cytoskeleton organization and extracellular matrix organization. It is crucial for cell adhesion and communication, contributing significantly to tissue integrity and function.
The ING2 complex is associated with chromatin modification and transcriptional regulation. It includes components that participate in the modulation of histone acetylation, influencing chromatin structure and gene expression.
The ITGA5-ITGB1-CAL4A3 Complex is involved in cellular processes related to cytoskeleton organization and cell adhesion. It plays a crucial role in maintaining tissue integrity and facilitating cell communication.
The NuA4/Tip60 HAT Complex, also known as the Nucleosome Acetyltransferase of H4 Complex, is associated with DNA-templated transcription initiation. It functions as a histone acetyltransferase complex, contributing to the acetylation of histone proteins and transcriptional regulation.
The ITGA2b-ITGB3-CD9-GP1b-CD47 Complex is involved in cellular processes related to platelet activation and blood clotting. It plays a crucial role in mediating interactions between platelet surface receptors and facilitating hemostasis.
The CD20-LCK-FYN-p75/80 Complex is associated with intracellular signaling pathways and immune responses. It influences cellular processes related to lymphocyte activation and plays a role in modulating signal transduction cascades in the context of the immune system.
The Ubiquitin E3 Ligase (FBXW11, SKP1, CUL1) is involved in the ubiquitin-dependent protein catabolic process and protein ubiquitination. It functions as a molecular machinery responsible for tagging specific proteins with ubiquitin for degradation, regulating various cellular processes.
The Ubiquitin E3 Ligase (BTRC, CUL1, RBX1, SKP1) is associated with the ubiquitin-dependent protein catabolic process and protein ubiquitination. It plays a role in tagging proteins with ubiquitin for degradation, contributing to the regulation of cellular processes and protein turnover.
The ITGA5-ITGB3-COL6A3 Complex is involved in cellular processes related to extracellular matrix organization and cell adhesion. It plays a crucial role in maintaining tissue integrity and facilitating cell communication in the extracellular environment.
The BCR-ABL (p210)-GRB2-SOS1 Complex is associated with intracellular signaling pathways. It influences cellular processes related to signal transduction and plays a role in regulating cell proliferation and survival.
The SHC-GRB2 Complex is involved in intracellular signaling cascades. It plays a role in mediating interactions between proteins, contributing to the transmission of signals within the cell.
The ITGA2B-ITGB3-CD47-FAK Complex is associated with cellular processes related to cell adhesion and integrin signaling. It plays a role in mediating interactions between cell surface receptors and the extracellular matrix, contributing to cell migration and adhesion.
The Respiratory Chain Complex I (Intermediate VII/650kD) is a component of the mitochondrial electron transport chain. It participates in the transfer of electrons from NADH to ubiquinone, generating a proton gradient across the inner mitochondrial membrane and contributing to ATP synthesis.
The Respiratory Chain Complex I (Intermediate) is a component of the mitochondrial electron transport chain. It plays a crucial role in the transfer of electrons from NADH to ubiquinone, contributing to the establishment of a proton gradient across the inner mitochondrial membrane for ATP production.
The Respiratory Chain Complex I (Intermediate II/230kD) is a component of the mitochondrial electron transport chain. It participates in the transfer of electrons from NADH to ubiquinone, contributing to the establishment of a proton gradient and ATP synthesis across the inner mitochondrial membrane.
The PLC-gamma-2-Syk-LAT-FcR-gamma Complex is associated with immune responses and intracellular signaling cascades. It plays a role in mediating interactions between proteins involved in B-cell receptor signaling and contributes to the activation of downstream signaling pathways.
The PLC-gamma-2-Lyn-FcR-gamma Complex is involved in immune responses and intracellular signaling. It plays a role in mediating interactions between proteins associated with Fc receptor signaling, contributing to the activation of downstream signaling pathways in immune cells.
The PLC-gamma-2-LAT Complex is associated with immune responses and intracellular signaling cascades. It plays a role in mediating interactions between proteins involved in T-cell receptor signaling, contributing to the activation of downstream signaling pathways.
The Respiratory Chain Complex I (Beta Subunit) is a component of the mitochondrial electron transport chain. It participates in the transfer of electrons from NADH to ubiquinone, contributing to the establishment of a proton gradient and ATP synthesis across the inner mitochondrial membrane.
The GRB2-SOS1 Complex is involved in intracellular signaling pathways, specifically in the regulation of Ras activation. It plays a crucial role in transmitting signals from cell surface receptors to downstream signaling cascades, influencing cellular processes such as cell growth and differentiation.
The Ku Antigen-YY1-alphaMyHC Promoter Complex is associated with the regulation of gene expression. It plays a role in the modulation of alphaMyHC promoter activity, influencing processes related to muscle development and function.
The Respiratory Chain Complex I (Lambda Subunit) is a component of the mitochondrial electron transport chain. It participates in the transfer of electrons from NADH to ubiquinone, contributing to the establishment of a proton gradient and ATP synthesis across the inner mitochondrial membrane.
The LAT-PLC-gamma-1-p85-GRB2-SOS Signaling Complex is associated with intracellular signaling cascades, particularly in T-cell receptor signaling. It plays a role in mediating interactions between proteins involved in signal transduction, contributing to the activation of downstream signaling pathways in immune cells.
Involved in intracellular signaling pathways, particularly in the context of Notch signaling. Plays a role in influencing downstream signaling events and cellular responses related to cell survival and proliferation.
Associated with the regulation of gene expression and the Notch signaling pathway. Plays a role in influencing target gene transcription and cellular processes related to development and differentiation.
Associated with the regulation of gene expression and the Notch signaling pathway. Plays a role in influencing target gene transcription and cellular processes related to development and differentiation.
A transitional state of Complex I in the mitochondrial electron transport chain. Participates in the transfer of electrons from NADH to ubiquinone, contributing to the establishment of a proton gradient and ATP synthesis across the inner mitochondrial membrane.
Associated with intracellular signaling pathways, specifically in T-cell receptor signaling. Plays a role in contributing to the activation of downstream signaling cascades in immune cells.
Associated with intracellular signaling pathways, particularly in T-cell receptor signaling. Plays a role in influencing signal transduction cascades and cellular responses in immune cells.
Involved in intracellular signaling, particularly in T-cell receptor signaling. Facilitates the activation of downstream signaling pathways, contributing to cellular responses in immune cells.
Participates in the regulation of gene expression through the interaction of SMAD1 with the transcriptional coactivator CBP. Involved in the modulation of target gene transcription related to BMP signaling.
Associated with SMAD1 signaling and transcriptional regulation. The interaction between SMAD1, OAZ, and HsN3 influences target gene expression and cellular processes related to BMP signaling.
Plays a role in T-cell receptor signaling by coordinating intracellular signaling events. Contributes to the activation of downstream signaling pathways, influencing immune cell responses.
Involved in cellular processes associated with integrin-mediated signaling and angiogenesis. Plays a role in mediating responses to VEGFA, contributing to cellular functions related to vascular development.
Associated with the regulation of gene expression and cell cycle control. The interaction between SMAD3, E2F4/5, p107, and DP1 influences target gene transcription and cellular responses related to TGF-beta signaling.
Functions as a ubiquitin E3 ligase complex involved in the regulation of TGF-beta signaling. Mediates the ubiquitination and degradation of target proteins, influencing cellular responses to TGF-beta pathway activation.
Involved in the regulation of Wnt/beta-catenin signaling. The complex modulates the phosphorylation status and degradation of beta-catenin, influencing target gene expression and cellular processes related to Wnt signaling.
Plays a crucial role in the regulation of Wnt/beta-catenin signaling. Involved in the degradation of beta-catenin, influencing the modulation of target gene transcription and cellular responses related to Wnt pathway activation.
Functions as a ubiquitin E3 ligase complex involved in the regulation of cell cycle progression. Mediates the ubiquitination and degradation of p27, influencing the cell cycle transition from G1 to S phase.
Participates in the TGF-beta signaling pathway. Mediates the binding of TGF-beta3 to its receptor, initiating downstream signaling events that influence cellular responses related to TGF-beta pathway activation.
Participates in the TGF-beta signaling pathway. Mediates the binding of TGF-beta1 to its receptor, initiating downstream signaling events that influence cellular responses related to TGF-beta pathway activation.
Complex involved in mediating TGF-beta signaling. Coordinates the interactions between TGF-beta receptors, influencing downstream signaling events and cellular responses related to TGF-beta pathway activation.
Complex involved in mediating TGF-beta signaling. Coordinates the interactions between TGF-beta receptors and TGF-beta1, influencing downstream signaling events and cellular responses related to TGF-beta pathway activation.
Involved in the RNA interference (RNAi) pathway. Participates in the processing of small RNA molecules, influencing gene silencing and post-transcriptional regulation of target mRNAs.
Functions as a ubiquitin E3 ligase complex involved in the regulation of various cellular processes. Mediates the ubiquitination and degradation of specific target proteins, influencing diverse cellular functions.
Associated with the regulation of gene expression and cell fate determination. The interaction between SMAD2, SMAD4, and FAST1 influences target gene transcription and cellular responses related to TGF-beta signaling.
Participates in BMP signaling, influencing cellular responses related to bone morphogenetic protein (BMP) pathway activation. The complex modulates gene expression and cellular processes associated with BMP signaling.
Associated with the regulation of gene expression through enhancer activity. The complex is involved in modulating the transcriptional control of target genes, influencing diverse cellular processes.
Associated with the regulation of gene expression through enhancer activity. The complex is involved in modulating the transcriptional control of target genes, influencing diverse cellular processes.
Functions as a corepressor complex involved in transcriptional regulation. mSin3A mediates the repression of target genes by recruiting histone deacetylases (HDACs) and modulating chromatin structure.
Plays a role in transcriptional regulation. The MYC-MAX complex functions as a transcription factor involved in the activation of target genes, influencing cellular processes such as cell growth and proliferation.
Involved in ribosomal RNA (rRNA) processing. The complex participates in the maturation of pre-rRNA, contributing to the assembly of functional ribosomes and protein synthesis.
Functions in cellular processes related to extracellular matrix interactions. The complex mediates cell adhesion and signaling events associated with collagen type I, contributing to cellular functions related to tissue structure.
Involved in transcriptional regulation and chromatin modification. The complex includes components that mediate histone acetylation, influencing gene expression and chromatin structure remodeling.
Participates in the transcription of protein-coding genes. RNA Polymerase II complexes are responsible for synthesizing messenger RNA (mRNA) molecules, essential for protein synthesis and cellular function.
Involved in chromatin remodeling and transcriptional regulation. The complex, associated with Brg1, plays a role in modulating chromatin structure, influencing gene expression and cellular processes.
Participates in the transcription of protein-coding genes. RNA Polymerase II complexes are responsible for synthesizing messenger RNA (mRNA) molecules, essential for protein synthesis and cellular function.
Participates in the transcription of protein-coding genes. RNA Polymerase II complexes are responsible for synthesizing messenger RNA (mRNA) molecules, essential for protein synthesis and cellular function.
Participates in the transcription of protein-coding genes. RNA Polymerase II complexes are responsible for synthesizing messenger RNA (mRNA) molecules, essential for protein synthesis and cellular function.
Involved in histone modification and transcriptional regulation. The complex mediates the demethylation of histone H3 lysine 27 (H3K27), influencing gene expression and chromatin dynamics.
Participates in microRNA (miRNA) biogenesis. The complex is involved in the processing of precursor miRNAs, contributing to the regulation of gene expression at the post-transcriptional level.
Involved in signaling events associated with integrin-mediated cell adhesion. The complex facilitates intracellular signaling pathways, contributing to cellular responses related to cell adhesion and migration.
The DHX9-ADAR-Vigilin-DNA-PK-Ku Antigen Complex is involved in RNA metabolism and DNA damage response, playing essential roles in RNA processing, modification, and DNA repair. It contributes to maintaining nucleic acid integrity and cellular homeostasis.
Mediates cell adhesion and signaling events related to extracellular matrix interactions. The complex contributes to cellular responses associated with SPP1 (osteopontin), influencing processes such as cell migration and tissue development.
Functions in cell adhesion and extracellular matrix interactions. The complex mediates cellular responses associated with vitronectin (VTN), influencing processes such as cell migration and tissue structure.
The SMN Complex, composed of GEMIN2, SMN1, SNRPB, and SNRPDs, is crucial for spliceosomal assembly and pre-mRNA splicing. It plays a central role in the biogenesis of small nuclear ribonucleoproteins (snRNPs), contributing to proper RNA splicing processes.
Involved in transcriptional regulation. The complex participates in signaling pathways related to immune responses and influences gene expression associated with specific cellular functions.
Functions as a corepressor complex involved in transcriptional regulation. The complex mediates the repression of target genes and influences cellular processes related to gene expression and differentiation.
Involved in transcriptional regulation and gene activation. The complex facilitates the expression of target genes, influencing cellular processes related to gene activation and differentiation.
The POSH-AKT2 complex is involved in the regulation of apoptosis and cell survival. POSH (Plenty of SH3s) interacts with AKT2, a serine/threonine kinase, influencing its activity. This complex plays a pivotal role in balancing cellular processes related to programmed cell death (apoptosis) and cell proliferation.
The CAMK2-delta-MASH1 promoter-coactivator complex participates in the regulation of gene expression. Specifically, it acts as a coactivator for the MASH1 promoter. This complex is implicated in neuronal development, contributing to the differentiation of specific cell types, particularly in the context of neural tissues.
The GRB2-SOS1 complex is a key player in intracellular signaling, particularly within the Ras/MAPK pathway, facilitating the activation of Ras. This complex is central to signal transduction, influencing cellular processes such as proliferation and differentiation.
The Sulphiredoxin-peroxiredoxin complex is involved in cellular antioxidant defense, contributing to the reduction of peroxides. This complex plays a crucial role in maintaining cellular redox balance, protecting cells from oxidative stress, and supporting overall cell health.
The GNAQ-GEFT-RHOA complex regulates signaling pathways associated with G-protein-coupled receptors (GPCRs) and RhoA. This complex modulates cellular responses, including cell migration and cytoskeletal dynamics. It plays a significant role in controlling cell motility and shape changes through the activation of downstream effectors like RhoA.
This complex plays a crucial role in Notch signaling, a highly conserved pathway that regulates cell fate decisions, differentiation, and embryonic development. It facilitates interactions between specific domains of Notch2 and the Delta ligand, influencing cellular responses and developmental processes.
Operating within the Wnt signaling pathway, this complex modulates gene expression, impacting various cellular processes such as proliferation, differentiation, and embryonic development. It is a key player in maintaining cellular homeostasis and tissue development.
Essential for blood coagulation, this complex is a crucial component of the coagulation cascade. It regulates the activation of Factor Xa, playing a pivotal role in hemostasis and preventing excessive bleeding by ensuring proper blood clot formation.
Central to the Wnt/beta-catenin signaling pathway, this complex tightly controls the levels of beta-catenin, thereby influencing processes such as cell proliferation and embryonic development. Dysregulation of this pathway has implications in various diseases, including cancer.
Participating in apoptosis and DNA damage response, this complex is involved in the regulation of p53-dependent apoptotic pathways. It contributes to cellular defense mechanisms, ensuring genomic stability and preventing the propagation of damaged cells.
Governing the tumor suppressor protein p53, this complex plays a critical role in regulating cell cycle progression. By controlling the activity of p53, it acts as a safeguard against uncontrolled cell growth and serves as a crucial defense mechanism against cancer development.
Operating within growth factor signaling pathways, this complex transduces signals that regulate cell proliferation, differentiation, and survival in response to growth factors like PDGF. It plays a key role in orchestrating cellular responses to external stimuli for overall tissue homeostasis.
Involved in intracellular signaling cascades, this complex facilitates the transduction of signals from receptor tyrosine kinases. It is a central player in regulating cellular responses such as proliferation and differentiation, contributing to the coordination of complex signaling networks.
Integral to the TGF-beta signaling pathway, this complex regulates crucial cellular processes, including cell growth, differentiation, and apoptosis. Dysregulation of this pathway, often involving the SMAD4-SNO-SKI complex, is implicated in various diseases, particularly cancer.
Contributing to the organization of membrane protein complexes, this complex plays a key role in the assembly and stabilization of membrane proteins. It contributes to the maintenance of cell structure and function by ensuring the proper organization of essential membrane-associated components.
Implicated in the organization of membrane protein complexes, this complex is involved in the assembly and stabilization of membrane proteins. It contributes to maintaining cell structure and function by ensuring the proper organization of key membrane-associated components.
Operating in immune responses, this complex regulates natural killer (NK) cell activation. It plays a crucial role in the recognition and elimination of stressed or infected cells, contributing to immune surveillance and defense against pathogens. It is a key component of the immune defense machinery.
Crucial for gene regulation through the TGF-beta signaling pathway, this complex modulates cellular processes such as cell growth, differentiation, and apoptosis in response to TGF-beta signals. It serves as a molecular switch orchestrating diverse cellular responses in development and homeostasis.
Associated with the TGF-beta signaling pathway and epigenetic regulation, this complex influences gene expression patterns in response to TGF-beta signals. It plays a role in controlling cellular processes and contributes to the regulation of gene expression through histone modification.
Integral to DNA repair processes, this complex contributes to the repair of DNA double-strand breaks. It plays a pivotal role in maintaining genomic stability by preventing the accumulation of DNA damage, which could lead to mutations and contribute to the development of various diseases.
Involved in nuclear receptor signaling, this complex modulates gene expression in response to mineralocorticoids. It plays a crucial role in regulating ion balance and blood pressure through the mineralocorticoid receptor (NR3C2).
Participates in epidermal growth factor receptor (EGFR) signaling, regulating cellular responses to growth factors. It influences processes such as cell proliferation and survival by transducing signals initiated by EGFR activation.
This complex is involved in BMP2 (Bone Morphogenetic Protein 2) signaling, regulating various cellular processes including differentiation and development. It modulates gene expression patterns in response to BMP2, contributing to tissue homeostasis and embryonic development.
Extending the BMP2 signaling pathway, this complex includes TSG (Twisted gastrulation), contributing to the regulation of BMP2-mediated cellular processes. It plays a role in embryonic development and tissue patterning by modulating BMP2 signaling.
This pentameric complex is part of the TGF-beta signaling pathway. It regulates gene expression, impacting cellular processes such as cell growth, differentiation, and apoptosis. SKI interacts with SMAD2 and SMAD4 to modulate TGF-beta signaling cascades.
Similar to the SKI-SMAD2-SMAD4 complex, this complex is involved in TGF-beta signaling. It includes SMAD3 and SMAD4, contributing to the regulation of gene expression and cellular responses mediated by the TGF-beta signaling pathway.
This hexameric complex integrates the functions of CREBBP (CREB-binding protein) with SMAD2 in the context of TGF-beta signaling. It plays a role in modulating gene expression patterns, influencing cellular responses to TGF-beta signals and contributing to developmental processes.
Similar to the CREBBP-SMAD2 complex, this hexameric complex includes SMAD3. It participates in TGF-beta signaling, regulating gene expression and impacting cellular processes such as cell differentiation and embryonic development.
This pentameric complex incorporates CREBBP along with SMAD2 and SMAD4 in the TGF-beta signaling pathway. It contributes to the modulation of gene expression and cellular responses to TGF-beta signals, playing a role in developmental processes and tissue homeostasis.
Analogous to the CREBBP-SMAD2-SMAD4 complex, this pentameric complex includes SMAD3. It participates in TGF-beta signaling, influencing gene expression patterns and cellular responses in various developmental and homeostatic contexts.
This complex is involved in AKT signaling, regulating cellular processes such as cell survival and proliferation. TCL1, in trimeric form, interacts with AKT1, contributing to the modulation of AKT signaling cascades and influencing various aspects of cellular behavior.
Similar to the TCL1(trimer)-AKT1 complex, this complex involves TCL1 in trimeric form interacting with AKT2. It plays a role in AKT signaling, contributing to the regulation of cell survival, proliferation, and other cellular responses influenced by AKT signaling.
Operating in TGF-beta signaling, this complex regulates the degradation of SnoN, a negative regulator of TGF-beta responses. It modulates the balance of TGF-beta signaling, influencing cellular processes such as cell differentiation and tissue homeostasis.
Involved in vascular endothelial growth factor (VEGF) signaling, this complex plays a crucial role in angiogenesis. It includes the VEGF-A165 isoform, the VEGF receptor KDR, and the co-receptor NRP1, contributing to the regulation of blood vessel formation and maintenance.
As part of the ubiquitin-proteasome system, this E3 ligase complex is involved in the targeted degradation of specific proteins. It plays a role in regulating protein levels, influencing various cellular processes, and maintaining cellular homeostasis.
Operating in Wnt signaling, this complex modulates the stability and activity of beta-catenin (CTNNB1). It is crucial for regulating gene expression patterns and influencing cellular processes such as cell proliferation and embryonic development.
Similar to the CTNNAL1-CTNNB1 complex, this complex is involved in Wnt signaling. It regulates beta-catenin stability and activity, contributing to the modulation of gene expression and impacting cellular processes including cell proliferation and embryonic development.
As part of the translation initiation machinery, this complex, consisting of EIF3A, plays a crucial role in protein synthesis. It facilitates the binding of mRNA to the ribosome, initiating translation and influencing the overall rate of protein production within the cell.
Involved in endoplasmic reticulum-associated degradation (ERAD), this complex participates in the elimination of misfolded proteins. It includes SVIP, VCP, and DERL1, contributing to the quality control mechanism that ensures proper protein folding and cellular homeostasis.
This complex is associated with cell cycle regulation, specifically in controlling cell cycle progression. It includes E2F1, p107, and cyclinA, contributing to the modulation of key cell cycle checkpoints and influencing cellular responses to proliferative signals.
Operating in transcriptional regulation, this complex is involved in the assembly of the transcription factor complex (CTFC). It includes TAF1, contributing to the modulation of gene expression patterns and influencing cellular processes through the regulation of transcription.
This complex involves CTCF and nucleophosmin, playing a role in transcriptional regulation. It contributes to the organization of chromatin structure and the modulation of gene expression patterns, impacting various cellular processes influenced by transcriptional control.
Involved in the regulation of gene expression, this complex includes ELK1, SRF, and ELK3. It modulates the activity of transcription factors, influencing the transcriptional program and impacting cellular responses such as cell growth, differentiation, and survival.
This multiprotein complex includes various proteins associated with the polycystin-1 receptor. It plays a role in mechanosensory signaling, cell adhesion, and cytoskeletal organization, contributing to the regulation of diverse cellular processes and tissue homeostasis.
Operating in cytokine signaling, this complex includes JAK2, PAFR, and TYK2. It contributes to the transduction of signals initiated by cytokines, influencing cellular responses such as immune regulation, inflammation, and hematopoiesis.
Involved in DNA repair mechanisms, this complex participates in the repair of DNA double-strand breaks. It includes NCOA6, DNA-PK, Ku, and PARP1, contributing to the maintenance of genomic stability and preventing the accumulation of DNA damage.
This complex is associated with DNA repair processes and translational regulation. It includes DNA-PK, Ku, eIF2, NF90, and NF45, playing a role in coordinating DNA damage responses and modulating translational control in response to cellular stress.
Involved in Eph-ephrin signaling, this complex includes TIAM1, EFNB1, and EPHA2. It plays a role in mediating cell-cell communication and influencing cellular processes such as cell migration and tissue development through the Eph-ephrin signaling pathway.
Central to the TNF-alpha/NF-kappa B signaling pathway, this complex includes key components such as CHUK, KPNA3, NFKB2, NFKBIB, REL, IKBKG, NFKB1, NFKBIE, RELB, NFKBIA, RELA, and TNIP2. It regulates gene expression, inflammation, and immune responses.
This complex, involved in histone methylation, includes PTIP. It plays a role in epigenetic regulation, influencing chromatin structure and gene expression patterns. The PTIP-HMT complex contributes to the maintenance of cellular identity and proper cellular functioning.
Central to the TNF-alpha/NF-kappa B signaling pathway, this complex includes key components such as CHUK, BTRC, NFKB2, PPP6C, REL, CUL1, IKBKE, SAPS2, SAPS1, ANKRD28, RELA, and SKP1. It regulates gene expression, inflammation, and immune responses.
Involved in the maturation of kinases, this complex facilitates the proper folding and activation of specific kinases. It plays a crucial role in regulating cellular signaling cascades and kinase-mediated cellular responses.
This complex is associated with the ubiquitin-proteasome system, participating in the targeted degradation of specific proteins. It plays a role in maintaining protein homeostasis, regulating the levels of proteins, and influencing various cellular processes through targeted protein degradation.
Similar to Kinase maturation complex 1, this complex is involved in the maturation of kinases, ensuring their proper folding and activation. It contributes to the regulation of cellular signaling pathways and the modulation of kinase-mediated cellular responses.
Participates in the MAPK signaling pathway. It plays a role in transducing extracellular signals to the nucleus, influencing cellular responses such as cell growth, differentiation, and survival through the activation of MAPK signaling.
This complex involves the beta-dimer and alpha'-dimer of Casein kinase II. It is associated with the regulation of various cellular processes, including cell cycle progression, apoptosis, and signal transduction. Casein kinase II is a serine/threonine kinase with diverse substrates and plays a role in the control of cell functions.
Similar to the Casein kinase II (beta-dimer, alpha'-dimer) complex, this complex involves the beta-dimer and both alpha subunits (alpha, alpha') of Casein kinase II. It is implicated in the regulation of cell cycle, apoptosis, and signaling pathways, contributing to the control of cellular functions through phosphorylation events.
This complex includes the beta-dimer and alpha-dimer of Casein kinase II. It participates in the phosphorylation of target proteins, regulating various cellular processes such as signal transduction, gene expression, and cell cycle progression. Casein kinase II is involved in the control of cellular functions through its kinase activity.
Associated with the MAPK signaling pathway. It plays a role in transducing signals from the cell surface to the nucleus, influencing cellular responses such as cell growth, differentiation, and survival through the activation of ERK2 in the MAPK pathway.
This complex is a comprehensive assembly of components involved in TNF-alpha/NF-kappa B signaling. It includes CHUK, NFKB2, REL, IKBKG, SPAG9, NFKB1, NFKBIE, COPB2, TNIP1, NFKBIA, RELA, and TNIP2. It regulates gene expression, inflammation, and immune responses, acting as a key mediator in the cellular responses to TNF-alpha and NF-kappa B activation.
This complex is associated with DNA repair processes. It plays a role in the maintenance of genomic stability by participating in the repair of DNA double-strand breaks. The 53BP1-containing complex is crucial for preventing the accumulation of DNA damage and ensuring the integrity of the genome.
Another representation of the TNF-alpha/NF-kappa B signaling complex, this variant includes additional components such as RPL6, RPL30, RPS13, DDX3X, MAP3K8, RELB, GLG1, and GTF2I. It is involved in the regulation of gene expression, inflammation, and immune responses initiated by TNF-alpha/NF-kappa B signaling.
A variant of the TNF-alpha/NF-kappa B signaling complex, this version includes key components CHUK, NFKB2, REL, IKBKG, NFKB1, RELA, and TNIP2. It is central to the TNF-alpha/NF-kappa B signaling pathway, regulating gene expression, inflammation, and immune responses.
This complex is associated with the regulation of protein folding and stability. It includes CDC37, HSP90AB1, HSP90AA1, IKBKB, and KIAA1967. It plays a role in maintaining the proper folding and stability of client proteins, including those involved in signaling pathways and cellular functions.
Involved in DNA repair mechanisms, this complex participates in the repair of DNA double-strand breaks. It contributes to the maintenance of genomic stability and preventing the accumulation of DNA damage.
Associated with DNA repair processes. It participates in the repair of single-strand breaks and other DNA lesions, contributing to the maintenance of genomic integrity and cellular responses to DNA damage.
This complex is associated with translation initiation. It plays a role in regulating protein synthesis, specifically at the translation initiation step, influencing the overall rate of translation and cellular responses to changes in translation activity.
Involved in transcriptional regulation. It modulates gene expression patterns by participating in the Wnt signaling pathway and influencing the transcriptional program of target genes. The complex plays a role in cellular processes such as development, differentiation, and cell fate determination.
This complex plays a role in the Wnt signaling pathway. It participates in the modulation of gene expression patterns, influencing cellular processes such as development, differentiation, and cell fate determination through the Wnt signaling cascade.
Associated with the Wnt signaling pathway. It plays a role in transcriptional regulation, modulating the expression of target genes and influencing cellular processes such as development, differentiation, and cell fate determination through the Wnt signaling cascade.
This complex is a key player in the Wnt signaling pathway, contributing to cellular processes such as embryonic development, tissue homeostasis, and stem cell maintenance. It functions by modulating transcriptional regulation and influencing the expression of target genes.
Acting within the TNF-alpha/NF-kappa B signaling pathway, this complex plays a crucial role in regulating immune and inflammatory responses. It modulates the expression of genes involved in inflammation, apoptosis, and cell survival, contributing to the overall immune response.
Similar to Complex 6, this complex is an integral part of the TNF-alpha/NF-kappa B signaling pathway. It actively participates in regulating gene expression, immune responses, and inflammation, influencing cellular outcomes in response to TNF-alpha stimulation.
Operating in the TNF-alpha/NF-kappa B signaling cascade, this complex modulates NF-kappa B signaling pathways. It influences the expression of genes involved in immune responses, inflammatory processes, and cellular survival, thereby contributing to the cellular response to TNF-alpha.
Playing a vital role in oxygen sensing, this complex regulates the hypoxia response. It is involved in the degradation of the hypoxia-inducible factor 1-alpha (HIF1A) under normoxic conditions, preventing its accumulation and impacting cellular responses to changes in oxygen levels.
This complex is integral to cell-cell junctions, influencing cellular adhesion, communication, and tissue organization. It is associated with maintaining tissue integrity and morphology, contributing to the structural and functional aspects of cells within tissues.
Involved in oxygen-sensing mechanisms, this complex regulates responses to hypoxia. It modulates the stability of HIF1A under normoxic conditions, controlling the cellular adaptation to changes in oxygen availability and influencing downstream hypoxia-responsive pathways.
Operating in intracellular trafficking, this complex plays a role in regulating insulin-like growth factor 2 receptor (IGF2R). It impacts cellular responses to insulin-like growth factors and contributes to the proper functioning of the endocytic pathway and vesicular transport.
This complex is involved in cell-cell junctions, contributing to cellular adhesion, communication, and tissue organization. It plays a role in maintaining tissue integrity and morphology, influencing cellular interactions within tissues.
Active in focal adhesion signaling, this complex influences cellular processes such as migration, adhesion, and cytoskeletal dynamics. It participates in the regulation of signaling pathways associated with focal adhesion points, contributing to cellular responses to extracellular cues.
A key component of the TNF-alpha/NF-kappa B signaling pathway, this complex regulates gene expression, immune responses, and inflammation. It actively modulates cellular outcomes in response to TNF-alpha stimulation, influencing downstream signaling events and cellular behaviors.
Operating within the TNF-alpha/NF-kappa B signaling pathway, this complex plays a role in regulating gene expression, immune responses, and inflammation. It contributes to cellular responses to TNF-alpha, influencing downstream signaling pathways and cellular outcomes.
Involved in DNA repair and cell cycle regulation, this complex plays a crucial role in recognizing and repairing DNA double-strand breaks. It is essential for maintaining genomic stability, influencing cell cycle checkpoints, apoptosis, and cellular responses to DNA damage.
Modulating cell cycle transitions and cell adhesion, this complex regulates the activity of the anaphase-promoting complex/cyclosome (APC/C). It contributes to the proper progression of the cell cycle, impacting cell division, adhesion, and overall cellular homeostasis.
This complex is involved in modulating the stability and function of TP53 (p53). It plays a critical role in cellular responses to DNA damage, influencing cell cycle arrest, apoptosis, and DNA repair. It is a key player in maintaining genomic integrity and regulating cellular outcomes in response to stress.
Contributing to Rac1-mediated signaling, this complex is involved in the regulation of cell migration, cytoskeletal dynamics, and cell adhesion. It participates in signaling pathways associated with extracellular cues, influencing cellular responses to changes in the external environment.
Participating in signaling pathways regulating cell migration and extracellular cue responses, this complex influences actin cytoskeleton organization and cellular behaviors. It is involved in coordinating cellular responses to changes in the extracellular environment and modulating cell morphology.
Operating in antigen processing and presentation, this complex trims and processes antigenic peptides for MHC class I molecules. It plays a crucial role in immune responses, influencing the recognition of antigens by T cells and contributing to the adaptive immune system's surveillance mechanisms.
Associated with calcium signaling, this complex regulates intracellular calcium levels. It modulates calcium-dependent processes and cellular responses, playing a role in maintaining calcium homeostasis within cells and contributing to various cellular functions.
Involved in RNA interference (RNAi) and microRNA (miRNA) processing, this complex plays a key role in the maturation and function of miRNAs. It influences post-transcriptional gene regulation, contributing to the fine-tuning of gene expression and cellular responses to RNA-based signaling.
The GAIT (Gamma-activated inhibitor of translation) complex regulates mRNA translation in response to gamma interferon. It inhibits the translation of specific mRNAs, thereby influencing gene expression and contributing to immune responses.
The MLL1-WDR5 complex is essential for histone methylation, impacting chromatin structure and gene expression. This complex maintains transcriptional activation states, regulating various cellular processes such as cell cycle progression, stem cell maintenance, and differentiation.
The SERPINA1-ELA2 complex regulates elastase activity, preventing excessive inflammation and maintaining immune homeostasis. By inhibiting the proteolytic activity of elastase, this complex contributes to the balance of immune responses and prevents potential tissue damage.
The SERPINA3-CTSG complex modulates neutrophil cathepsin G (CTSG) activity, balancing inflammatory processes and preventing potential tissue damage. It contributes to homeostasis in inflammatory responses by regulating the proteolytic activity of CTSG.
The SERPINA1-CTSG complex regulates cathepsin G (CTSG) activity, modulating protease activity and contributing to the maintenance of homeostasis in inflammatory responses. It prevents potential tissue damage by controlling the proteolytic activity of CTSG.
The NGF-TrkA complex is central to neurotrophic signaling, influencing neuronal survival, differentiation, and synaptic plasticity. It plays a crucial role in the development and maintenance of the nervous system, promoting neuronal health and functionality.
The Neurotrophin-3-p75 complex is involved in signaling pathways related to neuronal development and function. It influences cell migration, differentiation, and synaptic plasticity in the nervous system, contributing to the overall development and functionality of neurons.
The GABBR2-HTR1A complex modulates neurotransmitter signaling, influencing neuronal excitability, neurotransmitter release, and mood regulation. This complex plays a role in the regulation of mood-related processes, impacting overall mood and emotional states.
The HSP70-BAG5-PARK2 complex is associated with the cellular stress response and protein quality control. It contributes to protein folding, degradation, and the cellular stress response under stress conditions, promoting cellular homeostasis during challenging situations.
The NGF-p75 complex regulates apoptotic signaling and neuronal development. It influences cell survival, differentiation, and apoptosis, playing a crucial role in shaping the fate of neurons during development and maintaining neuronal health in mature tissues.
The NRG1-IKZF4 complex participates in neural development signaling pathways, influencing processes such as cell migration, differentiation, and synaptic plasticity. It contributes to the proper development and functionality of the nervous system.
The EPO-EPOR complex is crucial for erythropoiesis, stimulating red blood cell production in response to hypoxia and maintaining oxygen homeostasis. This complex plays a key role in ensuring an adequate supply of oxygen to tissues and organs in the body.
The Mediator complex acts as a molecular bridge between transcription factors and RNA polymerase II during transcription initiation. Essential for the proper regulation of gene transcription, this complex ensures accurate and controlled gene expression in various cellular processes.
The DISC complex, consisting of FAS, FADD, and CASP8, initiates apoptosis signaling through the Fas cell surface death receptor. It regulates cell survival and death by transmitting signals leading to programmed cell death (apoptosis) in response to specific stimuli.
The MURR1-NF(kappa)Bp65-IKBA complex is involved in the regulation of NF-kappaB signaling, modulating inflammatory responses and immune reactions. This complex controls the activation and nuclear translocation of NF-kappaB, influencing gene expression in response to external stimuli.
The NF(kappa)B p50-p65-IKBA complex plays a central role in NF-kappaB signaling, regulating immune responses and inflammation. It controls the activation and nuclear translocation of NF-kappaB, modulating the expression of genes involved in the inflammatory response.
The TNFR1-TRADD-TRAF2-cIAP1 complex is involved in TNF-alpha signaling, transducing signals from tumor necrosis factor receptor 1 (TNFR1). It influences cellular responses, including apoptosis, survival, and inflammation, by regulating downstream signaling pathways.
The FADD-TRADD-TRAF2 complex is part of the TNF-alpha signaling pathway, mediating signals from death receptors. It regulates apoptosis and coordinates cellular responses to death-inducing signals, contributing to the control of cell survival and death in response to specific stimuli.
The CCNB1-CDK1-GADD45A-PCNA complex is involved in cell cycle regulation and DNA repair processes. It ensures proper cell cycle transitions and coordinates cellular responses to DNA damage, contributing to genomic stability and the maintenance of cellular integrity.
The CCNB1-CDK1-GADD45B-PCNA complex contributes to cell cycle regulation and DNA repair. It coordinates cellular responses to DNA damage, maintaining genomic integrity and ensuring proper cell cycle progression in response to specific stimuli.
The CCNB1-CDK1-GADD45G-PCNA complex, specifically involving GADD45G, is a variant involved in cell cycle regulation and DNA repair processes. It coordinates responses to genotoxic stress, contributing to the maintenance of genomic stability and cellular integrity.
The LMO4-gp130 complex is involved in signaling pathways, likely related to cellular processes and responses. While specific functions may vary, it potentially participates in mediating signals that influence cell behavior, development, or other regulatory processes.
The Stat1-alpha-dimer-CBP DNA-protein complex is associated with transcriptional regulation. It involves the binding of Signal Transducer and Activator of Transcription 1 (Stat1) in its alpha-dimer form to CBP (CREB-binding protein) on DNA, modulating gene expression.
The CNTF-CNTFR-gp130-LIFR complex is likely involved in cytokine signaling, particularly associated with Ciliary Neurotrophic Factor (CNTF). It may play a role in cellular responses, differentiation, or survival by transducing signals through the receptors CNTFR, gp130, and LIFR.
The LIFR-LIF-gp130 complex is associated with Leukemia Inhibitory Factor (LIF) signaling, potentially influencing cellular responses such as differentiation, survival, or immune modulation. It involves the receptors LIFR and gp130 in conjunction with LIF.
The LINC complex is a structure formed by Linker of Nucleoskeleton and Cytoskeleton (LINC) proteins. It functions as a bridge connecting the nuclear envelope to the cytoskeleton, contributing to nuclear positioning, stability, and mechanical integrity of the cell.
The Emerin-actin-NMI-(alphaII)spectrin complex potentially participates in nuclear envelope architecture and function. Emerin, actin, NMI (N-myc interactor), and alphaII spectrin may collaborate in maintaining nuclear structure, stability, and regulating interactions with the cytoskeleton.
The Emerin architectural complex likely plays a role in shaping the architecture and function of the nuclear envelope. It may involve various protein-protein interactions that contribute to the stability, organization, and integrity of the nuclear envelope structure.
Emerin complex 24 refers to a specific configuration of the Emerin complex, and its detailed functions may be context-dependent. It could be involved in specific cellular processes, signaling pathways, or interactions associated with Emerin and related proteins.
Similar to Emerin complex 24, Emerin complex 25 represents a distinct configuration of the Emerin complex. Its functions may be specific to certain cellular contexts, contributing to processes related to nuclear envelope function, signaling, or other regulatory roles.
Emerin complex 32, like the other Emerin complexes, denotes a specific arrangement of Emerin and associated proteins. Its functions may vary, potentially influencing cellular processes related to the nuclear envelope, gene regulation, or interactions with the cytoskeleton.
Emerin complex 52 represents another specific configuration of the Emerin complex. Its functions may include roles in nuclear envelope organization, stability, and potential interactions with other cellular components, contributing to overall cellular integrity and function.
The PSD95-FYN-NR2A complex is crucial for synaptic function at the postsynaptic density. It regulates synaptic plasticity, influencing neurotransmission strength. The complex functions involve synaptic plasticity, neurotransmission, signal transduction, postsynaptic organization, and potential contributions to learning and memory.
The FARP2-NRP1-PlexinA1 complex is likely involved in semaphorin signaling pathways. It potentially influences processes related to cell guidance, migration, and axon pathfinding during neural development.
Similar to the FARP2-NRP1-PlexinA1 complex, the FARP2-NRP1-PlexinA4 complex is likely associated with semaphorin signaling pathways. It may participate in regulating cellular responses related to axon guidance, migration, and other processes during neural development.
The SEMA4A-PlexinD1 complex is likely involved in semaphorin signaling. It may contribute to cellular processes such as axon guidance, cell migration, and regulation of the cytoskeleton during neural development.
The Nrp1-PlexinD1 complex is associated with semaphorin signaling and likely influences cellular responses related to axon guidance, cell migration, and cytoskeletal regulation. It contributes to neural development processes.
The SEMA3C-PlexinD1-Nrp1 complex is involved in semaphorin signaling pathways. It potentially regulates cellular processes such as axon guidance, migration, and cytoskeletal dynamics during neural development.
The PlexinC1-SEMA7A complex is likely associated with semaphorin signaling. It potentially influences cellular responses related to axon guidance, cell migration, and cytoskeletal regulation during neural development.
This complex is crucial for semaphorin signaling, a pathway involved in axon guidance and neuronal development. It plays a pivotal role in orchestrating the formation of neural circuits, ensuring proper connectivity in the nervous system.
This complex is a key player in ER-associated degradation (ERAD) and membrane protein quality control. It facilitates the recognition, ubiquitination, and subsequent degradation of misfolded or unwanted membrane proteins, ensuring cellular homeostasis.
Operating within the semaphorin signaling pathway, this complex contributes to axon guidance and neural circuit formation. It plays a crucial role in directing the growth of neuronal processes and establishing proper connections in the developing nervous system.
This complex is integral to vascular endothelial growth factor (VEGF) signaling, particularly involving the isoform VEGF-A165b. It influences angiogenesis, the process of blood vessel formation, and contributes to the regulation of vascular development and maintenance.
Involved in various cellular processes, this complex exhibits ubiquitin ligase activity and is associated with cytoskeletal organization. It participates in signaling pathways that regulate cell proliferation, adhesion, and migration, impacting cellular responses to external stimuli.
Playing a role in focal adhesion kinase (FAK) signaling, this complex is closely tied to integrin-mediated cellular functions. It contributes to the regulation of cell adhesion, migration, and survival, influencing processes essential for tissue development and homeostasis.
This complex is implicated in signal transduction pathways, where it may modulate cellular responses to various stimuli. It interacts with components involved in cell signaling, potentially influencing processes such as growth, differentiation, and survival.
Essential for endocytosis and receptor tyrosine kinase signaling, this complex participates in the internalization of cell surface receptors. It regulates the activity of receptor tyrosine kinases, impacting downstream signaling events and cellular responses to growth factors.
Contributing to endocytosis and the regulation of receptor tyrosine kinase activity, this complex is involved in modulating intracellular signaling cascades. It plays a role in the internalization and downregulation of cell surface receptors, affecting cellular responses to extracellular cues.
This complex is a key player in vascular endothelial growth factor (VEGF) signaling, specifically in the context of VEGF-C. It influences angiogenesis, lymphangiogenesis, and vascular development, contributing to the formation and maintenance of blood and lymphatic vessels.
Involved in VEGF signaling, particularly with VEGF-C, this complex plays a role in angiogenesis and lymphangiogenesis. It contributes to the regulation of vascular development and maintenance, influencing processes essential for proper tissue perfusion.
Integral to the transforming growth factor-beta (TGF-beta) signaling pathway, this complex transduces signals that regulate various cellular responses. It impacts processes such as cell growth, differentiation, and immune responses, playing a crucial role in tissue development and homeostasis.
Contributing to VEGF signaling through VEGFR3, this complex influences vascular development and lymphangiogenesis. It plays a role in the formation and maintenance of blood and lymphatic vessels, crucial for proper tissue perfusion and immune function.
Mediating semaphorin signaling, this complex regulates axon guidance and neural connectivity. It plays a crucial role in shaping the intricate network of neural circuits during development, ensuring proper communication between neurons.
Operating within the semaphorin signaling pathway, this complex regulates axon guidance and neuronal development. It facilitates the repulsion of growing axons, contributing to the establishment of proper neural circuitry during development.
The MRIT complex is associated with mRNA localization and translational regulation. It plays a role in mediating the transport of specific mRNAs to distinct cellular locations, influencing local protein synthesis and cellular responses to spatial cues.
Involved in semaphorin signaling, this complex contributes to the regulation of axon guidance and neuronal development. It participates in the repulsion of growing axons, ensuring proper connectivity in the developing nervous system.
This complex is crucial in the context of endothelial cell junctions and vascular signaling. It integrates signals from adherens junction proteins and VEGFR2, playing a role in endothelial barrier function, angiogenesis, and vascular homeostasis.
Also known as the extrinsic apoptotic pathway complex, this cytosolic complex is activated by CD95L (Fas ligand) and plays a central role in apoptotic cell death. It orchestrates caspase activation and cell death in response to extracellular death signals.
This membrane-associated complex, triggered by CD95L, is part of the extrinsic apoptotic pathway. It promotes caspase activation, leading to apoptotic cell death. The involvement of CFLAR modulates the balance between apoptosis and cell survival signals.
As a simplified version of the death-inducing signaling complex (DISC), this cytosolic complex is activated by Fas ligand (FAS) and initiates apoptosis. It involves the recruitment and activation of caspase-8 (CASP8) through the adaptor protein FADD.
Involved in cellular responses to oxidative stress, this complex regulates the activity of NRF2, a transcription factor that controls the expression of antioxidant genes. It plays a crucial role in maintaining cellular redox balance and protecting against oxidative damage.
A simplified DISC complex activated by CD95, this cytosolic complex triggers apoptosis by recruiting FADD and activating caspase-8. It represents a key component of the extrinsic apoptotic pathway initiated by death ligands.
This complex plays a role in the regulation of apoptosis. The tumor suppressor protein p53 interacts with the anti-apoptotic protein BCL2, influencing the balance between pro-apoptotic and anti-apoptotic signals. It contributes to the control of cell survival and programmed cell death.
The apoptosome is a multi-protein complex that plays a pivotal role in the intrinsic apoptotic pathway. It is formed in response to mitochondrial damage and facilitates the activation of caspase-9, initiating a caspase cascade leading to programmed cell death (apoptosis).
The DJ-1-SNCA complex is involved in the regulation of oxidative stress and plays a role in protecting cells from damage. This complex is implicated in maintaining cellular homeostasis and mitigating cellular damage caused by oxidative stress.
The PPD complex is involved in programmed cell death, participating in apoptotic signaling pathways. Its components coordinate to regulate cellular responses to various stimuli, contributing to the control of cell survival and death.
The AIF-CYPA-DNA complex plays a role in apoptotic processes and DNA degradation. Upon apoptotic stimuli, this complex translocates to the nucleus, where AIF induces chromatin condensation and DNA fragmentation, contributing to programmed cell death. CYPA acts as a regulator in this process.
The HSP90-CDC37-LRRK2 complex regulates the stability and function of leucine-rich repeat kinase 2 (LRRK2). LRRK2 is implicated in Parkinson's disease, and this complex modulates its activity and degradation pathways.
The AFAC10 complex plays a role in the regulation of apoptosis. It contributes to the activation of caspase-10, a key mediator of the extrinsic apoptotic pathway.
This complex is pivotal in mediating FAS-induced apoptosis. It involves the activation of caspase-8 and caspase-10, initiating a cascade of events that lead to programmed cell death.
The DISC complex is involved in apoptotic signaling. FAS (Fas cell surface death receptor) activates FADD (Fas-associated death domain protein), recruiting CASP8 (Caspase-8). This complex triggers apoptosis by initiating caspase cascades, leading to cell death. It plays a crucial role in regulating immune responses and eliminating damaged cells.
This complex is part of the apoptotic pathway. FAS engages FADD, which in turn recruits CASP10. Activation of this complex leads to the initiation of caspase cascades, contributing to programmed cell death. It plays a role in immune regulation and the elimination of cells through apoptosis.
This complex plays a role in transcriptional regulation and chromatin remodeling. APBB1 interacts with TSHZ3, and HDAC1 may be involved in histone deacetylation. The complex's specific functions and implications in cellular processes warrant further investigation.
Associated with the MAPK/ERK signaling pathway, this complex regulates cell proliferation and differentiation in response to extracellular signals. It involves key kinases and scaffold proteins that modulate the activity of downstream effectors.
This complex is part of the MAPK/ERK signaling pathway, influencing cellular responses to growth factors and external signals. It plays a role in regulating cell growth, survival, and differentiation.
The PPP2R1A-PPP2R1B-PPP2CA-PPME1-EIF4A1 complex is associated with the regulation of protein phosphatase 2A (PP2A) activity. It may modulate cellular signaling pathways and processes by influencing the dephosphorylation of target proteins.
Linked to the MAPK/ERK pathway, this complex modulates cellular responses to extracellular stimuli. It includes kinases and scaffold proteins that regulate the activation of downstream signaling components.
The BRAF-RAF1-14-3-3 complex is a key player in the MAPK/ERK signaling pathway, which regulates various cellular processes, including cell growth, proliferation, and differentiation. This regulation is crucial for maintaining proper cellular responses to extracellular signals and ensuring homeostasis in normal physiological conditions.
Orchestrates the activation of the MAPK/ERK signaling pathway, playing a crucial role in cellular processes such as cell proliferation, differentiation, and survival. It serves as a scaffold for RAF1 and MEK, facilitating their interaction and subsequent phosphorylation cascade.
Acts as a pivotal module in the MAPK/ERK pathway, contributing to the transduction of extracellular signals to the nucleus. This complex is involved in the regulation of cell growth, differentiation, and responses to external stimuli.
Mediates the signal transduction from RAS to RAF1, initiating the MAPK/ERK signaling cascade. This complex is central to the transmission of growth-promoting signals and is implicated in various cellular processes.
Facilitates cross-talk within the MAPK/ERK pathway, modulating downstream signaling events. It plays a key role in relaying signals that influence cellular responses to environmental cues.
The CNK1-SRC-RAF1 complex acts as a molecular platform that brings together key signaling molecules to efficiently transduce signals from cell surface receptors to the nucleus.This complex represents a critical node in cellular signaling, influencing various physiological responses to external stimuli.
Associates with CHIP and HSP90, potentially influencing LRRK2 stability and function. This complex may play a role in protein homeostasis and cellular stress responses, with implications in neurodegenerative disorders.
The LRRK2-FADD-CASP8 complex is involved in apoptotic signaling pathways, contributing to the regulation of programmed cell death. It responds to signals that impact cell survival and death, playing a crucial role in maintaining cellular homeostasis.
Plays a vital role in ubiquitin signaling, modulating NF-kappa B activation and participating in DNA repair processes. This complex contributes to the regulation of immune responses and genomic stability.
Linked to protein quality control and degradation pathways. STUB1, an E3 ubiquitin ligase, collaborates with HSPA8 and UBE2D2 to maintain protein homeostasis. This complex may influence cellular responses to misfolded or damaged proteins.
Involved in chaperone-mediated autophagy and protein quality control. BAG3 acts as a co-chaperone, and HSC70/HSPB8 are chaperone proteins, working in conjunction with CHIP, an E3 ubiquitin ligase. This complex plays a crucial role in maintaining cellular proteostasis.
The APP-TNFRSF21 complex is involved in regulating cell death, influencing neuronal functions, and modulating cellular communication pathways. It plays a role in regulating immune responses. Ongoing research aims to uncover its specific implications in various cellular contexts and its potential relevance to diseases, including Alzheimer's.
The TRA2B1-SRSF9-SRSF6 complex is involved in RNA splicing and processing. It contributes to the regulation of alternative splicing of pre-mRNA transcripts. This complex plays a role in generating mRNA diversity and modulating gene expression patterns.
The ACR-HSPA2-PDIA6 complex is associated with acrosome formation during spermatogenesis. It contributes to processes related to fertilization and male reproductive function.
The CART complex is involved in regulating neuropeptide signaling. It contributes to the modulation of neurotransmitter release and synaptic transmission. This complex plays a role in the central nervous system, influencing processes such as appetite and addiction.
The AFF4 super elongation complex (SEC) is involved in transcriptional elongation. It contributes to the regulation of RNA polymerase II activity during transcription. This complex facilitates the elongation phase of transcription and regulates gene expression.
Involved in various cellular processes, potentially influencing cell signaling and organization. The specific functions may vary depending on the cellular context, contributing to the regulation of cellular activities.
Associated with angiotensinogen, this complex plays a role in regulating the renin-angiotensin system. It may influence blood pressure regulation by modulating the production of angiotensin peptides, impacting vascular tone and fluid balance.
Implicated in the regulation of insulin-like growth factor (IGF) signaling. This complex, involving pregnancy-associated plasma protein-A (PAPP-A) and proMBP, cleaves IGF-binding proteins, modulating the availability of IGF for cellular responses and growth regulation.
Involves proMBP, angiotensinogen, and c3dg, potentially linking immune responses and complement activation. The specific functions may depend on the cellular context, contributing to the modulation of immune-related processes and complement cascade activation.
Plays a crucial role in calcium signaling, where STIM1 interacts with TRPV4 to activate TRPV4 ion channels. This complex influences cellular responses to changes in calcium levels, impacting processes such as cell differentiation, migration, and the regulation of intracellular calcium homeostasis.
Participates in protein folding and quality control processes. The complex involving BAG1 as a co-chaperone for HSC70 contributes to cellular protein homeostasis, ensuring proper folding and preventing the accumulation of misfolded proteins that can lead to cellular dysfunction.
Similar to the BAG1-HSC70 complex, this complex involving BAG1 and HSP70 is essential for protein folding and quality control within cells. BAG1 acts as a co-chaperone for HSP70, contributing to the maintenance of cellular protein integrity and preventing the buildup of misfolded proteins.
Comprises selenoprotein K (SELK) and associated proteins, participating in various cellular functions. SELK is involved in the regulation of endoplasmic reticulum-associated degradation (ERAD) and may play roles in oxidative stress responses, contributing to cellular homeostasis and stress adaptation.
The GM-CSF receptor complex is vital for cellular responses to granulocyte-macrophage colony-stimulating factor (GM-CSF). This cytokine stimulates the production and function of white blood cells, influencing immune responses and hematopoiesis in the bone marrow.
Involved in nucleocytoplasmic transport, the CSE1L-KPNA2-RAN complex facilitates the movement of proteins between the nucleus and cytoplasm. This process is crucial for the regulation of gene expression and cellular activities requiring the dynamic interchange of proteins across cellular compartments.
Facilitating nucleocytoplasmic transport, the KPNA2-KPNB1 complex ensures the controlled movement of proteins between the nucleus and cytoplasm. This process is critical for the regulation of gene expression, allowing cells to respond to various signals and environmental cues by modulating the localization of key proteins.
The KPNB1-RAN complex plays a vital role in nucleocytoplasmic transport, where KPNB1 interacts with the small GTPase RAN. Together, they regulate the bidirectional movement of macromolecules through nuclear pores, ensuring the precise spatial distribution of proteins and RNA molecules within the cell, essential for cellular function and integrity.
Functioning in apoptotic signaling, the TRIAL-DR5 complex activates the extrinsic pathway of apoptosis. TRIAL binding to DR5 initiates a cascade of events leading to programmed cell death, a crucial mechanism for eliminating damaged or unnecessary cells in response to specific signals.
The ACK1 signaling complex plays a multifaceted role in cellular processes. It contributes to signal transduction pathways, influencing cell proliferation and responses to growth factors. ACK1's involvement in various cellular functions highlights its significance in orchestrating diverse signaling events crucial for cell behavior.
Playing a role in apoptotic regulation, it contributes to the intricate process of programmed cell death. Caspase-10 activation within this complex is central to the initiation of apoptosis, and the involvement of SUMO, FADD (Fas-associated death domain), and Drp1 adds complexity to the regulation of apoptotic cell death.
Implicated in cancer-related signaling, the CDCP1-Src-EGFR complex promotes cell survival, migration, and invasion. It contributes to cancer progression by influencing key cellular processes that are often dysregulated in cancer cells, making this complex a potential target for cancer therapy.
Essential for mitotic regulation, it is involved in ensuring the proper alignment and segregation of chromosomes during cell division. This complex plays a pivotal role in orchestrating events critical for accurate cell division, contributing to genomic stability and preventing aberrant cell fates.
The STIP-USP7-Mdm2 complex regulates the stability and activity of the tumor suppressor protein p53. It modulates the ubiquitination and degradation of p53, influencing cellular responses to stress, DNA damage, and other signals, ultimately impacting cell cycle control and apoptosis.
The STIP-USP7-p53 complex is crucial for modulating the deubiquitination and stabilization of the tumor suppressor protein p53. This complex influences the transcriptional activity of p53, shaping cellular responses to stress, DNA damage, and other signals. The dynamic interplay within this complex contributes to the fine-tuning of p53-mediated cellular processes.
Involved in cellular stress and proliferation signaling, the p38gamma-Hsp90-K-Ras complex plays a role in regulating responses to external stimuli. It influences cellular growth and survival, contributing to cellular adaptations in the face of various environmental challenges.
Orchestrates cellular growth and metabolic processes by delicately modulating insulin-like growth factor 2 (IGF2) activity, contributing to the intricate balance between growth and metabolism. Its regulatory role ensures cellular homeostasis and physiological well-being.
Serves as a guardian of cellular cleanliness, actively participating in the identification and clearance of damaged cellular components. This complex is instrumental in cellular housekeeping, preserving cellular health and contributing to overall cellular stability.
Guides cellular behavior in extracellular matrix remodeling, actively influencing processes like cell migration and invasion. This complex plays a pivotal role in orchestrating cellular responses and maintaining tissue integrity within dynamic cellular environments.
Modulates Wnt signaling to impact gene expression and cellular responses related to growth and development. Acting as a regulator, this complex shapes the communication between cells and their environment, influencing cellular fate determination and tissue maintenance.
Acts as a guardian over vascular integrity, actively contributing to the structural preservation of blood vessels and preventing aberrant angiogenesis. This complex plays a pivotal role in maintaining the stability and functionality of the vascular system, ensuring a delicate equilibrium of vascular architecture.
Governs the activation of genes crucial for cellular responses to diverse stimuli, acting as a molecular conductor to regulate processes like cell proliferation and differentiation. Its orchestration of gene expression patterns plays an essential role in shaping cellular responses and determining cellular fate.
Navigates the cellular landscape as a molecular transporter along microtubules, facilitating essential processes such as ciliary transport and cellular organization. This complex acts as a cellular navigator, ensuring the proper movement of cellular cargo and contributing to the spatial organization of cellular structures.
Plays a pivotal role in cellular signaling pathways, influencing responses to stress and signaling cascades. This complex contributes to the modulation of cellular processes like cell survival and adaptation to changing environmental conditions. Its involvement in cellular signaling reflects its role in maintaining cellular resilience in dynamic cellular environments.
Serves as an architect of cellular organization, actively influencing intracellular trafficking and ciliary function. This complex is vital in orchestrating the movement of cellular cargo, preventing disruptions to cellular organization and maintaining cellular health.
Governs Notch signaling, actively influencing cellular decisions related to differentiation and tissue formation. This complex plays a pivotal role in shaping the cellular landscape during development, maintaining the delicate balance of cell fate determination and contributing to overall tissue homeostasis.
Plays a crucial role in the intricate network of growth and hormone response signaling, influencing processes like cell proliferation and differentiation. This complex integrates signals from growth factors and hormones, regulating cellular behavior and playing a key role in orchestrating responses to external cues.
Contributes to the architectural blueprint of cell polarity and membrane organization, influencing cellular adhesion and tissue structure. This complex participates in the formation and maintenance of cell-cell junctions, playing a crucial role in shaping cellular architecture and maintaining cellular integrity within tissues.
Similar to its counterpart, this complex actively contributes to cell polarity and membrane organization, influencing cellular adhesion and tissue structure. Playing a crucial role in the formation and maintenance of cell-cell junctions, this collaborative complex contributes to cellular architecture and tissue organization within dynamic cellular environments.
Modulates the dance of cellular adhesion and signaling, impacting cellular behavior and tissue organization. This complex actively influences the interaction between cell adhesion molecules and signaling pathways, shaping cellular behavior and influencing tissue structure in dynamic cellular environments.
Contributes to the harmonious orchestration of Notch signaling and cellular adhesion, actively influencing processes related to cell fate determination and tissue organization. This complex modulates Notch pathway activation, playing a key role in shaping cellular fate and maintaining the structural integrity of tissues within dynamic cellular environments.
Assumes a crucial role in cellular signaling, impacting essential processes such as cell adhesion, migration, and the intricate organization of the cellular cytoskeleton. This complex's multifaceted functions contribute significantly to the dynamic behavior of cells, influencing their responsiveness within the cellular environment.
Holds indispensable importance in blood clotting, orchestrating platelet interaction with von Willebrand factor (VWF) to facilitate platelet adhesion and aggregation. This collaboration ensures effective responses to vascular injuries, playing a pivotal role in the formation of blood clots to prevent excessive bleeding and maintain hemostasis.
Governs the cell cycle, overseeing critical checkpoints, DNA replication, and responses to DNA damage. Its regulatory influence extends to cell proliferation and the preservation of genomic integrity, intricately shaping the delicate balance of cellular processes that dictate the progression and maintenance of the cell cycle.
Participates actively in intracellular transport, potentially facilitating the movement of cellular cargo and exerting influence over cellular organization. This intricate involvement in transport processes contributes to the dynamic organization of cellular components, playing a vital role in maintaining cellular order and orchestrating the targeted delivery of essential cargo within the cell.
Linked to transcriptional regulation, this complex has the potential to influence gene expression patterns and cellular responses through its involvement in the modulation of transcriptional processes. Its regulatory role hints at its contribution to shaping cellular behavior by finely tuning the expression of genes within the cellular milieu.
Stands as a cornerstone in synaptic function and organization within neurons, actively influencing synaptic signaling, plasticity, and overall neuronal communication. By regulating the molecular architecture of synapses, this complex contributes significantly to the dynamic and responsive nature of neuronal networks, shaping the intricate interplay of signals within the nervous system.
Exerts influence over cell adhesion and tissue organization through its involvement in the formation and maintenance of adherens junctions. This collaborative effort contributes to the stability of cell-cell junctions and tissue integrity, playing a crucial role in ensuring the structural cohesion of cells within tissues and influencing cellular behavior through adhesion processes.
Potentially engages in epigenetic regulation and cellular responses related to DNA methylation, impacting gene expression patterns. This regulatory role hints at its involvement in modulating cellular behavior by influencing the epigenetic landscape and the cellular response to various stimuli.
Contributes significantly to cell-cell adhesion and signaling processes, actively influencing cellular adhesion and communication. By regulating adherens junctions and organizing cell-cell contacts, this complex plays a pivotal role in shaping cellular behavior and tissue structure, ensuring the orderly organization of cells and influencing dynamic cellular responses through adhesion mechanisms.
Potentially serves as a key player in transcriptional regulation and cellular processes related to gene expression. It plays a regulatory role in shaping the cellular landscape by influencing gene expression patterns and responses to external signals through Wnt signaling pathways.
Plays a role in the regulation of gene expression and epigenetic modifications, potentially influencing cellular processes related to transcriptional control and chromatin organization. This complex may contribute to the dynamic regulation of gene activity and the maintenance of cellular identity within specific contexts.
Impacts cellular signaling pathways, potentially influencing processes related to cell proliferation, differentiation, and the intricate modulation of Wnt signaling. This complex may contribute to the regulation of gene expression patterns and cellular responses, playing a role in cellular fate determination and tissue homeostasis.
Governs signaling events initiated by TNF receptor 1 (TNFR1), potentially influencing cellular responses such as apoptosis, inflammation, and immune regulation. This complex plays a key role in mediating the cellular effects of TNF, contributing to diverse signaling cascades and cellular outcomes in response to external stimuli.
Orchestrates cellular responses to TNF signaling, modulating processes such as apoptosis, inflammation, and immune regulation. The components of this complex play crucial roles in transducing signals from TNF, shaping cellular behavior, and contributing to the regulation of inflammatory and immune responses in dynamic cellular environments.
Potentially involved in transcriptional regulation and cellular processes related to gene expression. This complex may influence cellular responses by modulating gene activity and participating in the regulation of diverse cellular functions, contributing to the dynamic orchestration of cellular behavior.
Impacts cellular processes related to cell adhesion, migration, and signaling. The interaction between RHAMM and beta-catenin suggests a role in modulating cellular behavior by influencing adhesion mechanisms and participating in signaling cascades, potentially contributing to the regulation of tissue organization and cellular responses within dynamic environments.
Influences cellular adhesion and tissue organization through the regulation of E-cadherin and beta-catenin interactions. This complex may contribute to the stability of cell-cell junctions, influencing cellular adhesion and tissue integrity within dynamic cellular environments.
Potentially involved in the modulation of Wnt signaling and cellular processes related to transcriptional control. The interaction between OVOL2, beta-catenin, and TCF4 suggests a role in regulating gene expression patterns and influencing cellular responses, potentially contributing to the dynamic orchestration of cellular fate and tissue homeostasis.
Impacts cellular processes related to calcium signaling and intracellular transport. The interaction between Synexin and sorcin may contribute to the regulation of calcium homeostasis and intracellular processes, potentially influencing cellular responses and contributing to the maintenance of dynamic cellular environments.
Potentially involved in cellular processes related to protein glycosylation and quality control. The interaction between PEF1 and ALG2 suggests a role in modulating glycosylation processes and protein folding, contributing to the maintenance of proper protein function and the dynamic regulation of cellular processes in response to changing cellular conditions.
Involved in post-transcriptional regulation, potentially influencing mRNA stability and translation. This complex may contribute to the dynamic control of gene expression by modulating mRNA processing and protein synthesis within the cellular environment.
Participates in protein folding and quality control processes, potentially influencing cellular responses to protein misfolding and stress. The components of this complex may collaborate to ensure proper protein folding, maintaining cellular homeostasis and contributing to cellular resilience in response to stress conditions.
Involved in the assembly and function of the cytochrome c oxidase (COX) complex in the mitochondrial respiratory chain. This complex plays a crucial role in cellular energy production by contributing to the functionality of the electron transport chain and oxidative phosphorylation processes within mitochondria.
Mediates signaling events in cell growth, differentiation, and tissue repair, potentially influencing cellular responses related to proliferation and angiogenesis. The interaction between PDGFB and PDGFRB plays a key role in transducing signals that regulate cell behavior, contributing to processes such as tissue development and wound healing.
Plays a central role in blood clotting, contributing to the formation of blood clots in response to vascular injury. The fibrinogen complex is essential for platelet aggregation and blood coagulation, playing a pivotal role in hemostasis and wound healing within the circulatory system.
Involved in transcriptional regulation and chromatin remodeling, potentially influencing cellular responses related to gene expression control. This repressor complex may contribute to the silencing of specific genes, playing a role in the regulation of cellular processes such as cell cycle progression and differentiation.
Potentially involved in the regulation of androgen receptor (AR) signaling and cellular responses related to hormone-mediated processes. The components of this complex may contribute to the modulation of AR activity, influencing gene expression patterns and cellular behavior in hormone-responsive tissues.
Involved in histone modification and transcriptional regulation, potentially influencing processes related to gene expression and cellular differentiation. The MLL1 core complex plays a key role in shaping the epigenetic landscape and regulating gene activity, contributing to cellular identity and developmental processes within the cell.
Similar to MLL1, the MLL2 complex is involved in histone modification and transcriptional regulation, potentially influencing gene expression patterns and cellular responses. This complex may contribute to the modulation of the epigenetic landscape, playing a role in cellular differentiation and the regulation of specific genes involved in developmental processes.
Participates in histone modification and transcriptional regulation, potentially influencing cellular processes related to gene expression control. The MLL3 complex may contribute to the dynamic regulation of the epigenetic landscape, shaping gene activity and participating in cellular responses such as differentiation and maintenance of cellular identity.
Involved in histone modification and transcriptional regulation, potentially influencing processes related to gene expression and cellular differentiation. The MLL1 complex plays a key role in shaping the epigenetic landscape and regulating gene activity, contributing to cellular identity and developmental processes within the cell.
Similar to MLL1, the MLL4 complex is involved in histone modification and transcriptional regulation, potentially influencing gene expression patterns and cellular responses. This complex may contribute to the modulation of the epigenetic landscape, playing a role in cellular differentiation and the regulation of specific genes involved in developmental processes.
Involved in intracellular vesicle trafficking, potentially influencing processes related to protein transport and secretion. The TRAPP complex oligomer plays a crucial role in mediating vesicle tethering and fusion events, contributing to the dynamic organization of the cellular secretory pathway and intracellular trafficking.
Involved in histone modification and transcriptional regulation, potentially influencing gene expression patterns and cellular responses. The Set1A complex plays a role in establishing specific histone modifications, contributing to the regulation of gene activity and cellular processes such as differentiation and response to external signals.
Similar to Set1A, the Set1B complex is involved in histone modification and transcriptional regulation, potentially influencing cellular processes related to gene expression control. This complex may contribute to the modulation of the epigenetic landscape and the regulation of specific genes involved in cellular responses and developmental processes.
Participates in autophagy, influencing cellular responses related to the degradation of cellular components. This complex plays a crucial role in autophagosome formation and autophagic processes, contributing to the maintenance of cellular homeostasis and the clearance of damaged or unnecessary cellular structures.
Plays a role in receptor-mediated endocytosis of vitamin B12 and other ligands, potentially influencing cellular processes related to nutrient uptake. The Cubam complex facilitates the internalization of specific molecules, contributing to the cellular acquisition of essential nutrients and the regulation of nutrient homeostasis.
Involved in the regulation of DNA replication and cell cycle progression, potentially influencing processes related to DNA synthesis and repair. The components of this complex play a role in coordinating cell cycle events and ensuring the faithful duplication of the genome, contributing to cellular proliferation and maintenance of genomic integrity.
Participates in the regulation of hypoxia-inducible factor 1 alpha (HIF1alpha), influencing cellular responses to changes in oxygen levels. This complex plays a key role in the degradation of HIF1alpha, modulating cellular adaptation to hypoxic conditions and influencing processes such as angiogenesis and metabolism.
Potentially involved in receptor tyrosine kinase signaling, influencing cellular responses related to cell growth and differentiation. The interaction between ERBB3 and SPG1 suggests a role in modulating intracellular signaling cascades, contributing to the regulation of cellular behavior and responses to extracellular signals.
Similar to ERBB3-SPG1, the ERBB2-SPG1 complex is potentially involved in receptor tyrosine kinase signaling, influencing cellular responses related to cell growth and differentiation. This complex may contribute to the modulation of intracellular signaling pathways and cellular behavior in response to extracellular signals.
Involved in cellular signaling pathways, potentially influencing processes related to cell proliferation, migration, and gene expression. The components of this complex may contribute to the modulation of intracellular signaling cascades, playing a role in cellular responses to growth factors and external stimuli.
Participates in cell signaling and protein folding, potentially influencing cellular responses related to cell adhesion, migration, and protein stability. The components of this complex play a role in modulating intracellular signaling pathways and ensuring proper protein folding, contributing to the regulation of cellular behavior and responses to external cues.
Involved in calcium signaling and regulation of muscle contraction, potentially influencing processes related to intracellular calcium homeostasis. This complex plays a crucial role in maintaining proper calcium levels within cells, contributing to the regulation of muscle function and cellular responses in excitable tissues.
Potentially involved in the regulation of protein degradation and quality control, influencing cellular responses related to proteostasis. The components of this complex may contribute to the removal of misfolded or damaged proteins, playing a role in maintaining cellular homeostasis and preventing the accumulation of toxic protein aggregates.
Plays a role in cellular signaling, potentially influencing processes related to cell adhesion, migration, and guidance. The complex may contribute to the regulation of neuronal development and connectivity by participating in signaling pathways that guide the growth of neuronal processes and the establishment of synaptic connections.
Similar to its counterpart with UNC5B, this complex may be involved in cellular signaling pathways influencing processes related to cell adhesion, migration, and guidance. It potentially contributes to the regulation of neuronal development and connectivity, participating in signaling cascades that guide the growth of neuronal processes and synaptic connections.
Involved in cellular signaling, potentially influencing processes related to cell adhesion, migration, and guidance. The complex may contribute to the regulation of neuronal development and connectivity, participating in signaling pathways that guide the growth of neuronal processes and the establishment of synaptic connections.
Potentially participates in intracellular membrane trafficking and lipid transport processes. The complex may play a role in regulating the movement of cellular components within the cell, contributing to membrane dynamics and cellular organization.
Involved in intracellular membrane trafficking and recycling processes. The complex may contribute to the regulation of endocytic pathways and the recycling of cellular components, influencing membrane dynamics and maintaining cellular organization.
Involved in intracellular vesicle trafficking and membrane dynamics, contributing to the regulation of cellular membrane structure and function.
Plays a role in membrane trafficking processes and cellular membrane dynamics, potentially influencing cellular organization and transport of vesicular cargo.
Functions in cellular processes that may include membrane dynamics, vesicle trafficking, or other molecular interactions contributing to cellular function. The specific functions of this complex may vary depending on the context and cellular environment.
Participates in signaling pathways related to vascular endothelial growth and development, potentially influencing cellular responses to angiogenic signals and contributing to the regulation of vascular integrity.
Involved in transcriptional regulation, modulating gene expression patterns related to cellular processes such as growth, differentiation, and survival. This complex may influence cellular responses to various signals, contributing to the control of gene expression and cellular behavior.
Functions in the regulation of actin cytoskeleton dynamics and membrane trafficking, potentially influencing cellular morphology, movement, and vesicle transport. This complex plays a role in cellular organization and dynamics.
Participates in chromatin remodeling and transcriptional regulation, influencing gene expression patterns and potentially contributing to cellular responses related to development, differentiation, and other processes.
Involved in cellular processes related to cell cycle regulation and proliferation. This complex may contribute to the control of cell cycle progression and the modulation of cellular growth through interactions with key regulators of the cell cycle, such as cyclin D1 (CCND1).
Functions in transcriptional regulation and chromatin remodeling, influencing gene expression patterns and contributing to cellular responses related to development, differentiation, and other processes. This complex plays a role in the modification of chromatin structure and the control of gene expression.
Plays a role in actin cytoskeleton dynamics and cellular membrane trafficking, contributing to cellular organization, vesicle transport, and potentially influencing processes such as cell movement and morphology. This complex is involved in the regulation of cellular structure and dynamics.
Participates in TGF-beta signaling, regulating cellular responses such as differentiation and proliferation. The complex modulates the Hippo pathway, influencing transcriptional activity and cellular growth.
Plays a role in TGF-beta signaling, regulating processes like cell differentiation and growth. Additionally, it modulates the Hippo pathway, impacting transcriptional activity and cellular responses to environmental cues.
Contributes to gene regulation, particularly in cardiac development. This complex influences transcriptional activity and participates in pathways related to heart development and homeostasis.
Modulates gene expression and cellular responses in cardiac development. The complex integrates signals from various pathways, impacting transcriptional activity and influencing the coordination of cellular processes during heart development.
Acts as a chromatin remodeling complex, influencing gene expression by modifying chromatin structure. The complex plays a role in regulating cellular processes such as transcription and is essential for maintaining genomic integrity and function.
Functions as a transcription coactivator complex, influencing gene expression and chromatin remodeling. The complex plays a role in regulating transcriptional activity and is involved in various cellular processes, contributing to genomic stability and function.
Participates in membrane trafficking processes, influencing vesicle formation and cellular organization. The complex is involved in regulating intracellular transport and maintaining cellular structure and function.
Modulates gene expression and cellular responses in developmental processes. The complex integrates signals from various pathways, impacting transcriptional activity and influencing the coordination of cellular processes during development.
Plays a role in tumor necrosis factor receptor 2 (TNFR2) signaling, influencing immune and inflammatory responses. The complex is involved in transmitting signals that regulate cellular processes, including apoptosis and immune modulation.
Contributes to cardiac ion channel regulation, influencing membrane potential and cellular excitability. The complex plays a role in modulating cardiac electrical activity and maintaining proper functioning of the heart.
Participates in tubulin folding and cytoskeleton organization. The complex is involved in maintaining the structure and function of microtubules, influencing cellular shape, division, and intracellular transport processes.
Modulates tubulin folding and cytoskeleton organization. The complex is involved in maintaining the structure and function of microtubules, influencing cellular shape, division, and intracellular transport processes.
Participates in centrosome maturation and cellular division processes. The complex is involved in regulating the activity of Aurora kinase A (AURKA) and influencing cellular processes related to cell cycle progression and mitosis.
Plays a role in ciliary function and intracellular transport within photoreceptor cells. The complex is involved in maintaining the structure and function of cilia, contributing to cellular organization and sensory processes in the retina.
Coordinates vital cellular processes by integrating RasGAP, AURKB, and survivin, regulating cell cycle progression and apoptosis. This complex ensures cellular integrity and influences cell fate decisions, striking a balance between cell survival and programmed cell death.
Orchestrates potent anti-inflammatory responses by uniting IL-10 receptor subunits (IL-10Ralpha/beta) with the cytokine IL-10. The complex finely regulates signaling pathways to suppress immune responses, playing a key role in immune balance and preventing excessive inflammation.
Plays a crucial role in cellular adhesion and membrane organization by incorporating CLIC5A, EZR, and PODXL. This collaborative complex influences cell adhesion, cytoskeletal organization, and membrane dynamics, maintaining cellular structure and tissue integrity. Its functions extend to regulating interactions with the extracellular environment and the dynamic regulation of membrane-associated proteins.
Integrates EGFR, NHERF1, and PTEN to modulate signaling pathways involved in cell proliferation and survival. This complex serves as a regulatory hub, influencing processes like cell growth and apoptosis. Its functions contribute to maintaining cellular homeostasis and playing a crucial role in cellular decision-making related to growth and survival.
Contributes to membrane organization and cellular structure by incorporating PDZK1, NHERF1, and EZR. This complex plays a crucial role in organizing membrane-associated proteins, influencing functions related to membrane dynamics and contributing to maintaining cellular structure. Its functions extend to dynamically regulating membrane-associated proteins and their impact on cellular responses to the surrounding environment.
Regulates cellular responses to vascular signaling by integrating VEGFR2, S1PR1, ERK1/2, and PKC-alpha. This complex plays a role in angiogenesis and vascular homeostasis, influencing processes like endothelial cell proliferation and migration. Its functions contribute to the intricate balance of vascular integrity, playing a crucial role in orchestrating cellular responses to vascular signals.
Orchestrates cellular responses to vascular signals by incorporating VEGFR2, S1PR2, ERK1/2, and PKC-alpha. This complex contributes to angiogenesis and vascular regulation, influencing endothelial cell behavior and maintaining vascular homeostasis. Its functions extend to modulating cellular responses to complex vascular signals, playing a crucial role in maintaining vascular integrity and the dynamic regulation of angiogenesis.
Regulates cellular responses to vascular signals by integrating VEGFR2, S1PR3, ERK1/2, and PKC-alpha. This complex plays a crucial role in angiogenesis and vascular homeostasis, influencing endothelial cell functions and contributing to maintaining vascular integrity. Its functions extend to modulating cellular responses to complex vascular signals, playing a crucial role in orchestrating cellular responses to vascular cues.
Orchestrates cellular responses to vascular signals by incorporating VEGFR2, S1PR5, ERK1/2, and PKC-alpha. This complex contributes to angiogenesis and vascular regulation, influencing endothelial cell behavior and maintaining vascular homeostasis. Its functions extend to modulating cellular responses to complex vascular signals, playing a crucial role in maintaining vascular integrity and the dynamic regulation of angiogenesis.
Participates in cellular signaling by forming a signalosome around RXFP1. This complex modulates signaling pathways related to relaxin, influencing cellular responses such as vasodilation, proliferation, and survival. The RXFP1 signalosome plays a multifaceted role in physiological processes, including reproductive functions and cardiovascular regulation, contributing to the finely orchestrated cellular responses to relaxin signaling.
Regulates dopamine receptor signaling by integrating DRD4, KLHL12, and CUL3. This complex plays a pivotal role in modulating cellular responses to dopamine, influencing processes related to neurotransmission and cellular communication. Its functions contribute to the dynamic regulation of dopamine signaling pathways, impacting cellular behaviors and responses to extracellular cues.
Facilitates ubiquitin-dependent protein degradation by forming an E3 ligase complex with CUL1, FBXO18, RBX1, and SKP1A. This complex targets specific proteins for degradation, regulating cellular processes such as cell cycle progression and protein turnover. Its functions extend to precise control of protein levels, ensuring dynamic regulation of cellular pathways and maintaining cellular homeostasis.
Participates in lipid metabolism and immune regulation by incorporating APOL1, APOA1, HPR, and C3. This complex is involved in lipid transport, immune response modulation, and potential roles in maintaining cellular homeostasis. Its functions extend to dynamic regulation of lipid metabolism and immune responses, contributing to cellular health and the balance of immune-related processes within the cellular environment.
Contributes to lipid metabolism and immune regulation by incorporating APOL1, APOA1, HPR, FN1, and IGHM. This complex is implicated in lipid transport, immune modulation, and potential roles in maintaining cellular homeostasis. Its functions extend to dynamic regulation of lipid metabolism and immune responses, contributing to cellular health and the balance of immune-related processes within the cellular environment.
This complex may play a role in lipid metabolism and immune regulation, influencing processes related to energy balance and potential immune modulation. Its functions extend to dynamic regulation of lipid metabolism and potential immune-related responses, contributing to the balance of cellular processes within the cellular environment
Coordinates immune responses by bringing together complement protein (CP), lactoferrin (LF), and myeloperoxidase (MPO). This complex plays a crucial role in antimicrobial activity, inflammation modulation, and oxidative stress responses, contributing to the defense against pathogens and maintenance of immune homeostasis.
Collaborates in immune responses, combining complement protein (CP) and lactoferrin (LF). This complex is involved in antimicrobial defense, immune regulation, and modulation of inflammatory processes, playing a role in maintaining immune homeostasis and responding to challenges posed by microbial invaders.
Integrates complement protein (CP) and myeloperoxidase (MPO) in immune responses. This complex contributes to antimicrobial activity, regulation of inflammation, and oxidative stress responses, playing a vital role in immune defense mechanisms and ensuring a balanced immune response to various challenges.
Orchestrates signaling in metabolic pathways, bringing together fibroblast growth factor 21 (FGF21), fibroblast growth factor receptor 1c (FGFR1c), and Klotho co-receptor (KLB). This complex regulates metabolic processes, energy homeostasis, and insulin sensitivity, influencing overall metabolic health and response to nutritional cues.
Plays a crucial role in metabolic regulation by combining fibroblast growth factor 19 (FGF19), fibroblast growth factor receptor 4 (FGFR4), and Klotho co-receptor (KLB). This complex regulates bile acid synthesis, glucose metabolism, and overall metabolic homeostasis, contributing to the maintenance of metabolic balance and adaptation to nutritional status.
Participates in metabolic signaling by combining fibroblast growth factor receptor 4 (FGFR4) and Klotho co-receptor (KLB). This complex is involved in regulating various metabolic processes, including liver function, bile acid synthesis, and glucose metabolism, contributing to metabolic homeostasis and adaptation to nutritional cues.
Orchestrates signaling in metabolic pathways, bringing together fibroblast growth factor 21 (FGF21), fibroblast growth factor receptor 1c (FGFR1c), and Klotho co-receptor (KLB). This complex regulates metabolic processes, energy homeostasis, and insulin sensitivity, influencing overall metabolic health and response to nutritional cues.
Regulates metabolic pathways by combining fibroblast growth factor 21 (FGF21), fibroblast growth factor receptor 4 (FGFR4), and Klotho co-receptor (KLB). This complex plays a role in metabolic processes, energy balance, and insulin sensitivity, contributing to the maintenance of metabolic homeostasis and adaptation to nutritional changes.
Involved in metabolic signaling by combining fibroblast growth factor receptor 1c (FGFR1c) and Klotho co-receptor (KLB). This complex plays a role in regulating metabolic processes, insulin sensitivity, and energy homeostasis, contributing to overall metabolic health and the adaptation of the body to changes in nutritional status.
Participates in metabolic regulation by combining fibroblast growth factor receptor 4 (FGFR4) and Klotho co-receptor (KLB). This complex is crucial for regulating liver function, bile acid synthesis, and glucose metabolism, contributing to metabolic homeostasis and the body's adaptive responses to variations in nutritional cues.
Plays a crucial role in post-transcriptional gene regulation, binding to target mRNAs and influencing their stability and translation. This complex, centered around IGF2BP1, participates in the control of cellular processes such as cell proliferation, survival, and differentiation by modulating the expression of specific mRNA targets, thereby contributing to the regulation of cellular homeostasis and response to environmental cues.
Orchestrates cellular responses to EphA1 receptor activation, influencing processes such as cell adhesion, migration, and axon guidance. This complex, formed upon EphA1 receptor activation, initiates signaling cascades that regulate diverse cellular behaviors, contributing to the establishment of tissue organization and connectivity. Its involvement in EphA1 receptor signaling positions it as a key player in cellular communication and coordination, particularly in neuronal and developmental contexts.
Functions as a regulatory hub in chromatin modification, contributing to the control of gene expression. This complex is involved in the deposition of histone modifications that influence chromatin structure and transcriptional activity. Its role in chromatin modification positions it as a crucial player in the epigenetic regulation of gene expression, impacting diverse cellular processes such as development, differentiation, and cellular identity maintenance.
Collaboratively regulates histone methylation and influences chromatin structure to control gene expression. The WRAD complex, comprising WDR5, RBBP5, ASH2L, and DPY30, plays a key role in the deposition of histone modifications associated with active transcription. Its involvement in chromatin modification contributes to the regulation of gene expression patterns, impacting cellular processes such as development, differentiation, and response to external signals. The WRAD complex is a crucial component of the epigenetic machinery that governs the dynamic landscape of the cellular epigenome.
Influences histone methylation and chromatin structure, contributing to the regulation of gene expression. The WRA complex, composed of WDR5, RBBP5, and ASH2L, collaboratively participates in the deposition of histone modifications associated with active transcription. Its role in chromatin modification positions it as a key player in the epigenetic regulation of gene expression, impacting cellular processes such as development, differentiation, and cellular identity maintenance. The WRA complex is an essential component of the cellular machinery that governs the dynamic epigenetic landscape.
Participates in histone methylation and chromatin remodeling, contributing to the regulation of gene expression. The MWRAD complex, comprising MLL1, WDR5, RBBP5, ASH2L, and DPY30, plays a pivotal role in the deposition of histone modifications associated with active transcription. Its involvement in chromatin modification positions it as a key player in the epigenetic regulation of gene expression, impacting cellular processes such as development, differentiation, and cellular identity maintenance. The MWRAD complex is a critical component of the epigenetic machinery that governs the dynamic cellular epigenome.
Functions as an E3 ubiquitin ligase involved in endoplasmic reticulum-associated degradation (ERAD), contributing to the quality control of cellular proteins. The HRD1 complex identifies and ubiquitinates misfolded or aberrant proteins in the endoplasmic reticulum, targeting them for degradation. Its role in ERAD ensures the proper folding and quality control of proteins, contributing to cellular proteostasis and preventing the accumulation of dysfunctional proteins that could otherwise lead to cellular stress and dysfunction.
Participates in ubiquitin-mediated protein degradation and modulation of cellular signaling pathways. This complex is associated with the ubiquitin-proteasome system, contributing to the targeted degradation of specific proteins. Additionally, it may play a role in the regulation of cellular signaling pathways, influencing processes such as cell proliferation and response to extracellular signals. Its involvement in protein degradation and signaling modulation positions it as a key player in cellular homeostasis and response to environmental cues.
Modulates chromatin structure and gene expression, contributing to the epigenetic regulation of cellular processes. The CBX3-EHMT2-NR3C1 complex is involved in the deposition of histone modifications and the interaction with specific chromatin regions, influencing the expression of target genes. Its role in chromatin modification positions it as a key player in the epigenetic regulation of gene expression, impacting cellular processes such as development, differentiation, and cellular identity maintenance. The complex is an essential component of the epigenetic machinery that shapes the cellular epigenome.
Plays a crucial role in the Fanconi anemia pathway, contributing to the repair of DNA interstrand crosslinks. The Fanconi anemia FAAP100 complex is part of the DNA repair machinery that responds to DNA damage. It participates in the recognition and repair of DNA interstrand crosslinks, contributing to the maintenance of genomic integrity and preventing the accumulation of DNA damage that could lead to cellular dysfunction and genomic instability.
Participates in endoplasmic reticulum-associated degradation (ERAD), a cellular process responsible for identifying and degrading misfolded proteins. This complex facilitates the recognition, ubiquitination, and subsequent degradation of unfolded or misfolded proteins, contributing to cellular quality control and protein homeostasis.
Functions as a ubiquitin E3 ligase complex involved in the ubiquitin-proteasome system. It targets specific proteins for ubiquitination, marking them for degradation by the proteasome. This complex, comprising CUL1, FBXO10, and SKP1, plays a role in regulating the turnover of specific cellular proteins, influencing processes such as cell cycle progression and protein homeostasis.
Acts as a ubiquitin E3 ligase complex involved in targeted protein degradation. Comprising CUL1, FBXO6, RBX1, and SKP1, this complex plays a role in recognizing specific substrates, ubiquitinating them, and targeting them for proteasomal degradation. It contributes to the regulation of cellular processes, including cell cycle control and protein turnover.
Functions as a ubiquitin E3 ligase complex, specifically involved in the recognition and ubiquitination of target proteins for proteasomal degradation. This complex, comprising CUL1, FBXO17, RBX1, and SKP1, plays a role in regulating the abundance of specific cellular proteins, influencing cellular processes such as signal transduction and protein stability.
Operates as a ubiquitin E3 ligase complex involved in the ubiquitin-proteasome pathway. With components CUL1, FBXO27, RBX1, and SKP1, this complex recognizes specific substrates, ubiquitinates them, and targets them for degradation, contributing to the regulation of protein levels and influencing cellular processes such as cell cycle progression and signal transduction.
Acts as a ubiquitin E3 ligase complex responsible for targeted protein degradation. Comprising CUL1, FBXO44, RBX1, and SKP1, this complex plays a role in recognizing specific substrates, ubiquitinating them, and marking them for proteasomal degradation. It contributes to the regulation of protein abundance, influencing cellular processes such as cell cycle control and signaling pathways.
Participates in the Wnt signaling pathway, where CTNNB1 (beta-catenin) interacts with FERMT2 and TCF7L2. This complex plays a crucial role in regulating gene expression, influencing cellular processes such as cell proliferation, differentiation, and embryonic development. It acts as a molecular switch in Wnt signaling, impacting the transcription of target genes and contributing to cellular fate determination.
This complex is involved in modulating gene expression and cellular responses, influencing processes like cell adhesion, migration, and invasion. It plays a role in the regulation of cellular behavior and the maintenance of tissue integrity, contributing to various physiological and pathological processes.
This complex is involved in mediating cellular responses to fibroblast growth factor (FGF) signaling, influencing processes such as cell proliferation, survival, and migration. It contributes to the regulation of cellular behavior and the coordination of cellular responses to extracellular cues.
This complex is involved in regulating processes such as cell adhesion, migration, and cytoskeletal dynamics. It plays a role in coordinating cellular responses to extracellular signals and contributes to the modulation of cellular behavior and tissue organization.
Orchestrates cellular signaling related to integrin-mediated processes, contributing to cell adhesion, migration, and cytoskeletal organization. This complex plays a key role in linking extracellular signals to intracellular responses, influencing cellular behavior and tissue dynamics.
Similar to its counterpart, this complex is involved in integrin-mediated signaling pathways, influencing processes such as cell adhesion, migration, and cytoskeletal organization. It contributes to the integration of extracellular signals, impacting cellular behavior and tissue dynamics within dynamic cellular environments.
Coordinates signaling cascades associated with focal adhesion dynamics and cell migration. This complex regulates the interplay between focal adhesions and the cytoskeleton, playing a pivotal role in cellular responses to extracellular cues and modulating processes related to cell movement and tissue organization.
Participates in signaling pathways associated with cell proliferation, migration, and cytoskeletal rearrangement. This complex integrates signals from mitogen-activated protein kinase (MAPK1), protein tyrosine kinase 2 (PTK2), and paxillin (PXN), influencing cellular decisions related to growth and movement within dynamic cellular environments.
Regulates intracellular vesicle trafficking and membrane dynamics. This complex, involving protein kinase C zeta (PRKCZ), vesicle-associated membrane protein 2 (VAMP2), and WD repeat and FYVE domain-containing protein 2 (WDFY2), contributes to cellular processes such as vesicle fusion and membrane organization, influencing intracellular transport and cellular organization.
Plays a role in cellular signaling cascades related to protein degradation and immune response. This complex, comprising protein kinase C zeta (PRKCZ), sequestosome 1 (SQSTM), and tumor necrosis factor receptor-associated factor 6 (TRAF6), modulates processes like autophagy and immune signaling, contributing to cellular homeostasis and responses to cellular stressors.
Governs gene expression and cellular responses related to growth and proliferation. This complex, involving the c-Myc proto-oncogene (MYC), transformation/transcription domain-associated protein (TRRAP), and lysine acetyltransferase 2A (KAT2A), influences the regulation of target genes, playing a crucial role in cellular decisions related to cell cycle progression, growth, and cellular identity.
Regulates cellular signaling pathways associated with cytoskeletal dynamics and cell movement. This complex, involving Rho/Rac guanine nucleotide exchange factor 2 (ARHGEF2), mitogen-activated protein kinase 1 (MAPK1), mitogen-activated protein kinase 3 (MAPK3), and paxillin (PXN), influences processes like cell migration and cytoskeletal rearrangement, contributing to cellular responses to extracellular cues.
Governs signaling pathways related to bone metabolism and homeostasis. This complex, comprising low-density lipoprotein receptor-related protein 6 (LRP6), parathyroid hormone (PTH), and parathyroid hormone receptor 1 (PTH1R), plays a crucial role in regulating bone development and mineralization, influencing cellular decisions related to bone remodeling and skeletal homeostasis.
Plays a pivotal role in DNA repair processes, particularly homologous recombination. This complex, involving BRCA1-associated RING domain protein 1 (BARD1), breast cancer type 1 susceptibility protein (BRCA1), and RAD51 recombinase, is crucial for maintaining genomic integrity and preventing the accumulation of DNA damage. It participates in the repair of double-strand breaks, safeguarding cellular genetic information.
Collaborates in cellular processes by mediating interactions between NG2, galectin-3, and alpha3beta1-integrin. This complex potentially influences cell adhesion, migration, and signaling pathways, contributing to diverse cellular responses in dynamic environments.
Orchestrates signaling events related to glial cell line-derived neurotrophic factor (GDNF) family ligands by involving ARTN, GFRA3, and RET. This complex plays a role in cellular responses such as survival, differentiation, and migration, contributing to the regulation of neural development and function.
Participates in redox regulation by bringing together BOLA2 and GLRX3. This complex may contribute to cellular responses involved in maintaining redox balance, potentially impacting processes such as antioxidant defense and overall cellular homeostasis.
Influences Wnt signaling by involving CTNNB1 and GID8. This complex plays a role in modulating gene expression and cellular responses related to growth and development, contributing to the regulation of Wnt signaling pathways within the cell.
Catalyzes the first step in sphingolipid biosynthesis, bringing together SPTLC1 and SPTLC2. This complex plays a crucial role in cellular lipid metabolism, contributing to the synthesis of sphingolipids involved in various cellular functions and signaling pathways.
Expands the role of serine-palmitoyltransferase by incorporating SPTLC3 along with SPTLC1 and SPTLC2. This complex potentially modulates sphingolipid biosynthesis, impacting cellular processes related to lipid metabolism, cell signaling, and regulation of cellular responses.
Broadens the functions of serine-palmitoyltransferase by including ssSPTb in conjunction with SPTLC1 and SPTLC2. This complex is implicated in sphingolipid biosynthesis, influencing cellular lipid composition and contributing to the regulation of diverse cellular activities and signaling cascades.
Expands the functional repertoire of serine-palmitoyltransferase by incorporating ssSPTa along with SPTLC1 and SPTLC2. This complex contributes to sphingolipid biosynthesis, potentially influencing cellular responses and signaling pathways associated with lipid metabolism and cellular homeostasis.
Facilitates cellular responses to insulin-like growth factor 1 (IGF1) by involving IGF1R, ITGAV, and ITGB3. This complex plays a role in signaling cascades related to cell growth, survival, and proliferation, contributing to the regulation of cellular activities influenced by IGF1 signaling pathways.
Participates in the assembly of the proteasome, involving PTMA, SET, ACTB and MARCKS. This complex plays a role in protein degradation, contributing to cellular quality control mechanisms and maintaining protein homeostasis within the cell.
Contributes to the formation of the proteasome, involving ANP32A, C1QB, PSMA1, PTMA and SLC25A3. This complex plays a role in regulating protein degradation processes, impacting cellular quality control and ensuring the removal of misfolded or unwanted proteins from the cellular environment.
Participates in proteasome assembly, involving PTMA, ANP32A and ANP32B. This complex plays a crucial role in protein degradation pathways, contributing to cellular quality control mechanisms and the maintenance of overall protein homeostasis within the cell.
Contributes to the assembly of the proteasome, involving PTMA, ANP32A, ANP32B and RAB11A. This complex plays a role in cellular protein degradation processes, impacting the removal of misfolded or obsolete proteins and maintaining cellular protein homeostasis and quality control mechanisms.
Influences cellular adhesion and migration processes. This complex potentially regulates focal adhesions, impacting cell-substrate interactions and cellular responses related to adhesion and migration in dynamic cellular environments.
Plays a role in collagen modification. This complex potentially influences collagen biosynthesis, impacting the structural properties of collagen within the extracellular matrix and contributing to tissue integrity and homeostasis.
Regulates glycosylation processes and influences epidermal growth factor receptor (EGFR) signaling, potentially impacting cell growth, proliferation, and differentiation. This complex plays a crucial role in modulating cellular responses to growth factors, contributing to the dynamic regulation of cellular behavior and fate.
Essential for selenocysteine biosynthesis, supporting various selenoproteins involved in cellular functions, redox balance, and antioxidant defense. This intricate complex ensures the availability of selenocysteine, a critical amino acid, and contributes to cellular resilience by maintaining redox homeostasis and defending against oxidative stress.
Contributes to insulin-like growth factor 1 (IGF1) signaling and cell adhesion, potentially influencing growth, survival, and adhesion-related processes. This complex forms a molecular nexus connecting growth factor signaling with cellular adhesion dynamics, orchestrating responses that shape cellular behavior and contribute to tissue organization and maintenance.
Plays a role in cellular signaling pathways, potentially impacting processes like cell proliferation, differentiation, and survival through the modulation of signaling cascades. This complex operates as a molecular switch, transmitting signals that govern key cellular decisions and responses, contributing to the fine-tuning of cellular behavior and adaptation to changing environmental cues.
Participates in interferon signaling, playing a crucial role in antiviral defense mechanisms and influencing immune responses to viral threats. This complex serves as a sentinel in the cellular immune arsenal, activating pathways that promote an antiviral state and contribute to the robust defense against viral infections, highlighting its significance in cellular immune surveillance.
Part of the interferon signaling pathway, promoting antiviral defense mechanisms and modulating immune responses against viral threats. This intricate complex engages in intricate signaling events that lead to the activation of cellular defenses against viruses, shaping immune responses and contributing to the establishment of an antiviral state within the cellular milieu.
Key in the innate immune response, sensing specific pathogen-associated molecular patterns (PAMPs) and potentially triggering inflammatory responses. This complex serves as a molecular sentinel, detecting microbial threats and initiating signaling cascades that culminate in inflammatory responses, contributing to the first line of defense against invading pathogens.
Modulates ubiquitin signaling, potentially impacting protein stability, DNA repair, and cellular responses to stress. This complex operates as a molecular regulator, fine-tuning the ubiquitin landscape within cells and influencing processes that govern protein turnover, DNA integrity, and cellular responses to environmental stressors.
Forms a heterotrimeric G protein complex composed of G protein subunit alpha i1 (GNAI1), G protein subunit beta-1 (GNB1), and G protein subunit gamma 11 (GNG11). This complex is involved in G protein-coupled receptor signaling, potentially modulating cellular responses to extracellular signals and regulating various physiological processes, including neurotransmission, hormone secretion, and cellular proliferation.
This complex involves G protein subunit alpha i1 (GNAI1), G protein subunit beta-2 (GNB2), and G protein subunit gamma 11 (GNG11). It is part of G protein-coupled receptor signaling, playing a role in transmitting extracellular signals and influencing cellular responses in various physiological contexts, such as neurotransmission, hormone regulation, and cell proliferation.
This complex involves G protein subunit alpha i1 (GNAI1), G protein subunit beta-3 (GNB3), and G protein subunit gamma 11 (GNG11). It functions in G protein-coupled receptor signaling, mediating cellular responses to diverse extracellular signals and contributing to the regulation of physiological processes like neurotransmission, hormone secretion, and cellular proliferation.
This complex involves G protein subunit alpha i1 (GNAI1), G protein subunit beta-4 (GNB4), and G protein subunit gamma 11 (GNG11). It participates in G protein-coupled receptor signaling, transmitting signals from extracellular stimuli and influencing cellular responses, including neurotransmission, hormone regulation, and cell proliferation in various physiological contexts.
This complex involves G protein subunit alpha i1 (GNAI1), G protein subunit beta-5 (GNB5), and G protein subunit gamma 11 (GNG11). It is part of G protein-coupled receptor signaling, contributing to the relay of extracellular signals and regulating diverse cellular responses, including neurotransmission, hormone secretion, and cell proliferation in various physiological contexts.
Participates in sphingolipid metabolism, impacting cellular processes such as apoptosis, cell signaling, and lipid homeostasis. This complex serves as a molecular orchestrator, influencing the breakdown of sphingolipids and regulating cellular processes that govern cell survival, signaling cascades, and lipid balance within the cellular milieu.
Involved in cell cycle regulation, influencing chromosome segregation, cell division, and overall cell cycle progression. This complex acts as a molecular regulator, contributing to the precise orchestration of mitotic processes, ensuring faithful chromosome segregation, and promoting orderly cell division, highlighting its crucial role in maintaining genomic stability during cell cycle progression.
This complex is pivotal in cellular processes related to gene regulation and cell cycle control. It plays a potential role in embryonic development and cellular differentiation by influencing the expression of genes critical for these processes.
Essential in the cellular response to DNA damage, this complex contributes to the repair of DNA lesions. By participating in DNA damage response pathways, it plays a crucial role in maintaining genomic stability and preventing the accumulation of harmful mutations.
This complex orchestrates cellular processes involved in cell adhesion and proteolysis, potentially influencing tissue remodeling and cellular interactions with the extracellular environment. It modulates the intricate balance of these processes, contributing to cellular homeostasis.
Involved in cell adhesion and signaling, this complex regulates cellular behavior and interactions with the extracellular matrix. It contributes to the modulation of cellular responses, potentially influencing processes related to growth and tissue development.
Regulating processes related to cell adhesion and proteolysis, this complex influences cellular interactions with the extracellular environment and contributes to tissue remodeling. Its multifaceted functions impact cellular behavior and play a role in maintaining the balance of extracellular processes.
This complex plays a vital role in cellular processes related to cell adhesion and proteolysis, significantly influencing tissue remodeling and cellular interactions with the extracellular matrix. It contributes to the intricate balance of these processes, potentially impacting cellular homeostasis and tissue structure.
Involved in cell adhesion and proteolysis, this complex regulates cellular interactions with the extracellular environment. It plays a crucial role in modulating processes related to tissue remodeling and maintaining the dynamic balance of extracellular interactions.
In cellular signaling pathways, this complex is a key player potentially influencing processes related to cell growth, proliferation, and survival. By participating in intricate signaling networks, it contributes to the orchestration of cellular responses to external stimuli and growth signals.
Playing a crucial role in mitochondrial protein import, this subcomplex facilitates the translocation of proteins into the mitochondria. It is an essential component in maintaining mitochondrial function and cellular energy metabolism, contributing to the dynamic balance of cellular energy homeostasis.
Essential for mitochondrial protein import, this subcomplex contributes to the translocation of proteins into the mitochondria. It is vital for maintaining mitochondrial function and cellular energy metabolism, ensuring the efficient functioning of these crucial cellular powerhouses.
This subcomplex is instrumental in mitochondrial protein import, facilitating the translocation of proteins into the mitochondria. It plays a crucial role in maintaining mitochondrial function and cellular energy metabolism, contributing to the dynamic equilibrium of cellular energy homeostasis.
Modulating cellular signaling pathways, this complex potentially influences processes related to cell differentiation and proliferation. Its intricate interactions contribute to the fine-tuning of signaling cascades, impacting cellular behavior and fate determination in response to external cues.
Participating in cellular signaling, this complex potentially influences processes related to cell differentiation and proliferation. By orchestrating signaling pathways, it plays a key role in shaping cellular responses and contributing to the regulation of cellular behavior in dynamic cellular environments.
Involved in cellular processes related to synaptic function and structure, this complex plays a role in neuronal signaling and synaptic plasticity. Its intricate interactions contribute to the regulation of synaptic activity, influencing cellular responses within the context of neural communication and information processing.
Participating in cellular signaling pathways, this complex potentially influences processes related to cell growth and division. By modulating signaling cascades, it plays a key role in orchestrating cellular responses to growth signals and contributing to the regulation of cellular proliferation.
Plays a role in cellular processes related to drug resistance and intracellular signaling. This complex may contribute to the regulation of drug efflux and cellular responses to signaling cascades, impacting cellular behavior in response to external stimuli.
Involved in cellular processes related to ion transport and membrane potential regulation. This complex may contribute to the maintenance of cellular homeostasis by modulating ion concentrations and membrane dynamics, influencing cellular function in various tissues.
Modulates cellular signaling pathways related to cell survival and oxidative stress response. This complex may contribute to the regulation of cellular responses to oxidative damage and play a role in influencing cell fate decisions in response to environmental stressors.
Participates in cellular processes related to histone acetylation and energy metabolism. This complex may contribute to the regulation of gene expression and cellular energy homeostasis, influencing cellular function in the context of chromatin dynamics and metabolism.
Involved in cellular processes related to ion transport, cell adhesion, and membrane dynamics. This complex may contribute to the regulation of cellular interactions and membrane potential, impacting cellular behavior in tissues where ion transport and adhesion are crucial.
Participates in cellular processes related to protein transport and stress response. This complex may contribute to the regulation of protein trafficking and cellular responses to stress, influencing cellular behavior in the context of proteostasis and stress adaptation.
Modulates cellular processes related to apoptosis and mitochondrial function. This complex may contribute to the regulation of cell survival and mitochondrial dynamics, influencing cellular fate decisions in response to apoptotic signals and changes in cellular energy status.
Plays a role in cellular processes related to protein processing and regulation of peptide hormones. This enzyme may contribute to the regulation of peptide metabolism and processing, influencing cellular function in the context of neuropeptide signaling and hormonal regulation.
Participates in cellular processes related to Wnt signaling and transcriptional regulation. This complex may contribute to the modulation of gene expression and cellular responses to Wnt signals, influencing cellular behavior in the context of developmental and signaling pathways.
Modulates cellular processes related to ubiquitin-mediated protein degradation and transcriptional regulation. This complex may contribute to the regulation of protein turnover and gene expression, influencing cellular responses to external signals and developmental cues.
Involved in cellular processes related to endocytosis and membrane trafficking. This complex may contribute to the regulation of intracellular membrane dynamics and protein transport, influencing cellular behavior in the context of vesicular trafficking and endosomal pathways.
Participates in cellular processes related to RNA processing, DNA repair, and transcriptional regulation. This complex may contribute to the regulation of gene expression and cellular responses to DNA damage, influencing cellular behavior in the context of RNA biology and genomic stability.
Modulates cellular processes related to ubiquitin-mediated protein degradation and signaling. This complex may contribute to the regulation of protein turnover and cellular responses to signaling pathways, influencing cellular behavior in the context of proteostasis and signal transduction.
Participates in cellular processes related to cytoskeletal dynamics, protein folding, and proteolysis. This complex may contribute to the regulation of cellular architecture, protein quality control, and proteolytic processes, influencing cellular behavior in the context of cytoskeletal organization and protein homeostasis.
Involved in cellular processes related to protein folding, proteolysis, and mitochondrial function. This complex may contribute to the regulation of protein quality control, cellular energy metabolism, and proteolytic pathways, influencing cellular behavior in the context of protein homeostasis and mitochondrial dynamics.
Involved in the assembly and maintenance of cytochrome c oxidase (COX), a crucial enzyme in the mitochondrial respiratory chain. This complex contributes to the proper formation and function of COX, ensuring efficient electron transport and ATP production in mitochondria.
Mediates the signaling of interleukin-10 (IL-10), an anti-inflammatory cytokine, by binding to its receptor IL10RA. This complex plays a key role in regulating immune responses, suppressing inflammation, and modulating cellular activities associated with immune regulation and homeostasis.
This complex contributes to the modulation of Wnt signaling and estrogen signaling pathways. This complex plays a role in cellular processes such as proliferation, differentiation, and gene expression, influencing cellular behavior in response to Wnt and estrogen signals.
This complex potentially regulates immune responses, inflammation, and cell survival by integrating signals from both NF-kappa-B and STAT3 pathways, contributing to the dynamic regulation of cellular processes in response to various stimuli.
This complex potentially influences processes related to transcriptional regulation and cellular proliferation, impacting the expression of genes associated with cell growth and survival. It may contribute to the dynamic regulation of cellular activities in response to various signaling cues.
This complex is potentially involved in protein ubiquitination and degradation. It may participate in the regulation of cellular processes related to protein turnover, influencing the stability of target proteins and contributing to cellular homeostasis.
Involves the interaction between cell adhesion molecule 1 (CADM1), discs large homolog 1 (DLG1), membrane palmitoylated protein 3 (MPP3), and phosphoinositide-3-kinase regulatory subunit 1 (PIK3R1). This complex may play a role in cellular adhesion, membrane organization, and intracellular signaling, influencing processes related to cell-cell interactions and cellular responses to external cues.
Comprising RAC1, RHOA, and VANGL2, this complex potentially modulates cellular processes related to cytoskeletal dynamics, cell migration, and tissue morphogenesis. It may contribute to the regulation of cellular architecture and behavior by integrating signals from the RAC1 and RHOA pathways, influencing processes such as cell movement and tissue organization.
This complex contributes to the formation and maintenance of synapses. This complex plays a role in synaptic adhesion and communication between neurons, influencing processes related to neuronal signaling and plasticity. It is crucial for the establishment and function of neural circuits in the nervous system.
This complex may be involved in cellular processes related to cell growth, survival, and signaling. It potentially contributes to the regulation of ERBB2 signaling pathways, influencing cellular responses to growth factors and modulating pathways associated with cell proliferation and survival.
This complex potentially participates in DNA repair processes. This complex may play a role in the repair of DNA lesions, contributing to the maintenance of genomic integrity and preventing the accumulation of DNA damage. It is crucial for cellular responses to DNA damage and the preservation of genome stability.
This complex may modulate cellular processes related to immune responses and tissue homeostasis. It potentially influences the functions of IL-15 in regulating immune cell activities and the interactions between immune cells and tissues, contributing to the dynamic regulation of immune homeostasis.
This complex plays a crucial role in iron homeostasis, influencing cellular processes related to iron transport and utilization. It is essential for cellular functions that require iron, including DNA synthesis, energy production, and various metabolic processes.
This complex may modulate the activation of PI3K signaling, influencing processes related to cell growth, survival, and metabolism. It is crucial for the integration of signals that regulate cellular responses to growth factors and other stimuli.
This complex potentially influences chromatin remodeling and gene expression. It may contribute to the regulation of transcriptional processes, impacting cellular functions related to development, differentiation, and cellular identity. This complex plays a role in shaping the epigenetic landscape of cells and influencing their fate determination.
Forms an E3 ubiquitin ligase complex involved in ubiquitin-mediated protein degradation. CUL3 acts as a scaffold, KEAP1 regulates substrate recognition, and RBX1 facilitates ubiquitin transfer, collectively targeting specific proteins for degradation and playing a crucial role in cellular homeostasis and response to oxidative stress.
Part of the SWI-SNF chromatin remodeling complex, BRD7 contributes to the regulation of gene expression by modifying chromatin structure. This complex plays a vital role in controlling cellular processes such as transcription, DNA repair, and genomic stability, influencing cell fate and development.
Participates in cellular signaling pathways, with FYN acting as a kinase, KHDRBS1 as an RNA-binding protein, and PLCG1 as a phospholipase. This complex modulates intracellular signaling cascades, impacting cellular responses to external stimuli and contributing to processes like cell growth, differentiation, and immune response.
Involved in immune response regulation, this complex includes DTX3L, PARP9, and STAT1. DTX3L functions as an E3 ubiquitin ligase, PARP9 has PARylation activity, and STAT1 is a transcription factor. Together, they regulate immune signaling pathways, influencing the expression of genes related to antiviral responses and immune system activation.
Contributes to cellular signaling and gene regulation. AKT1 is a serine/threonine kinase, APPL1 is an adaptor protein, and HDAC3 is a histone deacetylase. This complex modulates signaling cascades, affecting cell survival, proliferation, and gene expression. It plays a role in cellular responses to growth factors and environmental cues, influencing various aspects of cell behavior.
Involved in cytoskeletal dynamics and cell migration. ARRB1 is an adaptor protein, ARHGEF18 is a guanine nucleotide exchange factor, and ENAH is an actin-binding protein. This complex regulates actin cytoskeleton remodeling, influencing cellular processes such as migration and invasion. It plays a role in cellular responses to extracellular signals, contributing to dynamic changes in cell shape and movement.
Associated with cellular communication and stem cell pluripotency. GJB2 forms gap junctions, PTK2 is a focal adhesion kinase, and NANOG is a transcription factor. This complex may influence intercellular communication and impact stem cell self-renewal and differentiation, playing a role in developmental processes and cellular fate determination.
Implicated in vesicle trafficking and ion transport. CFTR is a chloride channel, GOPC is an adaptor protein, and STX6 is a syntaxin involved in vesicle fusion. This complex modulates vesicular trafficking and ion transport processes, potentially impacting cellular secretion and homeostasis. It may be involved in the regulation of cellular responses to changes in the extracellular environment.
Influences cellular responses to DNA damage and regulation of TP53. TSPY1 is a Y-linked proto-oncogene, and USP7 is a deubiquitinase. This complex may modulate the stability and activity of TP53, playing a role in DNA damage response pathways and potentially contributing to cellular decisions related to cell cycle progression, apoptosis, and genomic stability.
Associated with chromatin remodeling and cell division. KAT2B is a histone acetyltransferase, KIF11 is a motor protein involved in mitosis, and MYSM1 is a histone H2A deubiquitinase. This complex may modulate chromatin structure during cell division, influencing processes such as mitosis and cell cycle progression. It plays a role in the maintenance of genomic stability and proper cell division.
Involved in cytokinesis and cell cycle regulation. ECT2 is a guanine nucleotide exchange factor, KIF23 is a motor protein, and RACGAP1 is a GTPase-activating protein. This complex regulates the final stages of cell division, contributing to cytokinesis and proper cell cycle progression. It plays a role in maintaining genomic stability and preventing aberrant cell division.
Plays a crucial role in cytokinesis and cell cycle progression. KIF23 is a motor protein, and RACGAP1 is a GTPase-activating protein. This complex is involved in regulating the final stages of cell division, contributing to proper cytokinesis and ensuring accurate cell cycle progression. It plays a critical role in maintaining genomic stability and preventing abnormal cell division.
Functions as an extracellular vesicle involved in intercellular communication. The exosome contains various cellular components, including RNA and proteins, and is released by cells into the extracellular environment. It plays a role in cell-to-cell communication, influencing processes such as immune response, tissue repair, and cellular signaling. The exosome is crucial for maintaining cellular homeostasis and responding to external cues.
Associated with mitotic spindle organization and cell division. Astrin and kinastrin are microtubule-binding proteins involved in mitosis. This complex regulates mitotic spindle dynamics, contributing to proper chromosome segregation during cell division. It plays a vital role in ensuring accurate cell division and maintaining genomic stability.
Plays a role in nuclear envelope organization and cellular structure. LAP1 is a nuclear membrane protein, and TOR1A is a torsin ATPase. This complex may contribute to the organization of the nuclear envelope and impact cellular architecture. It plays a role in maintaining the structural integrity of the nucleus and influencing cellular responses to changes in nuclear organization.
Coordinates intracellular vesicular trafficking and membrane dynamics. This complex plays a key role in regulating the formation, budding, and fusion of vesicles, contributing to the dynamic processes of endocytosis and exocytosis within the cell.
Governs cellular responses to oxygen levels and energy metabolism. The complex participates in the oxygen-sensing pathway, influencing the expression of genes involved in mitochondrial biogenesis and oxidative phosphorylation. This intricate regulation contributes to cellular adaptation to varying oxygen levels and the modulation of energy production pathways.
Mediates signaling in angiogenesis and vascular development. The complex formed by FLT1 (VEGFR-1) and VEGF-A121 is involved in the activation of vascular endothelial growth factor (VEGF) signaling, playing a crucial role in angiogenesis, vascular permeability, and the development of blood vessels.
Modulates angiogenic and vascular responses. This complex is involved in the regulation of vascular endothelial growth factor (VEGF) signaling. It contributes to the orchestration of angiogenic processes and vascular development, influencing cellular responses critical for tissue growth and repair.
Participates in cellular signaling and migration. The CD44-ERK1-ERK2-RHAMM complex integrates signals from the extracellular matrix, leading to the activation of ERK1 and ERK2 signaling pathways. This activation contributes to cellular responses such as migration, proliferation, and survival, playing a role in processes like tissue development and wound healing.
Modulates immune responses and hematopoiesis. The complex is involved in interleukin-1 (IL-1) signaling and stem cell regulation. It influences immune responses and hematopoietic processes, contributing to the maintenance of immune system homeostasis and the regulation of blood cell development.
Regulates cellular responses to interleukin-1 (IL-1) signaling. The IL1RAP-KIT complex is involved in the transmission of IL-1 signals, influencing cellular responses such as inflammation and immune reactions. This complex plays a role in coordinating the cellular response to IL-1 stimuli, contributing to processes related to immunity and inflammatory responses.
Targets specific proteins for ubiquitination and degradation. This E3 ligase complex, composed of CUL3, KLHL7, and RBX1, facilitates the transfer of ubiquitin molecules onto target proteins, marking them for proteasomal degradation. It plays a crucial role in the regulation of protein levels within the cell, contributing to processes such as cell cycle control and protein quality control.
Mediates ubiquitin-dependent protein degradation. This E3 ligase complex, consisting of CUL3, KLHL12, PEF1, and PDCD6, is involved in the targeted ubiquitination and subsequent degradation of specific proteins. It plays a role in cellular processes such as cell cycle progression, apoptosis, and the regulation of protein turnover, contributing to the maintenance of cellular homeostasis.
Facilitates ubiquitin-mediated degradation of target proteins. The E3 ligase complex, comprising CUL3, KLHL9, KLHL13, and RBX1, is involved in the ubiquitination and subsequent degradation of specific proteins. This complex plays a role in regulating cellular processes such as cell cycle progression, signal transduction, and cellular homeostasis by controlling the turnover of key regulatory proteins.
Modulates Wnt signaling and cellular responses related to cell fate determination. This complex participates in the Wnt signaling pathway, influencing gene expression and cellular decisions related to differentiation and tissue formation. It plays a role in shaping cellular fate and maintaining the delicate balance of Wnt signaling cascades.
Participates in cellular adhesion and signal transduction. The CD44-LRP1 complex is involved in interactions with extracellular matrix components and signaling molecules. It contributes to cellular adhesion processes and influences cellular responses such as migration and survival, playing a role in tissue development and maintenance of cellular architecture.
Regulates chromosome segregation during cell division. The KNL1-MIS12-NDC80-SPC24-ZWINT complex, associated with the kinetochore, plays a crucial role in ensuring proper chromosome alignment and segregation during mitosis. It contributes to the fidelity of cell division and the maintenance of genomic stability.
Modulates Wnt signaling and cellular responses related to cell fate determination. The complex is involved in the regulation of Wnt signaling pathways, influencing gene expression and cellular decisions related to differentiation and tissue development. It plays a role in shaping cellular fate and maintaining the balance of Wnt signaling cascades.
Participates in cellular signaling and cytoskeletal organization. The MAPK6-MAPKAPK5-SEPT7 complex is involved in the activation of signaling cascades and cytoskeletal dynamics. It contributes to cellular responses such as cell proliferation, differentiation, and cytoskeletal organization, playing a role in processes like tissue development and cellular homeostasis.
The SMYLE 1 complex, localized at the centrosome, plays crucial roles in cellular processes. It is involved in regulating microtubule assembly, contributing to the structural framework of the cytoskeleton. The complex influences directed cell motility, guiding cells in specific directions, and participates in determining the orientation of cell division, ensuring proper alignment during this crucial process.
The SMYLE 2 complex is involved in regulating microtubule nucleation. Ongoing investigations seek to uncover the multifaceted roles and impact of SMYLE 2 in diverse cellular processes.
Orchestrates Wnt signaling by functioning as a receptor for RSPO ligands. The LGR4-RSPO supercomplex modulates the canonical Wnt pathway, influencing cellular decisions related to proliferation and differentiation in a context-dependent manner.
The LGR5-RNF43-RSPO1 complex acts as a modulator of the Wnt signaling pathway, playing pivotal roles in stem cell maintenance, tissue homeostasis, and implications for diseases such as cancer. Its functions are tightly regulated to ensure proper cellular responses and maintain tissue integrity.
The APP-APBB1-KAT5 complex is implicated in transcriptional regulation within cells. The cytoplasmic tail of Amyloid Precursor Protein (APP) forms a multimeric complex with the nuclear adaptor protein Fe65 and the histone acetyltransferase Tip60. This complex has the ability to stimulate transcription via heterologous Gal4- or LexA-DNA binding domains.
An incomplete form of the Mediator complex, this assembly involving APP(AICD), MED12, MED23, and MED4 is implicated in transcriptional regulation. It serves as a bridge connecting transcription factors with RNA polymerase II, thereby influencing gene expression and cellular responses.
The MAP2K4-MAP3K3-NBR1 complex plays a crucial role in regulating the JNK (c-Jun N-terminal kinase) cascade, which is a component of the MAPK (Mitogen-Activated Protein Kinase) signaling pathway.This complex serves as a key player in transducing signals from extracellular stimuli to intracellular responses, ultimately influencing cellular behavior during inflammatory conditions.
Engages in diverse cellular functions, with the APP(AICD)-FOXO3 complex potentially influencing transcriptional regulation and cellular responses. Ongoing investigations aim to unravel the specific roles and impact of this complex in cellular decision-making and homeostasis.
The AKAP13-MAP2K3-MAP3K20-MAPK14-PKN1 complex is involved in cellular signaling pathways, particularly in the regulation of the MAPK14 (p38alpha) activation in response to alpha1-adrenergic receptor stimulation.This complex plays a crucial role in the precise modulation of signaling cascades, highlighting its specific involvement in alpha1-adrenergic receptor signaling and MAPK14 activation.
The CTNNB1-RUNX3-TCF4 complex plays a critical role in negatively regulating the Wnt signaling pathway and DNA-templated transcription, with a focus on controlling gene expression within the nucleus. The interactions within this complex are intricately involved in modulating cellular responses to Wnt signals and maintaining proper transcriptional regulation.
Participates in transcriptional regulation by associating with the Mediator complex, playing a role in bridging transcription factors to the RNA polymerase II machinery. APLP1 may contribute to the modulation of gene expression and cellular processes, acting as a regulatory component in the transcriptional machinery.
Similar to the APLP1-containing complex, APLP2-MED12-MED23-MED4 is implicated in transcriptional regulation. This incomplete Mediator complex serves as a molecular bridge connecting transcription factors with the RNA polymerase II complex, influencing the expression of target genes and contributing to the regulation of cellular functions.
The MN-hexamer complex, also known as the nuclear pore complex, facilitates the transport of macromolecules between the nucleus and cytoplasm. It serves as a selective barrier and plays a crucial role in nucleocytoplasmic transport, allowing the controlled passage of proteins and RNAs across the nuclear envelope, regulating gene expression and cellular processes.
Involved in the regulation of the hypoxia-inducible factor (HIF) pathway. The PHD2-LIMD1-VHL complex participates in the oxygen-sensing mechanism, targeting HIF for degradation under normoxic conditions, thereby influencing cellular responses to changes in oxygen levels and playing a key role in the cellular adaptation to hypoxia.
Functions in stress response pathways. This complex participates in cellular stress responses, including DNA damage repair and regulation of heat shock proteins. It contributes to the maintenance of genomic integrity and cellular homeostasis under stress conditions.
Plays a role in protein quality control and degradation. The HSPA8-HSPBP1-STUB1 complex is involved in recognizing and targeting misfolded or damaged proteins for degradation through the ubiquitin-proteasome system. This complex contributes to cellular proteostasis, ensuring the removal of aberrant proteins and preventing the accumulation of protein aggregates that can be detrimental to cell function.
Similar to the HSPA8-HSPBP1-STUB1 complex, the BAG1-HSPA8-STUB1 complex is implicated in protein quality control and degradation. BAG1 acts as a co-chaperone for HSPA8, facilitating the recognition of misfolded proteins by the STUB1 ubiquitin ligase for subsequent degradation. This complex contributes to maintaining cellular protein homeostasis and preventing the buildup of dysfunctional proteins.
Involved in the antiviral response. The IFI1-IFI2-IFI3 complex, known as the interferon-induced GTPase (MX1) complex, plays a role in defending cells against viral infections. These interferon-inducible proteins contribute to the restriction of viral replication by disrupting viral components and inhibiting the spread of viral particles within infected cells.
Mediates the exchange of histone variant H2A.Z into chromatin, influencing gene expression and chromatin structure. The p400/TIP60 complex is involved in the dynamic regulation of chromatin architecture, contributing to transcriptional activation and modulation of cellular responses to various signals. The incorporation of H2A.Z is associated with gene regulatory regions and impacts gene expression patterns.
Associated with transcriptional regulation and Alzheimer's disease. The complex participates in transcriptional processes and is implicated in the pathogenesis of Alzheimer's disease. It may influence the expression of genes related to neuronal function and contribute to the molecular mechanisms underlying Alzheimer's pathology.
Potentially involved in cellular stress responses and protein homeostasis. The CAMK4-HSPA1L-HSPA8-IQCG complex may play a role in mediating responses to cellular stress, with heat shock proteins (HSPs) contributing to the maintenance of protein folding and cellular homeostasis under stress conditions. The involvement of CAMK4 suggests a connection to signaling pathways that respond to stress signals.
Plays a role in immune responses. The CD17-ITGAM-ITGB2 complex, also known as the Mac-1 or CR3 receptor complex, is involved in leukocyte adhesion and migration. It plays a crucial role in immune responses by facilitating the interaction of immune cells with endothelial cells and promoting the phagocytosis of pathogens, contributing to the defense against infections and inflammatory processes.
Involved in cell structure and signaling. The complex formed by ezrin (EZR), moesin (MSN), PAG1, radixin (RDX), and SLC9A3R1 participates in the organization of the cell's structural components and signaling processes. These proteins are associated with the regulation of cell morphology, adhesion, and migration, contributing to cellular functions such as cell shape maintenance and cytoskeletal dynamics.
Participates in innate immune responses. The TANK-TBK1-TRAF2 complex is involved in the regulation of antiviral signaling pathways. It contributes to the activation of TBK1, leading to the phosphorylation of IRF3 and induction of type I interferon responses. This complex plays a crucial role in the host defense against viral infections, linking pattern recognition receptors to downstream signaling cascades.
Functions in protein folding and quality control. The DNAJB11-SDF2 complex is involved in the recognition and processing of misfolded proteins. DNAJB11 acts as a co-chaperone, working with SDF2 to facilitate the proper folding of proteins and prevent the accumulation of unfolded or misfolded species. This complex contributes to cellular proteostasis and the maintenance of protein homeostasis.
Involved in endoplasmic reticulum (ER) quality control and protein folding. DNAJB11, a molecular chaperone, interacts with SDF2L1, contributing to the recognition and degradation of misfolded proteins, ensuring proper ER function and cellular proteostasis.
This complex regulates ubiquitin-mediated protein degradation. ITCH, an E3 ubiquitin ligase, forms a complex with NDFIP1 and UBE2L3, facilitating the ubiquitination and subsequent degradation of specific target proteins. It plays a role in the regulation of immune responses, cell signaling, and protein turnover.
Involved in cellular signaling pathways, this complex integrates signals related to cell survival and stress response. AKT1 activates MAPK14 (p38 MAPK), which, in turn, phosphorylates MAPKAPK2 and HSPB1, contributing to the regulation of cell growth, apoptosis, and the cellular response to stressors such as heat shock.
This complex plays a role in cell signaling, influencing processes such as cell survival, growth, and stress response. AKT1 activates MAPK14, leading to the phosphorylation of MAPKAPK2 and subsequent cellular responses.
This complex is part of the p38 MAPK signaling pathway. MAPK14 phosphorylates MAPKAPK3, which, in turn, regulates downstream targets involved in cellular responses to stress, inflammation, and apoptosis. The complex plays a role in mediating signals related to environmental stressors and inflammatory stimuli.
Central to the regulation of the tumor suppressor TP53 (p53), this complex modulates TP53's stability and activity. MDM2 and MDM4 function cooperatively to inhibit TP53, preventing excessive cell cycle arrest and apoptosis. The complex is crucial for maintaining cellular homeostasis and preventing uncontrolled cell proliferation.
Involves MDM2, TP53, and WWOX, contributing to the regulation of TP53 activity. WWOX acts as a tumor suppressor and may modulate TP53's function, impacting cell cycle control and apoptosis. The complex plays a role in cellular responses to DNA damage and stress, influencing the balance between cell survival and apoptosis.
Forms the GABAB receptor, a G protein-coupled receptor involved in inhibitory neurotransmission. The complex is activated by gamma-aminobutyric acid (GABA), regulating neuronal excitability and synaptic transmission. It plays a role in modulating neuronal activity and is implicated in various neurological processes, including learning and memory.
Involves GABA receptors GBR1 and GBR2 along with the metabotropic glutamate receptor mGluR1. This complex integrates GABAergic and glutamatergic signaling, influencing synaptic transmission and neuronal excitability. It plays a role in the modulation of neurotransmission, affecting cognitive and behavioral processes in the nervous system.
Involved in ubiquitin-mediated protein degradation and DNA repair. RNF8 ubiquitin ligase, ATX3 deubiquitinase, and p97 segregase form a complex that regulates the turnover of ubiquitinated proteins and contributes to the DNA damage response. The complex is crucial for maintaining genomic integrity and cellular responses to DNA damage.
The CDYL complex is involved in epigenetic regulation and transcriptional control. CDYL (Chromodomain Y-like protein) interacts with other proteins to modulate chromatin structure, influencing gene expression. The complex may play a role in developmental processes and the regulation of cell identity through epigenetic mechanisms.
Participates in DNA replication and cell cycle regulation. CDYL interacts with CAF1 (Chromatin Assembly Factor 1) and MCM (Mini-Chromosome Maintenance) proteins, contributing to the assembly and maintenance of chromatin structure during DNA replication. The complex is crucial for ensuring accurate DNA replication and cell cycle progression.
Involved in the regulation of cell migration and tissue remodeling. MRC2 interacts with PLAU (urokinase-type plasminogen activator) and PLAUR (urokinase plasminogen activator receptor), modulating the plasminogen activation system. The complex plays a role in extracellular matrix degradation, cell motility, and tissue remodeling processes.
This complex links MUC1 (Mucin 1) with the transcription factor RELA (p65), participating in the regulation of inflammatory responses and cell survival. The interaction may influence gene expression and cellular responses to inflammatory stimuli, impacting processes such as immune modulation and cancer progression.
Involves MUC1 and SH3KBP1, contributing to cell signaling and membrane dynamics. It potentially influences cellular responses to growth factors and the regulation of intracellular signaling pathways. The complex may play a role in modulating cell growth, survival, and signal transduction.
Participates in receptor tyrosine kinase signaling and cell proliferation. GRB2, MUC1, and SOS1 form a complex that links cell surface receptors with downstream signaling pathways. The complex is involved in regulating cell growth, survival, and differentiation by transmitting signals from extracellular stimuli to intracellular signaling cascades.
The dREAM-like complex, similar to the DREAM complex, is involved in cell cycle regulation and transcriptional repression. It helps control the expression of genes during the cell cycle, contributing to proper progression through different phases of cell division.
This complex plays a crucial role in the Toll-like receptor (TLR) signaling pathway, particularly TLR4-mediated responses. MYD88 and TIRAP are adapter proteins that link TLR4 activation to downstream signaling events, leading to the activation of immune responses and the production of inflammatory mediators in defense against pathogens.
The ANO1-KCNE5 complex involves ANO1 (anoctamin 1) and KCNE5, contributing to the regulation of ion channels. ANO1 is a calcium-activated chloride channel, and its interaction with KCNE5 may modulate the channel's activity, impacting cellular functions such as ion transport and membrane potential regulation.
This complex is associated with extracellular matrix remodeling, immune responses, and pattern recognition. Matrix metalloproteinase 9 (MMP9) interacts with NEU1 (sialidase) and TLR7 (Toll-like receptor 7), potentially linking the regulation of extracellular matrix components with innate immune responses to viral RNA, highlighting a connection between matrix dynamics and immune surveillance.
The BSG-JUP-NME1 complex may be implicated in cell adhesion, signaling, and metastasis regulation. BSG is a cell adhesion molecule, and JUP is involved in cell junctions, while NME1 has roles in cellular signaling and metastasis suppression. The complex might contribute to the coordination of these processes in various cellular contexts.
The MIF-NME1 complex may play a role in cellular processes such as inflammation, immune responses, and cell migration. MIF is associated with pro-inflammatory functions, and NME1 has roles in nucleotide metabolism and metastasis suppression. The complex could modulate signaling pathways involved in inflammation and cellular motility.
This multiprotein complex may be involved in chromatin remodeling, DNA repair, and gene expression regulation. The complex components participate in processes such as histone modification, DNA damage repair, and transcriptional regulation, collectively influencing cellular genomic stability and gene expression dynamics.
The IFI16 inflammasome complex is associated with innate immune responses. It activates inflammatory responses, including the cleavage of pro-inflammatory cytokines. This complex plays a role in recognizing DNA from pathogens or damaged cells, contributing to host defense against infections and the initiation of immune responses.
NADPH oxidase is a multi-subunit enzyme complex involved in the generation of reactive oxygen species (ROS). It plays a crucial role in the oxidative burst, contributing to antimicrobial defense and signaling. The complex includes CYBA, CYBB, NCF1, NCF2, and is essential for the production of ROS, which serve as signaling molecules and contribute to the elimination of pathogens by immune cells.
This inflammasome complex is associated with immune responses and apoptosis. It is involved in signaling pathways leading to the activation of inflammatory responses and programmed cell death. The complex coordinates immune activation and cell death, contributing to host defense against pathogens and the regulation of inflammatory processes.
This multiprotein complex involves ILF3, NR5A2, PPARA, and PRMT1. It may participate in transcriptional regulation and chromatin modification. The complex components contribute to the modulation of gene expression and epigenetic modifications, potentially influencing cellular processes such as metabolism and immune responses.
The ILF3-NR5A2-SERBP1 complex is associated with RNA metabolism and transcriptional regulation. ILF3, NR5A2, and SERBP1 interact to potentially modulate the processing and stability of specific RNAs. The complex may have roles in post-transcriptional regulation, influencing mRNA turnover and translation, and may contribute to cellular responses to various signaling cues.
Involved in intracellular membrane trafficking, particularly in the regulation of vesicle fusion and exocytosis. RAB8A-SYTL4 complex plays a role in the precise targeting and delivery of vesicles to specific cellular compartments, contributing to membrane dynamics and cellular organization.
Essential for cell signaling and communication. This complex is implicated in transmembrane signaling pathways, including those related to cell growth, differentiation, and survival. The interaction between ERBB3, integrins (ITGA6 and ITGB4), and NRG1 modulates cellular responses, influencing processes such as cell adhesion and proliferation.
Similar to the ERBB3-ITGA6-ITGB4-NRG1 complex, this complex is involved in transmembrane signaling, impacting cell growth, differentiation, and survival. The specific integrin subunits (ITGAV and ITGB3) in this complex may confer distinct cellular responses, contributing to diverse signaling cascades and cellular behaviors.
Participates in transcriptional regulation and RNA processing. The GTF2I-PARP1-SFPQ complex is involved in coordinating gene expression by influencing transcriptional activities and RNA splicing. The interactions within this complex contribute to the modulation of gene expression patterns and RNA processing events within the cell.
Implicated in cell adhesion, migration, and growth factor signaling. The TM4SF5-ITGA5-EGFR complex integrates signals from extracellular matrix interactions and growth factor stimulation, affecting cellular behaviors such as adhesion, migration, and proliferation. This complex plays a role in modulating cell responses to the surrounding microenvironment.
Involved in transcriptional regulation and chromatin remodeling. The SIX3-LSD1-NuRD(MTA3) complex participates in the modulation of gene expression patterns by influencing chromatin structure and accessibility. This complex is crucial for the regulation of developmental processes and cellular differentiation by orchestrating epigenetic modifications.
Plays a role in chromatin remodeling and gene regulation. The MBD3-NuRD complex is associated with modifying chromatin structure, influencing transcriptional activity. It contributes to the regulation of gene expression patterns and is involved in various cellular processes, including development, differentiation, and responses to environmental cues.
Involved in immune response and gene regulation. The IRF1-STAT1 complex is crucial for coordinating the expression of genes involved in the immune response. It participates in the regulation of antiviral and inflammatory genes, contributing to the cellular defense mechanisms against pathogens and environmental challenges.
Critical for autophagy regulation. The BIF1-UVRAG-Beclin1 complex is involved in the initiation and regulation of autophagy, a cellular process responsible for the degradation and recycling of cellular components. This complex plays a role in maintaining cellular homeostasis and responding to stress conditions by facilitating autophagic processes.
Central to apoptosis signaling. The CASP8-CASP10-FADD-FLIP(S)-RIPK1 complex is a key player in apoptotic pathways, regulating programmed cell death. This complex integrates signals from various death receptors and contributes to the activation of caspases, ultimately leading to apoptosis in response to specific cellular cues.
Implicated in the biogenesis of integral membrane proteins. The ER membrane protein complex, including EMC8, plays a role in ensuring the proper folding, assembly, and insertion of membrane proteins into the endoplasmic reticulum (ER). This complex contributes to the quality control of membrane protein synthesis and localization.
Similar to other EMC complexes, EMC9 is involved in the biogenesis of integral membrane proteins within the ER. It participates in processes that ensure the correct folding, assembly, and localization of membrane proteins, contributing to the integrity and functionality of the endoplasmic reticulum.
Plays a role in intracellular transport and mitotic regulation. The DCTN1-DYNC1I1-NUDC-PLK1 complex is associated with microtubule-based transport and mitotic spindle dynamics. This complex contributes to the proper distribution of cellular components and the regulation of cell division during mitosis.
Involved in nuclear mRNA export. The NXF1-NXT1 complex plays a crucial role in the export of mature messenger RNAs (mRNAs) from the nucleus to the cytoplasm. This complex facilitates the transport of mRNAs through nuclear pores, ensuring proper gene expression and cellular function.
Implicated in the regulation of protein ubiquitination and deubiquitination. The OTUB1-RNF128-USP8 complex participates in the dynamic control of protein ubiquitination, influencing various cellular processes. This complex is involved in maintaining protein stability and regulating signaling pathways by modulating the ubiquitin-proteasome system.
The cBAF complex, a variant of the ATP-dependent chromatin remodeling complex, plays a critical role in modulating chromatin structure. It regulates gene expression by altering the accessibility of DNA, influencing processes such as development, differentiation, and cellular response to external signals.
Similar to the cBAF complex, the PBAF complex is another variant of the ATP-dependent chromatin remodeling complex. It contributes to the regulation of gene expression by modifying chromatin structure, impacting cellular functions such as embryonic development, immune response, and cell cycle control.
This complex involves Kallikrein 6 and alpha-1-antichymotrypsin. Kallikrein 6 is a protease associated with processes like angiogenesis and neurodegeneration. The complex may influence proteolytic activities and contribute to the regulation of protein degradation, potentially impacting tissue remodeling and pathological conditions.
The complex formed by Prostate-specific antigen (PSA) and alpha-1-antichymotrypsin is relevant to prostate biology. PSA is a serine protease associated with prostate function, and the complex formation may play a role in regulating protease activity, affecting processes like seminal fluid liquefaction and potentially contributing to prostate-related conditions.
Involving glandular kallikrein and alpha-1-antichymotrypsin, this complex may influence proteolytic activities and contribute to the regulation of protein degradation. Glandular kallikrein is associated with processes such as blood pressure regulation and renal function, suggesting potential roles for the complex in these physiological functions.
The NPM1-PA2G4 complex is implicated in cell cycle regulation, ribosome biogenesis, and the control of cellular proliferation. It may influence processes related to cell growth, division, and response to cellular stress, contributing to the maintenance of cellular homeostasis.
The RNA polymerase III complex is responsible for transcribing genes that produce small RNA molecules, including transfer RNA (tRNA) and 5S ribosomal RNA. It plays a crucial role in protein synthesis and cellular function by ensuring the production of essential RNA components involved in translation. The complex is vital for maintaining cellular homeostasis and protein synthesis.
This complex is associated with cell cycle regulation and transcriptional control. E2F1 regulates the expression of genes involved in cell cycle progression, and the complex may modulate these regulatory pathways, impacting cellular proliferation, differentiation, and response to DNA damage, with implications for cancer and other diseases.
Involved in protein folding and quality control; HSPA8 (HSP70), PA2G4 (Eukaryotic translation initiation factor 3 subunit G), and STUB1 (CHIP) collectively participate in chaperone-mediated protein degradation, regulating the turnover of misfolded proteins and maintaining cellular protein homeostasis.
Implicated in RNA metabolism and translational control; ILF3 (Interleukin enhancer-binding factor 3) and PA2G4 (Eukaryotic translation initiation factor 3 subunit D) are involved in RNA binding and translation regulation, potentially influencing processes such as mRNA stability and protein synthesis.
Central to apoptosis regulation; the complex includes key apoptotic regulators, such as BAX, BCL2L11 (BIM), PACS2, TNFRSF10B (Death receptor 5), and TNFSF10 (TRAIL). It orchestrates apoptotic signaling pathways, influencing mitochondrial outer membrane permeabilization, caspase activation, and cell death in response to various cellular signals.
Involved in lysosomal functions and glycosphingolipid metabolism; the complex includes Cathepsin A, beta-galactosidase, and neuraminidase. It participates in the degradation of glycosphingolipids within lysosomes, influencing cellular processes related to lipid metabolism and lysosomal function.
Similar to the Cathepsin A-beta-galactosidase complex, this extended complex includes neuraminidase, contributing to glycosphingolipid metabolism and lysosomal functions. It enhances the degradation of glycosphingolipids, potentially impacting cellular processes related to lipid metabolism and lysosomal function.
Involved in transcriptional regulation and cellular responses to stress; the complex comprises CTBP1, EP300 (p300), and FOXO3. It modulates gene expression by participating in transcriptional regulation, potentially influencing cellular responses to various stress stimuli and contributing to the control of cell survival and proliferation.
Essential for cell cycle regulation; the Anaphase-Promoting Complex or Cyclosome (APC/C) complex plays a key role in controlling the cell cycle by promoting the degradation of specific proteins. It regulates transitions between different phases of the cell cycle, including entry into mitosis and exit from mitosis.
Involved in intracellular transport; the complex includes dynein light chains DYNLL1 and DYNLL2. It participates in the assembly of dynein motor complexes, essential for intracellular transport along microtubules. The complex facilitates the movement of cellular cargo, including organelles and vesicles, within the cell.
Involved in chromatin remodeling; the complex includes the SNF2-related CREBBP activator protein (SRCAP) and other associated proteins. It plays a role in modifying chromatin structure, potentially influencing gene expression by facilitating the incorporation of histone variants into chromatin.
Essential for immune responses; the CD4 receptor complex is crucial for T cell activation. CD4 interacts with major histocompatibility complex class II (MHC-II) molecules on antigen-presenting cells, facilitating T cell recognition of antigens and the initiation of immune responses.
Involved in innate immunity; the Mannose-Binding Lectin (MBL)-I complex is part of the lectin pathway of the complement system. MBL-I recognizes and binds to carbohydrate patterns on pathogens, leading to complement activation and the initiation of the immune response against invading microorganisms.
Plays a role in signaling pathways and cellular responses; the complex includes LYN kinase, PAG1 (Cbl-associated protein), and STAT3 (Signal Transducer and Activator of Transcription 3). It participates in cellular signal transduction, potentially influencing processes such as cell proliferation, survival, and immune responses.
Involved in cellular signaling; the complex includes LYN kinase and PAG1. It participates in intracellular signal transduction, potentially influencing cellular processes such as proliferation, differentiation, and immune responses.
Involved in the regulation of cellular signaling pathways; CSK negatively regulates FYN kinase activity, and PAG1 (Cbp/PAG1) serves as a scaffold linking CSK and FYN, modulating signal transduction. The complex may play a role in cellular processes such as proliferation, differentiation, and immune responses.
Participates in cellular signaling cascades; FYN kinase, PAG1, KHDRBS1, and RASA1 collectively regulate signal transduction pathways, potentially influencing cell growth, migration, and differentiation. The complex is implicated in the modulation of intracellular signaling events and may have implications for cellular responses to extracellular stimuli.
Involved in mitochondrial dynamics; PARL, STOML2, and YME1L1 form a complex associated with mitochondrial membranes, potentially influencing processes such as mitochondrial fission, fusion, and quality control. The complex may play a role in maintaining mitochondrial homeostasis and cellular energy balance.
Participates in mitotic processes; the complex involving multiple kinesin proteins (KIF4A, KIF14, KIF20A, KIF23) and PRC1 is associated with mitotic spindle dynamics and cytokinesis, contributing to accurate cell division. This complex is essential for proper chromosome segregation and cytokinesis during cell division.
Involved in the regulation of cell cycle and apoptosis; CABLES1 interacts with TP53 and TP73, contributing to the control of cell cycle progression and apoptosis. The complex may play a role in coordinating cellular responses to DNA damage and stress, influencing cell fate decisions.
Essential for immune responses; IL-15Ralpha associates with IL-15, forming a complex that plays a critical role in the activation and proliferation of natural killer (NK) and CD8+ T cells. The complex is involved in enhancing immune surveillance and defense against infections and tumors.
Crucial for immune regulation; the complex involving IL-2Rbeta/gamma receptors and IL-15 facilitates signaling cascades that influence the activation, proliferation, and survival of T cells and NK cells. This complex contributes to the regulation of immune responses and the maintenance of immune homeostasis.
Key for immune system modulation; the complex comprising IL-2Ralpha/beta/gamma receptors and IL-2 is central to the activation and survival of T cells. It plays a vital role in immune responses, including the regulation of T cell proliferation and differentiation. The complex is crucial for maintaining immune balance and preventing autoimmunity.
Crucial for immune regulation, the IL-2Rbeta/gamma receptor-IL-2 complex mediates the biological effects of interleukin-2 (IL-2). It plays a central role in T-cell activation, proliferation, and immune response modulation. The complex is essential for maintaining immune homeostasis and is implicated in therapeutic applications, including immunotherapy for certain diseases.
Involved in iron-sulfur cluster biogenesis; the complex plays a role in the maturation of iron-sulfur clusters, essential co-factors for various cellular processes. This complex participates in mitochondrial and cytosolic iron-sulfur cluster assembly, contributing to cellular functions such as respiration and DNA repair.
Important for hematopoiesis; the complex involving IL-3Ralpha/beta receptors and IL-3 is critical for the survival and differentiation of hematopoietic cells. It plays a key role in stimulating the production of various blood cell types, contributing to hematopoiesis and immune system function.
Essential for eosinophil development; the complex comprising IL-5Ralpha/IL-3Rbeta receptors and IL-5 is involved in the regulation of eosinophil production and function. This complex influences allergic responses and immune processes related to eosinophil-mediated inflammation.
Plays a role in immune responses, where the IL-20 receptor complex interacts with IL-20, contributing to inflammatory processes and tissue homeostasis. This complex is involved in the regulation of immune cell functions and may influence skin and mucosal responses, impacting conditions such as psoriasis and inflammatory bowel disease.
Essential for immune regulation, the IL-18 receptor complex binds IL-18, triggering signaling cascades that modulate the activity of immune cells. This complex is involved in the regulation of inflammation and immune responses, contributing to the defense against infections and the maintenance of immune system balance.
Similar to the IL-18Ralpha receptor-IL-18 complex, this complex is crucial for immune responses. The binding of IL-18 to its receptor initiates signaling pathways that regulate inflammatory processes and immune cell activities, playing a key role in host defense mechanisms and immune system homeostasis.
Involved in extracellular matrix remodeling, this complex regulates the activity of MMP-1, influencing tissue architecture and cell migration, with implications in processes such as tissue repair and cancer metastasis.
Participates in extracellular matrix modulation, where Mt-MMP-1, TIMP-2, and proMMP-2 collaborate. This complex regulates the activation of MMP-2, affecting processes such as tissue remodeling and angiogenesis. It plays a role in the balance of matrix metalloproteinase activities, impacting cellular behaviors and the tissue microenvironment.
The EMC2-EMC5-EMC8 complex is associated with endoplasmic reticulum membrane protein complex (EMC). It may play a role in protein folding, quality control, and the maintenance of endoplasmic reticulum integrity, contributing to cellular homeostasis and the prevention of misfolded protein accumulation.
Similar to the IL-20Ralpha/beta receptor-IL-20 complex, this complex involves the IL-20 receptor and IL-19. It contributes to immune responses, potentially affecting inflammatory processes and tissue homeostasis. The complex may influence conditions such as psoriasis and inflammatory bowel disease, modulating immune cell functions and tissue responses.
The VTN-TAT complex involves vitronectin (VTN) and the HIV-1 Tat protein (TAT). This complex may play a role in cellular processes related to HIV infection and interactions with host proteins, potentially impacting viral replication and host cell responses. The specific functions of this complex may vary in different cellular contexts.
Involved in the regulation of insulin-like growth factor 1 (IGF1) activity, this complex includes IGF1 and insulin-like growth factor-binding protein 5 (IGFBP5). It modulates the availability and function of IGF1, influencing cellular responses related to growth, survival, and metabolism. The complex plays a role in the fine-tuning of IGF1 signaling pathways.
An extension of the IGF1-IGFBP5 complex, this complex includes acid labile subunit (ALS). Together, these components regulate IGF1 bioavailability and stability in the circulation. The complex plays a role in systemic IGF1 signaling, impacting growth and metabolic processes at the organismal level.
Similar to the IGF1-IGFBP5 complex, this complex involves insulin-like growth factor 2 (IGF2) and IGFBP5. It modulates the activity of IGF2, influencing cellular responses related to growth, differentiation, and metabolism. The complex contributes to the regulation of IGF2 signaling pathways, playing a role in developmental and physiological processes.
An extension of the IGF2-IGFBP5 complex, this complex includes ALS. It regulates the stability and availability of IGF2 in the circulation, impacting systemic IGF2 signaling. The complex plays a role in coordinating IGF2-related physiological processes at the organismal level, including growth and metabolic regulation.
The IL6R/IL6ST receptor-IL6 complex is essential for the biological activities of interleukin-6 (IL-6). It mediates IL-6 signaling, influencing immune responses, inflammation, and various cellular processes. The complex plays a role in the regulation of immune cell functions and contributes to the pathogenesis of inflammatory and autoimmune conditions.
Involved in the formation of multivesicular bodies (MVBs), this complex participates in endosomal sorting and vesicle formation processes, playing a crucial role in the regulation of protein trafficking, degradation, and cellular membrane dynamics.
The TPA-PLG-TSP complex involves tissue plasminogen activator (TPA), plasminogen (PLG), and thrombospondin (TSP). It may play a role in fibrinolysis and tissue repair processes, where TPA activates PLG to plasmin, contributing to the degradation of fibrin clots. The complex's involvement in cellular interactions and tissue remodeling is implicated in various physiological and pathological contexts.
Involved in fibrinolysis; tissue plasminogen activator (TPA) activates plasminogen (PLG) to plasmin, contributing to the breakdown of blood clots. Histidine-rich glycoprotein (HRGP) may modulate this process and play roles in regulating hemostasis and thrombosis.
Associates plasminogen (PLG) with thrombospondin (TSP); may play a role in cell adhesion, angiogenesis, and tissue remodeling. PLG activation by TSP can influence the regulation of the extracellular matrix and cell-matrix interactions.
Histidine-rich glycoprotein (HRG) interacts with plasminogen (PLG) and may be involved in modulating the fibrinolytic system. The complex could play roles in hemostasis, thrombosis, and immune response regulation.
The CLC-CLF-CNTFR complex is associated with cytokine signaling. CLC and CLF are cytokines, and CNTFR is their common receptor. This complex is implicated in the regulation of cellular responses to cytokines, influencing immune responses and hematopoiesis.
Involved in MAPK signaling; MAP2K1 activates RAF1 in coordination with NEK10. This complex plays a role in cellular responses to extracellular signals, influencing processes such as cell proliferation, differentiation, and survival.
The Repairosome complex is involved in DNA repair processes. It consists of various proteins working together to detect and repair DNA damage, ensuring genomic integrity and preventing mutations that could lead to diseases such as cancer.
Critical for platelet adhesion and aggregation; this complex is part of the platelet glycoprotein Ib-IX-V receptor, mediating the interaction between platelets and exposed collagen at sites of vascular injury, contributing to hemostasis and thrombosis.
Involved in chemokine signaling; CXCR4 is a receptor for CXCL12. This complex plays a role in immune responses, hematopoiesis, and cell migration, influencing the movement and localization of cells in various tissues.
The Aposome complex is associated with apoptotic processes. It may play a role in regulating cellular responses to apoptotic signals, influencing programmed cell death and maintaining tissue homeostasis.
Participates in multivesicular body (MVB) formation and endosomal sorting; involved in the process of sorting and transporting proteins within cells. This complex is associated with the formation of intraluminal vesicles in multivesicular bodies, contributing to cellular processes such as protein degradation and receptor downregulation.
Similar to the MVB12B-PDCD6-PDCD6IP-TSG101-VPS28-VPS37B complex, involved in MVB formation and endosomal sorting; may have specific roles in cellular processes depending on the context and associated proteins.
Participates in MVB formation and endosomal sorting; may have specific functions in cellular processes, possibly related to protein degradation and receptor downregulation.
Involved in exosome biogenesis and secretion; the CD63-syntenin-1 complex contributes to the sorting of proteins into exosomes, influencing intercellular communication through the release of exosomal content.
Associated with JAK-STAT signaling; STAT1 and STAT3 are signal transducer and activator of transcription proteins. This complex is involved in transducing signals from cytokines and growth factors, influencing cellular responses such as inflammation, immune regulation, and cell proliferation.
Plays a role in exosome biogenesis and secretion; this complex is involved in the sorting of proteins into exosomes, contributing to intercellular communication through exosomal release. The specific functions may vary depending on the context and associated proteins.
This complex is central to interferon signaling, where IFNAR1 and IFNAR2 receptors form a complex with TYK2 kinase. Together, they activate downstream signaling pathways crucial for antiviral responses and immune regulation, contributing to the body's defense against infections and other immune-related processes.
Functioning in cell adhesion and signaling pathways, this complex influences cellular processes such as cell migration, invasion, and adhesion. This intricate interaction may play a pivotal role in cancer biology, impacting the progression and metastasis of cancer cells by modulating their ability to interact with the extracellular environment and neighboring cells.
This complex modulates cellular responses to cyclic AMP, affecting diverse processes such as cell proliferation, differentiation, and gene expression. The intricate crosstalk within this complex contributes to the fine-tuning of cellular activities influenced by cyclic AMP signaling pathways.
Playing a significant role in cytokine signaling, this complex helps regulate immune responses and inflammation. The inclusion of SOCS3 as a negative regulator ensures precise control of signaling downstream of GP130 and JAK2, preventing excessive immune activation and maintaining immune homeostasis. This complex is crucial for orchestrating appropriate immune responses while preventing unnecessary inflammation.
Involved in apoptotic pathways, this complex plays a role in the regulation of cell survival and death processes. This intricate interaction may influence cellular responses to various signals, contributing to the delicate balance between survival and apoptosis. The complex's involvement in apoptotic pathways underscores its significance in cellular decision-making related to programmed cell death.
Operating in DNA repair, the PAXX complex is instrumental in maintaining genomic stability. PAXX's participation in the non-homologous end joining (NHEJ) pathway contributes to the repair of double-strand breaks in DNA, ensuring the integrity of the genome. This complex plays a critical role in safeguarding the cell's genetic material from damage, contributing to overall genomic stability and preventing the accumulation of harmful mutations.
Participating in receptor tyrosine kinase signaling, this complex regulates downstream signaling pathways associated with cell growth, survival, and proliferation. This intricate interaction is particularly relevant in cellular responses to epidermal growth factor stimulation, influencing key processes that contribute to normal cellular functions and aberrant growth in certain pathological conditions, such as cancer.
Similar to the ACK1-GRB2-EGFR complex, this complex involves platelet-derived growth factor receptor (PPDGFR), extending its influence to growth factor signaling pathways. This interaction may modulate cellular responses to growth factor signals, impacting cell growth, survival, and proliferation. The complex's involvement in PPDGFR signaling highlights its relevance in processes related to cellular growth and tissue development.
This complex is implicated in oncogenic signaling. Their interactions may contribute to aberrant activation of ALK signaling pathways, potentially promoting cell transformation and cancer development. The intricate interplay within this complex underscores its significance in the context of oncogenic signaling, where dysregulation can lead to uncontrolled cell growth and contribute to the progression of certain cancers.
Functioning as a negative regulator of EGFR signaling, the MIG6-GRB2-EGFR complex inhibits EGFR activation, modulating downstream signaling pathways. This regulatory interaction plays a crucial role in attenuating cellular responses to epidermal growth factor stimulation, contributing to the precise control of EGFR-mediated signaling and influencing cellular processes such as cell proliferation and survival.
Similar to the MIG6-GRB2-EGFR complex, this complex involves platelet-derived growth factor receptor (PDGFR). MIG6 acts as a negative regulator, inhibiting PDGFR signaling and modulating cellular responses to PDGF stimulation. The complex's involvement in PDGFR signaling highlights its role in controlling cellular responses to growth factor signals, impacting processes such as cell growth, migration, and tissue development.
This complex contributes to the regulation of ALK signaling. MIG6 serves as a negative regulator, inhibiting ALK activation and downstream signaling pathways. The complex's involvement in ALK signaling pathways emphasizes its role in maintaining precise control over cellular responses related to ALK receptor activation, potentially influencing cell growth, survival, and differentiation.
Operating in cytoskeletal organization and cellular signaling, this complex influences cell adhesion, migration, and signaling pathways. This intricate interaction plays a pivotal role in tissue development and homeostasis, as the complex modulates cellular processes essential for maintaining proper tissue structure and function. The interplay within this complex contributes to the dynamic regulation of cell behavior in various physiological contexts.
Involved in cellular signaling pathways, this complex comprises protein kinase C delta (PRKCD), 3-phosphoinositide-dependent protein kinase-1 (PDPK1), and PRG2. This complex's interaction may contribute to the regulation of PRKCD signaling and downstream cellular responses, potentially influencing processes such as cell proliferation and survival. The intricate interplay within this complex underscores its importance in cellular decision-making related to signaling cascades.
Similar to the PRKCD-PDPK1-PRG2 complex, this complex involves protein kinase C zeta (PRKCZ). Operating in cellular signaling pathways, this complex's interaction may modulate PRKCZ signaling and downstream cellular responses. This complex's involvement highlights its potential influence on processes such as cell proliferation, survival, and differentiation, contributing to the regulation of cellular behavior in diverse physiological contexts.
Regulates cellular signaling pathways that impact cell proliferation and migration. The interaction between PEAK1, PPP1CA, and SHC1 contributes to the modulation of downstream signaling events, influencing cellular responses related to growth, migration, and survival.
Influences cellular signaling and modulates cell proliferation, impacting cellular responses related to growth, migration, and survival. The complex involving PEAK1, PPP1CC, and SHC1 is implicated in the regulation of signaling cascades, potentially affecting cellular behaviors.
Crucial for vascular biology, the complex formed by CDH5, KDR (VEGFR2), and PECAM1 plays a pivotal role in processes such as angiogenesis and vascular permeability. This complex is essential for the regulation of blood vessel formation and maintenance, contributing to vascular integrity and function.
Regulates endothelial cell junctions, contributing to the regulation of cell-cell adhesion and vascular integrity. The complex formed by CLDN1, ESAM, OCLN, and PECAM1 plays a vital role in the maintenance of endothelial cell junctions, influencing the barrier function of endothelial cells in tissues.
Plays a role in estrogen receptor signaling, modulating cellular responses related to growth, differentiation, and homeostasis. The complex involving ESR1, PELP1, and SRC contributes to the modulation of estrogen-dependent gene expression, influencing cellular behaviors.
Participates in the regulation of TGF-beta signaling, influencing cellular responses related to cell growth, differentiation, and immune control. The complex comprising PTEN, PP1MA, SMAD2, and SMAD3 is implicated in the modulation of the TGF-beta pathway, impacting cellular behaviors.
Regulates cellular responses to stress, impacting cellular adaptation to environmental challenges such as endoplasmic reticulum stress. The complex formed by EIF2S1, NCK1, PPP1CA, and PPP1R15B plays a key role in the control of protein synthesis under stress conditions, influencing cellular behaviors in response to stress.
Involved in DNA damage recognition and repair, contributing to the maintenance of genomic stability and prevention of mutations. The complex is essential for the recognition of DNA lesions, participating in nucleotide excision repair processes that are crucial for maintaining genomic integrity.
Participates in DNA damage recognition and repair, facilitating the detection of DNA lesions and initiation of nucleotide excision repair processes. The complex is crucial for the efficient detection of DNA lesions and the initiation of nucleotide excision repair mechanisms, influencing cellular behaviors in response to DNA damage.
Regulates nucleocytoplasmic transport, contributing to the regulation of gene expression and cellular activities requiring dynamic protein movement across cellular compartments. The complex is crucial for the transport of proteins between the nucleus and cytoplasm, influencing cellular behaviors related to gene regulation and protein movement.
Involved in protein quality control and chaperone functions, contributing to cellular protein homeostasis and prevention of protein misfolding. The complex participates in the recognition, folding, and degradation of misfolded proteins, contributing to cellular protein homeostasis and preventing the accumulation of aberrant proteins that could lead to cellular dysfunction.
Manages protein quality control, ensuring proper protein folding and preventing the buildup of protein aggregates that could be detrimental to cellular function. The interaction between DNAJB12 and DNAJB14 contributes to the recognition and handling of misfolded proteins within cells, ensuring proper protein folding and preventing the buildup of protein aggregates that could be detrimental to cellular function.
Participates in protein quality control and cellular stress responses, contributing to cellular proteostasis and stress adaptation. The complex is implicated in recognizing and managing misfolded proteins, contributing to cellular proteostasis and stress adaptation.
Plays a crucial role in sensing cytosolic DNA and triggering inflammatory responses, providing a defense mechanism against infections and cellular stress. The AIM2 PANoptosome complex is involved in the activation of pyroptosis and contributes to innate immune responses by recognizing cytosolic DNA, influencing cellular behaviors in response to infections and stress.
Critical for tumor necrosis factor receptor 1 (TNFR1) signaling, mediating cellular responses to TNF and influencing pathways related to inflammation, apoptosis, and immune regulation. The TNFR1-signaling complex I is formed during TNFR1 activation and transduces signals from the receptor to downstream effectors, modulating cellular behaviors in response to TNF stimulation.
Plays a role in promoting apoptotic cell death. The Pro-death complex II is involved in the activation of caspase-8, a key mediator in apoptotic signaling pathways, contributing to the regulation of programmed cell death.
Essential for inducing programmed cell death, particularly pyroptosis, apoptosis, and necroptosis. The PANoptosome is a multi-protein complex that integrates various signaling pathways, coordinating the cellular response to infections and stressors.
Regulates nucleocytoplasmic transport by facilitating the movement of proteins between the nucleus and cytoplasm. The interaction between RAN and RANBP1 is crucial for the transport of cargo molecules across cellular compartments.
Involved in the regulation of nucleocytoplasmic transport and the cell cycle. The RAN-RANBP1-RCC1 complex plays a role in coordinating the dynamics of the small GTPase RAN, influencing cellular processes related to nucleocytoplasmic shuttling and cell cycle progression.
Participates in protein folding and quality control processes. The AIPL1 chaperone complex, involving Aryl hydrocarbon Interacting Protein-like 1, assists in the proper folding and maintenance of specific target proteins, contributing to cellular protein homeostasis.
Critical for transmitting apoptotic signals. The FADDosome complex includes FADD (Fas-associated death domain), and its activation leads to the recruitment and activation of caspase-8, initiating the extrinsic apoptotic pathway and resulting in programmed cell death.
Involved in non-homologous end joining (NHEJ) repair of DNA double-strand breaks. The NHEJ1-XRCC4 complex participates in the ligation step of NHEJ, contributing to the repair of damaged DNA and maintenance of genomic stability.
Regulates cellular processes related to cell growth, survival, and signaling. This complex involves multiple proteins, influencing pathways such as PI3K-AKT-mTOR and regulating cellular responses to growth factors and stress signals.
Plays a crucial role in the activation of mTORC1 signaling in response to nutrient availability. The Ragulator-Rag complex regulates the recruitment of mTORC1 to the lysosomal surface, influencing cellular processes such as protein synthesis, growth, and metabolism.
Involved in immune responses and signaling. The IL15RA-TGFBR2 complex participates in the interaction between interleukin-15 receptor alpha (IL15RA) and transforming growth factor beta receptor 2 (TGFBR2), potentially influencing cellular responses related to immune regulation and inflammation.
Associated with cellular processes related to mitochondrial function and nucleocytoplasmic transport. The DLD-NFE2L1-RAN complex may play roles in energy metabolism and the regulation of protein transport between the nucleus and cytoplasm.
Participates in G protein signaling pathways. The GNAI1-GNB1-GNGT1-NTS-NTSR1 complex involves multiple G protein subunits and receptors, influencing cellular responses to neurotransmitters and other extracellular signals.
Regulates cellular responses to oxidative stress. The KEAP1-NRF2 complex is involved in the regulation of NRF2 (nuclear factor erythroid 2-related factor 2), a transcription factor that plays a key role in the antioxidant response, contributing to cellular defense against oxidative damage.
Participates in signaling pathways related to cyclic AMP (cAMP) and VIP receptors. The ADCYAP1-GNAS-GNB1-GNGT1-VIPR1 complex involves components associated with cAMP signaling and vasoactive intestinal peptide (VIP) receptor activation, potentially influencing cellular responses in various tissues.
Involved in nucleotide biosynthesis. The DHFR-SHMT1-TYMS complex includes key enzymes in the de novo synthesis of thymidylate, contributing to DNA synthesis and cell proliferation.
Involved in intracellular trafficking and vesicle formation. The complex, comprising AP1G1, LZTFL1, and TFRC, plays a role in regulating the transport of proteins within cells, particularly in endocytic pathways and the recycling of transferrin receptors (TFRC).
Implicated in extracellular matrix remodeling and proteolysis. The complex formed by ANXA2, MMP2, and WFDC2 participates in processes related to tissue remodeling, potentially influencing cell migration and invasion. ANXA2 and MMP2 are associated with matrix metalloproteinase activity, and WFDC2 may play a regulatory role in these processes.
Essential for transforming growth factor-beta (TGF-β) signaling. The complex involving SMAD3, SMAD4, and SKIL modulates the TGF-β pathway, influencing cellular responses related to growth, differentiation, and immune regulation. SMAD3 and SMAD4 are key mediators of TGF-β signaling, while SKIL acts as a negative regulator, contributing to the fine-tuning of TGF-β-mediated cellular processes.
Involved in protein folding and quality control. The complex formed by DNAJB1, HSPA4 (HSP70), and HSPA8 (HSC70) participates in chaperone functions, facilitating the folding of newly synthesized proteins and assisting in the refolding of misfolded proteins. This complex is crucial for maintaining cellular protein homeostasis and preventing the accumulation of aberrant protein structures.
Regulates the degradation of TP53 (p53) and impacts cell cycle control. The complex comprising MDM2, RSL1D1, and TP53 is involved in the ubiquitin-mediated degradation of TP53, a tumor suppressor protein. MDM2 acts as an E3 ubiquitin ligase, targeting TP53 for degradation, and RSL1D1 is implicated in the stabilization of MDM2. This complex plays a role in the regulation of TP53 levels and influences cellular responses related to cell cycle progression and apoptosis.
Participates in mRNA translation regulation. The complex formed by PAIP1 and YBX2 influences translation initiation and mRNA stability, potentially impacting the efficiency of protein synthesis within cells. PAIP1 interacts with the poly(A) tail of mRNA, and YBX2 is involved in mRNA binding, contributing to the control of translation processes. This complex plays a role in the regulation of gene expression at the translational level.
Essential for pre-mRNA splicing. The spliceosome is a dynamic ribonucleoprotein complex responsible for removing introns and joining exons during mRNA processing. It ensures the accurate and precise splicing of precursor mRNA, contributing to the generation of mature mRNA transcripts that can be translated into functional proteins. The spliceosome is fundamental to gene expression and the production of diverse protein isoforms from a single gene.
Involved in chromatin compaction and gene regulation. The complex formed by components of Polycomb Repressive Complex 1.3a participates in the maintenance of repressive chromatin structures, influencing the regulation of gene expression. This complex is associated with the Polycomb group proteins, contributing to the epigenetic control of gene transcription and cellular differentiation.
Plays a role in chromatin compaction and transcriptional regulation. The PRC1.3b complex, consisting of Polycomb group proteins, is implicated in the establishment and maintenance of repressive chromatin structures. It contributes to the epigenetic control of gene expression, influencing cellular processes such as development and differentiation.
Involved in chromatin organization and gene silencing. The PRC1.5a complex, formed by Polycomb group proteins, participates in the regulation of chromatin structure and gene expression. It contributes to the establishment of repressive chromatin marks, influencing cellular processes such as cellular identity and differentiation.
Associated with chromatin compaction and epigenetic regulation. The PRC1.5c complex, composed of Polycomb group proteins, is implicated in the maintenance of repressive chromatin structures. It plays a role in the epigenetic control of gene expression, influencing cellular processes related to cellular identity and differentiation.
Participates in chromatin compaction and gene silencing. The PRC1.6a complex, containing Polycomb group proteins, is involved in the regulation of chromatin structure and gene expression. It contributes to the establishment of repressive chromatin marks, influencing cellular processes such as development and differentiation.
Involved in chromatin organization and transcriptional regulation. The PRC1.6b complex, formed by Polycomb group proteins, plays a role in the maintenance of repressive chromatin structures. It contributes to the epigenetic control of gene expression, influencing cellular processes such as cellular identity and differentiation.
Implicated in the regulation of cellular signaling pathways. The complex modulates cellular signaling events, potentially influencing processes such as cell growth, differentiation, and immune responses. CSK is a tyrosine kinase involved in the negative regulation of signaling cascades, and HSP90AA1 and HSPA8 act as chaperones in maintaining protein conformation. This complex contributes to the fine-tuning of cellular responses to external stimuli.
Involved in the recognition of lipopolysaccharide (LPS) and initiation of immune responses. The LPS receptor complex plays a crucial role in the detection of LPS, a component of bacterial cell walls. Activation of this complex initiates signaling pathways leading to immune responses, including the production of inflammatory mediators and activation of the innate immune system. This complex is fundamental to host defense against bacterial infections.
Participates in the recognition of microbial patterns and immune responses. The complex is implicated in the detection of specific microbial molecules, triggering signaling pathways leading to immune responses. CD36 acts as a pattern recognition receptor, while TLR4 and TLR6 are Toll-like receptors involved in pathogen recognition. This complex plays a crucial role in the initiation of innate immune responses to microbial challenges.
Plays a central role in the interleukin-1 signaling pathway. The comple mediates cellular responses to IL-1, triggering downstream signaling cascades that regulate inflammatory and immune responses. It is involved in the activation of NF-kappaB and MAPK pathways, influencing gene expression and cytokine production.
Regulates receptor tyrosine kinase signaling. The complex is implicated in the downregulation of EGFR signaling through ubiquitination and subsequent degradation. It plays a role in controlling cellular responses to growth factors and is involved in the negative feedback regulation of receptor tyrosine kinase activities, impacting cell proliferation and survival.
Participates in intracellular vesicle trafficking. The complex is involved in the transport of vesicles between intracellular compartments, contributing to the regulation of membrane and protein trafficking. It plays a role in maintaining cellular homeostasis and the proper distribution of cellular components.
Modulates transcriptional regulation and DNA damage responses. The complex contributes to the acetylation of p53, influencing its transcriptional activity. This complex is involved in the regulation of genes related to cell cycle arrest, DNA repair, and apoptosis in response to cellular stress and DNA damage, impacting cellular responses to genomic instability.
Impacts estrogen receptor signaling and p53-mediated responses. The complex is involved in the interplay between estrogen receptor signaling and the p53 pathway, potentially influencing cellular responses related to cell growth, differentiation, and DNA damage. It may play a role in the context-dependent regulation of gene expression and cellular fate.
Involved in protein quality control and cellular processes. The complex is implicated in the recognition and handling of misfolded proteins, contributing to cellular protein homeostasis. Additionally, it may have roles in cellular processes associated with TMEM67, impacting cellular responses to specific stimuli or conditions.
Essential for interleukin-7 (IL-7) signaling. The complex is crucial for the activation of the IL-7 signaling pathway, promoting the survival, proliferation, and differentiation of T cells. It plays a fundamental role in the development and maintenance of the immune system, influencing cellular responses in lymphoid tissues and impacting immune cell homeostasis.
The ZFAND2B complex functions as a quality-control complex that plays a crucial role in the regulation of translocation into the endoplasmic reticulum (ER) for secretory and membrane proteins. This process is essential for maintaining the fidelity of protein folding and trafficking within the cell, contributing to cellular protein homeostasis and the prevention of aberrant protein accumulation that could lead to cellular dysfunction.
Facilitates interleukin-21 (IL-21) signaling. The complex is essential for the activation of the IL-21 signaling pathway, influencing immune responses and cellular activities in various immune cells. It plays a role in the regulation of immune functions, including the modulation of T and B cell responses, and impacts cellular behaviors related to immune homeostasis and inflammation.
Involved in Hedgehog signaling and cellular development. The complex participates in the Hedgehog signaling pathway, influencing cellular processes related to embryonic development, tissue patterning, and cell differentiation. It plays a role in regulating cellular fate and tissue morphogenesis during embryonic development, impacting the formation of various organs and tissues.
Plays a crucial role in interleukin-23 (IL-23) signaling. The complex is essential for the activation of the IL-23 signaling pathway, influencing immune responses and cellular activities in various immune cells. It plays a role in the regulation of inflammatory processes, impacting cellular behaviors related to immune homeostasis and the development of certain immune-mediated conditions.
Facilitates membrane fusion and intracellular vesicle trafficking. The SNARE complex plays a central role in mediating the fusion of vesicles with target membranes, facilitating the transport of cellular cargo. It is crucial for intracellular membrane trafficking, impacting cellular processes such as secretion, endocytosis, and the maintenance of organelle dynamics.
Involved in innate immune responses and antiviral defense. The complex plays a role in regulating the activity of IRF3, a transcription factor involved in the induction of interferon and antiviral responses. It contributes to the modulation of cellular responses to viral infections, impacting the host defense against invading pathogens.
Modulates NF-kappaB signaling and cellular responses to inflammation. The complexis implicated in the regulation of NF-kappaB pathway activity, influencing the expression of genes involved in inflammatory responses and immune regulation. It plays a role in modulating cellular behaviors related to inflammation, immune homeostasis, and the response to various external stimuli.
Essential for interferon signaling and antiviral defense. The ISGF3 complex plays a central role in the transcriptional response to interferon signaling. It regulates the expression of interferon-stimulated genes, contributing to antiviral defenses and cellular responses to infections. The ISGF3 complex impacts cellular behaviors related to the innate immune response and the establishment of an antiviral state within cells.
Involved in the regulation of innate immune responses and antiviral defense. The complex participates in the activation of TBK1 and the regulation of downstream signaling events. It plays a role in the modulation of innate immune responses, particularly in the induction of interferon and antiviral defenses. The complex impacts cellular behaviors related to the host defense against viral infections and the regulation of inflammatory processes.
This complex is pivotal in innate immune signaling, where TANK recruits TBK1 to activate IRF3. The activated IRF3 leads to the production of interferons, initiating a robust antiviral response to combat viral infections and contribute to overall immune defense mechanisms.
Involved in antiviral signaling pathways, this complex orchestrates the activation of IRF3. This activation triggers the induction of interferons, enhancing the cellular defense against viral infections and strengthening the host's ability to mount an effective immune response.
Integral to DNA damage response, this complex plays a crucial role in sensing DNA damage. It facilitates the repair processes required to maintain genomic stability, preventing the accumulation of mutations and contributing to the overall integrity of the cellular genome.
Functioning in DNA damage response, the IFI16-BRCA1 complex is instrumental in recognizing and repairing damaged DNA. By participating in these crucial cellular processes, the complex helps safeguard genomic integrity, reducing the risk of genetic abnormalities and supporting overall cellular health.
Essential for centrosome organization, the Pericentrin complex, along with associated proteins, contributes to the structural and functional integrity of the centrosome. This complex is crucial for proper cell division, spindle formation, and the organization of microtubules, ensuring accurate chromosome segregation during cell division.
Mediating signaling from TNF receptor 1 (TNFR1), this complex transduces signals that regulate diverse cellular processes, including inflammation, cell survival, and apoptosis. It plays a key role in cellular responses to TNF, a cytokine with broad implications in immune regulation and the inflammatory response.
Participating in mitochondrial protein import and membrane translocation, this complex facilitates the import of nuclear-encoded mitochondrial proteins. It plays a crucial role in the sorting and translocation of proteins across mitochondrial membranes, contributing to mitochondrial function, biogenesis, and overall cellular energy production.
Contributing to antiviral responses, this complex is an integral part of the innate immune signaling pathway. It leads to the activation of IRF3, inducing interferons and enhancing the cellular defense against viral infections. The complex is crucial for orchestrating an effective immune response to pathogenic threats.
Involved in mitochondrial protein import and membrane translocation, this complex mediates the sorting and translocation of proteins into mitochondria. Its role is critical for maintaining mitochondrial function and ensuring the proper localization of proteins within the mitochondrial compartments, contributing to cellular energy production and homeostasis.
Functioning in mitochondrial protein biogenesis, the MITRAC complex is involved in the assembly and insertion of respiratory chain complexes into the inner mitochondrial membrane. This complex is pivotal for the biogenesis of the mitochondrial respiratory chain, influencing cellular energy production and overall mitochondrial function.
Playing a key role in TNFR1 signaling, this complex contributes to the activation of downstream signaling pathways. It regulates cellular responses such as apoptosis and inflammation in response to TNFR1 activation, thereby influencing diverse physiological processes under the control of TNF signaling.
Essential for mitotic spindle assembly and chromosome segregation, the NDC80-ZW10-ZWINT complex is part of the kinetochore. It ensures proper attachment of chromosomes to the mitotic spindle during cell division, facilitating accurate segregation of genetic material and contributing to the fidelity of cellular division processes.
Involved in vesicle trafficking, the RAB3IP-TRAPP II complex facilitates vesicle transport within cells. By regulating membrane dynamics and intracellular trafficking processes, this complex plays a crucial role in maintaining cellular organization, vesicular traffic, and overall cellular homeostasis.
Participating in antiviral signaling, the DDX58-TRIM25-YWHAE complex is involved in the activation of RIG-I (DDX58). This activation leads to the induction of antiviral responses, including the production of interferons and the inhibition of viral replication, contributing to the cellular defense against viral infections.
Involved in nucleocytoplasmic transport; ILF3, RAN, XPO5, and ZNF346 form a complex that facilitates the transport of RNA molecules between the nucleus and cytoplasm, playing a crucial role in gene expression regulation and cellular processes dependent on dynamic RNA localization.
Essential for mitochondrial cristae organization; the Mitofilin complex participates in the organization of mitochondrial cristae, influencing mitochondrial structure and function. It is crucial for maintaining mitochondrial integrity and supporting cellular energy production through oxidative phosphorylation.
Participates in nuclear import; this complex is essential for transporting specific proteins into the nucleus, contributing to the regulation of gene expression and other nuclear processes critical for cellular function and homeostasis.
Mediates the response to interferon-lambda1 (IFN-lambda1); this complex is crucial for transmitting signals initiated by IFN-lambda1, leading to the activation of antiviral and immune responses, influencing gene expression, and enhancing the host defense against viral infections.
Involved in cell signaling and chaperone function; this complex is implicated in cell signaling pathways and protein folding. It may influence cellular responses to external signals and contribute to the proper folding of specific proteins critical for cellular function.
Participates in vesicle trafficking and membrane dynamics; the complex plays a role in regulating vesicle transport and membrane dynamics within cells, potentially impacting processes such as immune response and cellular communication.
Involved in vesicle trafficking and Golgi function; the TRAPP III complex is crucial for regulating vesicle transport between the endoplasmic reticulum and Golgi apparatus, influencing the secretory pathway and ensuring proper protein trafficking within the cell.
Participates in immune response; this complex is implicated in the recognition of microbial components and the initiation of immune responses. It contributes to the activation of immune cells and the modulation of inflammatory processes in response to external pathogens.
Plays a role in interleukin-1 (IL-1) signaling; the complex is crucial for transmitting signals initiated by IL-1, leading to the activation of inflammatory responses and immune defense mechanisms against infections or tissue damage.
Essential for IL-1 signaling; this complex mediates cellular responses to interleukin-1 (IL-1), leading to the activation of signaling pathways associated with inflammation, immune response, and cellular homeostasis.
Involved in vesicle trafficking and immune signaling; the complex plays a role in vesicle transport and immune signaling processes. It may contribute to the regulation of innate immune responses and the trafficking of specific vesicles involved in cellular communication.
Participates in vesicle trafficking and cellular adhesion; the complex is implicated in regulating vesicle transport and cellular adhesion processes. It may influence the movement of vesicles within cells and modulate cell-cell interactions critical for various cellular functions.
Involved in cell signaling; the CD44-ERBB2-GRB2-VAV2 complex participates in cell signaling pathways. It may influence cellular responses to growth factors and contribute to the regulation of cell proliferation, differentiation, and other processes associated with signal transduction.
Implicated in vesicle trafficking and cellular adhesion; the complex plays a role in regulating vesicle transport and cellular adhesion processes. It may contribute to the movement of vesicles within cells and modulate cell-cell interactions crucial for various cellular functions.
Involved in vesicle trafficking and cellular adhesion; the complex participates in regulating vesicle transport and cellular adhesion processes. It may contribute to the movement of vesicles within cells and modulate cell-cell interactions essential for various cellular functions.
Involved in autophagy initiation; the complex plays a crucial role in the autophagy pathway, where VPS34 generates phosphatidylinositol 3-phosphate (PI3P) to facilitate autophagosome formation. SLAMF1 may contribute to the regulation of this process in certain cellular contexts.
Functions in autophagy regulation; this extended complex, including UVRAG, enhances the autophagy process. UVRAG interacts with BECLIN1 to modulate VPS34 activity, influencing autophagosome formation and maturation. SLAMF1 may play a regulatory role in autophagy within specific cellular environments.
Involved in vesicle trafficking; the mTRAPP II complex participates in membrane trafficking events, regulating the transport of vesicles between cellular compartments. It plays a role in maintaining cellular organization and the proper delivery of proteins to their target destinations within the cell.
Plays a role in endosome-to-Golgi retrograde transport; the mTRAPP III complex is implicated in retrograde trafficking between endosomes and the Golgi apparatus. It contributes to the regulation of intracellular transport processes, ensuring the proper sorting and delivery of proteins within the endomembrane system.
Involved in MAPK signaling regulation; the complex facilitates the folding, stability, and activation of MAPKs (Mitogen-Activated Protein Kinases), influencing cellular responses to extracellular signals. CDC37 and HSP90AA1 act as chaperones for MAPKs, contributing to proper signaling and regulation of cellular processes such as proliferation and differentiation.
Participates in immune signaling; the complex involving PTPN6 (SHP-1) and VAV1 is implicated in immune cell signaling. PTPN6 negatively regulates signaling pathways, while VAV1 is involved in signaling cascades, contributing to the modulation of immune responses and cellular activation in response to external stimuli.
Regulates growth factor signaling; the complex connects growth factor receptors to downstream signaling pathways. GRB2 links to receptor tyrosine kinases, PTPN6 modulates signaling, and SOS1 activates RAS, collectively influencing cellular responses to growth factors and playing a role in cell growth, survival, and differentiation.
Involved in T-cell receptor signaling; this complex connects the T-cell receptor (TCR) to downstream signaling events. It facilitates signal transduction and influencing T-cell activation, proliferation, and immune responses.
Mediates Toll-like receptor (TLR) signaling; the complex is crucial for initiating immune responses to pathogens. MyD88 connects TLR4 to downstream signaling, and SYK contributes to intracellular signaling events, leading to the activation of immune responses and the production of inflammatory mediators upon recognition of microbial components.
Functions in TLR signaling; the complex is a key player in the Toll-like receptor signaling pathway. It mediates the activation of immune responses upon detection of pathogens, influencing the production of cytokines and the orchestration of innate immune defenses.
Involved in vesicle trafficking; this complex participates in retrograde transport from the Golgi to the endoplasmic reticulum (ER). TRAPP II and COP I regulate vesicle formation and coat recruitment, while RAB18 contributes to vesicle targeting and fusion, collectively ensuring proper membrane trafficking and maintenance of cellular compartmentalization.
Mediates nuclear import; the complex is involved in the import of proteins into the nucleus. KPNA4 recognizes nuclear localization signals, while KPNB1 facilitates translocation through the nuclear pore complex. This complex plays a crucial role in regulating gene expression and cellular processes requiring nuclear localization of specific proteins.
Functions in nuclear import; the complex mediates the transport of proteins into the nucleus. KPNA1 recognizes nuclear localization signals, and KPNB1 facilitates the translocation of cargo proteins across the nuclear envelope. This complex is essential for regulating gene expression and coordinating nuclear-cytoplasmic transport.
Plays a role in nuclear import; the complex is involved in transporting proteins into the nucleus. KPNA6 recognizes nuclear localization signals, and KPNB1 facilitates the translocation of cargo proteins through the nuclear envelope. This complex is crucial for regulating gene expression and ensuring proper cellular functions that rely on nuclear localization.
Involved in nucleocytoplasmic transport; the complex facilitates the movement of proteins between the nucleus and cytoplasm. CSE1L interacts with KPNA4, recognizing nuclear localization signals, and RAN regulates the translocation of cargo through the nuclear pore complex. This complex is vital for the dynamic interchange of proteins across cellular compartments, influencing gene expression and cellular processes.
Involved in nucleocytoplasmic transport; CSE1L, KPNA1, and RAN form a complex that facilitates the transport of proteins between the nucleus and cytoplasm, contributing to the regulation of gene expression and cellular activities requiring the dynamic interchange of proteins across cellular compartments.
Participates in nucleocytoplasmic transport; the complex facilitates the movement of proteins across the nuclear membrane, playing a role in regulating cellular processes such as gene expression, signal transduction, and overall cellular homeostasis.
Forms channels in the nuclear envelope; the nuclear pore complex regulates the transport of molecules between the nucleus and cytoplasm, allowing the controlled movement of proteins, RNA, and other macromolecules. It plays a crucial role in cellular communication, gene expression, and overall nuclear-cytoplasmic transport processes.
Mediates TLR3 signaling; this complex is involved in the activation of Toll-like receptor 3 (TLR3), initiating signaling cascades that lead to the production of interferons and inflammatory responses. It plays a crucial role in the detection of viral double-stranded RNA, contributing to the innate immune response against viral infections.
Implicated in TLR3-mediated apoptosis; this complex, formed upon TLR3 activation, may contribute to apoptotic signaling pathways, influencing cell survival and death in response to viral infections or other TLR3-activating stimuli.
Involved in TLR3-mediated death signaling; the TLR3-DISC complex is associated with death-inducing signaling cascades, potentially influencing apoptosis in response to TLR3 activation. It plays a role in cellular responses to viral infections and other TLR3-activating stimuli.
Key player in RIG-I signaling; this complex contributes to the activation of RIG-I and downstream signaling pathways. It leads to the production of interferons, enhancing the antiviral response and cellular defense mechanisms against viral infections.
Participates in RIG-I signaling; the complex is involved in the regulation of RIG-I-mediated antiviral responses. It may modulate signaling cascades and contribute to the fine-tuning of immune responses against viral infections.
Involved in apoptotic signaling pathways; this complex plays a role in regulating programmed cell death. It is associated with both apoptotic and necroptotic pathways, influencing cellular responses to various death-inducing signals.
Implicated in the Ras signaling pathway; this complex plays a role in transmitting signals downstream of Ras, influencing cellular processes such as cell growth, differentiation, and survival. It contributes to the regulation of the MAPK/ERK signaling pathway and cellular responses to extracellular signals.
Functions in Ras signaling; this trimeric complex is involved in transmitting signals downstream of MRAS within the Ras pathway. It contributes to the regulation of cellular processes, including cell growth, differentiation, and survival, by modulating the MAPK/ERK signaling pathway.
Plays a role in Ras signaling; the complex is involved in transmitting signals downstream of NRAS, influencing cellular processes such as cell growth, differentiation, and survival. It contributes to the regulation of the MAPK/ERK signaling pathway and cellular responses to extracellular signals.
Involved in Ras signaling; this hexameric complex functions in transmitting signals downstream of MRAS within the Ras pathway. It contributes to the regulation of cellular processes, including cell growth, differentiation, and survival, by modulating the MAPK/ERK signaling pathway.
Participates in Toll-like receptor signaling; this complex plays a role in recognizing pathogen-associated molecular patterns (PAMPs) and initiating signaling cascades that lead to inflammatory responses and immune activation. It is essential for the detection of bacterial and flagellar components, contributing to host defense mechanisms.
Involved in immune signaling; this complex plays a role in the regulation of immune responses. It is associated with pathways activated by Toll-like receptors and may contribute to the modulation of inflammatory signaling and host defense mechanisms against microbial infections.
Involved in mitochondrial protein import and membrane translocation, this complex mediates the sorting and translocation of proteins into mitochondria. It plays a crucial role in maintaining mitochondrial function and ensuring the proper localization of proteins within the mitochondrial compartments, contributing to cellular energy production and homeostasis.
Mediates signaling in response to interferon (IFN); the complex plays a key role in transducing signals from type I interferons, leading to the activation of STAT1 and the induction of interferon-stimulated genes (ISGs), crucial for antiviral responses and immune regulation.
Mediates signaling from tumor necrosis factor receptor 2 (TNFR2); this complex transduces signals that regulate cellular responses such as inflammation, cell survival, and immune regulation. It is involved in diverse physiological processes influenced by TNFR2 activation.
Involved in antiviral signaling pathways; the complex contributes to the activation of IRF3 and the induction of interferons, playing a crucial role in the cellular defense against viral infections and the regulation of antiviral immune responses.
This complex is part of the mitochondrial antiviral signaling pathway. The complex orchestrates antiviral responses by activating IRF3 and regulating mitochondrial antiviral signaling, contributing to the host's defense against viral infections.
Contributes to antiviral responses; the complex is integral to the innate immune signaling pathway, leading to the activation of IRF3 and induction of interferons in response to viral infections. The complex plays a key role in the host's defense against viral threats.
Part of the mitochondrial antiviral signaling pathway; the complex plays a role in the activation of IRF3 and regulation of mitochondrial antiviral signaling, contributing to the cellular defense against viral infections and the coordination of antiviral immune responses.
Involved in MAPK signaling; the complex participates in the mitogen-activated protein kinase (MAPK) signaling pathway. It regulates cellular responses to growth factors and environmental stimuli, influencing cell proliferation, differentiation, and survival.
Participates in TGF-β signaling; the complex plays a role in the transforming growth factor-beta (TGF-β) signaling pathway. It influences cellular responses to TGF-β, impacting processes such as cell differentiation, apoptosis, and immune regulation.
Involved in TGF-β signaling; the complex participates in the transforming growth factor-beta (TGF-β) signaling pathway. It modulates cellular responses to TGF-β, affecting processes like cell growth, differentiation, and the regulation of immune and inflammatory responses.
Functions in TGF-β and p53 signaling; the complex plays a role in the transforming growth factor-beta (TGF-β) signaling pathway and interacts with the p53 pathway. It influences cellular responses to TGF-β and contributes to the regulation of cell cycle and apoptosis.
Acts as a transcriptional corepressor; the mSin3A complex is involved in transcriptional regulation by recruiting histone deacetylases (HDACs) and other regulatory proteins. It participates in the repression of specific genes, influencing cellular processes such as cell cycle control, differentiation, and development.
Constitutes the troponin complex in muscle cells; the complex plays a critical role in muscle contraction. It regulates the calcium-dependent interaction between actin and myosin filaments, contributing to the control of muscle contraction and overall muscle function.
Essential for TSLP signaling; the complex participates in the signaling pathway activated by thymic stromal lymphopoietin (TSLP). It plays a role in regulating immune responses, particularly in the context of TSLP-mediated effects on various immune cell populations.
Involved in immune responses and hemostasis; the complex participates in the recognition of pathogens by dendritic cells. Additionally, VWF is involved in hemostasis, playing a crucial role in blood clotting. The complex contributes to immune surveillance and the regulation of coagulation processes.
Critical for hemostasis, the F8-VWF complex plays a pivotal role in the coagulation cascade. This complex facilitates platelet adhesion and aggregation at the site of vascular injury, ensuring proper blood clot formation and preventing excessive bleeding.
Central to cellular iron homeostasis, the SNX1A-TFRC complex regulates the endocytic trafficking of transferrin receptors. By modulating iron uptake, this complex contributes to the maintenance of intracellular iron levels essential for various cellular processes, including DNA synthesis and energy production.
The EGFR-SNX1A complex is involved in orchestrating endocytic trafficking and signaling modulation. This complex influences the internalization, recycling, and downstream signaling pathways of EGFR, impacting cellular responses to growth factors and environmental cues.
Similar to the EGFR-SNX1A complex, the EGFR-SNX2 complex involves sorting nexin 2 (SNX2) and contributes to the regulation of EGFR endocytic trafficking. This complex plays a role in modulating EGFR signaling by influencing receptor internalization, recycling, and subsequent cellular responses to extracellular stimuli.
The EGFR-SNX4 complex is integral to endocytic trafficking pathways. This complex modulates EGFR internalization, sorting, and trafficking, influencing the regulation of EGFR signaling and cellular responses to growth factors.
In innate immunity, the NOD2-RIPK2 complex plays a pivotal role in sensing bacterial pathogens and activating inflammatory responses, contributing to the defense against microbial infections.
Central to cellular stress responses, the KEAP1-SQSTM1 complex regulates the degradation of Nrf2. This complex modulates cellular responses to oxidative stress and autophagy processes, influencing cellular adaptation to environmental challenges.
Instrumental in neurotransmission, the ACHE-NRXN1 complex modulates cholinergic signaling at the neuromuscular junction. This complex influences synaptic transmission, acetylcholine levels, and plays a crucial role in regulating neuromuscular function.
Contributing to lipid metabolism, the APOA1-BCHE complex participates in lipoprotein metabolism. This complex regulates cholesterol levels and lipid homeostasis in the bloodstream, playing a key role in lipid transport and overall cardiovascular health.
In lipoprotein metabolism, the APOB-BCHE complex plays a crucial role in the regulation of lipoprotein synthesis and processing. This complex influences lipid transport and metabolism, contributing to overall cardiovascular health and lipid homeostasis.
Essential for acetylcholine clearance, the BCHE-CLU complex participates in the hydrolysis and clearance of acetylcholine. This complex influences cholinergic signaling, contributing to neurotransmitter regulation and cellular responses to acetylcholine.
The BCHE-KRT1 complex may have roles in cellular structure and organization. While the specific functions are context-dependent, the association with keratin 1 suggests potential involvement in the structural integrity of specific cell types and tissues.
Participating in plasma protein binding and transport, the ALB-BCHE complex contributes to the binding and transport of various molecules in the bloodstream. This complex plays a role in modulating the distribution and metabolism of substances, influencing overall physiological processes.
Involved in plasma protein interactions, the AHSG-BCHE complex may modulate the functions of both AHSG and BCHE. This complex potentially influences diverse physiological processes, serving roles in plasma protein interactions and regulatory activities.
The BCHE-TF complex may have dual roles in cholinergic signaling and iron homeostasis. This complex, associating with the iron transport protein transferrin, suggests potential involvement in both neurotransmitter regulation and the modulation of cellular iron levels.
The BCHE-KRT5 complex may participate in cellular structural support or signaling events. KRT5, a type II keratin, is often associated with cytoskeletal elements, and the interaction with BCHE might influence cell adhesion or other cellular processes related to the cytoskeleton.
The BCHE-C1S complex suggests a potential interplay between the cholinergic system and the complement system. This interaction may impact immune responses and inflammatory processes, potentially modulating complement activation and contributing to the regulation of immune-related pathways.
This complex may play a role in cellular structural functions or signaling processes. KRT16, a type I keratin, is involved in maintaining cellular integrity, and BCHE may contribute to additional functions, potentially influencing cell adhesion or participating in signaling cascades.
The BCHE-VTN complex might be involved in cell adhesion, migration, or other processes associated with vitronectin. This interaction may have implications for cellular responses to the extracellular matrix, influencing cell behavior and potentially contributing to various physiological contexts.
The BCHE-HBB complex suggests a potential link between cholinergic signaling and hemoglobin-related functions. This interaction may impact oxygen transport, cellular responses to hypoxia, or other processes related to the physiological roles of hemoglobin.
This complex may be associated with cellular processes related to thrombospondin. These processes could include cell adhesion, angiogenesis, or modulation of cellular responses to the extracellular matrix. The interaction may contribute to the regulation of tissue homeostasis and physiological functions.
The BCHE-LGALS3BP complex may participate in processes influenced by galectin-3. This interaction may play a role in cell adhesion, signaling, or other cellular responses associated with galectin-3 and its diverse functions in various physiological contexts.
This complex may be associated with protease inhibition or other functions related to the activities of these proteins. A2M is known for its role in inhibiting proteases, and BCHE may contribute to this inhibitory function within the context of this complex, potentially influencing protease-related pathways.
The BCHE-HP complex may be associated with processes related to haptoglobin. This interaction could have implications for functions such as immune response modulation or the regulation of oxidative stress, as haptoglobin is involved in binding free hemoglobin and exerting protective effects in response to hemolysis.
Enhances gene expression by forming a complex that interacts with nuclear receptors. This interaction stimulates transcriptional activities in a hormone-dependent manner, playing a crucial role in regulating gene expression and cellular responses.
Regulates actin dynamics by promoting the nucleation and formation of branched actin filaments. This complex is essential for various cellular processes, including cell motility, endocytosis, and the maintenance of cell shape.
Activates the immunoproteasome, a specialized form of the proteasome responsible for degrading proteins involved in antigen presentation. This activation contributes to immune responses by influencing the degradation of specific proteins.
Acts as the regulatory particle of the 26S proteasome, participating in the ATP-dependent degradation of ubiquitinated proteins. This process is crucial for maintaining cellular homeostasis by eliminating damaged or unwanted proteins.
Mediates vesicle trafficking by assembling clathrin-coated vesicles. This process is vital for intracellular transport, allowing cells to regulate the movement of proteins and other molecules between cellular compartments.
The Mi2/NuRD complex remodels chromatin and regulates gene expression through enzymes like histone deacetylases, maintaining genomic stability. It is crucial for fundamental cellular processes, including DNA repair and development.
The TRAP complex regulates transcription by influencing RNA polymerase II, impacting RNA synthesis and cellular processes like development and stress responses.
The NUMAC complex regulates gene expression through histone methylation, influencing chromatin structure. Comprising various subunits, it participates in cellular processes like differentiation and environmental responses.
The Nup 107-160 subcomplex is integral to the nuclear pore complex, governing nucleocytoplasmic transport by forming a scaffold. Composed of multiple nucleoporins, it regulates molecule passage, contributing to diverse cellular functions. It plays a crucial role in genetic information exchange within the cell.
The Anaphase-promoting Complex (APC) regulates cell cycle progression by ensuring the timely degradation of key proteins during mitosis and cytokinesis. It safeguards genomic stability and prevents uncontrolled cell division.
The p300-MDM2-p53 protein complex responds to stress and DNA damage by modulating the activity of the tumor suppressor protein p53. This intricate network helps maintain genomic integrity and regulates cell growth.
The hNURF complex remodels chromatin architecture, influencing gene expression and contributing to cellular processes like development and differentiation.
The RNA Polymerase II Holoenzyme Complex facilitates mRNA synthesis by providing the necessary machinery for transcription initiation and elongation. It is crucial for the accurate flow of genetic information.
The RNA Polymerase II Core Complex is essential for transcription, synthesizing mRNA from DNA templates during initiation and elongation. It ensures controlled and accurate gene expression.
The Prefoldin Complex aids in proper protein folding, acting as a chaperone to prevent misfolding and aggregation. It helps maintain protein homeostasis within the cell.
The Polycomb Repressive Complex 1 (PRC1) regulates gene expression through histone modifications, contributing to gene silencing and cellular identity maintenance. It plays a crucial role in development and cellular differentiation.
The Lymphotoxin Beta Receptor Complex is vital for immune system regulation, influencing inflammation, immune response, and lymphoid tissue development. It coordinates cellular interactions within the immune system to defend against pathogens.
The CCT complex, also known as the chaperonin-containing TCP1 complex, is involved in protein folding by assisting in the proper folding of nascent polypeptides. It provides a protected environment for protein maturation, ensuring correct three-dimensional structures. This complex is essential for cellular homeostasis and prevents the aggregation of misfolded proteins.
The PIDDsome complex plays a role in apoptosis regulation by facilitating the activation of caspase-2. It serves as a platform for assembling apoptotic signaling components, contributing to programmed cell death. This complex is crucial for maintaining cellular integrity and responding to various cellular stresses.
The Telomere-Associated Protein Complex is involved in telomere maintenance, ensuring the protection and regulation of chromosome ends. It participates in processes like DNA replication and repair, contributing to genomic stability and cellular longevity.
The APP695-APBB1-LRP1 complex is associated with Alzheimer's disease and is involved in the processing and clearance of amyloid-beta peptides. It modulates the trafficking and signaling of amyloid precursor protein (APP), impacting neurodegenerative processes.
The PBAF complex is a chromatin remodeling complex that regulates gene expression by altering the structure of chromatin. Comprising Polybromo and BAF components, it influences transcription and cellular differentiation, contributing to various biological processes.
The TFIID complex is essential for transcription initiation in eukaryotes. It recognizes and binds to the promoter region of genes, facilitating the assembly of the pre-initiation complex. TFIID is a key player in the regulation of gene expression and the initiation of mRNA synthesis.
The Condensin I-PARP-1-XRCC1 complex is involved in DNA repair and chromosome condensation. It participates in maintaining genomic stability by facilitating DNA repair processes and ensuring proper chromosome organization during cell division.
The Respiratory Chain Complex I, also known as the holoenzyme, is a component of the mitochondrial electron transport chain. It plays a crucial role in oxidative phosphorylation, generating ATP and facilitating energy transfer within the cell. This complex is essential for cellular respiration and energy production.
The 26S proteasome is a protein complex responsible for degrading ubiquitinated proteins. It plays a central role in cellular protein quality control, removing damaged or unwanted proteins and regulating various cellular processes, including cell cycle progression and signaling.
The PA28-20S proteasome complex is involved in the regulation of protein degradation. It enhances the activity of the 20S proteasome, contributing to the efficient breakdown of proteins and maintaining cellular homeostasis.
The PA700-20S-PA28 complex is associated with proteasomal protein degradation. It enhances the activity of the 20S proteasome, facilitating the breakdown of ubiquitinated proteins. This complex plays a role in maintaining cellular protein quality and turnover.
The PA28gamma-20S proteasome complex is involved in regulating protein degradation. It associates with the 20S proteasome, enhancing its activity and contributing to the efficient breakdown of ubiquitinated proteins within the cell.
The CAND1-CUL1-RBX1 complex is involved in the regulation of protein ubiquitination and degradation. It modulates the activity of the CUL1-based ubiquitin ligase, contributing to the targeted degradation of specific proteins within the cell.
The CAND1-CUL3-RBX1 complex participates in the regulation of protein ubiquitination and degradation. It modulates the activity of the CUL3-based ubiquitin ligase, playing a role in targeted protein turnover and cellular homeostasis.
The CAND1-CUL4B-RBX1 complex is involved in the regulation of protein ubiquitination and degradation. It modulates the activity of the CUL4B-based ubiquitin ligase, contributing to targeted protein turnover and maintaining cellular homeostasis.
The Mediator complex is essential for transcriptional regulation by facilitating communication between transcription factors and RNA polymerase II. It acts as a bridge, coordinating the assembly of the transcription machinery and influencing gene expression.
The ARC complex is associated with activity-regulated cytoskeleton-associated protein (Arc), playing a role in synaptic plasticity and memory formation. It modulates the strength and structure of synapses, contributing to neuronal communication and learning processes.
The BRAFT complex is associated with transcriptional regulation and cellular response to environmental signals. It plays a role in coordinating cellular processes by modulating gene expression and contributing to adaptive cellular responses.
The FA Core Complex, associated with Fanconi anemia, is involved in DNA repair and maintenance of genomic stability. It plays a crucial role in resolving DNA interstrand crosslinks, contributing to the prevention of chromosomal instability and cancer development.
The HMGB1-HMGB2-HSC70-ERP60-GAPDH complex is associated with various cellular processes, including chromatin organization, protein folding, and energy metabolism. It brings together different proteins with diverse functions, contributing to the coordination of cellular activities.
The SNF2h-Cohesin-NuRD complex is involved in chromatin remodeling and gene regulation. It influences gene expression by altering chromatin structure and plays a role in cellular processes such as development and differentiation.
The SIN3 complex is a transcriptional corepressor involved in gene regulation. It plays a role in the repression of specific genes by modifying chromatin structure, contributing to the control of cellular processes.
The PCNA-MSH2-MSH6 complex is involved in DNA repair processes, particularly in the recognition and correction of mismatched DNA bases. It plays a crucial role in maintaining genomic integrity and preventing the accumulation of mutations.
The MSH2-MLH1-PMS2-PCNA complex is crucial for DNA repair initiation, specifically in the mismatch repair pathway. It coordinates the recognition and correction of mismatched DNA bases, contributing to genomic stability and preventing the occurrence of mutations.
The MSH2-MLH1-PMS2 complex is pivotal in DNA repair initiation, particularly in the mismatch repair pathway. It coordinates the recognition and correction of mismatched DNA bases, contributing to genomic stability and preventing mutations.
The PCNA-DNA Polymerase Delta complex plays a key role in DNA replication. PCNA, in conjunction with DNA Polymerase Delta, ensures accurate and efficient synthesis of DNA strands during replication. This complex is essential for maintaining genomic integrity during cell division.
The VEGF Transcriptional Complex is involved in the regulation of vascular endothelial growth factor (VEGF) expression. It coordinates the transcriptional machinery to control the expression of genes involved in angiogenesis, contributing to the formation of blood vessels.
The CBP-IRF3 complex is associated with the regulation of immune responses. It involves the interaction between CREB-binding protein (CBP) and interferon regulatory factor 3 (IRF3), modulating the transcription of genes involved in antiviral defense and immune activation.
The SRCAP complex is a chromatin remodeling complex that plays a role in histone exchange. It replaces histone variants, contributing to the regulation of chromatin structure and gene expression. This complex is involved in various cellular processes, including development and differentiation.
The 40S ribosomal subunit is a component of the eukaryotic ribosome involved in protein synthesis. It associates with the 60S subunit to form the complete ribosome, facilitating the translation of mRNA into functional proteins.
The Ribosome is the cellular machinery responsible for protein synthesis. Comprising both the 40S and 60S subunits, it translates the genetic code carried by mRNA into polypeptide chains, playing a fundamental role in cellular function and protein production.
The 60S ribosomal subunit, in conjunction with the 40S subunit, forms the eukaryotic ribosome. It participates in protein synthesis by catalyzing the formation of peptide bonds between amino acids, contributing to the translation of mRNA into functional proteins.
The Cell Cycle Kinase Complex CDC2, also known as cyclin-dependent kinase 1 (CDK1), is a key regulator of the cell cycle. It controls cell division by phosphorylating target proteins, orchestrating the progression through various phases of the cell cycle.
The Cell Cycle Kinase Complex CDK2 is a cyclin-dependent kinase that regulates the cell cycle. It plays a crucial role in coordinating DNA synthesis and cell division, contributing to the orderly progression through the cell cycle.
The 55S ribosome is found in mitochondria and is involved in mitochondrial protein synthesis. Comprising both small and large subunits, it translates the genetic information carried by mitochondrial mRNA into functional proteins within the mitochondria.
The DNA Ligase IV-XRCC4-PNK complex is involved in DNA repair, particularly in the non-homologous end-joining (NHEJ) pathway. It participates in the sealing of DNA double-strand breaks, ensuring genomic stability and integrity.
The DNA Ligase IV-XRCC4-XLF complex is crucial for DNA repair, specifically in the non-homologous end-joining (NHEJ) pathway. It plays a role in rejoining broken DNA ends, contributing to the maintenance of genomic stability.
The DNA Ligase III-XRCC1-PNK-DNA-Pol III complex is involved in various aspects of DNA metabolism, including base excision repair and DNA replication. It participates in sealing nicks in DNA strands and ensuring accurate DNA synthesis.
The ERCC1-ERCC4-MSH2 complex is involved in DNA repair processes, participating in nucleotide excision repair and mismatch repair. It plays a role in removing damaged DNA bases and maintaining genomic integrity.
The CAV3-DAG1 complex is associated with caveolae formation and signal transduction. It involves the interaction between caveolin-3 (CAV3) and dystroglycan (DAG1), contributing to cellular membrane organization and communication.
The 18S U11/U12 snRNP is involved in pre-mRNA splicing, specifically recognizing and processing U11/U12-type introns. It contributes to the precision of spliceosomal machinery, ensuring accurate mRNA splicing and gene expression.
The N-NOS-CHIP-HSP70-1 complex is associated with the regulation of neuronal nitric oxide synthase (N-NOS). It involves the interaction between CHIP, HSP70-1, and N-NOS, contributing to the maintenance of protein homeostasis and cellular function.
The GCN5-TRRAP histone acetyltransferase complex is involved in chromatin remodeling and gene regulation. It acetylates histone proteins, influencing chromatin structure and contributing to the control of gene expression.
The TFTC-type histone acetyl transferase complex is involved in chromatin modification and gene regulation. It acetylates histone proteins, influencing chromatin structure and playing a role in the control of gene expression.
The BP-SMAD complex is associated with the TGF-beta signaling pathway. It involves the interaction between bone morphogenetic protein (BMP) receptors and SMAD proteins, contributing to the regulation of cellular responses to TGF-beta family signals.
The TFTC complex is involved in transcriptional regulation by influencing the assembly of the transcription machinery. Comprising TATA-binding protein-free TAF-II-containing components, it participates in the control of gene expression and cellular processes.
The PCAF complex is a histone acetyltransferase complex involved in chromatin remodeling and gene regulation. It acetylates histone proteins, influencing chromatin structure and playing a role in the control of gene expression.
Prolyl 4-hydroxylase (alpha(I)-type) is an enzyme complex involved in the post-translational modification of collagen. It catalyzes the hydroxylation of proline residues, contributing to the stability and structure of collagen in the extracellular matrix.
The RYK-WNT3A Complex is involved in Wnt signaling pathways. It facilitates the interaction between the receptor-like tyrosine kinase RYK and the WNT3A ligand, influencing cellular responses and developmental processes governed by Wnt signaling.
The AKAP250-PKA-PDE4D complex is involved in cellular signaling and cAMP regulation. It brings together AKAP250, PKA, and PDE4D, contributing to the spatial and temporal control of cAMP signaling pathways. The complex plays a role in cellular responses to various stimuli and regulatory processes.
The KCNQ1 macromolecular complex is integral in ion channel regulation and cardiac function. It involves KCNQ1 and associated proteins, contributing to the modulation of potassium channels. The complex plays a crucial role in controlling membrane potential and cellular excitability in cardiac tissues.
The Polycystin-1-E-Cadherin-Beta-Catenin complex is associated with cell adhesion and signaling. It brings together Polycystin-1, E-Cadherin, and Beta-Catenin, playing a role in cellular adhesion, signal transduction, and regulation of the cytoskeleton. The complex is essential for cellular interactions and tissue integrity.
The NuA4/Tip60-HAT complex is associated with histone acetylation and transcriptional regulation. It involves NuA4/Tip60 histone acetyltransferase, influencing chromatin structure and gene expression. The complex plays a crucial role in the modulation of gene transcription and cellular responses.
The XPA-ERCC1-ERCC4 complex is involved in nucleotide excision repair, recognizing and repairing DNA lesions caused by UV radiation and chemical agents. It coordinates the removal of damaged DNA segments, contributing to genomic stability and integrity.
The TRAP complex is associated with transcriptional regulation and RNA polymerase II activity. It facilitates the assembly of the transcription pre-initiation complex, influencing gene expression and contributing to mRNA synthesis.
The IGF1-IGFBP3-ALS complex is involved in insulin-like growth factor (IGF) signaling and regulation. It includes components that modulate the activity and transport of IGF1, influencing cellular growth and metabolic processes.
The DRIP complex, or Vitamin D receptor-interacting protein complex, is involved in the regulation of gene expression in response to vitamin D. It interacts with the vitamin D receptor, modulating transcription and cellular responses to vitamin D.
The IFNAR1-IFNAR2-IFNB1 complex is associated with interferon signaling, particularly in response to interferon-beta (IFNB1). It includes components that mediate the cellular response to interferon, influencing antiviral and immune processes.
The Decapping complex is involved in mRNA degradation by removing the 5' cap structure from mRNA molecules. It plays a role in the regulation of mRNA stability and turnover, influencing gene expression and cellular responses.
The LSm1-7 complex is associated with mRNA processing and degradation. It participates in the assembly of the mRNA decay machinery, influencing the degradation of specific mRNA transcripts and contributing to cellular homeostasis.
The p300-CBP-p270-SWI/SNF complex is involved in chromatin remodeling and transcriptional regulation. It includes components that modify chromatin structure, influencing gene expression and contributing to diverse cellular processes.
The p300-CBP-p270 complex is associated with chromatin modification and transcriptional regulation. It includes components that modify chromatin structure, influencing gene expression and contributing to diverse cellular processes.
The SAP complex, or Sin3-associated protein complex, is a transcriptional corepressor complex involved in gene regulation. It modulates chromatin structure and inhibits transcription, contributing to the repression of specific genes and cellular processes.
The mSin3A corepressor complex is associated with transcriptional regulation and chromatin modification. It functions as a corepressor, influencing gene expression by modifying chromatin structure and contributing to the control of cellular processes.
The CASK-LIN7C-APBA1 complex is associated with synaptic function and protein-protein interactions. It includes components that regulate the assembly of synaptic proteins, contributing to neuronal communication and function.
The CoREST-HDAC complex is involved in transcriptional regulation and chromatin modification. It acts as a corepressor by recruiting histone deacetylases (HDACs), influencing chromatin structure and gene expression control.
The LSD1 complex is a histone demethylase complex involved in chromatin modification and gene regulation. It participates in the removal of methyl groups from histone proteins, influencing chromatin structure and gene expression.
The Anti-HDAC2 complex is associated with the regulation of histone deacetylase 2 (HDAC2) activity. It includes components that modulate HDAC2 function, influencing chromatin structure and gene expression control.
The Anti-BHC110 complex is associated with the regulation of the BHC110 corepressor. It includes components that modulate BHC110 function, influencing chromatin structure and gene expression control.
The XFIM complex is associated with X-chromosome inactivation. It includes components that participate in the silencing of one of the X chromosomes in female cells, contributing to dosage compensation and gene regulation.
The CtBP complex is associated with transcriptional regulation and chromatin modification. It acts as a corepressor by recruiting histone-modifying enzymes, influencing chromatin structure and gene expression control.
The VPS35-VPS29-VPS26A complex is associated with the retromer, a cellular machinery involved in endosomal sorting and vesicle trafficking. It plays a role in the recycling of membrane proteins, contributing to cellular homeostasis and membrane dynamics.
The Retromer Complex, including SNX1, SNX2, VPS35, VPS29, and VPS26A, is involved in endosomal trafficking and recycling of membrane proteins. It facilitates the sorting of proteins within endosomes, contributing to cellular membrane organization and protein homeostasis.
The RANBMP-CD39 complex is associated with nucleotide metabolism and signal transduction. It includes CD39, influencing the hydrolysis of nucleotides and participating in purinergic signaling pathways.
The C-CFTR-NHERF-Ezrin complex is associated with the regulation of CFTR (Cystic Fibrosis Transmembrane Conductance Regulator) activity. It includes components that modulate CFTR function, contributing to ion transport and cellular homeostasis.
The SIN3-SAP25 complex is associated with transcriptional regulation and chromatin modification. It includes components involved in histone deacetylation and transcriptional repression, contributing to the control of gene expression.
The SNARE Complex, including HGS, SNAP25, and STX13, is involved in membrane fusion during vesicle trafficking. It facilitates the fusion of vesicles with target membranes, contributing to intracellular transport and cellular membrane dynamics.
The SNARE Complex, including SNAP25, STX13, and VAMP2, is involved in membrane fusion during vesicle trafficking. It facilitates the fusion of vesicles with target membranes, contributing to intracellular transport and cellular membrane dynamics.
The BRG1-SIN3A Complex is associated with transcriptional regulation and chromatin modification. It includes the BRG1 ATPase and mSin3A, contributing to the modification of chromatin structure and the control of gene expression.
The MORF4L1-MRFAP1-RB1 Complex is involved in transcriptional regulation and chromatin modification. It includes components that modulate gene expression and interact with the retinoblastoma protein (RB1).
The P2X7 Receptor Signaling Complex is associated with P2X7 receptors and signal transduction. It includes components involved in P2X7 receptor-mediated cellular responses, contributing to purinergic signaling pathways.
The SNARE Complex, including SNAP23, STX4, and VAMP1, is involved in membrane fusion during vesicle trafficking. It facilitates the fusion of vesicles with target membranes, contributing to intracellular transport and cellular membrane dynamics.
The SNARE Complex, including SNAP23, STX4, and VAMP2, is involved in membrane fusion during vesicle trafficking. It facilitates the fusion of vesicles with target membranes, contributing to intracellular transport and cellular membrane dynamics.
The SNARE Complex, including STX4, VAMP1, and VAMP7, is involved in membrane fusion during vesicle trafficking. It facilitates the fusion of vesicles with target membranes, contributing to intracellular transport and cellular membrane dynamics.
The SIN3-ING1b Complex I is associated with transcriptional regulation and chromatin modification. It includes components involved in histone deacetylation and transcriptional repression, contributing to the control of gene expression.
The SIN3-ING1b Complex II is associated with transcriptional regulation and chromatin modification. It includes components involved in histone deacetylation and transcriptional repression, contributing to the control of gene expression.
The eIF3 Complex is involved in protein translation initiation. It includes multiple subunits, such as EIF3S6, EIF3S5, EIF3S4, EIF3S3, EIF3S6IP, EIF3S2, EIF3S9, EIF3S12, EIF3S10, EIF3S8, EIF3S1, and EIF3S7, contributing to the assembly of the translation initiation complex and protein synthesis.
The MeCP2-SIN3A-HDAC complex is involved in transcriptional regulation and chromatin modification. It includes components that modulate gene expression by interacting with MeCP2, SIN3A, and histone deacetylases (HDACs).
The TREX complex is involved in mRNA export from the nucleus to the cytoplasm. It includes components that facilitate the coupling of mRNA processing and export, contributing to the efficient transport of mRNA transcripts.
The LARC complex, or LCR-Associated Remodeling Complex, is involved in chromatin remodeling and gene regulation. It includes components that contribute to the modification of chromatin structure, influencing gene expression and cellular processes.
The URI complex is associated with transcriptional regulation and RNA polymerase II activity. It includes components that interact with the RNA polymerase II subunit RPB5, contributing to the regulation of gene expression.
The Exon Junction Complex is involved in mRNA processing and surveillance. It is associated with spliced mRNA transcripts and contributes to mRNA quality control and nuclear-cytoplasmic transport.
The NuA4/Tip60-HAT Complex B is involved in histone acetylation and transcriptional regulation. It includes components that modify histone acetylation, influencing chromatin structure and the control of gene expression.
The Exosome is a cellular complex involved in RNA degradation and processing. It functions as a ribonuclease, contributing to the degradation of various RNA species, including mRNA and non-coding RNAs.
The SNARE Complex, including CPLX1, SNAP25, STX1A, and VAMP2, is involved in membrane fusion during vesicle trafficking. It facilitates the fusion of vesicles with target membranes, contributing to intracellular transport and cellular membrane dynamics.
The SNARE Complex, including CPLX2, SNAP25, STX1A, and VAMP2, is involved in membrane fusion during vesicle trafficking. It facilitates the fusion of vesicles with target membranes, contributing to intracellular transport and cellular membrane dynamics.
The BRG1-SIN3A-HDAC Containing SWI/SNF Remodeling Complex I is involved in chromatin remodeling and gene regulation. It includes components that contribute to the modification of chromatin structure and the control of gene expression.
The PAR-3-VE-Cadherin-Beta-Catenin Complex is associated with cell adhesion and polarity. It includes components that contribute to the formation of adherens junctions, regulating cell-cell adhesion and establishing cellular polarity.
The 20S Methylosome and RG-Containing Sm Protein Complex is associated with small nuclear ribonucleoprotein (snRNP) assembly and methylation. It includes components that participate in the modification of snRNPs, contributing to pre-mRNA splicing.
The 6S Methyltransferase and RG-Containing Sm Proteins Complex is associated with small nuclear ribonucleoprotein (snRNP) assembly and methylation. It includes components that participate in the modification of snRNPs, contributing to pre-mRNA splicing.
The PCI-PSA-SCG2 complex is involved in protein ubiquitination and degradation. It includes components that participate in the ubiquitin-proteasome system, contributing to the regulation of protein abundance and cellular processes.
The RICH1/AMOT Polarity Complex is associated with cellular polarity and cytoskeletal regulation. It includes components that contribute to the establishment of cell polarity, influencing cellular architecture and organization.
The DNMT1-EHMT2-PCNA complex is associated with DNA methylation and maintenance of chromatin structure. It includes components that participate in the regulation of DNA methylation and replication, contributing to genomic stability.
The SNARE Complex, including STX1A and SNAP29, is involved in membrane fusion during vesicle trafficking. It facilitates the fusion of vesicles with target membranes, contributing to intracellular transport and cellular membrane dynamics.
The SNARE Complex, including STX6, VAMP3, VAMP4, and VAMP8, is involved in membrane fusion during vesicle trafficking. It facilitates the fusion of vesicles with target membranes, contributing to intracellular transport and cellular membrane dynamics.
The SNARE Complex, including STX16, VAMP3, and VAMP4, is involved in membrane fusion during vesicle trafficking. It facilitates the fusion of vesicles with target membranes, contributing to intracellular transport and cellular membrane dynamics.
The SNARE Complex, including STX6, VAMP3, and VTI1A, is involved in membrane fusion during vesicle trafficking. It facilitates the fusion of vesicles with target membranes, contributing to intracellular transport and cellular membrane dynamics.
The SNARE Complex, including STX6, STX16, VAMP4, VTI1A, and VTI1B, is involved in membrane fusion during vesicle trafficking. It facilitates the fusion of vesicles with target membranes, contributing to intracellular transport and cellular membrane dynamics.
The KIF3A/B-PAR-3-aPKC-PAR-6 Complex is associated with cellular polarity and cytoskeletal regulation. It includes components that contribute to the establishment of cell polarity and influence cytoskeletal dynamics.
The Toposome is associated with DNA topoisomerase function and DNA structure regulation. It includes components that participate in the regulation of DNA topology, contributing to processes such as DNA replication and transcription.
The CEN Complex is associated with centromere function and chromosome segregation. It includes components that contribute to the assembly and maintenance of the centromere, ensuring proper chromosome segregation during cell division.
The FACT Complex is involved in chromatin transcription and nucleosome disassembly. It includes components that facilitate the passage of RNA polymerase through nucleosomes, contributing to the regulation of gene expression.
The KIN17-PCNA-RPA70 complex is associated with DNA repair and replication. It includes components that participate in the coordination of DNA replication and repair processes, contributing to genomic stability.
The p23 Protein Complex is involved in chaperone-mediated protein folding and stability. It includes components that assist in the folding of newly synthesized proteins, contributing to protein conformation and cellular function.
The RC Complex, S-Phase-Specific, is associated with DNA replication and cell cycle progression. It includes components that participate in the initiation of DNA replication during the S phase of the cell cycle, ensuring accurate genome duplication.
The RC Complex during G2/M-Phase of the cell cycle is associated with DNA replication and cell cycle progression. It includes components that participate in the regulation of DNA replication during the G2/M phase, ensuring accurate genome duplication.
The HNF4A-SUB1 complex is associated with transcriptional regulation and chromatin modification. It includes components that contribute to the modification of chromatin structure, influencing gene expression and cellular processes.
The RAN-SNUPN-XPO1 complex is involved in nucleocytoplasmic transport and cargo export. It includes components that mediate the transport of proteins between the nucleus and cytoplasm, contributing to cellular compartmentalization.
The Retromer Complex, including SNX1, SNX2, VPS35, VPS29, and VPS26B, is involved in endosomal trafficking and recycling of membrane proteins. It plays a role in the recycling of membrane proteins, contributing to cellular homeostasis and membrane dynamics.
The BAR-BCL2-CASP8 complex is associated with apoptosis and cell death regulation. It includes components that participate in the regulation of apoptosis, influencing cell survival and programmed cell death pathways.
The CD8A-LCK complex is associated with T-cell receptor signaling and immune response. It includes components that mediate T-cell activation, contributing to the immune response against specific antigens.
The 12S U11 snRNP is associated with pre-mRNA splicing and spliceosome assembly. It includes components that participate in the recognition and processing of U11 snRNA, contributing to the formation of functional spliceosomes.
The DNA Repair Complex NEIL2-PNK-Pol(Beta)-LigIII(Alpha)-XRCC1 is associated with base excision repair and genomic stability. It includes components that participate in the repair of DNA damage, contributing to the maintenance of genomic integrity.
The BIRC5-AURKB-INCENP-EVI5 complex is associated with mitosis and chromosome segregation. It includes components that contribute to the regulation of mitotic processes, ensuring accurate chromosome segregation during cell division.
The PCNA-KU Antigen complex is associated with DNA repair and replication. It includes components that participate in the coordination of DNA replication and repair processes, contributing to genomic stability.
The Frataxin complex is associated with iron-sulfur cluster biogenesis and mitochondrial function. It includes components that contribute to the maturation of iron-sulfur proteins, influencing cellular energy metabolism and mitochondrial function.
The DNA synthesome complex with 13 subunits is associated with DNA replication and synthesis. It includes components that participate in the coordinated synthesis of DNA strands during DNA replication, ensuring accurate genome duplication.
The TFIIIC containing-TOP1-SUB1 complex is associated with transcriptional regulation and chromatin modification. It includes components that mediate the interaction between transcriptional activators, DNA topoisomerase I (TOP1), and SUB1, contributing to gene expression control.
The DNA synthesome core complex is associated with DNA replication and synthesis. It includes core components that participate in the coordinated synthesis of DNA strands during DNA replication, ensuring accurate genome duplication.
The DNA synthesome complex with 15 subunits is associated with DNA replication and synthesis. It includes components that participate in the coordinated synthesis of DNA strands during DNA replication, ensuring accurate genome duplication.
The DNA synthesome complex with 17 subunits is associated with DNA replication and synthesis. It includes components that participate in the coordinated synthesis of DNA strands during DNA replication, ensuring accurate genome duplication.
The 5S-DNA-TFIIIA-TFIIIC2-TFIIIB subcomplex is associated with transcription initiation and RNA polymerase III activity. It includes components that contribute to the assembly of the RNA polymerase III preinitiation complex, ensuring the initiation of transcription for 5S ribosomal RNA.
The CF IIAm complex is associated with pre-mRNA processing and cleavage during polyadenylation. It includes components that participate in the cleavage of pre-mRNA, contributing to the maturation of mRNA transcripts.
The Histone H3.1 complex is associated with chromatin structure and histone deposition. It includes components that contribute to the incorporation of histone H3.1 into nucleosomes, influencing chromatin organization and gene regulation.
The FA complex, or Fanconi Anemia Complex, is associated with DNA repair and genomic stability. It includes components that participate in the repair of DNA damage, contributing to the maintenance of genomic integrity.
The ING1-p300-PCNA complex is associated with transcriptional regulation and DNA replication. It includes components that modulate gene expression by interacting with ING1, p300, and PCNA, contributing to chromatin modification and DNA replication processes.
The SNARE Complex, including SNAP23, STX4, and VAMP3, is involved in membrane fusion during vesicle trafficking. It facilitates the fusion of vesicles with target membranes, contributing to intracellular transport and cellular membrane dynamics.
The c-MYC-ATPase-Helicase Complex is associated with transcriptional regulation and chromatin remodeling. It includes components that participate in the regulation of gene expression, influencing chromatin structure and cellular processes.
The BCOR complex is associated with transcriptional regulation and chromatin modification. It includes components that contribute to the modification of chromatin structure, influencing gene expression and cellular processes.
The C complex spliceosome is associated with pre-mRNA splicing and spliceosome assembly. It includes components that participate in the formation of the spliceosome, ensuring the proper splicing of pre-mRNA transcripts.
The CDC5L complex is associated with pre-mRNA splicing and spliceosome assembly. It includes components that participate in the formation of the spliceosome, ensuring the proper splicing of pre-mRNA transcripts.
The EGFR-containing signaling complex is associated with receptor tyrosine kinase signaling and cellular responses. It includes components that mediate intracellular signaling cascades in response to epidermal growth factor receptor (EGFR) activation.
The ESCRT-III complex is involved in membrane remodeling and vesicle scission. It includes components that participate in the endosomal sorting complex required for transport (ESCRT), contributing to membrane abscission and vesicle formation.
The DNA Double-Strand Break End-Joining Complex is associated with DNA repair and rejoining of broken DNA ends. It includes components that participate in the non-homologous end-joining pathway, contributing to the repair of double-strand DNA breaks.
The ESCRT-I complex is involved in membrane remodeling and vesicle formation. It includes components that participate in the endosomal sorting complex required for transport (ESCRT), contributing to membrane abscission and vesicle formation.
The Rap1 complex is associated with cell adhesion and signaling. It includes components that participate in the regulation of cellular adhesion and intracellular signaling, influencing cellular responses and communication.
The E2F-6 complex is associated with cell cycle regulation and transcriptional control. It includes components that participate in the modulation of E2F transcription factors, influencing cell cycle progression and gene expression.
The Oligosaccharyltransferase complex with the Stt3A variant is involved in protein glycosylation. It includes components that facilitate the transfer of oligosaccharides to nascent proteins, contributing to proper protein folding and function.
The TRF1 telomere length regulation complex is associated with telomere maintenance and regulation. It includes components that participate in the protection and length regulation of telomeres, influencing cellular senescence and genomic stability.
The Tankyrin 1-Tankyrin 2-TRF1 complex is associated with telomere maintenance and regulation. It includes components that participate in the protection and length regulation of telomeres, influencing cellular senescence and genomic stability.
The H2AX complex is associated with DNA damage response and repair. It includes components that participate in the recognition and repair of DNA double-strand breaks, contributing to genomic stability.
The Ubiquitin E3 Ligase with BMI1, SPOP, and CUL3 is involved in protein ubiquitination and degradation. It marks specific proteins for degradation by the 26S proteasome, contributing to the regulation of cellular processes by controlling protein abundance.
The H2AX complex I is associated with DNA damage response and repair. It includes components that participate in the recognition and repair of DNA double-strand breaks, contributing to genomic stability.
The H2AX complex II is associated with DNA damage response and repair. It includes components that participate in the recognition and repair of DNA double-strand breaks, contributing to genomic stability.
The WINAC complex is associated with transcriptional regulation and chromatin modification. It includes components that contribute to the modulation of gene expression and chromatin structure, influencing cellular processes.
The FIB-associated protein complex is associated with transcriptional regulation and chromatin modification. It includes components that contribute to the modulation of gene expression and chromatin structure, influencing cellular processes.
The Apoptosome is associated with apoptosis and programmed cell death. It includes components that participate in the activation of caspases, leading to the initiation of apoptosis and cellular dismantling.
The Menin-associated histone methyltransferase complex is associated with transcriptional regulation and chromatin modification. It includes components that contribute to the methylation of histones, influencing gene expression and cellular processes.
The Ubiquitin E3 Ligase with SIAH1, SIP, SKP1A, and TBL1X is involved in protein ubiquitination and degradation. It marks specific proteins for degradation by the 26S proteasome, contributing to the regulation of cellular processes by controlling protein abundance.
The MLL-HCF complex is associated with transcriptional regulation and chromatin modification. It includes components that contribute to the modulation of gene expression and chromatin structure, influencing cellular processes.
The ALL-1 supercomplex is associated with transcriptional regulation and chromatin modification. It includes components that contribute to the modulation of gene expression and chromatin structure, influencing cellular processes.
The HNRPF-HNRPH1 complex is associated with pre-mRNA splicing and mRNA processing. It includes components that participate in the splicing of pre-mRNA transcripts, contributing to the maturation of mRNA and gene expression.
The MKK4-ARRB2-JNK3 complex is associated with signaling pathways and cellular responses. It includes components that mediate the activation of JNK3 through the MKK4-ARRB2 signaling axis, influencing cellular responses to extracellular stimuli.
The Multiprotein Bridging Complex involved in Translationally Coupled mRNA Turnover is associated with mRNA degradation and turnover. It includes components that facilitate the coordinated turnover of translationally coupled mRNAs, influencing post-transcriptional gene regulation and mRNA stability.
The EIF4G1-HSP70-HSPA8-HNRNPD-PABPC1 complex is associated with mRNA translation and stability. It includes components that participate in the regulation of translation initiation, mRNA stability, and protein synthesis, influencing cellular processes related to gene expression.
The Large Drosha Complex is associated with miRNA biogenesis and mRNA processing. It includes components that participate in the cleavage of primary miRNA transcripts, contributing to the generation of mature miRNAs and post-transcriptional gene regulation.
The SNW1 complex is associated with RNA splicing and transcriptional regulation. It includes components that participate in the regulation of pre-mRNA splicing and transcriptional processes, influencing gene expression and cellular responses.
The FOXO3-PCAF complex is associated with transcriptional regulation and chromatin modification. It includes components that participate in the acetylation of FOXO3 transcription factor, influencing gene expression and cellular processes.
The GALNS-Lysosomal Hydrolase 1.27 MDa complex is associated with lysosomal function and degradation. It includes components that participate in the activity of lysosomal hydrolases, contributing to the degradation of cellular substrates and maintenance of cellular homeostasis.
The WDR5-ASH2L-RBBP5-MLL2 complex is associated with histone methylation and transcriptional regulation. It includes components that participate in the methylation of histones, influencing chromatin structure and gene expression.
The ASCOM complex is associated with transcriptional regulation and chromatin modification. It includes components that contribute to the modulation of gene expression and chromatin structure, influencing cellular processes.
The MOF complex is associated with histone acetylation and transcriptional regulation. It includes components that participate in the acetylation of histones, influencing chromatin structure and gene expression.
The LIN2-LIN7-SAP97 complex is associated with cell adhesion and signaling. It includes components that mediate the interaction between LIN2, LIN7, and SAP97, influencing cellular adhesion and intracellular signaling.
The Mis12 centromere complex is associated with chromosome segregation and kinetochore function. It includes components that participate in the assembly of the kinetochore complex, ensuring proper chromosome alignment and segregation during cell division.
The SMAD3/4-E2F4/5-p107-DP1 complex is associated with signaling pathways and cell cycle regulation. It includes components that mediate the crosstalk between SMAD and E2F signaling, influencing cellular responses and progression through the cell cycle.
The NCOR2 complex is associated with transcriptional regulation and chromatin modification. It includes components that contribute to the modulation of gene expression and chromatin structure, influencing cellular processes.
The IL4-IL4R complex is associated with cytokine signaling and immune responses. It includes components that mediate the interaction between interleukin-4 (IL4) and its receptor (IL4R), influencing cellular responses and immune regulation.
The IL-2Rgamma/IL-4R receptor-IL-4 complex is associated with cytokine signaling and immune responses. It includes components that mediate the interaction between IL-2Rgamma, IL-4R, and IL-4, influencing cellular responses and immune regulation.
The IL6ST-PRKCD-STAT3 complex is associated with cytokine signaling and cellular responses. It includes components that mediate the activation of STAT3 through IL6ST and PRKCD, influencing cellular responses to interleukin-6 (IL6) signaling.
The p300-SMAD1-STAT3 complex is associated with transcriptional regulation and signaling. It includes components that participate in the activation of STAT3 through p300 and SMAD1, influencing gene expression and cellular responses.
The PPP2CA-PPP2R1A-PPP2R3A complex is associated with protein phosphatase activity and cellular regulation. It includes components that participate in the regulation of protein phosphatase 2A (PPP2A), influencing cellular processes and signaling.
The IPO13-RAN-EIF1AX complex is associated with nuclear transport and protein synthesis. It includes components that participate in the import of EIF1AX into the nucleus, influencing translation initiation and cellular processes.
The TNPO2-RAN-NXF1 complex is associated with nuclear transport and mRNA export. It includes components that participate in the export of mRNAs from the nucleus, influencing post-transcriptional gene regulation and cellular processes.
The KPNB1-RAN-RANBP1 complex is associated with nuclear transport and regulation. It includes components that participate in the import of proteins into the nucleus, influencing cellular processes related to nuclear transport.
The Vigilin-DNA-PK-Ku Antigen complex is associated with DNA repair and processing. It includes components that participate in the repair of DNA double-strand breaks, influencing genomic stability and cellular responses to DNA damage.
The E2F4-p107-CyclinA complex is associated with cell cycle regulation and transcriptional control. It includes components that participate in the inhibition of E2F transcription factors, influencing cell cycle progression and gene expression.
The ABL2-HRAS-RIN1 complex is associated with signaling pathways and cellular responses. It includes components that mediate the crosstalk between ABL2, HRAS, and RIN1, influencing cellular responses to extracellular stimuli.
The IL2-IL2RA-IL2RB complex is associated with cytokine signaling and immune responses. It includes components that mediate the interaction between interleukin-2 (IL2), IL2RA, and IL2RB, influencing cellular responses and immune regulation.
The TICAM1-TICAM2-TLR4 complex is associated with Toll-like receptor (TLR) signaling and immune responses. It includes components that mediate the activation of TLR4 through TICAM1 and TICAM2, influencing cellular responses to microbial stimuli.
The CTCF-Nucleophosmin-PARP-HIS-KPNA-LMNA-TOP complex is associated with chromatin organization and gene regulation. It includes components that participate in the regulation of gene expression and chromatin structure, influencing cellular processes.
The TLE1 Corepressor Complex (MASH1 Promoter-Corepressor Complex) is associated with transcriptional regulation and chromatin modification. It includes components that contribute to the modulation of gene expression and chromatin structure, influencing cellular processes.
The (E.F.G) complex is associated with protein synthesis and translation. It includes components that participate in the binding and hydrolysis of GTP during the elongation phase of protein synthesis, influencing the accuracy and efficiency of translation.
The SMN complex is associated with mRNA splicing and RNA processing. It includes components that participate in the assembly of small nuclear ribonucleoproteins (snRNPs), influencing pre-mRNA splicing and gene expression.
The SMN-containing complex is associated with mRNA splicing and RNA processing. It includes components that participate in the assembly of snRNPs, contributing to the regulation of pre-mRNA splicing and gene expression.
The SMN-PolII-RHA complex is associated with transcriptional regulation and RNA metabolism. It includes components that interact with RNA polymerase II (PolII) and RNA helicase A (RHA), influencing transcription and RNA processing.
The CPSF6-EWSR1-ITCH-NUDT21-POLR2A-UBAP2L complex is associated with RNA processing and mRNA stability. It includes components that participate in the regulation of mRNA cleavage and polyadenylation, influencing post-transcriptional gene regulation.
The MICB-KLRK1-HCST Complex is associated with immune responses and cell activation. It influences cellular processes related to immune recognition and activation. The complex plays a role in modulating natural killer (NK) cell activity and immune surveillance against infected or stressed cells.
The ULBP3-KLRK1-HCST Complex is crucial for immune responses and cell activation, particularly in regulating natural killer (NK) cell activity. It plays a vital role in immune surveillance, helping identify and respond to infected or stressed cells. The complex is essential for coordinating effective immune responses, emphasizing its importance in the body's defense mechanisms.
The MICA-KLRK1-HCST Complex is intricately involved in immune responses and NK cell activation. It acts as a key player in immune surveillance, facilitating the detection and response to infected or stressed cells. This complex plays a crucial role in enhancing the body's defense mechanisms against potential threats.
Crucial for immune responses, the ULBP2-KLRK1-HCST Complex actively regulates NK cell activity and contributes significantly to immune surveillance. By modulating the detection and response to infected or stressed cells, this complex plays a vital role in bolstering the body's immune defenses.
The Ubiquitin E3 Ligase (SMURF2) is associated with protein ubiquitination and degradation. It includes components that participate in the ubiquitination of target proteins, marking them for degradation and influencing cellular processes related to protein turnover.
The RNF11-SMURF2-STAMBP complex is associated with endocytic processes and signal transduction. It includes components that participate in the regulation of ubiquitin-dependent endocytosis, influencing cellular responses to extracellular signals.
The LINGO1-RTN4R-NGFR Complex is intricately associated with cellular functions related to nerve growth and guidance. It influences processes that regulate neural development and communication, playing a pivotal role in shaping the nervous system. This complex contributes to the intricate network of signaling events essential for proper neural function.
The SORT1-NGFR Complex plays a crucial role in cellular processes related to nerve growth and signaling. It actively participates in the modulation of neural development and communication, contributing to the intricate network of events governing proper nervous system function. This complex is vital for orchestrating signaling pathways essential for neural development.
The SORT1-NGFR-NGFB Complex is intimately involved in cellular functions crucial for nerve growth and guidance. It actively influences processes related to neural development and communication, contributing to the intricate signaling network governing proper nervous system function. This complex plays a vital role in shaping and regulating neural processes essential for overall neural function.
The MAD1L1-MAD2L1 complex is associated with mitotic checkpoint regulation and cell cycle control. It includes components that participate in the spindle assembly checkpoint, influencing the fidelity of chromosome segregation during cell division.
The JUN-TCF4-CTNNB1 complex is associated with transcriptional regulation and Wnt signaling. It includes components that participate in the modulation of gene expression and cellular responses to Wnt signals, influencing developmental processes.
The SMAD3-HEF1-APC10-CDH1 complex is associated with cell cycle regulation and TGF-beta signaling. It includes components that mediate the crosstalk between SMAD3, HEF1, and the anaphase-promoting complex (APC), influencing cellular responses to TGF-beta signals.
The PML-SMAD2/3-SARA complex is associated with TGF-beta signaling and cellular responses. It includes components that participate in the regulation of SMAD2/3 activation by TGF-beta, influencing cellular processes related to growth and differentiation.
The PIAS3-SMAD3-P300 complex is associated with transcriptional regulation and TGF-beta signaling. It includes components that participate in the modulation of SMAD3 activity, influencing gene expression and cellular responses to TGF-beta signals.
The ITGAE-ITGB2-CD11 complex is associated with cell adhesion and immune responses. It includes components that mediate the interaction between integrins and CD11, influencing cellular adhesion and immune cell functions.
The BMP4-TWSG1 Complex plays a crucial role in cellular functions related to growth factor signaling. It actively influences processes such as cell differentiation and proliferation, contributing to the regulation of cellular growth and development. This complex is essential for orchestrating signaling pathways crucial for proper cellular responses.
The BMP4-BGN Complex is intimately involved in cellular processes crucial for growth factor signaling. It actively participates in the modulation of cellular events related to cell growth, differentiation, and development, contributing to the intricate signaling network governing proper cellular responses. This complex is vital for cellular growth regulation.
The IL12A-IL12B-IL12RB1 Complex is associated with immune responses and cytokine signaling. It influences cellular processes related to immune regulation and response to infections, playing a pivotal role in shaping immune system activities. This complex contributes to the intricate network of signaling events essential for proper immune function.
The IL12B-IL12RB1-IL12RB2 Complex is intricately involved in immune responses and cytokine signaling. It actively participates in the modulation of cellular events related to immune regulation, contributing to the intricate signaling network governing proper immune function. This complex plays a vital role in shaping immune system activities.
The IL12A-IL12B-IL12RB2 Complex is associated with immune responses and cytokine signaling. It influences cellular processes related to immune regulation and response to infections, playing a pivotal role in shaping immune system activities. This complex contributes to the intricate network of signaling events essential for proper immune function.
The JAK2-IL12RB2 Complex is intricately associated with immune responses and cytokine signaling. It actively participates in the modulation of cellular events related to immune regulation, contributing to the intricate signaling network governing proper immune function. This complex plays a vital role in shaping immune system activities.
The CASP8-FADD-MALT1-BCL10 complex is associated with apoptotic signaling and immune responses. It includes components that participate in the activation of caspase-8 and downstream signaling, influencing cellular responses to apoptotic stimuli.
The CASP8-CHUK-IKBKB-MALT1-BCL10 complex is associated with NF-kappaB signaling and immune responses. It includes components that participate in the regulation of NF-kappaB activation, influencing cellular responses to inflammatory signals.
The NFKB1-NFKB2-REL-RELA-RELB complex is associated with NF-kappaB signaling and immune responses. It includes components that participate in the modulation of NF-kappaB activity, influencing cellular responses to inflammatory signals.
The CDC37-HSP90AA1-HSP90AB1-MAP3K11 complex is associated with protein folding and kinase regulation. It includes components that participate in the chaperone activity of HSP90, influencing the stability and activity of MAP3K11 and other client kinases.
The DNAJB2-HSPA8-PSMA3 complex is associated with protein folding and proteasomal degradation. It includes components that participate in the chaperone activity of HSPA8 and the regulation of proteasomal degradation, influencing protein quality control.
The MAP2K5-PRKCI-SQSTM1 complex is associated with cellular signaling and autophagy. It includes components that participate in the regulation of MAP2K5 and PRKCI, influencing cellular responses to stress and autophagic processes.
The HSF1-YWHAE complex is associated with heat shock response and cellular stress. It includes components that participate in the regulation of heat shock factor 1 (HSF1) activity, influencing cellular responses to heat stress and proteotoxicity.
The ITGAM-ITGB2-CD11 Complex is intricately involved in cellular processes related to immune responses and cell adhesion. It actively participates in modulating immune cell activities and cellular adhesion events, contributing to overall immune system function. This complex plays a vital role in mediating immune cell interactions and responses to various stimuli.
The YBX1-AKT1 Complex is associated with cellular processes crucial for signaling and regulation. It actively influences processes such as cell growth, survival, and proliferation, contributing to the regulation of cellular activities. This complex is essential for orchestrating signaling pathways crucial for proper cellular responses.
The AR-AKT-APPL complex is associated with androgen receptor (AR) signaling, AKT activation, and APPL1-mediated processes. It participates in the regulation of cellular responses to androgens, Akt signaling, and APPL1-mediated cellular functions.
The Ubiquitin E3 Ligase (CDC34, CUL1, RBX1) complex is a key player in the cellular machinery responsible for protein ubiquitination and degradation. It facilitates the transfer of ubiquitin molecules to target proteins, marking them for degradation. The complex is involved in the ubiquitin-proteasome system, a fundamental mechanism for controlling protein turnover and maintaining proper cellular function.
The CNS-P53 complex is associated with central nervous system (CNS) function and p53-mediated processes. It includes components that participate in the regulation of p53 activity within the context of CNS-related cellular functions.
The Ubiquitin E3 Ligase (SMAD3, BTRC, CUL1, SKP1A, RBX1) complex is associated with ubiquitination and degradation of SMAD3. It includes components that regulate the turnover of SMAD3, influencing TGF-beta signaling and cellular responses to growth factors.
The 9-1-1-FEN1 complex is associated with DNA repair and replication. It includes components that participate in the recognition of DNA damage, checkpoint activation, and recruitment of FEN1 during DNA repair and replication processes.
The MSH2/6-BLM-p53-RAD51 complex is associated with DNA repair and recombination. It includes components that participate in mismatch repair, DNA unwinding, p53-mediated responses, and the recruitment of RAD51 during homologous recombination.
The MutS-alpha-PK-zeta complex is associated with DNA repair and translesion synthesis. It includes components that participate in mismatch repair, DNA damage tolerance, and translesion DNA synthesis through the recruitment of DNA polymerase zeta (PK-zeta).
The ASF1-histone containing complex is associated with histone chaperone activity and chromatin assembly. It includes components that facilitate the deposition of histones onto DNA during chromatin assembly and histone exchange processes.
The Cofilin-Actin-CAP1 complex is associated with actin dynamics and cytoskeletal regulation. It includes components that participate in the regulation of actin filament turnover and actin cytoskeleton dynamics through the activity of cofilin and CAP1.
The ITGAV-ITGB8-MMP14-TGFB1 Complex is intricately involved in the signaling cascades initiated by transforming growth factor-beta 1 (TGF-beta1). It plays a crucial role in cellular responses associated with TGF-beta1 signaling, including extracellular matrix remodeling. This complex significantly influences cell adhesion, migration, and various cellular processes mediated by TGF-beta1.
The ITGAV-ITGB5-PLAUR Complex is a key player in regulating cell adhesion and migration. It actively participates in cellular interactions with the extracellular matrix, modulating processes related to cell motility and adhesion. This complex holds significance in cellular dynamics and responses to extracellular cues, contributing to the orchestration of cell behavior.
The ITGAV-ITGB5-ICAM4 Complex is instrumental in orchestrating cellular adhesion and immune responses. By influencing interactions between cells and modulating adhesion molecules, this complex actively shapes immune responses. Its role extends to the modulation of cellular processes related to immune recognition and adhesion-based immune responses.
The ITGAV-ITGB5-ADAM9 Complex is a central player in cell adhesion and signaling processes. It actively influences cellular interactions, signaling pathways, and processes related to cell adhesion and the dynamics of the extracellular matrix. This complex's activity is crucial for cellular behavior and the modulation of extracellular signaling cues.
The ITGAV-ITGB5-SPP1 Complex holds significance in cell adhesion and signaling pathways associated with osteopontin (SPP1). It actively participates in cellular interactions and signaling cascades related to osteopontin-mediated processes. This complex plays a vital role in cellular responses to osteopontin, contributing to various physiological and pathological processes.
The ITGB6-FYN-FN1 Complex is a key participant in cell adhesion and signaling processes. It influences cellular interactions, signaling pathways, and processes associated with cell adhesion and the dynamics of the extracellular matrix. This complex's activity is integral to cellular behavior and responses to extracellular cues.
The ITGAV-ITGB6-SPP1 Complex plays a crucial role in cell adhesion and signaling pathways related to osteopontin (SPP1). It actively participates in cellular interactions and signaling cascades associated with osteopontin-mediated processes. This complex is essential for cellular responses to osteopontin, contributing to various physiological and pathological processes.
The ITGAV-ITGB6-TGFB3 Complex is associated with signaling events initiated by transforming growth factor-beta 3 (TGF-beta3). It actively participates in cellular responses related to TGF-beta3 signaling, influencing cell adhesion, migration, and processes mediated by TGF-beta3. This complex holds significance in orchestrating cellular dynamics in response to TGF-beta3 cues.
The ITGAV-ITGB3-CD47-FCER2 Complex plays a crucial role in cell adhesion and immune responses. It actively influences interactions between cells and immune responses by modulating adhesion molecules and immune receptors. This complex is central to shaping immune recognition and adhesion-based immune responses.
The FN1-TGM2 Complex is associated with interactions between fibronectin (FN1) and transglutaminase 2 (TGM2). It actively influences cellular adhesion, extracellular matrix dynamics, and processes related to tissue repair and remodeling. This complex plays a crucial role in orchestrating cellular responses to extracellular cues and contributing to tissue homeostasis.
The ITGA2b-ITGB3-CD47-SRC Complex is involved in platelet activation and signaling. It actively influences platelet adhesion, activation, and signaling processes during hemostasis and vascular responses. This complex is central to maintaining platelet homeostasis and orchestrating responses to vascular cues.
The ITGA5-ITGB1-FN1-TGM2 Complex is associated with cell adhesion and signaling processes. It actively influences cellular interactions, signaling pathways, and processes related to cell adhesion and the dynamics of the extracellular matrix. This complex's activity is integral to cellular behavior and responses to extracellular cues.
The ITGA5-ITGB1-ADAM15 Complex is involved in cell adhesion and signaling processes. It actively influences cellular interactions, signaling pathways, and processes related to cell adhesion and the dynamics of the extracellular matrix. This complex's activity is integral to cellular behavior and responses to extracellular signaling cues.
The ITGA2-ITGB1-CD47 Complex is crucial for cell adhesion and signaling processes. It actively influences cellular interactions, signaling pathways, and processes related to cell adhesion and immune responses. This complex plays a central role in shaping immune recognition and adhesion-based immune responses.
The ITGA2-ITGB1-CHAD Complex is associated with cell adhesion and signaling processes. It actively influences cellular interactions, signaling pathways, and processes related to cell adhesion and the dynamics of the extracellular matrix. This complex's activity is integral to cellular behavior and responses to extracellular cues.
The ITGA2-ITGB1-COL6A3 Complex is involved in cell adhesion and signaling processes. It actively influences cellular interactions, signaling pathways, and processes related to cell adhesion and the dynamics of the extracellular matrix. This complex's activity is integral to cellular behavior and responses to extracellular cues.
The CBL-EGFR-SH3GL2-SH3KBP1 Complex is involved in the regulation of epidermal growth factor receptor (EGFR) signaling. It modulates pathways associated with cell growth, proliferation, and survival. This complex plays a pivotal role in mediating cellular responses to EGFR activation, contributing to cellular homeostasis and dynamic signaling.
The MET-CIN85-SH3GL3-CBL Complex is associated with hepatocyte growth factor receptor (MET) signaling. It modulates pathways related to cell growth, survival, and migration. This complex plays a crucial role in mediating cellular responses to MET activation, contributing to cellular homeostasis and dynamic signaling.
The p130Cas-ER-alpha-cSrc-kinase-PI3-kinase p85-Subunit Complex is involved in estrogen receptor (ER-alpha) signaling. It modulates pathways related to cell proliferation, survival, and estrogen receptor responses. This complex plays a crucial role in mediating cellular responses to estrogen, contributing to cellular homeostasis and dynamic signaling.
The SRC-PRKCD-CDCP1 Complex is associated with signaling cascades involving Src kinase and protein kinase C delta (PRKCD). It modulates pathways related to cell survival, migration, and cellular responses to external stimuli. This complex plays a vital role in mediating cellular responses to Src kinase and PRKCD activation, contributing to cellular homeostasis and dynamic signaling.
The CRK-CRKL-PDGFRA-RAPGEF1 Complex is involved in platelet-derived growth factor receptor alpha (PDGFRA) signaling. It modulates pathways related to cell growth, proliferation, and migration. This complex plays a crucial role in mediating cellular responses to PDGFRA activation, contributing to cellular homeostasis and dynamic signaling.
Involved in various cellular processes, the CIN85 Complex serves as a central hub for signaling cascades and cellular responses. It plays roles in endocytosis, vesicle trafficking, cytoskeletal organization, integrin signaling, and protein degradation. The components, including CIN85, CRK, BCAR1, CBL, PIK3R1, GRB2, and SOS1, collectively impact cell adhesion, migration, and growth.
The GIPC1-LHCGR Complex is associated with luteinizing hormone/choriogonadotropin receptor (LHCGR) signaling. It modulates pathways related to hormone signaling and cellular responses to luteinizing hormone. This complex plays a crucial role in mediating cellular responses to LHCGR activation, contributing to cellular homeostasis and dynamic signaling.
The GIPC1-NTRK1-RGS19 Complex is involved in neurotrophic tyrosine kinase receptor type 1 (NTRK1) signaling. It modulates pathways related to neuronal growth, survival, and neurotrophic signaling. This complex plays a crucial role in mediating cellular responses to NTRK1 activation, contributing to cellular homeostasis and dynamic signaling.
The NCR3-CD247 Complex is associated with immune responses and natural cytotoxicity. It modulates pathways related to natural killer (NK) cell activation and immune surveillance. This complex plays a vital role in mediating cellular responses to immune activation, contributing to cellular homeostasis and dynamic signaling.
The CRKL-WAS-WIPF1-ZAP70 Complex is involved in immune signaling cascades. It modulates pathways related to immune cell activation, including the activation of T cells. This complex plays a crucial role in mediating cellular responses to immune activation, contributing to cellular homeostasis and dynamic signaling.
The ERBB2-MEMO-SHC Complex is associated with ERBB2 (HER2) signaling. It modulates pathways related to cell growth, survival, and responses to ERBB2 activation. This complex plays a crucial role in mediating cellular responses to ERBB2, contributing to cellular homeostasis and dynamic signaling.
The LAT-PLC-gamma-1-p85-GRB2-CBL-VAV-SLP-76 Signaling Complex is involved in T cell receptor signaling. It modulates pathways related to T cell activation, including activation of downstream signaling molecules. This complex plays a crucial role in mediating cellular responses to T cell activation, contributing to cellular homeostasis and dynamic signaling.
The Cbl-SLP-76-Grb2 Complex is associated with immune signaling cascades. It modulates pathways related to immune cell activation and downstream signaling events. This complex plays a vital role in mediating cellular responses to immune activation, contributing to cellular homeostasis and dynamic signaling.
The SLP-76-Cbl-Grb2-Shc Complex is involved in immune signaling cascades. It modulates pathways related to immune cell activation and downstream signaling events. This complex plays a crucial role in mediating cellular responses to immune activation, contributing to cellular homeostasis and dynamic signaling.
The PLC-gamma-2-SLP-76-Lyn-Grb2 Complex is associated with immune signaling cascades. It modulates pathways related to immune cell activation and downstream signaling events. This complex plays a vital role in mediating cellular responses to immune activation, contributing to cellular homeostasis and dynamic signaling.
The PKC-alpha-PLD1-PLC-gamma-2 Signaling Complex is involved in signaling cascades associated with protein kinase C alpha (PKC-alpha) and phospholipase D1 (PLD1). It modulates pathways related to cellular responses to PKC-alpha activation and downstream signaling events. This complex plays a crucial role in mediating cellular responses to PKC-alpha activation, contributing to cellular homeostasis and dynamic signaling.
The HGF-Met Complex is associated with hepatocyte growth factor (HGF) signaling. It modulates pathways related to cell growth, survival, and responses to HGF activation. This complex plays a crucial role in mediating cellular responses to HGF, contributing to cellular homeostasis and dynamic signaling.
The EGFR-CBL-GRB2 Complex is involved in epidermal growth factor receptor (EGFR) signaling. It modulates pathways related to cell growth, proliferation, and responses to EGFR activation. This complex plays a crucial role in mediating cellular responses to EGFR, contributing to cellular homeostasis and dynamic signaling.
The PLC-gamma-1-SLP-76-SOS1-LAT Complex is associated with T cell receptor signaling. It modulates pathways related to T cell activation, including activation of downstream signaling molecules. This complex plays a crucial role in mediating cellular responses to T cell activation, contributing to cellular homeostasis and dynamic signaling.
The PDGFRA-PLC-gamma-1-PI3K-SHP-2 Complex is involved in platelet-derived growth factor receptor alpha (PDGFRA) signaling. It modulates pathways related to cell growth, proliferation, and migration. This complex plays a crucial role in mediating cellular responses to PDGFRA activation, contributing to cellular homeostasis and dynamic signaling.
The FGFR2-c-Cbl-Lyn-Fyn Complex is involved in fibroblast growth factor receptor 2 (FGFR2) signaling. It modulates pathways related to cell growth, survival, and responses to FGFR2 activation. This complex plays a crucial role in mediating cellular responses to FGFR2, contributing to cellular homeostasis and dynamic signaling.
The p21(ras)GAP-Fyn-Lyn-Yes Complex is associated with signaling cascades involving p21(ras)GAP, Fyn, Lyn, and Yes kinases. It modulates pathways related to cell growth, survival, and responses to external stimuli. This complex plays a vital role in mediating cellular responses to various signaling inputs, contributing to cellular homeostasis and dynamic signaling.
The CD20-LCK-LYN-FYN-p75/80 Complex is integral to B-cell receptor signaling, playing a crucial role in the modulation of B-cell activation and subsequent antibody production. Its components, including CD20, LCK, LYN, FYN, and p75/80, collectively contribute to the orchestration of immune responses.
Facilitating early endosome fusion and regulating vesicle trafficking, the RAB5-EEA1 Complex, featuring RAB5 and EEA1, is essential for maintaining cellular dynamics. It governs endocytic processes and ensures the efficient transport of cargo molecules within the cell.
Critical for B-cell receptor signaling, the CD19-VAV1-PIK3R1 Complex, consisting of CD19, VAV1, and PIK3R1, is instrumental in influencing B-cell proliferation and differentiation. Its activities significantly contribute to the proper functioning of the immune system.
Involved in insulin receptor signaling, the Sam68-p85 PI3K-IRS-1-IR Signaling Complex, comprising Sam68, p85 PI3K, IRS-1, and the insulin receptor (IR), modulates glucose metabolism and cellular sensitivity to insulin. It plays a crucial role in cellular responses to insulin stimulation.
Regulating cell cycle progression and mitosis, the RasGAP-AURKA-Survivin Complex, featuring RasGAP, AURKA, and Survivin, plays a critical role in controlling cell division, spindle assembly, and maintaining chromosomal stability. Its activities impact the fidelity of cellular replication.
This complex is involved in the regulation of pre-mRNA splicing, consisting of PGC-1, SRp40, SRp55, and SRp75, modulates alternative splicing patterns. It exerts influence on gene expression and RNA processing, contributing to cellular diversity in mRNA transcripts.
Engaged in transcriptional regulation and mRNA processing, the POLR2A-CCNT1-CDK9-NCL-LEM6-CPSF2 Complex, composed of various subunits, actively participates in RNA polymerase activity and mRNA maturation. Its functions are crucial for the proper regulation of gene expression.
The BRD4 Complex is involved in the regulation of gene expression by recognizing acetylated lysine residues on histones. It acts as a crucial mediator in chromatin remodeling and transcriptional activation, contributing to the modulation of various cellular processes.
The HES1 Promoter-Notch Enhancer Complex is crucial for Notch signaling pathway activation and subsequent transcriptional regulation. It modulates the expression of HES1, a key downstream target, influencing cellular differentiation and development.
Playing a role in transcriptional regulation, the MYC-MAX-KAT2A-TRRAP Complex is associated with the activation of MYC target genes. It modulates gene expression patterns, influencing cellular proliferation, apoptosis, and other MYC-associated functions.
The ESR1-CDK7-CCNH-MNAT1-MTA1-HDAC2 Complex is involved in estrogen receptor signaling and transcriptional regulation. It modulates the activity of estrogen receptor alpha (ESR1) and contributes to the regulation of estrogen-responsive genes, impacting cellular responses.
The FOXO3-TP53 Complex involves the interaction between FOXO3 and TP53, contributing to the modulation of cell cycle progression and apoptosis. It plays a role in coordinating cellular responses to stress and regulating genes involved in cell fate determination.
The SMAD3-SMAD4-cJun-cFos Complex is a signaling assembly within the transforming growth factor-beta (TGF-beta) pathway. It plays a role in mediating cellular responses to TGF-beta signaling, impacting cell growth, differentiation, and other essential cellular processes.
The ETS2-FOS-JUN Complex is implicated in gene expression regulation and cellular responses. This complex involves the ETS2 transcription factor, along with the FOS and JUN transcription factors, forming a regulatory network that modulates the expression of target genes, influencing various cellular functions.
The SMAD3-SMAD4-CTCF Protein-DNA Complex is a regulatory complex involved in gene expression control. Comprising SMAD3, SMAD4, and the CCCTC-binding factor (CTCF), this complex contributes to the modulation of transcriptional programs, influencing the accessibility of genes within the genome.
The SMAD3-SMAD4-SP1 Complex is associated with TGF-beta signaling and gene regulation. This complex involves SMAD3, SMAD4, and the SP1 transcription factor, contributing to the control of gene expression and influencing cellular responses to TGF-beta signaling.
The complex integrates TGF-beta signaling with the FOXO3-FOXG1, regulating cell cycle, apoptosis, and differentiation. SMAD3 and SMAD4 mediate TGF-beta, while FOXO3 and FOXG1 impact FOXO3-responsive genes and development. It modulates cell survival, proliferation, and overall cellular function.
The LRP1-MMP9-TIMP1 Complex is involved in the regulation of extracellular matrix remodeling and tissue homeostasis. It plays a crucial role in controlling processes such as cell migration and angiogenesis by balancing the activity of matrix metalloproteinases.
Crucial for cellular regulation, this complex ubiquitinates proteins like CHEK1, influencing cell cycle progression and DNA damage responses. It ensures genomic stability and proper responses to stressors by controlling regulatory protein levels. Dysregulation can lead to aberrant cell cycle and compromised DNA repair.
This multisubunit complex regulates protein stability through ubiquitination, impacting cell cycle control, signal transduction, and homeostasis. It involves cullin proteins, the COP9 signalosome, RING box protein, and Skp1-like proteins in ubiquitinating specific substrates. Dysregulation is implicated in various diseases, highlighting its significance in cellular physiology.
Involved in phosphorylation events, this complex modulates chromatin dynamics and cellular processes. It includes casein kinase II and HMG1, impacting gene expression and participating in various pathways through phosphorylation. Dysregulation may contribute to aberrant signaling and diseases.
Essential in cellular phosphorylation, this complex with beta-dimer and alpha subunits influences signal transduction, transcriptional regulation, and the cell cycle. The beta-dimer provides stability and substrate recognition, and the alpha subunits catalyze phosphorylation reactions. It plays a crucial role in regulating diverse cellular functions and diseases.
A multifunctional complex in transcriptional regulation, this assembly with HCF-1 influences gene expression, cell cycle, and DNA repair. HCF-1, a coactivator and chromatin modifier, modulates gene expression and contributes to genomic stability through DNA repair processes. Dysregulation may impact various cellular processes and diseases.
Instrumental in NF-kappa-B signaling, this complex ubiquitinates NFKBIA, activating NF-kappa-B and modulating immune responses. Comprising BTRC, CUL1, and SKP1A, dysregulation disrupts NF-kappa-B signaling, contributing to inflammatory diseases and cancer.
Crucial in cellular adhesion and signaling, this complex links the extracellular matrix to the cytoskeleton. ITGB5 associates with PTK2 and PXN, impacting adhesion, migration, and signal transduction. Dysregulation can affect cell motility and contribute to conditions, including cancer metastasis.
A coactivator in transcriptional regulation, SRC-3 modulates hormone signaling, cell cycle, and cellular differentiation. Interacting with nuclear receptors, it enhances transcriptional activity, playing a crucial role in development, metabolism, and immune responses. Dysregulation is implicated in cancer and diseases.
The TROY-NGR-LINGO1 Complex is involved in regulating nerve growth factor (NGF) signaling and axon regeneration. It comprises TROY, NGR, and LINGO1, influencing neurite outgrowth and axon regeneration responses to NGF. This complex plays a crucial role in neuroplasticity and neuronal growth regulation.
BLM Complex II is involved in DNA repair and maintenance of genomic stability. It includes components that participate in resolving DNA structures and preventing genomic instability. Dysregulation may lead to impaired DNA repair and increased susceptibility to genetic abnormalities.
The JUND-FOSB-SMAD3-SMAD4 complex is associated with transcriptional regulation and signaling pathways. It includes components that mediate the crosstalk between JUND, FOSB, SMAD3, and SMAD4, influencing cellular responses and gene expression. Dysregulation can impact cell fate decisions and contribute to diseases.
The 17S U2 snRNP is involved in pre-mRNA splicing, contributing to mRNA processing and maturation. It includes components that participate in the splicing of introns, influencing gene expression and post-transcriptional regulation. Dysregulation can lead to aberrant splicing events and affect cellular functions.
This ubiquitin ligase complex, involving UBE2N and UBE2V2, is crucial for protein ubiquitination and degradation. It regulates the stability of target proteins, impacting cellular processes such as signal transduction and protein turnover. Dysregulation can contribute to various diseases by affecting protein homeostasis.
The SMAD3-SMAD4-FOXO3 Complex plays a crucial role in the TGF-beta pathway, regulating cell growth, apoptosis, and differentiation. It controls FOXO3's transcriptional activity in response to TGF-beta signals, influencing the expression of genes involved in various cellular functions and maintaining homeostasis.
The MBD1-Suv39h1-HP1 complex is associated with epigenetic regulation and chromatin modification. It includes components that participate in DNA methylation and histone modifications, influencing gene expression and chromatin structure. Dysregulation can impact cellular processes and contribute to diseases.
The TERF2-RAP1 complex is involved in telomere maintenance and protection. It includes components that contribute to the regulation of telomere length and chromatin structure, impacting cellular senescence and genomic stability. Dysregulation can lead to telomere-related disorders and affect cellular lifespan.
The BRCA1 B complex is associated with DNA repair and maintenance of genomic stability. It includes components that participate in homologous recombination and repair of DNA double-strand breaks, influencing cellular responses to DNA damage. Dysregulation is linked to breast and ovarian cancers.
The POU2F1-SOX2 complex is known to be involved in the regulation of genes associated with cell fate determination, development, and differentiation. It binds to specific DNA sequences in the regulatory regions of target genes, influencing their transcriptional activity. It plays crucial role in the regulation of gene expression, particularly in the context of embryonic development, stem cell maintenance, and cell differentiation.
The 9-1-1-APE1 complex is involved in DNA damage response and repair. It includes components that recognize and bind to DNA damage, activating repair processes. Dysregulation can lead to impaired DNA repair and genomic instability.
The BRCA1-BARD1-BACH1-DNA Damage Complex II is associated with DNA repair and cellular responses to DNA damage. It includes components that participate in the recognition and repair of DNA double-strand breaks, influencing genomic stability. Dysregulation is linked to breast and ovarian cancers.
The E3 Ubiquitin Ligase (BRCA1, BARD1) - UbcH5c complex is associated with protein ubiquitination and degradation. It includes components that participate in the ubiquitination of target proteins, marking them for degradation and influencing cellular processes such as cell cycle regulation and DNA repair.
The BRCA1-BARD1-UbcH7c complex is associated with protein ubiquitination and degradation. It includes components that participate in the ubiquitination of target proteins, marking them for degradation and influencing cellular processes such as cell cycle regulation and DNA repair.
The RSmad complex is associated with signaling pathways and cellular responses. It includes components that mediate the transmission of signals through receptor-regulated SMADs (RSmads), influencing cellular responses to TGF-beta and BMP signaling.
The SMAD4-SMAD2-SMAD3 complex is associated with signaling pathways and cellular responses. It includes components that mediate the crosstalk between SMAD2, SMAD3, and SMAD4, influencing cellular responses to TGF-beta and BMP signaling.
The ITGA5-ITGB1-FN-1-NOV Complex is a multiprotein complex that actively participates in cellular processes related to cytoskeleton organization and extracellular matrix organization. It is crucial for cell adhesion and communication, contributing significantly to tissue integrity and function.
The ITGA5-ITGB1-CAL4A3 Complex is involved in cellular processes related to cytoskeleton organization and cell adhesion. It plays a crucial role in maintaining tissue integrity and facilitating cell communication.
The ITGA2b-ITGB3-CD9-GP1b-CD47 Complex is involved in cellular processes related to platelet activation and blood clotting. It plays a crucial role in mediating interactions between platelet surface receptors and facilitating hemostasis.
The CD20-LCK-FYN-p75/80 Complex is associated with intracellular signaling pathways and immune responses. It influences cellular processes related to lymphocyte activation and plays a role in modulating signal transduction cascades in the context of the immune system.
The ITGA5-ITGB3-COL6A3 Complex is involved in cellular processes related to extracellular matrix organization and cell adhesion. It plays a crucial role in maintaining tissue integrity and facilitating cell communication in the extracellular environment.
The BCR-ABL (p210)-GRB2-SOS1 Complex is associated with intracellular signaling pathways. It influences cellular processes related to signal transduction and plays a role in regulating cell proliferation and survival.
The SHC-GRB2 Complex is involved in intracellular signaling cascades. It plays a role in mediating interactions between proteins, contributing to the transmission of signals within the cell.
The ITGA2B-ITGB3-CD47-FAK Complex is associated with cellular processes related to cell adhesion and integrin signaling. It plays a role in mediating interactions between cell surface receptors and the extracellular matrix, contributing to cell migration and adhesion.
The Respiratory Chain Complex I (Intermediate VII/650kD) is a component of the mitochondrial electron transport chain. It participates in the transfer of electrons from NADH to ubiquinone, generating a proton gradient across the inner mitochondrial membrane and contributing to ATP synthesis.
The PLC-gamma-2-Syk-LAT-FcR-gamma Complex is associated with immune responses and intracellular signaling cascades. It plays a role in mediating interactions between proteins involved in B-cell receptor signaling and contributes to the activation of downstream signaling pathways.
The PLC-gamma-2-Lyn-FcR-gamma Complex is involved in immune responses and intracellular signaling. It plays a role in mediating interactions between proteins associated with Fc receptor signaling, contributing to the activation of downstream signaling pathways in immune cells.
The PLC-gamma-2-LAT Complex is associated with immune responses and intracellular signaling cascades. It plays a role in mediating interactions between proteins involved in T-cell receptor signaling, contributing to the activation of downstream signaling pathways.
The Respiratory Chain Complex I (Beta Subunit) is a component of the mitochondrial electron transport chain. It participates in the transfer of electrons from NADH to ubiquinone, contributing to the establishment of a proton gradient and ATP synthesis across the inner mitochondrial membrane.
The Ku Antigen-YY1-alphaMyHC Promoter Complex is associated with the regulation of gene expression. It plays a role in the modulation of alphaMyHC promoter activity, influencing processes related to muscle development and function.
The Respiratory Chain Complex I (Lambda Subunit) is a component of the mitochondrial electron transport chain. It participates in the transfer of electrons from NADH to ubiquinone, contributing to the establishment of a proton gradient and ATP synthesis across the inner mitochondrial membrane.
The LAT-PLC-gamma-1-p85-GRB2-SOS Signaling Complex is associated with intracellular signaling cascades, particularly in T-cell receptor signaling. It plays a role in mediating interactions between proteins involved in signal transduction, contributing to the activation of downstream signaling pathways in immune cells.
Involved in intracellular signaling pathways, particularly in the context of Notch signaling. Plays a role in influencing downstream signaling events and cellular responses related to cell survival and proliferation.
Associated with the regulation of gene expression and the Notch signaling pathway. Plays a role in influencing target gene transcription and cellular processes related to development and differentiation.
A transitional state of Complex I in the mitochondrial electron transport chain. Participates in the transfer of electrons from NADH to ubiquinone, contributing to the establishment of a proton gradient and ATP synthesis across the inner mitochondrial membrane.
Associated with intracellular signaling pathways, specifically in T-cell receptor signaling. Plays a role in contributing to the activation of downstream signaling cascades in immune cells.
Associated with intracellular signaling pathways, particularly in T-cell receptor signaling. Plays a role in influencing signal transduction cascades and cellular responses in immune cells.
Involved in intracellular signaling, particularly in T-cell receptor signaling. Facilitates the activation of downstream signaling pathways, contributing to cellular responses in immune cells.
Participates in the regulation of gene expression through the interaction of SMAD1 with the transcriptional coactivator CBP. Involved in the modulation of target gene transcription related to BMP signaling.
Associated with SMAD1 signaling and transcriptional regulation. The interaction between SMAD1, OAZ, and HsN3 influences target gene expression and cellular processes related to BMP signaling.
Plays a role in T-cell receptor signaling by coordinating intracellular signaling events. Contributes to the activation of downstream signaling pathways, influencing immune cell responses.
Associated with the regulation of gene expression and cell cycle control. The interaction between SMAD3, E2F4/5, p107, and DP1 influences target gene transcription and cellular responses related to TGF-beta signaling.
Functions as a ubiquitin E3 ligase complex involved in the regulation of TGF-beta signaling. Mediates the ubiquitination and degradation of target proteins, influencing cellular responses to TGF-beta pathway activation.
Involved in the regulation of Wnt/beta-catenin signaling. The complex modulates the phosphorylation status and degradation of beta-catenin, influencing target gene expression and cellular processes related to Wnt signaling.
Functions as a ubiquitin E3 ligase complex involved in the regulation of cell cycle progression. Mediates the ubiquitination and degradation of p27, influencing the cell cycle transition from G1 to S phase.
Participates in the TGF-beta signaling pathway. Mediates the binding of TGF-beta3 to its receptor, initiating downstream signaling events that influence cellular responses related to TGF-beta pathway activation.
Participates in the TGF-beta signaling pathway. Mediates the binding of TGF-beta1 to its receptor, initiating downstream signaling events that influence cellular responses related to TGF-beta pathway activation.
Involved in the RNA interference (RNAi) pathway. Participates in the processing of small RNA molecules, influencing gene silencing and post-transcriptional regulation of target mRNAs.
Functions as a ubiquitin E3 ligase complex involved in the regulation of various cellular processes. Mediates the ubiquitination and degradation of specific target proteins, influencing diverse cellular functions.
Associated with the regulation of gene expression and cell fate determination. The interaction between SMAD2, SMAD4, and FAST1 influences target gene transcription and cellular responses related to TGF-beta signaling.
Participates in BMP signaling, influencing cellular responses related to bone morphogenetic protein (BMP) pathway activation. The complex modulates gene expression and cellular processes associated with BMP signaling.
Associated with the regulation of gene expression through enhancer activity. The complex is involved in modulating the transcriptional control of target genes, influencing diverse cellular processes.
Associated with the regulation of gene expression through enhancer activity. The complex is involved in modulating the transcriptional control of target genes, influencing diverse cellular processes.
Plays a role in transcriptional regulation. The MYC-MAX complex functions as a transcription factor involved in the activation of target genes, influencing cellular processes such as cell growth and proliferation.
Involved in ribosomal RNA (rRNA) processing. The complex participates in the maturation of pre-rRNA, contributing to the assembly of functional ribosomes and protein synthesis.
Participates in the transcription of protein-coding genes. RNA Polymerase II complexes are responsible for synthesizing messenger RNA (mRNA) molecules, essential for protein synthesis and cellular function.
Involved in histone modification and transcriptional regulation. The complex mediates the demethylation of histone H3 lysine 27 (H3K27), influencing gene expression and chromatin dynamics.
Participates in microRNA (miRNA) biogenesis. The complex is involved in the processing of precursor miRNAs, contributing to the regulation of gene expression at the post-transcriptional level.
The DHX9-ADAR-Vigilin-DNA-PK-Ku Antigen Complex is involved in RNA metabolism and DNA damage response, playing essential roles in RNA processing, modification, and DNA repair. It contributes to maintaining nucleic acid integrity and cellular homeostasis.
Mediates cell adhesion and signaling events related to extracellular matrix interactions. The complex contributes to cellular responses associated with SPP1 (osteopontin), influencing processes such as cell migration and tissue development.
Functions in cell adhesion and extracellular matrix interactions. The complex mediates cellular responses associated with vitronectin (VTN), influencing processes such as cell migration and tissue structure.
Involved in transcriptional regulation. The complex participates in signaling pathways related to immune responses and influences gene expression associated with specific cellular functions.
Involved in transcriptional regulation and gene activation. The complex facilitates the expression of target genes, influencing cellular processes related to gene activation and differentiation.
The CAMK2-delta-MASH1 promoter-coactivator complex participates in the regulation of gene expression. Specifically, it acts as a coactivator for the MASH1 promoter. This complex is implicated in neuronal development, contributing to the differentiation of specific cell types, particularly in the context of neural tissues.
The Sulphiredoxin-peroxiredoxin complex is involved in cellular antioxidant defense, contributing to the reduction of peroxides. This complex plays a crucial role in maintaining cellular redox balance, protecting cells from oxidative stress, and supporting overall cell health.
The GNAQ-GEFT-RHOA complex regulates signaling pathways associated with G-protein-coupled receptors (GPCRs) and RhoA. This complex modulates cellular responses, including cell migration and cytoskeletal dynamics. It plays a significant role in controlling cell motility and shape changes through the activation of downstream effectors like RhoA.
This complex plays a crucial role in Notch signaling, a highly conserved pathway that regulates cell fate decisions, differentiation, and embryonic development. It facilitates interactions between specific domains of Notch2 and the Delta ligand, influencing cellular responses and developmental processes.
Essential for blood coagulation, this complex is a crucial component of the coagulation cascade. It regulates the activation of Factor Xa, playing a pivotal role in hemostasis and preventing excessive bleeding by ensuring proper blood clot formation.
Operating within growth factor signaling pathways, this complex transduces signals that regulate cell proliferation, differentiation, and survival in response to growth factors like PDGF. It plays a key role in orchestrating cellular responses to external stimuli for overall tissue homeostasis.
Involved in intracellular signaling cascades, this complex facilitates the transduction of signals from receptor tyrosine kinases. It is a central player in regulating cellular responses such as proliferation and differentiation, contributing to the coordination of complex signaling networks.
Integral to the TGF-beta signaling pathway, this complex regulates crucial cellular processes, including cell growth, differentiation, and apoptosis. Dysregulation of this pathway, often involving the SMAD4-SNO-SKI complex, is implicated in various diseases, particularly cancer.
Operating in immune responses, this complex regulates natural killer (NK) cell activation. It plays a crucial role in the recognition and elimination of stressed or infected cells, contributing to immune surveillance and defense against pathogens. It is a key component of the immune defense machinery.
Integral to DNA repair processes, this complex contributes to the repair of DNA double-strand breaks. It plays a pivotal role in maintaining genomic stability by preventing the accumulation of DNA damage, which could lead to mutations and contribute to the development of various diseases.
Involved in nuclear receptor signaling, this complex modulates gene expression in response to mineralocorticoids. It plays a crucial role in regulating ion balance and blood pressure through the mineralocorticoid receptor (NR3C2).
This complex is involved in BMP2 (Bone Morphogenetic Protein 2) signaling, regulating various cellular processes including differentiation and development. It modulates gene expression patterns in response to BMP2, contributing to tissue homeostasis and embryonic development.
Extending the BMP2 signaling pathway, this complex includes TSG (Twisted gastrulation), contributing to the regulation of BMP2-mediated cellular processes. It plays a role in embryonic development and tissue patterning by modulating BMP2 signaling.
This hexameric complex integrates the functions of CREBBP (CREB-binding protein) with SMAD2 in the context of TGF-beta signaling. It plays a role in modulating gene expression patterns, influencing cellular responses to TGF-beta signals and contributing to developmental processes.
Similar to the CREBBP-SMAD2 complex, this hexameric complex includes SMAD3. It participates in TGF-beta signaling, regulating gene expression and impacting cellular processes such as cell differentiation and embryonic development.
This pentameric complex incorporates CREBBP along with SMAD2 and SMAD4 in the TGF-beta signaling pathway. It contributes to the modulation of gene expression and cellular responses to TGF-beta signals, playing a role in developmental processes and tissue homeostasis.
Analogous to the CREBBP-SMAD2-SMAD4 complex, this pentameric complex includes SMAD3. It participates in TGF-beta signaling, influencing gene expression patterns and cellular responses in various developmental and homeostatic contexts.
This complex is involved in AKT signaling, regulating cellular processes such as cell survival and proliferation. TCL1, in trimeric form, interacts with AKT1, contributing to the modulation of AKT signaling cascades and influencing various aspects of cellular behavior.
Similar to the TCL1(trimer)-AKT1 complex, this complex involves TCL1 in trimeric form interacting with AKT2. It plays a role in AKT signaling, contributing to the regulation of cell survival, proliferation, and other cellular responses influenced by AKT signaling.
Operating in TGF-beta signaling, this complex regulates the degradation of SnoN, a negative regulator of TGF-beta responses. It modulates the balance of TGF-beta signaling, influencing cellular processes such as cell differentiation and tissue homeostasis.
Involved in vascular endothelial growth factor (VEGF) signaling, this complex plays a crucial role in angiogenesis. It includes the VEGF-A165 isoform, the VEGF receptor KDR, and the co-receptor NRP1, contributing to the regulation of blood vessel formation and maintenance.
Involved in endoplasmic reticulum-associated degradation (ERAD), this complex participates in the elimination of misfolded proteins. It includes SVIP, VCP, and DERL1, contributing to the quality control mechanism that ensures proper protein folding and cellular homeostasis.
Operating in transcriptional regulation, this complex is involved in the assembly of the transcription factor complex (CTFC). It includes TAF1, contributing to the modulation of gene expression patterns and influencing cellular processes through the regulation of transcription.
This complex involves CTCF and nucleophosmin, playing a role in transcriptional regulation. It contributes to the organization of chromatin structure and the modulation of gene expression patterns, impacting various cellular processes influenced by transcriptional control.
Involved in the regulation of gene expression, this complex includes ELK1, SRF, and ELK3. It modulates the activity of transcription factors, influencing the transcriptional program and impacting cellular responses such as cell growth, differentiation, and survival.
This multiprotein complex includes various proteins associated with the polycystin-1 receptor. It plays a role in mechanosensory signaling, cell adhesion, and cytoskeletal organization, contributing to the regulation of diverse cellular processes and tissue homeostasis.
Operating in cytokine signaling, this complex includes JAK2, PAFR, and TYK2. It contributes to the transduction of signals initiated by cytokines, influencing cellular responses such as immune regulation, inflammation, and hematopoiesis.
This complex is associated with DNA repair processes and translational regulation. It includes DNA-PK, Ku, eIF2, NF90, and NF45, playing a role in coordinating DNA damage responses and modulating translational control in response to cellular stress.
Involved in Eph-ephrin signaling, this complex includes TIAM1, EFNB1, and EPHA2. It plays a role in mediating cell-cell communication and influencing cellular processes such as cell migration and tissue development through the Eph-ephrin signaling pathway.
Central to the TNF-alpha/NF-kappa B signaling pathway, this complex includes key components such as CHUK, KPNA3, NFKB2, NFKBIB, REL, IKBKG, NFKB1, NFKBIE, RELB, NFKBIA, RELA, and TNIP2. It regulates gene expression, inflammation, and immune responses.
This complex, involved in histone methylation, includes PTIP. It plays a role in epigenetic regulation, influencing chromatin structure and gene expression patterns. The PTIP-HMT complex contributes to the maintenance of cellular identity and proper cellular functioning.
Involved in the maturation of kinases, this complex facilitates the proper folding and activation of specific kinases. It plays a crucial role in regulating cellular signaling cascades and kinase-mediated cellular responses.
This complex is associated with the ubiquitin-proteasome system, participating in the targeted degradation of specific proteins. It plays a role in maintaining protein homeostasis, regulating the levels of proteins, and influencing various cellular processes through targeted protein degradation.
Similar to Kinase maturation complex 1, this complex is involved in the maturation of kinases, ensuring their proper folding and activation. It contributes to the regulation of cellular signaling pathways and the modulation of kinase-mediated cellular responses.
Participates in the MAPK signaling pathway. It plays a role in transducing extracellular signals to the nucleus, influencing cellular responses such as cell growth, differentiation, and survival through the activation of MAPK signaling.
This complex involves the beta-dimer and alpha'-dimer of Casein kinase II. It is associated with the regulation of various cellular processes, including cell cycle progression, apoptosis, and signal transduction. Casein kinase II is a serine/threonine kinase with diverse substrates and plays a role in the control of cell functions.
This complex includes the beta-dimer and alpha-dimer of Casein kinase II. It participates in the phosphorylation of target proteins, regulating various cellular processes such as signal transduction, gene expression, and cell cycle progression. Casein kinase II is involved in the control of cellular functions through its kinase activity.
Associated with the MAPK signaling pathway. It plays a role in transducing signals from the cell surface to the nucleus, influencing cellular responses such as cell growth, differentiation, and survival through the activation of ERK2 in the MAPK pathway.
This complex is a comprehensive assembly of components involved in TNF-alpha/NF-kappa B signaling. It includes CHUK, NFKB2, REL, IKBKG, SPAG9, NFKB1, NFKBIE, COPB2, TNIP1, NFKBIA, RELA, and TNIP2. It regulates gene expression, inflammation, and immune responses, acting as a key mediator in the cellular responses to TNF-alpha and NF-kappa B activation.
This complex is associated with DNA repair processes. It plays a role in the maintenance of genomic stability by participating in the repair of DNA double-strand breaks. The 53BP1-containing complex is crucial for preventing the accumulation of DNA damage and ensuring the integrity of the genome.
Another representation of the TNF-alpha/NF-kappa B signaling complex, this variant includes additional components such as RPL6, RPL30, RPS13, DDX3X, MAP3K8, RELB, GLG1, and GTF2I. It is involved in the regulation of gene expression, inflammation, and immune responses initiated by TNF-alpha/NF-kappa B signaling.
A variant of the TNF-alpha/NF-kappa B signaling complex, this version includes key components CHUK, NFKB2, REL, IKBKG, NFKB1, RELA, and TNIP2. It is central to the TNF-alpha/NF-kappa B signaling pathway, regulating gene expression, inflammation, and immune responses.
Associated with DNA repair processes. It participates in the repair of single-strand breaks and other DNA lesions, contributing to the maintenance of genomic integrity and cellular responses to DNA damage.
This complex is associated with translation initiation. It plays a role in regulating protein synthesis, specifically at the translation initiation step, influencing the overall rate of translation and cellular responses to changes in translation activity.
Involved in transcriptional regulation. It modulates gene expression patterns by participating in the Wnt signaling pathway and influencing the transcriptional program of target genes. The complex plays a role in cellular processes such as development, differentiation, and cell fate determination.
This complex is a key player in the Wnt signaling pathway, contributing to cellular processes such as embryonic development, tissue homeostasis, and stem cell maintenance. It functions by modulating transcriptional regulation and influencing the expression of target genes.
Acting within the TNF-alpha/NF-kappa B signaling pathway, this complex plays a crucial role in regulating immune and inflammatory responses. It modulates the expression of genes involved in inflammation, apoptosis, and cell survival, contributing to the overall immune response.
Playing a vital role in oxygen sensing, this complex regulates the hypoxia response. It is involved in the degradation of the hypoxia-inducible factor 1-alpha (HIF1A) under normoxic conditions, preventing its accumulation and impacting cellular responses to changes in oxygen levels.
Involved in oxygen-sensing mechanisms, this complex regulates responses to hypoxia. It modulates the stability of HIF1A under normoxic conditions, controlling the cellular adaptation to changes in oxygen availability and influencing downstream hypoxia-responsive pathways.
Operating in intracellular trafficking, this complex plays a role in regulating insulin-like growth factor 2 receptor (IGF2R). It impacts cellular responses to insulin-like growth factors and contributes to the proper functioning of the endocytic pathway and vesicular transport.
Active in focal adhesion signaling, this complex influences cellular processes such as migration, adhesion, and cytoskeletal dynamics. It participates in the regulation of signaling pathways associated with focal adhesion points, contributing to cellular responses to extracellular cues.
A key component of the TNF-alpha/NF-kappa B signaling pathway, this complex regulates gene expression, immune responses, and inflammation. It actively modulates cellular outcomes in response to TNF-alpha stimulation, influencing downstream signaling events and cellular behaviors.
Operating within the TNF-alpha/NF-kappa B signaling pathway, this complex plays a role in regulating gene expression, immune responses, and inflammation. It contributes to cellular responses to TNF-alpha, influencing downstream signaling pathways and cellular outcomes.
Involved in DNA repair and cell cycle regulation, this complex plays a crucial role in recognizing and repairing DNA double-strand breaks. It is essential for maintaining genomic stability, influencing cell cycle checkpoints, apoptosis, and cellular responses to DNA damage.
Modulating cell cycle transitions and cell adhesion, this complex regulates the activity of the anaphase-promoting complex/cyclosome (APC/C). It contributes to the proper progression of the cell cycle, impacting cell division, adhesion, and overall cellular homeostasis.
This complex is involved in modulating the stability and function of TP53 (p53). It plays a critical role in cellular responses to DNA damage, influencing cell cycle arrest, apoptosis, and DNA repair. It is a key player in maintaining genomic integrity and regulating cellular outcomes in response to stress.
Contributing to Rac1-mediated signaling, this complex is involved in the regulation of cell migration, cytoskeletal dynamics, and cell adhesion. It participates in signaling pathways associated with extracellular cues, influencing cellular responses to changes in the external environment.
Participating in signaling pathways regulating cell migration and extracellular cue responses, this complex influences actin cytoskeleton organization and cellular behaviors. It is involved in coordinating cellular responses to changes in the extracellular environment and modulating cell morphology.
Operating in antigen processing and presentation, this complex trims and processes antigenic peptides for MHC class I molecules. It plays a crucial role in immune responses, influencing the recognition of antigens by T cells and contributing to the adaptive immune system's surveillance mechanisms.
Associated with calcium signaling, this complex regulates intracellular calcium levels. It modulates calcium-dependent processes and cellular responses, playing a role in maintaining calcium homeostasis within cells and contributing to various cellular functions.
The GAIT (Gamma-activated inhibitor of translation) complex regulates mRNA translation in response to gamma interferon. It inhibits the translation of specific mRNAs, thereby influencing gene expression and contributing to immune responses.
The MLL1-WDR5 complex is essential for histone methylation, impacting chromatin structure and gene expression. This complex maintains transcriptional activation states, regulating various cellular processes such as cell cycle progression, stem cell maintenance, and differentiation.
The SERPINA1-ELA2 complex regulates elastase activity, preventing excessive inflammation and maintaining immune homeostasis. By inhibiting the proteolytic activity of elastase, this complex contributes to the balance of immune responses and prevents potential tissue damage.
The SERPINA3-CTSG complex modulates neutrophil cathepsin G (CTSG) activity, balancing inflammatory processes and preventing potential tissue damage. It contributes to homeostasis in inflammatory responses by regulating the proteolytic activity of CTSG.
The SERPINA1-CTSG complex regulates cathepsin G (CTSG) activity, modulating protease activity and contributing to the maintenance of homeostasis in inflammatory responses. It prevents potential tissue damage by controlling the proteolytic activity of CTSG.
The NGF-TrkA complex is central to neurotrophic signaling, influencing neuronal survival, differentiation, and synaptic plasticity. It plays a crucial role in the development and maintenance of the nervous system, promoting neuronal health and functionality.
The Neurotrophin-3-p75 complex is involved in signaling pathways related to neuronal development and function. It influences cell migration, differentiation, and synaptic plasticity in the nervous system, contributing to the overall development and functionality of neurons.
The HSP70-BAG5-PARK2 complex is associated with the cellular stress response and protein quality control. It contributes to protein folding, degradation, and the cellular stress response under stress conditions, promoting cellular homeostasis during challenging situations.
The NGF-p75 complex regulates apoptotic signaling and neuronal development. It influences cell survival, differentiation, and apoptosis, playing a crucial role in shaping the fate of neurons during development and maintaining neuronal health in mature tissues.
The EPO-EPOR complex is crucial for erythropoiesis, stimulating red blood cell production in response to hypoxia and maintaining oxygen homeostasis. This complex plays a key role in ensuring an adequate supply of oxygen to tissues and organs in the body.
The DISC complex, consisting of FAS, FADD, and CASP8, initiates apoptosis signaling through the Fas cell surface death receptor. It regulates cell survival and death by transmitting signals leading to programmed cell death (apoptosis) in response to specific stimuli.
The MURR1-NF(kappa)Bp65-IKBA complex is involved in the regulation of NF-kappaB signaling, modulating inflammatory responses and immune reactions. This complex controls the activation and nuclear translocation of NF-kappaB, influencing gene expression in response to external stimuli.
The TNFR1-TRADD-TRAF2-cIAP1 complex is involved in TNF-alpha signaling, transducing signals from tumor necrosis factor receptor 1 (TNFR1). It influences cellular responses, including apoptosis, survival, and inflammation, by regulating downstream signaling pathways.
The FADD-TRADD-TRAF2 complex is part of the TNF-alpha signaling pathway, mediating signals from death receptors. It regulates apoptosis and coordinates cellular responses to death-inducing signals, contributing to the control of cell survival and death in response to specific stimuli.
The CCNB1-CDK1-GADD45A-PCNA complex is involved in cell cycle regulation and DNA repair processes. It ensures proper cell cycle transitions and coordinates cellular responses to DNA damage, contributing to genomic stability and the maintenance of cellular integrity.
The LMO4-gp130 complex is involved in signaling pathways, likely related to cellular processes and responses. While specific functions may vary, it potentially participates in mediating signals that influence cell behavior, development, or other regulatory processes.
The Stat1-alpha-dimer-CBP DNA-protein complex is associated with transcriptional regulation. It involves the binding of Signal Transducer and Activator of Transcription 1 (Stat1) in its alpha-dimer form to CBP (CREB-binding protein) on DNA, modulating gene expression.
The CNTF-CNTFR-gp130-LIFR complex is likely involved in cytokine signaling, particularly associated with Ciliary Neurotrophic Factor (CNTF). It may play a role in cellular responses, differentiation, or survival by transducing signals through the receptors CNTFR, gp130, and LIFR.
The LIFR-LIF-gp130 complex is associated with Leukemia Inhibitory Factor (LIF) signaling, potentially influencing cellular responses such as differentiation, survival, or immune modulation. It involves the receptors LIFR and gp130 in conjunction with LIF.
The LINC complex is a structure formed by Linker of Nucleoskeleton and Cytoskeleton (LINC) proteins. It functions as a bridge connecting the nuclear envelope to the cytoskeleton, contributing to nuclear positioning, stability, and mechanical integrity of the cell.
The Emerin-actin-NMI-(alphaII)spectrin complex potentially participates in nuclear envelope architecture and function. Emerin, actin, NMI (N-myc interactor), and alphaII spectrin may collaborate in maintaining nuclear structure, stability, and regulating interactions with the cytoskeleton.
The Emerin architectural complex likely plays a role in shaping the architecture and function of the nuclear envelope. It may involve various protein-protein interactions that contribute to the stability, organization, and integrity of the nuclear envelope structure.
Emerin complex 24 refers to a specific configuration of the Emerin complex, and its detailed functions may be context-dependent. It could be involved in specific cellular processes, signaling pathways, or interactions associated with Emerin and related proteins.
Similar to Emerin complex 24, Emerin complex 25 represents a distinct configuration of the Emerin complex. Its functions may be specific to certain cellular contexts, contributing to processes related to nuclear envelope function, signaling, or other regulatory roles.
Emerin complex 32, like the other Emerin complexes, denotes a specific arrangement of Emerin and associated proteins. Its functions may vary, potentially influencing cellular processes related to the nuclear envelope, gene regulation, or interactions with the cytoskeleton.
Emerin complex 52 represents another specific configuration of the Emerin complex. Its functions may include roles in nuclear envelope organization, stability, and potential interactions with other cellular components, contributing to overall cellular integrity and function.
The PSD95-FYN-NR2A complex is crucial for synaptic function at the postsynaptic density. It regulates synaptic plasticity, influencing neurotransmission strength. The complex functions involve synaptic plasticity, neurotransmission, signal transduction, postsynaptic organization, and potential contributions to learning and memory.
The FARP2-NRP1-PlexinA1 complex is likely involved in semaphorin signaling pathways. It potentially influences processes related to cell guidance, migration, and axon pathfinding during neural development.
Similar to the FARP2-NRP1-PlexinA1 complex, the FARP2-NRP1-PlexinA4 complex is likely associated with semaphorin signaling pathways. It may participate in regulating cellular responses related to axon guidance, migration, and other processes during neural development.
The SEMA4A-PlexinD1 complex is likely involved in semaphorin signaling. It may contribute to cellular processes such as axon guidance, cell migration, and regulation of the cytoskeleton during neural development.
The Nrp1-PlexinD1 complex is associated with semaphorin signaling and likely influences cellular responses related to axon guidance, cell migration, and cytoskeletal regulation. It contributes to neural development processes.
The SEMA3C-PlexinD1-Nrp1 complex is involved in semaphorin signaling pathways. It potentially regulates cellular processes such as axon guidance, migration, and cytoskeletal dynamics during neural development.
The PlexinC1-SEMA7A complex is likely associated with semaphorin signaling. It potentially influences cellular responses related to axon guidance, cell migration, and cytoskeletal regulation during neural development.
This complex is crucial for semaphorin signaling, a pathway involved in axon guidance and neuronal development. It plays a pivotal role in orchestrating the formation of neural circuits, ensuring proper connectivity in the nervous system.
This complex is a key player in ER-associated degradation (ERAD) and membrane protein quality control. It facilitates the recognition, ubiquitination, and subsequent degradation of misfolded or unwanted membrane proteins, ensuring cellular homeostasis.
Involved in various cellular processes, this complex exhibits ubiquitin ligase activity and is associated with cytoskeletal organization. It participates in signaling pathways that regulate cell proliferation, adhesion, and migration, impacting cellular responses to external stimuli.
This complex is implicated in signal transduction pathways, where it may modulate cellular responses to various stimuli. It interacts with components involved in cell signaling, potentially influencing processes such as growth, differentiation, and survival.
Essential for endocytosis and receptor tyrosine kinase signaling, this complex participates in the internalization of cell surface receptors. It regulates the activity of receptor tyrosine kinases, impacting downstream signaling events and cellular responses to growth factors.
Contributing to endocytosis and the regulation of receptor tyrosine kinase activity, this complex is involved in modulating intracellular signaling cascades. It plays a role in the internalization and downregulation of cell surface receptors, affecting cellular responses to extracellular cues.
This complex is a key player in vascular endothelial growth factor (VEGF) signaling, specifically in the context of VEGF-C. It influences angiogenesis, lymphangiogenesis, and vascular development, contributing to the formation and maintenance of blood and lymphatic vessels.
Involved in VEGF signaling, particularly with VEGF-C, this complex plays a role in angiogenesis and lymphangiogenesis. It contributes to the regulation of vascular development and maintenance, influencing processes essential for proper tissue perfusion.
Integral to the transforming growth factor-beta (TGF-beta) signaling pathway, this complex transduces signals that regulate various cellular responses. It impacts processes such as cell growth, differentiation, and immune responses, playing a crucial role in tissue development and homeostasis.
Contributing to VEGF signaling through VEGFR3, this complex influences vascular development and lymphangiogenesis. It plays a role in the formation and maintenance of blood and lymphatic vessels, crucial for proper tissue perfusion and immune function.
Operating within the semaphorin signaling pathway, this complex regulates axon guidance and neuronal development. It facilitates the repulsion of growing axons, contributing to the establishment of proper neural circuitry during development.
The MRIT complex is associated with mRNA localization and translational regulation. It plays a role in mediating the transport of specific mRNAs to distinct cellular locations, influencing local protein synthesis and cellular responses to spatial cues.
Involved in semaphorin signaling, this complex contributes to the regulation of axon guidance and neuronal development. It participates in the repulsion of growing axons, ensuring proper connectivity in the developing nervous system.
This complex is crucial in the context of endothelial cell junctions and vascular signaling. It integrates signals from adherens junction proteins and VEGFR2, playing a role in endothelial barrier function, angiogenesis, and vascular homeostasis.
Also known as the extrinsic apoptotic pathway complex, this cytosolic complex is activated by CD95L (Fas ligand) and plays a central role in apoptotic cell death. It orchestrates caspase activation and cell death in response to extracellular death signals.
This membrane-associated complex, triggered by CD95L, is part of the extrinsic apoptotic pathway. It promotes caspase activation, leading to apoptotic cell death. The involvement of CFLAR modulates the balance between apoptosis and cell survival signals.
A simplified DISC complex activated by CD95, this cytosolic complex triggers apoptosis by recruiting FADD and activating caspase-8. It represents a key component of the extrinsic apoptotic pathway initiated by death ligands.
This complex plays a role in the regulation of apoptosis. The tumor suppressor protein p53 interacts with the anti-apoptotic protein BCL2, influencing the balance between pro-apoptotic and anti-apoptotic signals. It contributes to the control of cell survival and programmed cell death.
The DJ-1-SNCA complex is involved in the regulation of oxidative stress and plays a role in protecting cells from damage. This complex is implicated in maintaining cellular homeostasis and mitigating cellular damage caused by oxidative stress.
The AIF-CYPA-DNA complex plays a role in apoptotic processes and DNA degradation. Upon apoptotic stimuli, this complex translocates to the nucleus, where AIF induces chromatin condensation and DNA fragmentation, contributing to programmed cell death. CYPA acts as a regulator in this process.
The HSP90-CDC37-LRRK2 complex regulates the stability and function of leucine-rich repeat kinase 2 (LRRK2). LRRK2 is implicated in Parkinson's disease, and this complex modulates its activity and degradation pathways.
The AFAC10 complex plays a role in the regulation of apoptosis. It contributes to the activation of caspase-10, a key mediator of the extrinsic apoptotic pathway.
This complex is pivotal in mediating FAS-induced apoptosis. It involves the activation of caspase-8 and caspase-10, initiating a cascade of events that lead to programmed cell death.
This complex is part of the apoptotic pathway. FAS engages FADD, which in turn recruits CASP10. Activation of this complex leads to the initiation of caspase cascades, contributing to programmed cell death. It plays a role in immune regulation and the elimination of cells through apoptosis.
Associated with the MAPK/ERK signaling pathway, this complex regulates cell proliferation and differentiation in response to extracellular signals. It involves key kinases and scaffold proteins that modulate the activity of downstream effectors.
This complex is part of the MAPK/ERK signaling pathway, influencing cellular responses to growth factors and external signals. It plays a role in regulating cell growth, survival, and differentiation.
The PPP2R1A-PPP2R1B-PPP2CA-PPME1-EIF4A1 complex is associated with the regulation of protein phosphatase 2A (PP2A) activity. It may modulate cellular signaling pathways and processes by influencing the dephosphorylation of target proteins.
Linked to the MAPK/ERK pathway, this complex modulates cellular responses to extracellular stimuli. It includes kinases and scaffold proteins that regulate the activation of downstream signaling components.
The BRAF-RAF1-14-3-3 complex is a key player in the MAPK/ERK signaling pathway, which regulates various cellular processes, including cell growth, proliferation, and differentiation. This regulation is crucial for maintaining proper cellular responses to extracellular signals and ensuring homeostasis in normal physiological conditions.
Orchestrates the activation of the MAPK/ERK signaling pathway, playing a crucial role in cellular processes such as cell proliferation, differentiation, and survival. It serves as a scaffold for RAF1 and MEK, facilitating their interaction and subsequent phosphorylation cascade.
Acts as a pivotal module in the MAPK/ERK pathway, contributing to the transduction of extracellular signals to the nucleus. This complex is involved in the regulation of cell growth, differentiation, and responses to external stimuli.
Mediates the signal transduction from RAS to RAF1, initiating the MAPK/ERK signaling cascade. This complex is central to the transmission of growth-promoting signals and is implicated in various cellular processes.
Facilitates cross-talk within the MAPK/ERK pathway, modulating downstream signaling events. It plays a key role in relaying signals that influence cellular responses to environmental cues.
The CNK1-SRC-RAF1 complex acts as a molecular platform that brings together key signaling molecules to efficiently transduce signals from cell surface receptors to the nucleus.This complex represents a critical node in cellular signaling, influencing various physiological responses to external stimuli.
Associates with CHIP and HSP90, potentially influencing LRRK2 stability and function. This complex may play a role in protein homeostasis and cellular stress responses, with implications in neurodegenerative disorders.
The LRRK2-FADD-CASP8 complex is involved in apoptotic signaling pathways, contributing to the regulation of programmed cell death. It responds to signals that impact cell survival and death, playing a crucial role in maintaining cellular homeostasis.
Plays a vital role in ubiquitin signaling, modulating NF-kappa B activation and participating in DNA repair processes. This complex contributes to the regulation of immune responses and genomic stability.
Linked to protein quality control and degradation pathways. STUB1, an E3 ubiquitin ligase, collaborates with HSPA8 and UBE2D2 to maintain protein homeostasis. This complex may influence cellular responses to misfolded or damaged proteins.
Involved in chaperone-mediated autophagy and protein quality control. BAG3 acts as a co-chaperone, and HSC70/HSPB8 are chaperone proteins, working in conjunction with CHIP, an E3 ubiquitin ligase. This complex plays a crucial role in maintaining cellular proteostasis.
The APP-TNFRSF21 complex is involved in regulating cell death, influencing neuronal functions, and modulating cellular communication pathways. It plays a role in regulating immune responses. Ongoing research aims to uncover its specific implications in various cellular contexts and its potential relevance to diseases, including Alzheimer's.
The TRA2B1-SRSF9-SRSF6 complex is involved in RNA splicing and processing. It contributes to the regulation of alternative splicing of pre-mRNA transcripts. This complex plays a role in generating mRNA diversity and modulating gene expression patterns.
The ACR-HSPA2-PDIA6 complex is associated with acrosome formation during spermatogenesis. It contributes to processes related to fertilization and male reproductive function.
The CART complex is involved in regulating neuropeptide signaling. It contributes to the modulation of neurotransmitter release and synaptic transmission. This complex plays a role in the central nervous system, influencing processes such as appetite and addiction.
The AFF4 super elongation complex (SEC) is involved in transcriptional elongation. It contributes to the regulation of RNA polymerase II activity during transcription. This complex facilitates the elongation phase of transcription and regulates gene expression.
Involved in various cellular processes, potentially influencing cell signaling and organization. The specific functions may vary depending on the cellular context, contributing to the regulation of cellular activities.
Associated with angiotensinogen, this complex plays a role in regulating the renin-angiotensin system. It may influence blood pressure regulation by modulating the production of angiotensin peptides, impacting vascular tone and fluid balance.
Implicated in the regulation of insulin-like growth factor (IGF) signaling. This complex, involving pregnancy-associated plasma protein-A (PAPP-A) and proMBP, cleaves IGF-binding proteins, modulating the availability of IGF for cellular responses and growth regulation.
Involves proMBP, angiotensinogen, and c3dg, potentially linking immune responses and complement activation. The specific functions may depend on the cellular context, contributing to the modulation of immune-related processes and complement cascade activation.
Participates in protein folding and quality control processes. The complex involving BAG1 as a co-chaperone for HSC70 contributes to cellular protein homeostasis, ensuring proper folding and preventing the accumulation of misfolded proteins that can lead to cellular dysfunction.
Similar to the BAG1-HSC70 complex, this complex involving BAG1 and HSP70 is essential for protein folding and quality control within cells. BAG1 acts as a co-chaperone for HSP70, contributing to the maintenance of cellular protein integrity and preventing the buildup of misfolded proteins.
Comprises selenoprotein K (SELK) and associated proteins, participating in various cellular functions. SELK is involved in the regulation of endoplasmic reticulum-associated degradation (ERAD) and may play roles in oxidative stress responses, contributing to cellular homeostasis and stress adaptation.
The GM-CSF receptor complex is vital for cellular responses to granulocyte-macrophage colony-stimulating factor (GM-CSF). This cytokine stimulates the production and function of white blood cells, influencing immune responses and hematopoiesis in the bone marrow.
Involved in nucleocytoplasmic transport, the CSE1L-KPNA2-RAN complex facilitates the movement of proteins between the nucleus and cytoplasm. This process is crucial for the regulation of gene expression and cellular activities requiring the dynamic interchange of proteins across cellular compartments.
Facilitating nucleocytoplasmic transport, the KPNA2-KPNB1 complex ensures the controlled movement of proteins between the nucleus and cytoplasm. This process is critical for the regulation of gene expression, allowing cells to respond to various signals and environmental cues by modulating the localization of key proteins.
The KPNB1-RAN complex plays a vital role in nucleocytoplasmic transport, where KPNB1 interacts with the small GTPase RAN. Together, they regulate the bidirectional movement of macromolecules through nuclear pores, ensuring the precise spatial distribution of proteins and RNA molecules within the cell, essential for cellular function and integrity.
Functioning in apoptotic signaling, the TRIAL-DR5 complex activates the extrinsic pathway of apoptosis. TRIAL binding to DR5 initiates a cascade of events leading to programmed cell death, a crucial mechanism for eliminating damaged or unnecessary cells in response to specific signals.
The ACK1 signaling complex plays a multifaceted role in cellular processes. It contributes to signal transduction pathways, influencing cell proliferation and responses to growth factors. ACK1's involvement in various cellular functions highlights its significance in orchestrating diverse signaling events crucial for cell behavior.
Playing a role in apoptotic regulation, it contributes to the intricate process of programmed cell death. Caspase-10 activation within this complex is central to the initiation of apoptosis, and the involvement of SUMO, FADD (Fas-associated death domain), and Drp1 adds complexity to the regulation of apoptotic cell death.
Implicated in cancer-related signaling, the CDCP1-Src-EGFR complex promotes cell survival, migration, and invasion. It contributes to cancer progression by influencing key cellular processes that are often dysregulated in cancer cells, making this complex a potential target for cancer therapy.
Essential for mitotic regulation, it is involved in ensuring the proper alignment and segregation of chromosomes during cell division. This complex plays a pivotal role in orchestrating events critical for accurate cell division, contributing to genomic stability and preventing aberrant cell fates.
The STIP-USP7-Mdm2 complex regulates the stability and activity of the tumor suppressor protein p53. It modulates the ubiquitination and degradation of p53, influencing cellular responses to stress, DNA damage, and other signals, ultimately impacting cell cycle control and apoptosis.
The STIP-USP7-p53 complex is crucial for modulating the deubiquitination and stabilization of the tumor suppressor protein p53. This complex influences the transcriptional activity of p53, shaping cellular responses to stress, DNA damage, and other signals. The dynamic interplay within this complex contributes to the fine-tuning of p53-mediated cellular processes.
Involved in cellular stress and proliferation signaling, the p38gamma-Hsp90-K-Ras complex plays a role in regulating responses to external stimuli. It influences cellular growth and survival, contributing to cellular adaptations in the face of various environmental challenges.
Orchestrates cellular growth and metabolic processes by delicately modulating insulin-like growth factor 2 (IGF2) activity, contributing to the intricate balance between growth and metabolism. Its regulatory role ensures cellular homeostasis and physiological well-being.
Serves as a guardian of cellular cleanliness, actively participating in the identification and clearance of damaged cellular components. This complex is instrumental in cellular housekeeping, preserving cellular health and contributing to overall cellular stability.
Guides cellular behavior in extracellular matrix remodeling, actively influencing processes like cell migration and invasion. This complex plays a pivotal role in orchestrating cellular responses and maintaining tissue integrity within dynamic cellular environments.
Acts as a guardian over vascular integrity, actively contributing to the structural preservation of blood vessels and preventing aberrant angiogenesis. This complex plays a pivotal role in maintaining the stability and functionality of the vascular system, ensuring a delicate equilibrium of vascular architecture.
Governs the activation of genes crucial for cellular responses to diverse stimuli, acting as a molecular conductor to regulate processes like cell proliferation and differentiation. Its orchestration of gene expression patterns plays an essential role in shaping cellular responses and determining cellular fate.
Navigates the cellular landscape as a molecular transporter along microtubules, facilitating essential processes such as ciliary transport and cellular organization. This complex acts as a cellular navigator, ensuring the proper movement of cellular cargo and contributing to the spatial organization of cellular structures.
Plays a pivotal role in cellular signaling pathways, influencing responses to stress and signaling cascades. This complex contributes to the modulation of cellular processes like cell survival and adaptation to changing environmental conditions. Its involvement in cellular signaling reflects its role in maintaining cellular resilience in dynamic cellular environments.
Serves as an architect of cellular organization, actively influencing intracellular trafficking and ciliary function. This complex is vital in orchestrating the movement of cellular cargo, preventing disruptions to cellular organization and maintaining cellular health.
Governs Notch signaling, actively influencing cellular decisions related to differentiation and tissue formation. This complex plays a pivotal role in shaping the cellular landscape during development, maintaining the delicate balance of cell fate determination and contributing to overall tissue homeostasis.
Plays a crucial role in the intricate network of growth and hormone response signaling, influencing processes like cell proliferation and differentiation. This complex integrates signals from growth factors and hormones, regulating cellular behavior and playing a key role in orchestrating responses to external cues.
Contributes to the architectural blueprint of cell polarity and membrane organization, influencing cellular adhesion and tissue structure. This complex participates in the formation and maintenance of cell-cell junctions, playing a crucial role in shaping cellular architecture and maintaining cellular integrity within tissues.
Similar to its counterpart, this complex actively contributes to cell polarity and membrane organization, influencing cellular adhesion and tissue structure. Playing a crucial role in the formation and maintenance of cell-cell junctions, this collaborative complex contributes to cellular architecture and tissue organization within dynamic cellular environments.
Modulates the dance of cellular adhesion and signaling, impacting cellular behavior and tissue organization. This complex actively influences the interaction between cell adhesion molecules and signaling pathways, shaping cellular behavior and influencing tissue structure in dynamic cellular environments.
Contributes to the harmonious orchestration of Notch signaling and cellular adhesion, actively influencing processes related to cell fate determination and tissue organization. This complex modulates Notch pathway activation, playing a key role in shaping cellular fate and maintaining the structural integrity of tissues within dynamic cellular environments.
Assumes a crucial role in cellular signaling, impacting essential processes such as cell adhesion, migration, and the intricate organization of the cellular cytoskeleton. This complex's multifaceted functions contribute significantly to the dynamic behavior of cells, influencing their responsiveness within the cellular environment.
Holds indispensable importance in blood clotting, orchestrating platelet interaction with von Willebrand factor (VWF) to facilitate platelet adhesion and aggregation. This collaboration ensures effective responses to vascular injuries, playing a pivotal role in the formation of blood clots to prevent excessive bleeding and maintain hemostasis.
Governs the cell cycle, overseeing critical checkpoints, DNA replication, and responses to DNA damage. Its regulatory influence extends to cell proliferation and the preservation of genomic integrity, intricately shaping the delicate balance of cellular processes that dictate the progression and maintenance of the cell cycle.
Participates actively in intracellular transport, potentially facilitating the movement of cellular cargo and exerting influence over cellular organization. This intricate involvement in transport processes contributes to the dynamic organization of cellular components, playing a vital role in maintaining cellular order and orchestrating the targeted delivery of essential cargo within the cell.
Linked to transcriptional regulation, this complex has the potential to influence gene expression patterns and cellular responses through its involvement in the modulation of transcriptional processes. Its regulatory role hints at its contribution to shaping cellular behavior by finely tuning the expression of genes within the cellular milieu.
Stands as a cornerstone in synaptic function and organization within neurons, actively influencing synaptic signaling, plasticity, and overall neuronal communication. By regulating the molecular architecture of synapses, this complex contributes significantly to the dynamic and responsive nature of neuronal networks, shaping the intricate interplay of signals within the nervous system.
Contributes significantly to cell-cell adhesion and signaling processes, actively influencing cellular adhesion and communication. By regulating adherens junctions and organizing cell-cell contacts, this complex plays a pivotal role in shaping cellular behavior and tissue structure, ensuring the orderly organization of cells and influencing dynamic cellular responses through adhesion mechanisms.
Plays a role in the regulation of gene expression and epigenetic modifications, potentially influencing cellular processes related to transcriptional control and chromatin organization. This complex may contribute to the dynamic regulation of gene activity and the maintenance of cellular identity within specific contexts.
Governs signaling events initiated by TNF receptor 1 (TNFR1), potentially influencing cellular responses such as apoptosis, inflammation, and immune regulation. This complex plays a key role in mediating the cellular effects of TNF, contributing to diverse signaling cascades and cellular outcomes in response to external stimuli.
Orchestrates cellular responses to TNF signaling, modulating processes such as apoptosis, inflammation, and immune regulation. The components of this complex play crucial roles in transducing signals from TNF, shaping cellular behavior, and contributing to the regulation of inflammatory and immune responses in dynamic cellular environments.
Influences cellular adhesion and tissue organization through the regulation of E-cadherin and beta-catenin interactions. This complex may contribute to the stability of cell-cell junctions, influencing cellular adhesion and tissue integrity within dynamic cellular environments.
Impacts cellular processes related to calcium signaling and intracellular transport. The interaction between Synexin and sorcin may contribute to the regulation of calcium homeostasis and intracellular processes, potentially influencing cellular responses and contributing to the maintenance of dynamic cellular environments.
Potentially involved in cellular processes related to protein glycosylation and quality control. The interaction between PEF1 and ALG2 suggests a role in modulating glycosylation processes and protein folding, contributing to the maintenance of proper protein function and the dynamic regulation of cellular processes in response to changing cellular conditions.
Involved in post-transcriptional regulation, potentially influencing mRNA stability and translation. This complex may contribute to the dynamic control of gene expression by modulating mRNA processing and protein synthesis within the cellular environment.
Participates in protein folding and quality control processes, potentially influencing cellular responses to protein misfolding and stress. The components of this complex may collaborate to ensure proper protein folding, maintaining cellular homeostasis and contributing to cellular resilience in response to stress conditions.
Involved in the assembly and function of the cytochrome c oxidase (COX) complex in the mitochondrial respiratory chain. This complex plays a crucial role in cellular energy production by contributing to the functionality of the electron transport chain and oxidative phosphorylation processes within mitochondria.
Mediates signaling events in cell growth, differentiation, and tissue repair, potentially influencing cellular responses related to proliferation and angiogenesis. The interaction between PDGFB and PDGFRB plays a key role in transducing signals that regulate cell behavior, contributing to processes such as tissue development and wound healing.
Plays a central role in blood clotting, contributing to the formation of blood clots in response to vascular injury. The fibrinogen complex is essential for platelet aggregation and blood coagulation, playing a pivotal role in hemostasis and wound healing within the circulatory system.
Involved in transcriptional regulation and chromatin remodeling, potentially influencing cellular responses related to gene expression control. This repressor complex may contribute to the silencing of specific genes, playing a role in the regulation of cellular processes such as cell cycle progression and differentiation.
Similar to MLL1, the MLL2 complex is involved in histone modification and transcriptional regulation, potentially influencing gene expression patterns and cellular responses. This complex may contribute to the modulation of the epigenetic landscape, playing a role in cellular differentiation and the regulation of specific genes involved in developmental processes.
Similar to MLL1, the MLL4 complex is involved in histone modification and transcriptional regulation, potentially influencing gene expression patterns and cellular responses. This complex may contribute to the modulation of the epigenetic landscape, playing a role in cellular differentiation and the regulation of specific genes involved in developmental processes.
Involved in intracellular vesicle trafficking, potentially influencing processes related to protein transport and secretion. The TRAPP complex oligomer plays a crucial role in mediating vesicle tethering and fusion events, contributing to the dynamic organization of the cellular secretory pathway and intracellular trafficking.
Participates in autophagy, influencing cellular responses related to the degradation of cellular components. This complex plays a crucial role in autophagosome formation and autophagic processes, contributing to the maintenance of cellular homeostasis and the clearance of damaged or unnecessary cellular structures.
Plays a role in receptor-mediated endocytosis of vitamin B12 and other ligands, potentially influencing cellular processes related to nutrient uptake. The Cubam complex facilitates the internalization of specific molecules, contributing to the cellular acquisition of essential nutrients and the regulation of nutrient homeostasis.
Involved in the regulation of DNA replication and cell cycle progression, potentially influencing processes related to DNA synthesis and repair. The components of this complex play a role in coordinating cell cycle events and ensuring the faithful duplication of the genome, contributing to cellular proliferation and maintenance of genomic integrity.
Potentially involved in receptor tyrosine kinase signaling, influencing cellular responses related to cell growth and differentiation. The interaction between ERBB3 and SPG1 suggests a role in modulating intracellular signaling cascades, contributing to the regulation of cellular behavior and responses to extracellular signals.
Similar to ERBB3-SPG1, the ERBB2-SPG1 complex is potentially involved in receptor tyrosine kinase signaling, influencing cellular responses related to cell growth and differentiation. This complex may contribute to the modulation of intracellular signaling pathways and cellular behavior in response to extracellular signals.
Involved in cellular signaling pathways, potentially influencing processes related to cell proliferation, migration, and gene expression. The components of this complex may contribute to the modulation of intracellular signaling cascades, playing a role in cellular responses to growth factors and external stimuli.
Participates in cell signaling and protein folding, potentially influencing cellular responses related to cell adhesion, migration, and protein stability. The components of this complex play a role in modulating intracellular signaling pathways and ensuring proper protein folding, contributing to the regulation of cellular behavior and responses to external cues.
Involved in calcium signaling and regulation of muscle contraction, potentially influencing processes related to intracellular calcium homeostasis. This complex plays a crucial role in maintaining proper calcium levels within cells, contributing to the regulation of muscle function and cellular responses in excitable tissues.
Plays a role in cellular signaling, potentially influencing processes related to cell adhesion, migration, and guidance. The complex may contribute to the regulation of neuronal development and connectivity by participating in signaling pathways that guide the growth of neuronal processes and the establishment of synaptic connections.
Similar to its counterpart with UNC5B, this complex may be involved in cellular signaling pathways influencing processes related to cell adhesion, migration, and guidance. It potentially contributes to the regulation of neuronal development and connectivity, participating in signaling cascades that guide the growth of neuronal processes and synaptic connections.
Potentially participates in intracellular membrane trafficking and lipid transport processes. The complex may play a role in regulating the movement of cellular components within the cell, contributing to membrane dynamics and cellular organization.
Involved in intracellular membrane trafficking and recycling processes. The complex may contribute to the regulation of endocytic pathways and the recycling of cellular components, influencing membrane dynamics and maintaining cellular organization.
Involved in intracellular vesicle trafficking and membrane dynamics, contributing to the regulation of cellular membrane structure and function.
Plays a role in membrane trafficking processes and cellular membrane dynamics, potentially influencing cellular organization and transport of vesicular cargo.
Functions in cellular processes that may include membrane dynamics, vesicle trafficking, or other molecular interactions contributing to cellular function. The specific functions of this complex may vary depending on the context and cellular environment.
Participates in signaling pathways related to vascular endothelial growth and development, potentially influencing cellular responses to angiogenic signals and contributing to the regulation of vascular integrity.
Involved in transcriptional regulation, modulating gene expression patterns related to cellular processes such as growth, differentiation, and survival. This complex may influence cellular responses to various signals, contributing to the control of gene expression and cellular behavior.
Functions in the regulation of actin cytoskeleton dynamics and membrane trafficking, potentially influencing cellular morphology, movement, and vesicle transport. This complex plays a role in cellular organization and dynamics.
Involved in cellular processes related to cell cycle regulation and proliferation. This complex may contribute to the control of cell cycle progression and the modulation of cellular growth through interactions with key regulators of the cell cycle, such as cyclin D1 (CCND1).
Contributes to gene regulation, particularly in cardiac development. This complex influences transcriptional activity and participates in pathways related to heart development and homeostasis.
Modulates gene expression and cellular responses in cardiac development. The complex integrates signals from various pathways, impacting transcriptional activity and influencing the coordination of cellular processes during heart development.
Acts as a chromatin remodeling complex, influencing gene expression by modifying chromatin structure. The complex plays a role in regulating cellular processes such as transcription and is essential for maintaining genomic integrity and function.
Participates in membrane trafficking processes, influencing vesicle formation and cellular organization. The complex is involved in regulating intracellular transport and maintaining cellular structure and function.
Plays a role in tumor necrosis factor receptor 2 (TNFR2) signaling, influencing immune and inflammatory responses. The complex is involved in transmitting signals that regulate cellular processes, including apoptosis and immune modulation.
Participates in tubulin folding and cytoskeleton organization. The complex is involved in maintaining the structure and function of microtubules, influencing cellular shape, division, and intracellular transport processes.
Modulates tubulin folding and cytoskeleton organization. The complex is involved in maintaining the structure and function of microtubules, influencing cellular shape, division, and intracellular transport processes.
Participates in centrosome maturation and cellular division processes. The complex is involved in regulating the activity of Aurora kinase A (AURKA) and influencing cellular processes related to cell cycle progression and mitosis.
Plays a role in ciliary function and intracellular transport within photoreceptor cells. The complex is involved in maintaining the structure and function of cilia, contributing to cellular organization and sensory processes in the retina.
Coordinates vital cellular processes by integrating RasGAP, AURKB, and survivin, regulating cell cycle progression and apoptosis. This complex ensures cellular integrity and influences cell fate decisions, striking a balance between cell survival and programmed cell death.
Orchestrates potent anti-inflammatory responses by uniting IL-10 receptor subunits (IL-10Ralpha/beta) with the cytokine IL-10. The complex finely regulates signaling pathways to suppress immune responses, playing a key role in immune balance and preventing excessive inflammation.
Plays a crucial role in cellular adhesion and membrane organization by incorporating CLIC5A, EZR, and PODXL. This collaborative complex influences cell adhesion, cytoskeletal organization, and membrane dynamics, maintaining cellular structure and tissue integrity. Its functions extend to regulating interactions with the extracellular environment and the dynamic regulation of membrane-associated proteins.
Integrates EGFR, NHERF1, and PTEN to modulate signaling pathways involved in cell proliferation and survival. This complex serves as a regulatory hub, influencing processes like cell growth and apoptosis. Its functions contribute to maintaining cellular homeostasis and playing a crucial role in cellular decision-making related to growth and survival.
Contributes to membrane organization and cellular structure by incorporating PDZK1, NHERF1, and EZR. This complex plays a crucial role in organizing membrane-associated proteins, influencing functions related to membrane dynamics and contributing to maintaining cellular structure. Its functions extend to dynamically regulating membrane-associated proteins and their impact on cellular responses to the surrounding environment.
Regulates cellular responses to vascular signaling by integrating VEGFR2, S1PR1, ERK1/2, and PKC-alpha. This complex plays a role in angiogenesis and vascular homeostasis, influencing processes like endothelial cell proliferation and migration. Its functions contribute to the intricate balance of vascular integrity, playing a crucial role in orchestrating cellular responses to vascular signals.
Participates in cellular signaling by forming a signalosome around RXFP1. This complex modulates signaling pathways related to relaxin, influencing cellular responses such as vasodilation, proliferation, and survival. The RXFP1 signalosome plays a multifaceted role in physiological processes, including reproductive functions and cardiovascular regulation, contributing to the finely orchestrated cellular responses to relaxin signaling.
Regulates dopamine receptor signaling by integrating DRD4, KLHL12, and CUL3. This complex plays a pivotal role in modulating cellular responses to dopamine, influencing processes related to neurotransmission and cellular communication. Its functions contribute to the dynamic regulation of dopamine signaling pathways, impacting cellular behaviors and responses to extracellular cues.
Participates in lipid metabolism and immune regulation by incorporating APOL1, APOA1, HPR, and C3. This complex is involved in lipid transport, immune response modulation, and potential roles in maintaining cellular homeostasis. Its functions extend to dynamic regulation of lipid metabolism and immune responses, contributing to cellular health and the balance of immune-related processes within the cellular environment.
Contributes to lipid metabolism and immune regulation by incorporating APOL1, APOA1, HPR, FN1, and IGHM. This complex is implicated in lipid transport, immune modulation, and potential roles in maintaining cellular homeostasis. Its functions extend to dynamic regulation of lipid metabolism and immune responses, contributing to cellular health and the balance of immune-related processes within the cellular environment.
This complex may play a role in lipid metabolism and immune regulation, influencing processes related to energy balance and potential immune modulation. Its functions extend to dynamic regulation of lipid metabolism and potential immune-related responses, contributing to the balance of cellular processes within the cellular environment
Coordinates immune responses by bringing together complement protein (CP), lactoferrin (LF), and myeloperoxidase (MPO). This complex plays a crucial role in antimicrobial activity, inflammation modulation, and oxidative stress responses, contributing to the defense against pathogens and maintenance of immune homeostasis.
Collaborates in immune responses, combining complement protein (CP) and lactoferrin (LF). This complex is involved in antimicrobial defense, immune regulation, and modulation of inflammatory processes, playing a role in maintaining immune homeostasis and responding to challenges posed by microbial invaders.
Integrates complement protein (CP) and myeloperoxidase (MPO) in immune responses. This complex contributes to antimicrobial activity, regulation of inflammation, and oxidative stress responses, playing a vital role in immune defense mechanisms and ensuring a balanced immune response to various challenges.
Orchestrates signaling in metabolic pathways, bringing together fibroblast growth factor 21 (FGF21), fibroblast growth factor receptor 1c (FGFR1c), and Klotho co-receptor (KLB). This complex regulates metabolic processes, energy homeostasis, and insulin sensitivity, influencing overall metabolic health and response to nutritional cues.
Plays a crucial role in metabolic regulation by combining fibroblast growth factor 19 (FGF19), fibroblast growth factor receptor 4 (FGFR4), and Klotho co-receptor (KLB). This complex regulates bile acid synthesis, glucose metabolism, and overall metabolic homeostasis, contributing to the maintenance of metabolic balance and adaptation to nutritional status.
Participates in metabolic signaling by combining fibroblast growth factor receptor 4 (FGFR4) and Klotho co-receptor (KLB). This complex is involved in regulating various metabolic processes, including liver function, bile acid synthesis, and glucose metabolism, contributing to metabolic homeostasis and adaptation to nutritional cues.
Plays a crucial role in post-transcriptional gene regulation, binding to target mRNAs and influencing their stability and translation. This complex, centered around IGF2BP1, participates in the control of cellular processes such as cell proliferation, survival, and differentiation by modulating the expression of specific mRNA targets, thereby contributing to the regulation of cellular homeostasis and response to environmental cues.
Orchestrates cellular responses to EphA1 receptor activation, influencing processes such as cell adhesion, migration, and axon guidance. This complex, formed upon EphA1 receptor activation, initiates signaling cascades that regulate diverse cellular behaviors, contributing to the establishment of tissue organization and connectivity. Its involvement in EphA1 receptor signaling positions it as a key player in cellular communication and coordination, particularly in neuronal and developmental contexts.
Functions as an E3 ubiquitin ligase involved in endoplasmic reticulum-associated degradation (ERAD), contributing to the quality control of cellular proteins. The HRD1 complex identifies and ubiquitinates misfolded or aberrant proteins in the endoplasmic reticulum, targeting them for degradation. Its role in ERAD ensures the proper folding and quality control of proteins, contributing to cellular proteostasis and preventing the accumulation of dysfunctional proteins that could otherwise lead to cellular stress and dysfunction.
Participates in ubiquitin-mediated protein degradation and modulation of cellular signaling pathways. This complex is associated with the ubiquitin-proteasome system, contributing to the targeted degradation of specific proteins. Additionally, it may play a role in the regulation of cellular signaling pathways, influencing processes such as cell proliferation and response to extracellular signals. Its involvement in protein degradation and signaling modulation positions it as a key player in cellular homeostasis and response to environmental cues.
Modulates chromatin structure and gene expression, contributing to the epigenetic regulation of cellular processes. The CBX3-EHMT2-NR3C1 complex is involved in the deposition of histone modifications and the interaction with specific chromatin regions, influencing the expression of target genes. Its role in chromatin modification positions it as a key player in the epigenetic regulation of gene expression, impacting cellular processes such as development, differentiation, and cellular identity maintenance. The complex is an essential component of the epigenetic machinery that shapes the cellular epigenome.
Participates in endoplasmic reticulum-associated degradation (ERAD), a cellular process responsible for identifying and degrading misfolded proteins. This complex facilitates the recognition, ubiquitination, and subsequent degradation of unfolded or misfolded proteins, contributing to cellular quality control and protein homeostasis.
This complex is involved in modulating gene expression and cellular responses, influencing processes like cell adhesion, migration, and invasion. It plays a role in the regulation of cellular behavior and the maintenance of tissue integrity, contributing to various physiological and pathological processes.
This complex is involved in mediating cellular responses to fibroblast growth factor (FGF) signaling, influencing processes such as cell proliferation, survival, and migration. It contributes to the regulation of cellular behavior and the coordination of cellular responses to extracellular cues.
This complex is involved in regulating processes such as cell adhesion, migration, and cytoskeletal dynamics. It plays a role in coordinating cellular responses to extracellular signals and contributes to the modulation of cellular behavior and tissue organization.
Orchestrates cellular signaling related to integrin-mediated processes, contributing to cell adhesion, migration, and cytoskeletal organization. This complex plays a key role in linking extracellular signals to intracellular responses, influencing cellular behavior and tissue dynamics.
Coordinates signaling cascades associated with focal adhesion dynamics and cell migration. This complex regulates the interplay between focal adhesions and the cytoskeleton, playing a pivotal role in cellular responses to extracellular cues and modulating processes related to cell movement and tissue organization.
Participates in signaling pathways associated with cell proliferation, migration, and cytoskeletal rearrangement. This complex integrates signals from mitogen-activated protein kinase (MAPK1), protein tyrosine kinase 2 (PTK2), and paxillin (PXN), influencing cellular decisions related to growth and movement within dynamic cellular environments.
Regulates intracellular vesicle trafficking and membrane dynamics. This complex, involving protein kinase C zeta (PRKCZ), vesicle-associated membrane protein 2 (VAMP2), and WD repeat and FYVE domain-containing protein 2 (WDFY2), contributes to cellular processes such as vesicle fusion and membrane organization, influencing intracellular transport and cellular organization.
Plays a role in cellular signaling cascades related to protein degradation and immune response. This complex, comprising protein kinase C zeta (PRKCZ), sequestosome 1 (SQSTM), and tumor necrosis factor receptor-associated factor 6 (TRAF6), modulates processes like autophagy and immune signaling, contributing to cellular homeostasis and responses to cellular stressors.
Governs gene expression and cellular responses related to growth and proliferation. This complex, involving the c-Myc proto-oncogene (MYC), transformation/transcription domain-associated protein (TRRAP), and lysine acetyltransferase 2A (KAT2A), influences the regulation of target genes, playing a crucial role in cellular decisions related to cell cycle progression, growth, and cellular identity.
Regulates cellular signaling pathways associated with cytoskeletal dynamics and cell movement. This complex, involving Rho/Rac guanine nucleotide exchange factor 2 (ARHGEF2), mitogen-activated protein kinase 1 (MAPK1), mitogen-activated protein kinase 3 (MAPK3), and paxillin (PXN), influences processes like cell migration and cytoskeletal rearrangement, contributing to cellular responses to extracellular cues.
Governs signaling pathways related to bone metabolism and homeostasis. This complex, comprising low-density lipoprotein receptor-related protein 6 (LRP6), parathyroid hormone (PTH), and parathyroid hormone receptor 1 (PTH1R), plays a crucial role in regulating bone development and mineralization, influencing cellular decisions related to bone remodeling and skeletal homeostasis.
Plays a pivotal role in DNA repair processes, particularly homologous recombination. This complex, involving BRCA1-associated RING domain protein 1 (BARD1), breast cancer type 1 susceptibility protein (BRCA1), and RAD51 recombinase, is crucial for maintaining genomic integrity and preventing the accumulation of DNA damage. It participates in the repair of double-strand breaks, safeguarding cellular genetic information.
Collaborates in cellular processes by mediating interactions between NG2, galectin-3, and alpha3beta1-integrin. This complex potentially influences cell adhesion, migration, and signaling pathways, contributing to diverse cellular responses in dynamic environments.
Orchestrates signaling events related to glial cell line-derived neurotrophic factor (GDNF) family ligands by involving ARTN, GFRA3, and RET. This complex plays a role in cellular responses such as survival, differentiation, and migration, contributing to the regulation of neural development and function.
Participates in redox regulation by bringing together BOLA2 and GLRX3. This complex may contribute to cellular responses involved in maintaining redox balance, potentially impacting processes such as antioxidant defense and overall cellular homeostasis.
Catalyzes the first step in sphingolipid biosynthesis, bringing together SPTLC1 and SPTLC2. This complex plays a crucial role in cellular lipid metabolism, contributing to the synthesis of sphingolipids involved in various cellular functions and signaling pathways.
Facilitates cellular responses to insulin-like growth factor 1 (IGF1) by involving IGF1R, ITGAV, and ITGB3. This complex plays a role in signaling cascades related to cell growth, survival, and proliferation, contributing to the regulation of cellular activities influenced by IGF1 signaling pathways.
Participates in the assembly of the proteasome, involving PTMA, SET, ACTB and MARCKS. This complex plays a role in protein degradation, contributing to cellular quality control mechanisms and maintaining protein homeostasis within the cell.
Contributes to the formation of the proteasome, involving ANP32A, C1QB, PSMA1, PTMA and SLC25A3. This complex plays a role in regulating protein degradation processes, impacting cellular quality control and ensuring the removal of misfolded or unwanted proteins from the cellular environment.
Participates in proteasome assembly, involving PTMA, ANP32A and ANP32B. This complex plays a crucial role in protein degradation pathways, contributing to cellular quality control mechanisms and the maintenance of overall protein homeostasis within the cell.
Contributes to the assembly of the proteasome, involving PTMA, ANP32A, ANP32B and RAB11A. This complex plays a role in cellular protein degradation processes, impacting the removal of misfolded or obsolete proteins and maintaining cellular protein homeostasis and quality control mechanisms.
Influences cellular adhesion and migration processes. This complex potentially regulates focal adhesions, impacting cell-substrate interactions and cellular responses related to adhesion and migration in dynamic cellular environments.
Plays a role in collagen modification. This complex potentially influences collagen biosynthesis, impacting the structural properties of collagen within the extracellular matrix and contributing to tissue integrity and homeostasis.
Regulates glycosylation processes and influences epidermal growth factor receptor (EGFR) signaling, potentially impacting cell growth, proliferation, and differentiation. This complex plays a crucial role in modulating cellular responses to growth factors, contributing to the dynamic regulation of cellular behavior and fate.
Essential for selenocysteine biosynthesis, supporting various selenoproteins involved in cellular functions, redox balance, and antioxidant defense. This intricate complex ensures the availability of selenocysteine, a critical amino acid, and contributes to cellular resilience by maintaining redox homeostasis and defending against oxidative stress.
Plays a role in cellular signaling pathways, potentially impacting processes like cell proliferation, differentiation, and survival through the modulation of signaling cascades. This complex operates as a molecular switch, transmitting signals that govern key cellular decisions and responses, contributing to the fine-tuning of cellular behavior and adaptation to changing environmental cues.
Participates in interferon signaling, playing a crucial role in antiviral defense mechanisms and influencing immune responses to viral threats. This complex serves as a sentinel in the cellular immune arsenal, activating pathways that promote an antiviral state and contribute to the robust defense against viral infections, highlighting its significance in cellular immune surveillance.
Part of the interferon signaling pathway, promoting antiviral defense mechanisms and modulating immune responses against viral threats. This intricate complex engages in intricate signaling events that lead to the activation of cellular defenses against viruses, shaping immune responses and contributing to the establishment of an antiviral state within the cellular milieu.
Key in the innate immune response, sensing specific pathogen-associated molecular patterns (PAMPs) and potentially triggering inflammatory responses. This complex serves as a molecular sentinel, detecting microbial threats and initiating signaling cascades that culminate in inflammatory responses, contributing to the first line of defense against invading pathogens.
Forms a heterotrimeric G protein complex composed of G protein subunit alpha i1 (GNAI1), G protein subunit beta-1 (GNB1), and G protein subunit gamma 11 (GNG11). This complex is involved in G protein-coupled receptor signaling, potentially modulating cellular responses to extracellular signals and regulating various physiological processes, including neurotransmission, hormone secretion, and cellular proliferation.
Participates in sphingolipid metabolism, impacting cellular processes such as apoptosis, cell signaling, and lipid homeostasis. This complex serves as a molecular orchestrator, influencing the breakdown of sphingolipids and regulating cellular processes that govern cell survival, signaling cascades, and lipid balance within the cellular milieu.
Involved in cell cycle regulation, influencing chromosome segregation, cell division, and overall cell cycle progression. This complex acts as a molecular regulator, contributing to the precise orchestration of mitotic processes, ensuring faithful chromosome segregation, and promoting orderly cell division, highlighting its crucial role in maintaining genomic stability during cell cycle progression.
This complex is pivotal in cellular processes related to gene regulation and cell cycle control. It plays a potential role in embryonic development and cellular differentiation by influencing the expression of genes critical for these processes.
Essential in the cellular response to DNA damage, this complex contributes to the repair of DNA lesions. By participating in DNA damage response pathways, it plays a crucial role in maintaining genomic stability and preventing the accumulation of harmful mutations.
This complex orchestrates cellular processes involved in cell adhesion and proteolysis, potentially influencing tissue remodeling and cellular interactions with the extracellular environment. It modulates the intricate balance of these processes, contributing to cellular homeostasis.
Involved in cell adhesion and signaling, this complex regulates cellular behavior and interactions with the extracellular matrix. It contributes to the modulation of cellular responses, potentially influencing processes related to growth and tissue development.
Regulating processes related to cell adhesion and proteolysis, this complex influences cellular interactions with the extracellular environment and contributes to tissue remodeling. Its multifaceted functions impact cellular behavior and play a role in maintaining the balance of extracellular processes.
This complex plays a vital role in cellular processes related to cell adhesion and proteolysis, significantly influencing tissue remodeling and cellular interactions with the extracellular matrix. It contributes to the intricate balance of these processes, potentially impacting cellular homeostasis and tissue structure.
Involved in cell adhesion and proteolysis, this complex regulates cellular interactions with the extracellular environment. It plays a crucial role in modulating processes related to tissue remodeling and maintaining the dynamic balance of extracellular interactions.
In cellular signaling pathways, this complex is a key player potentially influencing processes related to cell growth, proliferation, and survival. By participating in intricate signaling networks, it contributes to the orchestration of cellular responses to external stimuli and growth signals.
Playing a crucial role in mitochondrial protein import, this subcomplex facilitates the translocation of proteins into the mitochondria. It is an essential component in maintaining mitochondrial function and cellular energy metabolism, contributing to the dynamic balance of cellular energy homeostasis.
Modulating cellular signaling pathways, this complex potentially influences processes related to cell differentiation and proliferation. Its intricate interactions contribute to the fine-tuning of signaling cascades, impacting cellular behavior and fate determination in response to external cues.
Involved in cellular processes related to synaptic function and structure, this complex plays a role in neuronal signaling and synaptic plasticity. Its intricate interactions contribute to the regulation of synaptic activity, influencing cellular responses within the context of neural communication and information processing.
Participating in cellular signaling pathways, this complex potentially influences processes related to cell growth and division. By modulating signaling cascades, it plays a key role in orchestrating cellular responses to growth signals and contributing to the regulation of cellular proliferation.
Plays a role in cellular processes related to drug resistance and intracellular signaling. This complex may contribute to the regulation of drug efflux and cellular responses to signaling cascades, impacting cellular behavior in response to external stimuli.
Involved in cellular processes related to ion transport and membrane potential regulation. This complex may contribute to the maintenance of cellular homeostasis by modulating ion concentrations and membrane dynamics, influencing cellular function in various tissues.
Modulates cellular signaling pathways related to cell survival and oxidative stress response. This complex may contribute to the regulation of cellular responses to oxidative damage and play a role in influencing cell fate decisions in response to environmental stressors.
Participates in cellular processes related to histone acetylation and energy metabolism. This complex may contribute to the regulation of gene expression and cellular energy homeostasis, influencing cellular function in the context of chromatin dynamics and metabolism.
Involved in cellular processes related to ion transport, cell adhesion, and membrane dynamics. This complex may contribute to the regulation of cellular interactions and membrane potential, impacting cellular behavior in tissues where ion transport and adhesion are crucial.
Participates in cellular processes related to protein transport and stress response. This complex may contribute to the regulation of protein trafficking and cellular responses to stress, influencing cellular behavior in the context of proteostasis and stress adaptation.
Modulates cellular processes related to apoptosis and mitochondrial function. This complex may contribute to the regulation of cell survival and mitochondrial dynamics, influencing cellular fate decisions in response to apoptotic signals and changes in cellular energy status.
Plays a role in cellular processes related to protein processing and regulation of peptide hormones. This enzyme may contribute to the regulation of peptide metabolism and processing, influencing cellular function in the context of neuropeptide signaling and hormonal regulation.
Involved in cellular processes related to endocytosis and membrane trafficking. This complex may contribute to the regulation of intracellular membrane dynamics and protein transport, influencing cellular behavior in the context of vesicular trafficking and endosomal pathways.
Participates in cellular processes related to RNA processing, DNA repair, and transcriptional regulation. This complex may contribute to the regulation of gene expression and cellular responses to DNA damage, influencing cellular behavior in the context of RNA biology and genomic stability.
Modulates cellular processes related to ubiquitin-mediated protein degradation and signaling. This complex may contribute to the regulation of protein turnover and cellular responses to signaling pathways, influencing cellular behavior in the context of proteostasis and signal transduction.
Involved in cellular processes related to protein folding, proteolysis, and mitochondrial function. This complex may contribute to the regulation of protein quality control, cellular energy metabolism, and proteolytic pathways, influencing cellular behavior in the context of protein homeostasis and mitochondrial dynamics.
Involved in the assembly and maintenance of cytochrome c oxidase (COX), a crucial enzyme in the mitochondrial respiratory chain. This complex contributes to the proper formation and function of COX, ensuring efficient electron transport and ATP production in mitochondria.
Mediates the signaling of interleukin-10 (IL-10), an anti-inflammatory cytokine, by binding to its receptor IL10RA. This complex plays a key role in regulating immune responses, suppressing inflammation, and modulating cellular activities associated with immune regulation and homeostasis.
This complex potentially regulates immune responses, inflammation, and cell survival by integrating signals from both NF-kappa-B and STAT3 pathways, contributing to the dynamic regulation of cellular processes in response to various stimuli.
This complex potentially influences processes related to transcriptional regulation and cellular proliferation, impacting the expression of genes associated with cell growth and survival. It may contribute to the dynamic regulation of cellular activities in response to various signaling cues.
This complex is potentially involved in protein ubiquitination and degradation. It may participate in the regulation of cellular processes related to protein turnover, influencing the stability of target proteins and contributing to cellular homeostasis.
Involves the interaction between cell adhesion molecule 1 (CADM1), discs large homolog 1 (DLG1), membrane palmitoylated protein 3 (MPP3), and phosphoinositide-3-kinase regulatory subunit 1 (PIK3R1). This complex may play a role in cellular adhesion, membrane organization, and intracellular signaling, influencing processes related to cell-cell interactions and cellular responses to external cues.
Comprising RAC1, RHOA, and VANGL2, this complex potentially modulates cellular processes related to cytoskeletal dynamics, cell migration, and tissue morphogenesis. It may contribute to the regulation of cellular architecture and behavior by integrating signals from the RAC1 and RHOA pathways, influencing processes such as cell movement and tissue organization.
This complex contributes to the formation and maintenance of synapses. This complex plays a role in synaptic adhesion and communication between neurons, influencing processes related to neuronal signaling and plasticity. It is crucial for the establishment and function of neural circuits in the nervous system.
This complex may be involved in cellular processes related to cell growth, survival, and signaling. It potentially contributes to the regulation of ERBB2 signaling pathways, influencing cellular responses to growth factors and modulating pathways associated with cell proliferation and survival.
This complex may modulate cellular processes related to immune responses and tissue homeostasis. It potentially influences the functions of IL-15 in regulating immune cell activities and the interactions between immune cells and tissues, contributing to the dynamic regulation of immune homeostasis.
This complex plays a crucial role in iron homeostasis, influencing cellular processes related to iron transport and utilization. It is essential for cellular functions that require iron, including DNA synthesis, energy production, and various metabolic processes.
This complex may modulate the activation of PI3K signaling, influencing processes related to cell growth, survival, and metabolism. It is crucial for the integration of signals that regulate cellular responses to growth factors and other stimuli.
Forms an E3 ubiquitin ligase complex involved in ubiquitin-mediated protein degradation. CUL3 acts as a scaffold, KEAP1 regulates substrate recognition, and RBX1 facilitates ubiquitin transfer, collectively targeting specific proteins for degradation and playing a crucial role in cellular homeostasis and response to oxidative stress.
Participates in cellular signaling pathways, with FYN acting as a kinase, KHDRBS1 as an RNA-binding protein, and PLCG1 as a phospholipase. This complex modulates intracellular signaling cascades, impacting cellular responses to external stimuli and contributing to processes like cell growth, differentiation, and immune response.
Involved in immune response regulation, this complex includes DTX3L, PARP9, and STAT1. DTX3L functions as an E3 ubiquitin ligase, PARP9 has PARylation activity, and STAT1 is a transcription factor. Together, they regulate immune signaling pathways, influencing the expression of genes related to antiviral responses and immune system activation.
Involved in cytoskeletal dynamics and cell migration. ARRB1 is an adaptor protein, ARHGEF18 is a guanine nucleotide exchange factor, and ENAH is an actin-binding protein. This complex regulates actin cytoskeleton remodeling, influencing cellular processes such as migration and invasion. It plays a role in cellular responses to extracellular signals, contributing to dynamic changes in cell shape and movement.
Associated with cellular communication and stem cell pluripotency. GJB2 forms gap junctions, PTK2 is a focal adhesion kinase, and NANOG is a transcription factor. This complex may influence intercellular communication and impact stem cell self-renewal and differentiation, playing a role in developmental processes and cellular fate determination.
Implicated in vesicle trafficking and ion transport. CFTR is a chloride channel, GOPC is an adaptor protein, and STX6 is a syntaxin involved in vesicle fusion. This complex modulates vesicular trafficking and ion transport processes, potentially impacting cellular secretion and homeostasis. It may be involved in the regulation of cellular responses to changes in the extracellular environment.
Associated with chromatin remodeling and cell division. KAT2B is a histone acetyltransferase, KIF11 is a motor protein involved in mitosis, and MYSM1 is a histone H2A deubiquitinase. This complex may modulate chromatin structure during cell division, influencing processes such as mitosis and cell cycle progression. It plays a role in the maintenance of genomic stability and proper cell division.
Involved in cytokinesis and cell cycle regulation. ECT2 is a guanine nucleotide exchange factor, KIF23 is a motor protein, and RACGAP1 is a GTPase-activating protein. This complex regulates the final stages of cell division, contributing to cytokinesis and proper cell cycle progression. It plays a role in maintaining genomic stability and preventing aberrant cell division.
Associated with mitotic spindle organization and cell division. Astrin and kinastrin are microtubule-binding proteins involved in mitosis. This complex regulates mitotic spindle dynamics, contributing to proper chromosome segregation during cell division. It plays a vital role in ensuring accurate cell division and maintaining genomic stability.
Coordinates intracellular vesicular trafficking and membrane dynamics. This complex plays a key role in regulating the formation, budding, and fusion of vesicles, contributing to the dynamic processes of endocytosis and exocytosis within the cell.
Governs cellular responses to oxygen levels and energy metabolism. The complex participates in the oxygen-sensing pathway, influencing the expression of genes involved in mitochondrial biogenesis and oxidative phosphorylation. This intricate regulation contributes to cellular adaptation to varying oxygen levels and the modulation of energy production pathways.
Participates in cellular signaling and migration. The CD44-ERK1-ERK2-RHAMM complex integrates signals from the extracellular matrix, leading to the activation of ERK1 and ERK2 signaling pathways. This activation contributes to cellular responses such as migration, proliferation, and survival, playing a role in processes like tissue development and wound healing.
Modulates immune responses and hematopoiesis. The complex is involved in interleukin-1 (IL-1) signaling and stem cell regulation. It influences immune responses and hematopoietic processes, contributing to the maintenance of immune system homeostasis and the regulation of blood cell development.
Regulates cellular responses to interleukin-1 (IL-1) signaling. The IL1RAP-KIT complex is involved in the transmission of IL-1 signals, influencing cellular responses such as inflammation and immune reactions. This complex plays a role in coordinating the cellular response to IL-1 stimuli, contributing to processes related to immunity and inflammatory responses.
Targets specific proteins for ubiquitination and degradation. This E3 ligase complex, composed of CUL3, KLHL7, and RBX1, facilitates the transfer of ubiquitin molecules onto target proteins, marking them for proteasomal degradation. It plays a crucial role in the regulation of protein levels within the cell, contributing to processes such as cell cycle control and protein quality control.
Mediates ubiquitin-dependent protein degradation. This E3 ligase complex, consisting of CUL3, KLHL12, PEF1, and PDCD6, is involved in the targeted ubiquitination and subsequent degradation of specific proteins. It plays a role in cellular processes such as cell cycle progression, apoptosis, and the regulation of protein turnover, contributing to the maintenance of cellular homeostasis.
Facilitates ubiquitin-mediated degradation of target proteins. The E3 ligase complex, comprising CUL3, KLHL9, KLHL13, and RBX1, is involved in the ubiquitination and subsequent degradation of specific proteins. This complex plays a role in regulating cellular processes such as cell cycle progression, signal transduction, and cellular homeostasis by controlling the turnover of key regulatory proteins.
Participates in cellular adhesion and signal transduction. The CD44-LRP1 complex is involved in interactions with extracellular matrix components and signaling molecules. It contributes to cellular adhesion processes and influences cellular responses such as migration and survival, playing a role in tissue development and maintenance of cellular architecture.
Regulates chromosome segregation during cell division. The KNL1-MIS12-NDC80-SPC24-ZWINT complex, associated with the kinetochore, plays a crucial role in ensuring proper chromosome alignment and segregation during mitosis. It contributes to the fidelity of cell division and the maintenance of genomic stability.
Modulates Wnt signaling and cellular responses related to cell fate determination. The complex is involved in the regulation of Wnt signaling pathways, influencing gene expression and cellular decisions related to differentiation and tissue development. It plays a role in shaping cellular fate and maintaining the balance of Wnt signaling cascades.
The SMYLE 1 complex, localized at the centrosome, plays crucial roles in cellular processes. It is involved in regulating microtubule assembly, contributing to the structural framework of the cytoskeleton. The complex influences directed cell motility, guiding cells in specific directions, and participates in determining the orientation of cell division, ensuring proper alignment during this crucial process.
The SMYLE 2 complex is involved in regulating microtubule nucleation. Ongoing investigations seek to uncover the multifaceted roles and impact of SMYLE 2 in diverse cellular processes.
Orchestrates Wnt signaling by functioning as a receptor for RSPO ligands. The LGR4-RSPO supercomplex modulates the canonical Wnt pathway, influencing cellular decisions related to proliferation and differentiation in a context-dependent manner.
The LGR5-RNF43-RSPO1 complex acts as a modulator of the Wnt signaling pathway, playing pivotal roles in stem cell maintenance, tissue homeostasis, and implications for diseases such as cancer. Its functions are tightly regulated to ensure proper cellular responses and maintain tissue integrity.
The APP-APBB1-KAT5 complex is implicated in transcriptional regulation within cells. The cytoplasmic tail of Amyloid Precursor Protein (APP) forms a multimeric complex with the nuclear adaptor protein Fe65 and the histone acetyltransferase Tip60. This complex has the ability to stimulate transcription via heterologous Gal4- or LexA-DNA binding domains.
An incomplete form of the Mediator complex, this assembly involving APP(AICD), MED12, MED23, and MED4 is implicated in transcriptional regulation. It serves as a bridge connecting transcription factors with RNA polymerase II, thereby influencing gene expression and cellular responses.
The MAP2K4-MAP3K3-NBR1 complex plays a crucial role in regulating the JNK (c-Jun N-terminal kinase) cascade, which is a component of the MAPK (Mitogen-Activated Protein Kinase) signaling pathway.This complex serves as a key player in transducing signals from extracellular stimuli to intracellular responses, ultimately influencing cellular behavior during inflammatory conditions.
Engages in diverse cellular functions, with the APP(AICD)-FOXO3 complex potentially influencing transcriptional regulation and cellular responses. Ongoing investigations aim to unravel the specific roles and impact of this complex in cellular decision-making and homeostasis.
The AKAP13-MAP2K3-MAP3K20-MAPK14-PKN1 complex is involved in cellular signaling pathways, particularly in the regulation of the MAPK14 (p38alpha) activation in response to alpha1-adrenergic receptor stimulation.This complex plays a crucial role in the precise modulation of signaling cascades, highlighting its specific involvement in alpha1-adrenergic receptor signaling and MAPK14 activation.
The CTNNB1-RUNX3-TCF4 complex plays a critical role in negatively regulating the Wnt signaling pathway and DNA-templated transcription, with a focus on controlling gene expression within the nucleus. The interactions within this complex are intricately involved in modulating cellular responses to Wnt signals and maintaining proper transcriptional regulation.
Participates in transcriptional regulation by associating with the Mediator complex, playing a role in bridging transcription factors to the RNA polymerase II machinery. APLP1 may contribute to the modulation of gene expression and cellular processes, acting as a regulatory component in the transcriptional machinery.
Similar to the APLP1-containing complex, APLP2-MED12-MED23-MED4 is implicated in transcriptional regulation. This incomplete Mediator complex serves as a molecular bridge connecting transcription factors with the RNA polymerase II complex, influencing the expression of target genes and contributing to the regulation of cellular functions.
The MN-hexamer complex, also known as the nuclear pore complex, facilitates the transport of macromolecules between the nucleus and cytoplasm. It serves as a selective barrier and plays a crucial role in nucleocytoplasmic transport, allowing the controlled passage of proteins and RNAs across the nuclear envelope, regulating gene expression and cellular processes.
Involved in the regulation of the hypoxia-inducible factor (HIF) pathway. The PHD2-LIMD1-VHL complex participates in the oxygen-sensing mechanism, targeting HIF for degradation under normoxic conditions, thereby influencing cellular responses to changes in oxygen levels and playing a key role in the cellular adaptation to hypoxia.
Functions in stress response pathways. This complex participates in cellular stress responses, including DNA damage repair and regulation of heat shock proteins. It contributes to the maintenance of genomic integrity and cellular homeostasis under stress conditions.
Plays a role in protein quality control and degradation. The HSPA8-HSPBP1-STUB1 complex is involved in recognizing and targeting misfolded or damaged proteins for degradation through the ubiquitin-proteasome system. This complex contributes to cellular proteostasis, ensuring the removal of aberrant proteins and preventing the accumulation of protein aggregates that can be detrimental to cell function.
Similar to the HSPA8-HSPBP1-STUB1 complex, the BAG1-HSPA8-STUB1 complex is implicated in protein quality control and degradation. BAG1 acts as a co-chaperone for HSPA8, facilitating the recognition of misfolded proteins by the STUB1 ubiquitin ligase for subsequent degradation. This complex contributes to maintaining cellular protein homeostasis and preventing the buildup of dysfunctional proteins.
Involved in the antiviral response. The IFI1-IFI2-IFI3 complex, known as the interferon-induced GTPase (MX1) complex, plays a role in defending cells against viral infections. These interferon-inducible proteins contribute to the restriction of viral replication by disrupting viral components and inhibiting the spread of viral particles within infected cells.
Mediates the exchange of histone variant H2A.Z into chromatin, influencing gene expression and chromatin structure. The p400/TIP60 complex is involved in the dynamic regulation of chromatin architecture, contributing to transcriptional activation and modulation of cellular responses to various signals. The incorporation of H2A.Z is associated with gene regulatory regions and impacts gene expression patterns.
Associated with transcriptional regulation and Alzheimer's disease. The complex participates in transcriptional processes and is implicated in the pathogenesis of Alzheimer's disease. It may influence the expression of genes related to neuronal function and contribute to the molecular mechanisms underlying Alzheimer's pathology.
Potentially involved in cellular stress responses and protein homeostasis. The CAMK4-HSPA1L-HSPA8-IQCG complex may play a role in mediating responses to cellular stress, with heat shock proteins (HSPs) contributing to the maintenance of protein folding and cellular homeostasis under stress conditions. The involvement of CAMK4 suggests a connection to signaling pathways that respond to stress signals.
Plays a role in immune responses. The CD17-ITGAM-ITGB2 complex, also known as the Mac-1 or CR3 receptor complex, is involved in leukocyte adhesion and migration. It plays a crucial role in immune responses by facilitating the interaction of immune cells with endothelial cells and promoting the phagocytosis of pathogens, contributing to the defense against infections and inflammatory processes.
Involved in cell structure and signaling. The complex formed by ezrin (EZR), moesin (MSN), PAG1, radixin (RDX), and SLC9A3R1 participates in the organization of the cell's structural components and signaling processes. These proteins are associated with the regulation of cell morphology, adhesion, and migration, contributing to cellular functions such as cell shape maintenance and cytoskeletal dynamics.
Participates in innate immune responses. The TANK-TBK1-TRAF2 complex is involved in the regulation of antiviral signaling pathways. It contributes to the activation of TBK1, leading to the phosphorylation of IRF3 and induction of type I interferon responses. This complex plays a crucial role in the host defense against viral infections, linking pattern recognition receptors to downstream signaling cascades.
Functions in protein folding and quality control. The DNAJB11-SDF2 complex is involved in the recognition and processing of misfolded proteins. DNAJB11 acts as a co-chaperone, working with SDF2 to facilitate the proper folding of proteins and prevent the accumulation of unfolded or misfolded species. This complex contributes to cellular proteostasis and the maintenance of protein homeostasis.
Involved in endoplasmic reticulum (ER) quality control and protein folding. DNAJB11, a molecular chaperone, interacts with SDF2L1, contributing to the recognition and degradation of misfolded proteins, ensuring proper ER function and cellular proteostasis.
This complex regulates ubiquitin-mediated protein degradation. ITCH, an E3 ubiquitin ligase, forms a complex with NDFIP1 and UBE2L3, facilitating the ubiquitination and subsequent degradation of specific target proteins. It plays a role in the regulation of immune responses, cell signaling, and protein turnover.
Involved in cellular signaling pathways, this complex integrates signals related to cell survival and stress response. AKT1 activates MAPK14 (p38 MAPK), which, in turn, phosphorylates MAPKAPK2 and HSPB1, contributing to the regulation of cell growth, apoptosis, and the cellular response to stressors such as heat shock.
This complex plays a role in cell signaling, influencing processes such as cell survival, growth, and stress response. AKT1 activates MAPK14, leading to the phosphorylation of MAPKAPK2 and subsequent cellular responses.
This complex is part of the p38 MAPK signaling pathway. MAPK14 phosphorylates MAPKAPK3, which, in turn, regulates downstream targets involved in cellular responses to stress, inflammation, and apoptosis. The complex plays a role in mediating signals related to environmental stressors and inflammatory stimuli.
Central to the regulation of the tumor suppressor TP53 (p53), this complex modulates TP53's stability and activity. MDM2 and MDM4 function cooperatively to inhibit TP53, preventing excessive cell cycle arrest and apoptosis. The complex is crucial for maintaining cellular homeostasis and preventing uncontrolled cell proliferation.
Involves MDM2, TP53, and WWOX, contributing to the regulation of TP53 activity. WWOX acts as a tumor suppressor and may modulate TP53's function, impacting cell cycle control and apoptosis. The complex plays a role in cellular responses to DNA damage and stress, influencing the balance between cell survival and apoptosis.
Forms the GABAB receptor, a G protein-coupled receptor involved in inhibitory neurotransmission. The complex is activated by gamma-aminobutyric acid (GABA), regulating neuronal excitability and synaptic transmission. It plays a role in modulating neuronal activity and is implicated in various neurological processes, including learning and memory.
Involved in ubiquitin-mediated protein degradation and DNA repair. RNF8 ubiquitin ligase, ATX3 deubiquitinase, and p97 segregase form a complex that regulates the turnover of ubiquitinated proteins and contributes to the DNA damage response. The complex is crucial for maintaining genomic integrity and cellular responses to DNA damage.
The CDYL complex is involved in epigenetic regulation and transcriptional control. CDYL (Chromodomain Y-like protein) interacts with other proteins to modulate chromatin structure, influencing gene expression. The complex may play a role in developmental processes and the regulation of cell identity through epigenetic mechanisms.
Participates in DNA replication and cell cycle regulation. CDYL interacts with CAF1 (Chromatin Assembly Factor 1) and MCM (Mini-Chromosome Maintenance) proteins, contributing to the assembly and maintenance of chromatin structure during DNA replication. The complex is crucial for ensuring accurate DNA replication and cell cycle progression.
Involved in the regulation of cell migration and tissue remodeling. MRC2 interacts with PLAU (urokinase-type plasminogen activator) and PLAUR (urokinase plasminogen activator receptor), modulating the plasminogen activation system. The complex plays a role in extracellular matrix degradation, cell motility, and tissue remodeling processes.
Participates in receptor tyrosine kinase signaling and cell proliferation. GRB2, MUC1, and SOS1 form a complex that links cell surface receptors with downstream signaling pathways. The complex is involved in regulating cell growth, survival, and differentiation by transmitting signals from extracellular stimuli to intracellular signaling cascades.
This complex plays a crucial role in the Toll-like receptor (TLR) signaling pathway, particularly TLR4-mediated responses. MYD88 and TIRAP are adapter proteins that link TLR4 activation to downstream signaling events, leading to the activation of immune responses and the production of inflammatory mediators in defense against pathogens.
This complex is associated with extracellular matrix remodeling, immune responses, and pattern recognition. Matrix metalloproteinase 9 (MMP9) interacts with NEU1 (sialidase) and TLR7 (Toll-like receptor 7), potentially linking the regulation of extracellular matrix components with innate immune responses to viral RNA, highlighting a connection between matrix dynamics and immune surveillance.
The BSG-JUP-NME1 complex may be implicated in cell adhesion, signaling, and metastasis regulation. BSG is a cell adhesion molecule, and JUP is involved in cell junctions, while NME1 has roles in cellular signaling and metastasis suppression. The complex might contribute to the coordination of these processes in various cellular contexts.
The MIF-NME1 complex may play a role in cellular processes such as inflammation, immune responses, and cell migration. MIF is associated with pro-inflammatory functions, and NME1 has roles in nucleotide metabolism and metastasis suppression. The complex could modulate signaling pathways involved in inflammation and cellular motility.
This multiprotein complex may be involved in chromatin remodeling, DNA repair, and gene expression regulation. The complex components participate in processes such as histone modification, DNA damage repair, and transcriptional regulation, collectively influencing cellular genomic stability and gene expression dynamics.
NADPH oxidase is a multi-subunit enzyme complex involved in the generation of reactive oxygen species (ROS). It plays a crucial role in the oxidative burst, contributing to antimicrobial defense and signaling. The complex includes CYBA, CYBB, NCF1, NCF2, and is essential for the production of ROS, which serve as signaling molecules and contribute to the elimination of pathogens by immune cells.
This inflammasome complex is associated with immune responses and apoptosis. It is involved in signaling pathways leading to the activation of inflammatory responses and programmed cell death. The complex coordinates immune activation and cell death, contributing to host defense against pathogens and the regulation of inflammatory processes.
This multiprotein complex involves ILF3, NR5A2, PPARA, and PRMT1. It may participate in transcriptional regulation and chromatin modification. The complex components contribute to the modulation of gene expression and epigenetic modifications, potentially influencing cellular processes such as metabolism and immune responses.
The ILF3-NR5A2-SERBP1 complex is associated with RNA metabolism and transcriptional regulation. ILF3, NR5A2, and SERBP1 interact to potentially modulate the processing and stability of specific RNAs. The complex may have roles in post-transcriptional regulation, influencing mRNA turnover and translation, and may contribute to cellular responses to various signaling cues.
Essential for cell signaling and communication. This complex is implicated in transmembrane signaling pathways, including those related to cell growth, differentiation, and survival. The interaction between ERBB3, integrins (ITGA6 and ITGB4), and NRG1 modulates cellular responses, influencing processes such as cell adhesion and proliferation.
Participates in transcriptional regulation and RNA processing. The GTF2I-PARP1-SFPQ complex is involved in coordinating gene expression by influencing transcriptional activities and RNA splicing. The interactions within this complex contribute to the modulation of gene expression patterns and RNA processing events within the cell.
Implicated in cell adhesion, migration, and growth factor signaling. The TM4SF5-ITGA5-EGFR complex integrates signals from extracellular matrix interactions and growth factor stimulation, affecting cellular behaviors such as adhesion, migration, and proliferation. This complex plays a role in modulating cell responses to the surrounding microenvironment.
Plays a role in chromatin remodeling and gene regulation. The MBD3-NuRD complex is associated with modifying chromatin structure, influencing transcriptional activity. It contributes to the regulation of gene expression patterns and is involved in various cellular processes, including development, differentiation, and responses to environmental cues.
Involved in immune response and gene regulation. The IRF1-STAT1 complex is crucial for coordinating the expression of genes involved in the immune response. It participates in the regulation of antiviral and inflammatory genes, contributing to the cellular defense mechanisms against pathogens and environmental challenges.
Critical for autophagy regulation. The BIF1-UVRAG-Beclin1 complex is involved in the initiation and regulation of autophagy, a cellular process responsible for the degradation and recycling of cellular components. This complex plays a role in maintaining cellular homeostasis and responding to stress conditions by facilitating autophagic processes.
Central to apoptosis signaling. The CASP8-CASP10-FADD-FLIP(S)-RIPK1 complex is a key player in apoptotic pathways, regulating programmed cell death. This complex integrates signals from various death receptors and contributes to the activation of caspases, ultimately leading to apoptosis in response to specific cellular cues.
Implicated in the biogenesis of integral membrane proteins. The ER membrane protein complex, including EMC8, plays a role in ensuring the proper folding, assembly, and insertion of membrane proteins into the endoplasmic reticulum (ER). This complex contributes to the quality control of membrane protein synthesis and localization.
Similar to other EMC complexes, EMC9 is involved in the biogenesis of integral membrane proteins within the ER. It participates in processes that ensure the correct folding, assembly, and localization of membrane proteins, contributing to the integrity and functionality of the endoplasmic reticulum.
Plays a role in intracellular transport and mitotic regulation. The DCTN1-DYNC1I1-NUDC-PLK1 complex is associated with microtubule-based transport and mitotic spindle dynamics. This complex contributes to the proper distribution of cellular components and the regulation of cell division during mitosis.
Involved in nuclear mRNA export. The NXF1-NXT1 complex plays a crucial role in the export of mature messenger RNAs (mRNAs) from the nucleus to the cytoplasm. This complex facilitates the transport of mRNAs through nuclear pores, ensuring proper gene expression and cellular function.
Implicated in the regulation of protein ubiquitination and deubiquitination. The OTUB1-RNF128-USP8 complex participates in the dynamic control of protein ubiquitination, influencing various cellular processes. This complex is involved in maintaining protein stability and regulating signaling pathways by modulating the ubiquitin-proteasome system.
This complex involves Kallikrein 6 and alpha-1-antichymotrypsin. Kallikrein 6 is a protease associated with processes like angiogenesis and neurodegeneration. The complex may influence proteolytic activities and contribute to the regulation of protein degradation, potentially impacting tissue remodeling and pathological conditions.
The complex formed by Prostate-specific antigen (PSA) and alpha-1-antichymotrypsin is relevant to prostate biology. PSA is a serine protease associated with prostate function, and the complex formation may play a role in regulating protease activity, affecting processes like seminal fluid liquefaction and potentially contributing to prostate-related conditions.
The NPM1-PA2G4 complex is implicated in cell cycle regulation, ribosome biogenesis, and the control of cellular proliferation. It may influence processes related to cell growth, division, and response to cellular stress, contributing to the maintenance of cellular homeostasis.
The RNA polymerase III complex is responsible for transcribing genes that produce small RNA molecules, including transfer RNA (tRNA) and 5S ribosomal RNA. It plays a crucial role in protein synthesis and cellular function by ensuring the production of essential RNA components involved in translation. The complex is vital for maintaining cellular homeostasis and protein synthesis.
This complex is associated with cell cycle regulation and transcriptional control. E2F1 regulates the expression of genes involved in cell cycle progression, and the complex may modulate these regulatory pathways, impacting cellular proliferation, differentiation, and response to DNA damage, with implications for cancer and other diseases.
Involved in protein folding and quality control; HSPA8 (HSP70), PA2G4 (Eukaryotic translation initiation factor 3 subunit G), and STUB1 (CHIP) collectively participate in chaperone-mediated protein degradation, regulating the turnover of misfolded proteins and maintaining cellular protein homeostasis.
Implicated in RNA metabolism and translational control; ILF3 (Interleukin enhancer-binding factor 3) and PA2G4 (Eukaryotic translation initiation factor 3 subunit D) are involved in RNA binding and translation regulation, potentially influencing processes such as mRNA stability and protein synthesis.
Central to apoptosis regulation; the complex includes key apoptotic regulators, such as BAX, BCL2L11 (BIM), PACS2, TNFRSF10B (Death receptor 5), and TNFSF10 (TRAIL). It orchestrates apoptotic signaling pathways, influencing mitochondrial outer membrane permeabilization, caspase activation, and cell death in response to various cellular signals.
Involved in lysosomal functions and glycosphingolipid metabolism; the complex includes Cathepsin A, beta-galactosidase, and neuraminidase. It participates in the degradation of glycosphingolipids within lysosomes, influencing cellular processes related to lipid metabolism and lysosomal function.
Involved in transcriptional regulation and cellular responses to stress; the complex comprises CTBP1, EP300 (p300), and FOXO3. It modulates gene expression by participating in transcriptional regulation, potentially influencing cellular responses to various stress stimuli and contributing to the control of cell survival and proliferation.
Essential for cell cycle regulation; the Anaphase-Promoting Complex or Cyclosome (APC/C) complex plays a key role in controlling the cell cycle by promoting the degradation of specific proteins. It regulates transitions between different phases of the cell cycle, including entry into mitosis and exit from mitosis.
Involved in intracellular transport; the complex includes dynein light chains DYNLL1 and DYNLL2. It participates in the assembly of dynein motor complexes, essential for intracellular transport along microtubules. The complex facilitates the movement of cellular cargo, including organelles and vesicles, within the cell.
Essential for immune responses; the CD4 receptor complex is crucial for T cell activation. CD4 interacts with major histocompatibility complex class II (MHC-II) molecules on antigen-presenting cells, facilitating T cell recognition of antigens and the initiation of immune responses.
Involved in innate immunity; the Mannose-Binding Lectin (MBL)-I complex is part of the lectin pathway of the complement system. MBL-I recognizes and binds to carbohydrate patterns on pathogens, leading to complement activation and the initiation of the immune response against invading microorganisms.
Plays a role in signaling pathways and cellular responses; the complex includes LYN kinase, PAG1 (Cbl-associated protein), and STAT3 (Signal Transducer and Activator of Transcription 3). It participates in cellular signal transduction, potentially influencing processes such as cell proliferation, survival, and immune responses.
Involved in the regulation of cellular signaling pathways; CSK negatively regulates FYN kinase activity, and PAG1 (Cbp/PAG1) serves as a scaffold linking CSK and FYN, modulating signal transduction. The complex may play a role in cellular processes such as proliferation, differentiation, and immune responses.
Participates in cellular signaling cascades; FYN kinase, PAG1, KHDRBS1, and RASA1 collectively regulate signal transduction pathways, potentially influencing cell growth, migration, and differentiation. The complex is implicated in the modulation of intracellular signaling events and may have implications for cellular responses to extracellular stimuli.
Involved in mitochondrial dynamics; PARL, STOML2, and YME1L1 form a complex associated with mitochondrial membranes, potentially influencing processes such as mitochondrial fission, fusion, and quality control. The complex may play a role in maintaining mitochondrial homeostasis and cellular energy balance.
Participates in mitotic processes; the complex involving multiple kinesin proteins (KIF4A, KIF14, KIF20A, KIF23) and PRC1 is associated with mitotic spindle dynamics and cytokinesis, contributing to accurate cell division. This complex is essential for proper chromosome segregation and cytokinesis during cell division.
Essential for immune responses; IL-15Ralpha associates with IL-15, forming a complex that plays a critical role in the activation and proliferation of natural killer (NK) and CD8+ T cells. The complex is involved in enhancing immune surveillance and defense against infections and tumors.
Crucial for immune regulation; the complex involving IL-2Rbeta/gamma receptors and IL-15 facilitates signaling cascades that influence the activation, proliferation, and survival of T cells and NK cells. This complex contributes to the regulation of immune responses and the maintenance of immune homeostasis.
Key for immune system modulation; the complex comprising IL-2Ralpha/beta/gamma receptors and IL-2 is central to the activation and survival of T cells. It plays a vital role in immune responses, including the regulation of T cell proliferation and differentiation. The complex is crucial for maintaining immune balance and preventing autoimmunity.
Crucial for immune regulation, the IL-2Rbeta/gamma receptor-IL-2 complex mediates the biological effects of interleukin-2 (IL-2). It plays a central role in T-cell activation, proliferation, and immune response modulation. The complex is essential for maintaining immune homeostasis and is implicated in therapeutic applications, including immunotherapy for certain diseases.
Involved in iron-sulfur cluster biogenesis; the complex plays a role in the maturation of iron-sulfur clusters, essential co-factors for various cellular processes. This complex participates in mitochondrial and cytosolic iron-sulfur cluster assembly, contributing to cellular functions such as respiration and DNA repair.
Important for hematopoiesis; the complex involving IL-3Ralpha/beta receptors and IL-3 is critical for the survival and differentiation of hematopoietic cells. It plays a key role in stimulating the production of various blood cell types, contributing to hematopoiesis and immune system function.
Essential for eosinophil development; the complex comprising IL-5Ralpha/IL-3Rbeta receptors and IL-5 is involved in the regulation of eosinophil production and function. This complex influences allergic responses and immune processes related to eosinophil-mediated inflammation.
Plays a role in immune responses, where the IL-20 receptor complex interacts with IL-20, contributing to inflammatory processes and tissue homeostasis. This complex is involved in the regulation of immune cell functions and may influence skin and mucosal responses, impacting conditions such as psoriasis and inflammatory bowel disease.
Essential for immune regulation, the IL-18 receptor complex binds IL-18, triggering signaling cascades that modulate the activity of immune cells. This complex is involved in the regulation of inflammation and immune responses, contributing to the defense against infections and the maintenance of immune system balance.
Similar to the IL-18Ralpha receptor-IL-18 complex, this complex is crucial for immune responses. The binding of IL-18 to its receptor initiates signaling pathways that regulate inflammatory processes and immune cell activities, playing a key role in host defense mechanisms and immune system homeostasis.
Involved in extracellular matrix remodeling, this complex regulates the activity of MMP-1, influencing tissue architecture and cell migration, with implications in processes such as tissue repair and cancer metastasis.
Participates in extracellular matrix modulation, where Mt-MMP-1, TIMP-2, and proMMP-2 collaborate. This complex regulates the activation of MMP-2, affecting processes such as tissue remodeling and angiogenesis. It plays a role in the balance of matrix metalloproteinase activities, impacting cellular behaviors and the tissue microenvironment.
The EMC2-EMC5-EMC8 complex is associated with endoplasmic reticulum membrane protein complex (EMC). It may play a role in protein folding, quality control, and the maintenance of endoplasmic reticulum integrity, contributing to cellular homeostasis and the prevention of misfolded protein accumulation.
Similar to the IL-20Ralpha/beta receptor-IL-20 complex, this complex involves the IL-20 receptor and IL-19. It contributes to immune responses, potentially affecting inflammatory processes and tissue homeostasis. The complex may influence conditions such as psoriasis and inflammatory bowel disease, modulating immune cell functions and tissue responses.
The VTN-TAT complex involves vitronectin (VTN) and the HIV-1 Tat protein (TAT). This complex may play a role in cellular processes related to HIV infection and interactions with host proteins, potentially impacting viral replication and host cell responses. The specific functions of this complex may vary in different cellular contexts.
Involved in the regulation of insulin-like growth factor 1 (IGF1) activity, this complex includes IGF1 and insulin-like growth factor-binding protein 5 (IGFBP5). It modulates the availability and function of IGF1, influencing cellular responses related to growth, survival, and metabolism. The complex plays a role in the fine-tuning of IGF1 signaling pathways.
An extension of the IGF1-IGFBP5 complex, this complex includes acid labile subunit (ALS). Together, these components regulate IGF1 bioavailability and stability in the circulation. The complex plays a role in systemic IGF1 signaling, impacting growth and metabolic processes at the organismal level.
Similar to the IGF1-IGFBP5 complex, this complex involves insulin-like growth factor 2 (IGF2) and IGFBP5. It modulates the activity of IGF2, influencing cellular responses related to growth, differentiation, and metabolism. The complex contributes to the regulation of IGF2 signaling pathways, playing a role in developmental and physiological processes.
An extension of the IGF2-IGFBP5 complex, this complex includes ALS. It regulates the stability and availability of IGF2 in the circulation, impacting systemic IGF2 signaling. The complex plays a role in coordinating IGF2-related physiological processes at the organismal level, including growth and metabolic regulation.
The IL6R/IL6ST receptor-IL6 complex is essential for the biological activities of interleukin-6 (IL-6). It mediates IL-6 signaling, influencing immune responses, inflammation, and various cellular processes. The complex plays a role in the regulation of immune cell functions and contributes to the pathogenesis of inflammatory and autoimmune conditions.
Involved in the formation of multivesicular bodies (MVBs), this complex participates in endosomal sorting and vesicle formation processes, playing a crucial role in the regulation of protein trafficking, degradation, and cellular membrane dynamics.
The TPA-PLG-TSP complex involves tissue plasminogen activator (TPA), plasminogen (PLG), and thrombospondin (TSP). It may play a role in fibrinolysis and tissue repair processes, where TPA activates PLG to plasmin, contributing to the degradation of fibrin clots. The complex's involvement in cellular interactions and tissue remodeling is implicated in various physiological and pathological contexts.
Involved in fibrinolysis; tissue plasminogen activator (TPA) activates plasminogen (PLG) to plasmin, contributing to the breakdown of blood clots. Histidine-rich glycoprotein (HRGP) may modulate this process and play roles in regulating hemostasis and thrombosis.
Associates plasminogen (PLG) with thrombospondin (TSP); may play a role in cell adhesion, angiogenesis, and tissue remodeling. PLG activation by TSP can influence the regulation of the extracellular matrix and cell-matrix interactions.
Histidine-rich glycoprotein (HRG) interacts with plasminogen (PLG) and may be involved in modulating the fibrinolytic system. The complex could play roles in hemostasis, thrombosis, and immune response regulation.
The CLC-CLF-CNTFR complex is associated with cytokine signaling. CLC and CLF are cytokines, and CNTFR is their common receptor. This complex is implicated in the regulation of cellular responses to cytokines, influencing immune responses and hematopoiesis.
Similar to the IGF1-IGFBP5 complex, this complex involves insulin-like growth factor 2 (IGF2) and IGFBP5. It modulates the activity of IGF2, influencing cellular responses related to growth, differentiation, and metabolism. The complex contributes to the regulation of IGF2 signaling pathways, playing a role in developmental and physiological processes.
An extension of the IGF2-IGFBP5 complex, this complex includes ALS. It regulates the stability and availability of IGF2 in the circulation, impacting systemic IGF2 signaling. The complex plays a role in coordinating IGF2-related physiological processes at the organismal level, including growth and metabolic regulation.
The Aposome complex is associated with apoptotic processes. It may play a role in regulating cellular responses to apoptotic signals, influencing programmed cell death and maintaining tissue homeostasis.
Involved in exosome biogenesis and secretion; the CD63-syntenin-1 complex contributes to the sorting of proteins into exosomes, influencing intercellular communication through the release of exosomal content.
Associated with JAK-STAT signaling; STAT1 and STAT3 are signal transducer and activator of transcription proteins. This complex is involved in transducing signals from cytokines and growth factors, influencing cellular responses such as inflammation, immune regulation, and cell proliferation.
Plays a role in exosome biogenesis and secretion; this complex is involved in the sorting of proteins into exosomes, contributing to intercellular communication through exosomal release. The specific functions may vary depending on the context and associated proteins.
This complex is central to interferon signaling, where IFNAR1 and IFNAR2 receptors form a complex with TYK2 kinase. Together, they activate downstream signaling pathways crucial for antiviral responses and immune regulation, contributing to the body's defense against infections and other immune-related processes.
Functioning in cell adhesion and signaling pathways, this complex influences cellular processes such as cell migration, invasion, and adhesion. This intricate interaction may play a pivotal role in cancer biology, impacting the progression and metastasis of cancer cells by modulating their ability to interact with the extracellular environment and neighboring cells.
Playing a significant role in cytokine signaling, this complex helps regulate immune responses and inflammation. The inclusion of SOCS3 as a negative regulator ensures precise control of signaling downstream of GP130 and JAK2, preventing excessive immune activation and maintaining immune homeostasis. This complex is crucial for orchestrating appropriate immune responses while preventing unnecessary inflammation.
Involved in apoptotic pathways, this complex plays a role in the regulation of cell survival and death processes. This intricate interaction may influence cellular responses to various signals, contributing to the delicate balance between survival and apoptosis. The complex's involvement in apoptotic pathways underscores its significance in cellular decision-making related to programmed cell death.
Operating in DNA repair, the PAXX complex is instrumental in maintaining genomic stability. PAXX's participation in the non-homologous end joining (NHEJ) pathway contributes to the repair of double-strand breaks in DNA, ensuring the integrity of the genome. This complex plays a critical role in safeguarding the cell's genetic material from damage, contributing to overall genomic stability and preventing the accumulation of harmful mutations.
Participating in receptor tyrosine kinase signaling, this complex regulates downstream signaling pathways associated with cell growth, survival, and proliferation. This intricate interaction is particularly relevant in cellular responses to epidermal growth factor stimulation, influencing key processes that contribute to normal cellular functions and aberrant growth in certain pathological conditions, such as cancer.
Similar to the ACK1-GRB2-EGFR complex, this complex involves platelet-derived growth factor receptor (PPDGFR), extending its influence to growth factor signaling pathways. This interaction may modulate cellular responses to growth factor signals, impacting cell growth, survival, and proliferation. The complex's involvement in PPDGFR signaling highlights its relevance in processes related to cellular growth and tissue development.
This complex is implicated in oncogenic signaling. Their interactions may contribute to aberrant activation of ALK signaling pathways, potentially promoting cell transformation and cancer development. The intricate interplay within this complex underscores its significance in the context of oncogenic signaling, where dysregulation can lead to uncontrolled cell growth and contribute to the progression of certain cancers.
Operating in cytoskeletal organization and cellular signaling, this complex influences cell adhesion, migration, and signaling pathways. This intricate interaction plays a pivotal role in tissue development and homeostasis, as the complex modulates cellular processes essential for maintaining proper tissue structure and function. The interplay within this complex contributes to the dynamic regulation of cell behavior in various physiological contexts.
Involved in cellular signaling pathways, this complex comprises protein kinase C delta (PRKCD), 3-phosphoinositide-dependent protein kinase-1 (PDPK1), and PRG2. This complex's interaction may contribute to the regulation of PRKCD signaling and downstream cellular responses, potentially influencing processes such as cell proliferation and survival. The intricate interplay within this complex underscores its importance in cellular decision-making related to signaling cascades.
Similar to the PRKCD-PDPK1-PRG2 complex, this complex involves protein kinase C zeta (PRKCZ). Operating in cellular signaling pathways, this complex's interaction may modulate PRKCZ signaling and downstream cellular responses. This complex's involvement highlights its potential influence on processes such as cell proliferation, survival, and differentiation, contributing to the regulation of cellular behavior in diverse physiological contexts.
Influences cellular signaling and modulates cell proliferation, impacting cellular responses related to growth, migration, and survival. The complex involving PEAK1, PPP1CC, and SHC1 is implicated in the regulation of signaling cascades, potentially affecting cellular behaviors.
Crucial for vascular biology, the complex formed by CDH5, KDR (VEGFR2), and PECAM1 plays a pivotal role in processes such as angiogenesis and vascular permeability. This complex is essential for the regulation of blood vessel formation and maintenance, contributing to vascular integrity and function.
Regulates endothelial cell junctions, contributing to the regulation of cell-cell adhesion and vascular integrity. The complex formed by CLDN1, ESAM, OCLN, and PECAM1 plays a vital role in the maintenance of endothelial cell junctions, influencing the barrier function of endothelial cells in tissues.
Participates in the regulation of TGF-beta signaling, influencing cellular responses related to cell growth, differentiation, and immune control. The complex comprising PTEN, PP1MA, SMAD2, and SMAD3 is implicated in the modulation of the TGF-beta pathway, impacting cellular behaviors.
Regulates cellular responses to stress, impacting cellular adaptation to environmental challenges such as endoplasmic reticulum stress. The complex formed by EIF2S1, NCK1, PPP1CA, and PPP1R15B plays a key role in the control of protein synthesis under stress conditions, influencing cellular behaviors in response to stress.
Involved in DNA damage recognition and repair, contributing to the maintenance of genomic stability and prevention of mutations. The complex is essential for the recognition of DNA lesions, participating in nucleotide excision repair processes that are crucial for maintaining genomic integrity.
Participates in DNA damage recognition and repair, facilitating the detection of DNA lesions and initiation of nucleotide excision repair processes. The complex is crucial for the efficient detection of DNA lesions and the initiation of nucleotide excision repair mechanisms, influencing cellular behaviors in response to DNA damage.
Regulates nucleocytoplasmic transport, contributing to the regulation of gene expression and cellular activities requiring dynamic protein movement across cellular compartments. The complex is crucial for the transport of proteins between the nucleus and cytoplasm, influencing cellular behaviors related to gene regulation and protein movement.
Involved in protein quality control and chaperone functions, contributing to cellular protein homeostasis and prevention of protein misfolding. The complex participates in the recognition, folding, and degradation of misfolded proteins, contributing to cellular protein homeostasis and preventing the accumulation of aberrant proteins that could lead to cellular dysfunction.
Manages protein quality control, ensuring proper protein folding and preventing the buildup of protein aggregates that could be detrimental to cellular function. The interaction between DNAJB12 and DNAJB14 contributes to the recognition and handling of misfolded proteins within cells, ensuring proper protein folding and preventing the buildup of protein aggregates that could be detrimental to cellular function.
Participates in protein quality control and cellular stress responses, contributing to cellular proteostasis and stress adaptation. The complex is implicated in recognizing and managing misfolded proteins, contributing to cellular proteostasis and stress adaptation.
Plays a role in promoting apoptotic cell death. The Pro-death complex II is involved in the activation of caspase-8, a key mediator in apoptotic signaling pathways, contributing to the regulation of programmed cell death.
Regulates nucleocytoplasmic transport by facilitating the movement of proteins between the nucleus and cytoplasm. The interaction between RAN and RANBP1 is crucial for the transport of cargo molecules across cellular compartments.
Participates in protein folding and quality control processes. The AIPL1 chaperone complex, involving Aryl hydrocarbon Interacting Protein-like 1, assists in the proper folding and maintenance of specific target proteins, contributing to cellular protein homeostasis.
Regulates cellular processes related to cell growth, survival, and signaling. This complex involves multiple proteins, influencing pathways such as PI3K-AKT-mTOR and regulating cellular responses to growth factors and stress signals.
Plays a crucial role in the activation of mTORC1 signaling in response to nutrient availability. The Ragulator-Rag complex regulates the recruitment of mTORC1 to the lysosomal surface, influencing cellular processes such as protein synthesis, growth, and metabolism.
Involved in immune responses and signaling. The IL15RA-TGFBR2 complex participates in the interaction between interleukin-15 receptor alpha (IL15RA) and transforming growth factor beta receptor 2 (TGFBR2), potentially influencing cellular responses related to immune regulation and inflammation.
Associated with cellular processes related to mitochondrial function and nucleocytoplasmic transport. The DLD-NFE2L1-RAN complex may play roles in energy metabolism and the regulation of protein transport between the nucleus and cytoplasm.
Participates in G protein signaling pathways. The GNAI1-GNB1-GNGT1-NTS-NTSR1 complex involves multiple G protein subunits and receptors, influencing cellular responses to neurotransmitters and other extracellular signals.
Involved in nucleotide biosynthesis. The DHFR-SHMT1-TYMS complex includes key enzymes in the de novo synthesis of thymidylate, contributing to DNA synthesis and cell proliferation.
Implicated in extracellular matrix remodeling and proteolysis. The complex formed by ANXA2, MMP2, and WFDC2 participates in processes related to tissue remodeling, potentially influencing cell migration and invasion. ANXA2 and MMP2 are associated with matrix metalloproteinase activity, and WFDC2 may play a regulatory role in these processes.
Essential for transforming growth factor-beta (TGF-β) signaling. The complex involving SMAD3, SMAD4, and SKIL modulates the TGF-β pathway, influencing cellular responses related to growth, differentiation, and immune regulation. SMAD3 and SMAD4 are key mediators of TGF-β signaling, while SKIL acts as a negative regulator, contributing to the fine-tuning of TGF-β-mediated cellular processes.
Participates in mRNA translation regulation. The complex formed by PAIP1 and YBX2 influences translation initiation and mRNA stability, potentially impacting the efficiency of protein synthesis within cells. PAIP1 interacts with the poly(A) tail of mRNA, and YBX2 is involved in mRNA binding, contributing to the control of translation processes. This complex plays a role in the regulation of gene expression at the translational level.
Essential for pre-mRNA splicing. The spliceosome is a dynamic ribonucleoprotein complex responsible for removing introns and joining exons during mRNA processing. It ensures the accurate and precise splicing of precursor mRNA, contributing to the generation of mature mRNA transcripts that can be translated into functional proteins. The spliceosome is fundamental to gene expression and the production of diverse protein isoforms from a single gene.
Participates in chromatin compaction and gene silencing. The PRC1.6a complex, containing Polycomb group proteins, is involved in the regulation of chromatin structure and gene expression. It contributes to the establishment of repressive chromatin marks, influencing cellular processes such as development and differentiation.
Implicated in the regulation of cellular signaling pathways. The complex modulates cellular signaling events, potentially influencing processes such as cell growth, differentiation, and immune responses. CSK is a tyrosine kinase involved in the negative regulation of signaling cascades, and HSP90AA1 and HSPA8 act as chaperones in maintaining protein conformation. This complex contributes to the fine-tuning of cellular responses to external stimuli.
Involved in the recognition of lipopolysaccharide (LPS) and initiation of immune responses. The LPS receptor complex plays a crucial role in the detection of LPS, a component of bacterial cell walls. Activation of this complex initiates signaling pathways leading to immune responses, including the production of inflammatory mediators and activation of the innate immune system. This complex is fundamental to host defense against bacterial infections.
Participates in the recognition of microbial patterns and immune responses. The complex is implicated in the detection of specific microbial molecules, triggering signaling pathways leading to immune responses. CD36 acts as a pattern recognition receptor, while TLR4 and TLR6 are Toll-like receptors involved in pathogen recognition. This complex plays a crucial role in the initiation of innate immune responses to microbial challenges.
Plays a central role in the interleukin-1 signaling pathway. The comple mediates cellular responses to IL-1, triggering downstream signaling cascades that regulate inflammatory and immune responses. It is involved in the activation of NF-kappaB and MAPK pathways, influencing gene expression and cytokine production.
Regulates receptor tyrosine kinase signaling. The complex is implicated in the downregulation of EGFR signaling through ubiquitination and subsequent degradation. It plays a role in controlling cellular responses to growth factors and is involved in the negative feedback regulation of receptor tyrosine kinase activities, impacting cell proliferation and survival.
Participates in intracellular vesicle trafficking. The complex is involved in the transport of vesicles between intracellular compartments, contributing to the regulation of membrane and protein trafficking. It plays a role in maintaining cellular homeostasis and the proper distribution of cellular components.
Involved in protein quality control and cellular processes. The complex is implicated in the recognition and handling of misfolded proteins, contributing to cellular protein homeostasis. Additionally, it may have roles in cellular processes associated with TMEM67, impacting cellular responses to specific stimuli or conditions.
Essential for interleukin-7 (IL-7) signaling. The complex is crucial for the activation of the IL-7 signaling pathway, promoting the survival, proliferation, and differentiation of T cells. It plays a fundamental role in the development and maintenance of the immune system, influencing cellular responses in lymphoid tissues and impacting immune cell homeostasis.
The ZFAND2B complex functions as a quality-control complex that plays a crucial role in the regulation of translocation into the endoplasmic reticulum (ER) for secretory and membrane proteins. This process is essential for maintaining the fidelity of protein folding and trafficking within the cell, contributing to cellular protein homeostasis and the prevention of aberrant protein accumulation that could lead to cellular dysfunction.
Facilitates interleukin-21 (IL-21) signaling. The complex is essential for the activation of the IL-21 signaling pathway, influencing immune responses and cellular activities in various immune cells. It plays a role in the regulation of immune functions, including the modulation of T and B cell responses, and impacts cellular behaviors related to immune homeostasis and inflammation.
Involved in Hedgehog signaling and cellular development. The complex participates in the Hedgehog signaling pathway, influencing cellular processes related to embryonic development, tissue patterning, and cell differentiation. It plays a role in regulating cellular fate and tissue morphogenesis during embryonic development, impacting the formation of various organs and tissues.
Plays a crucial role in interleukin-23 (IL-23) signaling. The complex is essential for the activation of the IL-23 signaling pathway, influencing immune responses and cellular activities in various immune cells. It plays a role in the regulation of inflammatory processes, impacting cellular behaviors related to immune homeostasis and the development of certain immune-mediated conditions.
Facilitates membrane fusion and intracellular vesicle trafficking. The SNARE complex plays a central role in mediating the fusion of vesicles with target membranes, facilitating the transport of cellular cargo. It is crucial for intracellular membrane trafficking, impacting cellular processes such as secretion, endocytosis, and the maintenance of organelle dynamics.
Involved in innate immune responses and antiviral defense. The complex plays a role in regulating the activity of IRF3, a transcription factor involved in the induction of interferon and antiviral responses. It contributes to the modulation of cellular responses to viral infections, impacting the host defense against invading pathogens.
Modulates NF-kappaB signaling and cellular responses to inflammation. The complexis implicated in the regulation of NF-kappaB pathway activity, influencing the expression of genes involved in inflammatory responses and immune regulation. It plays a role in modulating cellular behaviors related to inflammation, immune homeostasis, and the response to various external stimuli.
Essential for interferon signaling and antiviral defense. The ISGF3 complex plays a central role in the transcriptional response to interferon signaling. It regulates the expression of interferon-stimulated genes, contributing to antiviral defenses and cellular responses to infections. The ISGF3 complex impacts cellular behaviors related to the innate immune response and the establishment of an antiviral state within cells.
This complex is pivotal in innate immune signaling, where TANK recruits TBK1 to activate IRF3. The activated IRF3 leads to the production of interferons, initiating a robust antiviral response to combat viral infections and contribute to overall immune defense mechanisms.
Participating in mitochondrial protein import and membrane translocation, this complex facilitates the import of nuclear-encoded mitochondrial proteins. It plays a crucial role in the sorting and translocation of proteins across mitochondrial membranes, contributing to mitochondrial function, biogenesis, and overall cellular energy production.
Involved in mitochondrial protein import and membrane translocation, this complex mediates the sorting and translocation of proteins into mitochondria. Its role is critical for maintaining mitochondrial function and ensuring the proper localization of proteins within the mitochondrial compartments, contributing to cellular energy production and homeostasis.
Functioning in mitochondrial protein biogenesis, the MITRAC complex is involved in the assembly and insertion of respiratory chain complexes into the inner mitochondrial membrane. This complex is pivotal for the biogenesis of the mitochondrial respiratory chain, influencing cellular energy production and overall mitochondrial function.
Playing a key role in TNFR1 signaling, this complex contributes to the activation of downstream signaling pathways. It regulates cellular responses such as apoptosis and inflammation in response to TNFR1 activation, thereby influencing diverse physiological processes under the control of TNF signaling.
Participating in antiviral signaling, the DDX58-TRIM25-YWHAE complex is involved in the activation of RIG-I (DDX58). This activation leads to the induction of antiviral responses, including the production of interferons and the inhibition of viral replication, contributing to the cellular defense against viral infections.
Involved in nucleocytoplasmic transport; ILF3, RAN, XPO5, and ZNF346 form a complex that facilitates the transport of RNA molecules between the nucleus and cytoplasm, playing a crucial role in gene expression regulation and cellular processes dependent on dynamic RNA localization.
Participates in nuclear import; this complex is essential for transporting specific proteins into the nucleus, contributing to the regulation of gene expression and other nuclear processes critical for cellular function and homeostasis.
Mediates the response to interferon-lambda1 (IFN-lambda1); this complex is crucial for transmitting signals initiated by IFN-lambda1, leading to the activation of antiviral and immune responses, influencing gene expression, and enhancing the host defense against viral infections.
Involved in cell signaling and chaperone function; this complex is implicated in cell signaling pathways and protein folding. It may influence cellular responses to external signals and contribute to the proper folding of specific proteins critical for cellular function.
Participates in vesicle trafficking and membrane dynamics; the complex plays a role in regulating vesicle transport and membrane dynamics within cells, potentially impacting processes such as immune response and cellular communication.
Participates in immune response; this complex is implicated in the recognition of microbial components and the initiation of immune responses. It contributes to the activation of immune cells and the modulation of inflammatory processes in response to external pathogens.
Plays a role in interleukin-1 (IL-1) signaling; the complex is crucial for transmitting signals initiated by IL-1, leading to the activation of inflammatory responses and immune defense mechanisms against infections or tissue damage.
Involved in vesicle trafficking and immune signaling; the complex plays a role in vesicle transport and immune signaling processes. It may contribute to the regulation of innate immune responses and the trafficking of specific vesicles involved in cellular communication.
Participates in vesicle trafficking and cellular adhesion; the complex is implicated in regulating vesicle transport and cellular adhesion processes. It may influence the movement of vesicles within cells and modulate cell-cell interactions critical for various cellular functions.
Involved in cell signaling; the CD44-ERBB2-GRB2-VAV2 complex participates in cell signaling pathways. It may influence cellular responses to growth factors and contribute to the regulation of cell proliferation, differentiation, and other processes associated with signal transduction.
Involved in autophagy initiation; the complex plays a crucial role in the autophagy pathway, where VPS34 generates phosphatidylinositol 3-phosphate (PI3P) to facilitate autophagosome formation. SLAMF1 may contribute to the regulation of this process in certain cellular contexts.
Involved in MAPK signaling regulation; the complex facilitates the folding, stability, and activation of MAPKs (Mitogen-Activated Protein Kinases), influencing cellular responses to extracellular signals. CDC37 and HSP90AA1 act as chaperones for MAPKs, contributing to proper signaling and regulation of cellular processes such as proliferation and differentiation.
Participates in immune signaling; the complex involving PTPN6 (SHP-1) and VAV1 is implicated in immune cell signaling. PTPN6 negatively regulates signaling pathways, while VAV1 is involved in signaling cascades, contributing to the modulation of immune responses and cellular activation in response to external stimuli.
Regulates growth factor signaling; the complex connects growth factor receptors to downstream signaling pathways. GRB2 links to receptor tyrosine kinases, PTPN6 modulates signaling, and SOS1 activates RAS, collectively influencing cellular responses to growth factors and playing a role in cell growth, survival, and differentiation.
Involved in T-cell receptor signaling; this complex connects the T-cell receptor (TCR) to downstream signaling events. It facilitates signal transduction and influencing T-cell activation, proliferation, and immune responses.
Mediates Toll-like receptor (TLR) signaling; the complex is crucial for initiating immune responses to pathogens. MyD88 connects TLR4 to downstream signaling, and SYK contributes to intracellular signaling events, leading to the activation of immune responses and the production of inflammatory mediators upon recognition of microbial components.
Involved in vesicle trafficking; this complex participates in retrograde transport from the Golgi to the endoplasmic reticulum (ER). TRAPP II and COP I regulate vesicle formation and coat recruitment, while RAB18 contributes to vesicle targeting and fusion, collectively ensuring proper membrane trafficking and maintenance of cellular compartmentalization.
Mediates nuclear import; the complex is involved in the import of proteins into the nucleus. KPNA4 recognizes nuclear localization signals, while KPNB1 facilitates translocation through the nuclear pore complex. This complex plays a crucial role in regulating gene expression and cellular processes requiring nuclear localization of specific proteins.
Functions in nuclear import; the complex mediates the transport of proteins into the nucleus. KPNA1 recognizes nuclear localization signals, and KPNB1 facilitates the translocation of cargo proteins across the nuclear envelope. This complex is essential for regulating gene expression and coordinating nuclear-cytoplasmic transport.
Plays a role in nuclear import; the complex is involved in transporting proteins into the nucleus. KPNA6 recognizes nuclear localization signals, and KPNB1 facilitates the translocation of cargo proteins through the nuclear envelope. This complex is crucial for regulating gene expression and ensuring proper cellular functions that rely on nuclear localization.
Involved in nucleocytoplasmic transport; the complex facilitates the movement of proteins between the nucleus and cytoplasm. CSE1L interacts with KPNA4, recognizing nuclear localization signals, and RAN regulates the translocation of cargo through the nuclear pore complex. This complex is vital for the dynamic interchange of proteins across cellular compartments, influencing gene expression and cellular processes.
Involved in nucleocytoplasmic transport; CSE1L, KPNA1, and RAN form a complex that facilitates the transport of proteins between the nucleus and cytoplasm, contributing to the regulation of gene expression and cellular activities requiring the dynamic interchange of proteins across cellular compartments.
Participates in nucleocytoplasmic transport; the complex facilitates the movement of proteins across the nuclear membrane, playing a role in regulating cellular processes such as gene expression, signal transduction, and overall cellular homeostasis.
Mediates TLR3 signaling; this complex is involved in the activation of Toll-like receptor 3 (TLR3), initiating signaling cascades that lead to the production of interferons and inflammatory responses. It plays a crucial role in the detection of viral double-stranded RNA, contributing to the innate immune response against viral infections.
Implicated in TLR3-mediated apoptosis; this complex, formed upon TLR3 activation, may contribute to apoptotic signaling pathways, influencing cell survival and death in response to viral infections or other TLR3-activating stimuli.
Key player in RIG-I signaling; this complex contributes to the activation of RIG-I and downstream signaling pathways. It leads to the production of interferons, enhancing the antiviral response and cellular defense mechanisms against viral infections.
Participates in RIG-I signaling; the complex is involved in the regulation of RIG-I-mediated antiviral responses. It may modulate signaling cascades and contribute to the fine-tuning of immune responses against viral infections.
Implicated in the Ras signaling pathway; this complex plays a role in transmitting signals downstream of Ras, influencing cellular processes such as cell growth, differentiation, and survival. It contributes to the regulation of the MAPK/ERK signaling pathway and cellular responses to extracellular signals.
Functions in Ras signaling; this trimeric complex is involved in transmitting signals downstream of MRAS within the Ras pathway. It contributes to the regulation of cellular processes, including cell growth, differentiation, and survival, by modulating the MAPK/ERK signaling pathway.
Plays a role in Ras signaling; the complex is involved in transmitting signals downstream of NRAS, influencing cellular processes such as cell growth, differentiation, and survival. It contributes to the regulation of the MAPK/ERK signaling pathway and cellular responses to extracellular signals.
Participates in Toll-like receptor signaling; this complex plays a role in recognizing pathogen-associated molecular patterns (PAMPs) and initiating signaling cascades that lead to inflammatory responses and immune activation. It is essential for the detection of bacterial and flagellar components, contributing to host defense mechanisms.
Mediates signaling in response to interferon (IFN); the complex plays a key role in transducing signals from type I interferons, leading to the activation of STAT1 and the induction of interferon-stimulated genes (ISGs), crucial for antiviral responses and immune regulation.
Mediates signaling from tumor necrosis factor receptor 2 (TNFR2); this complex transduces signals that regulate cellular responses such as inflammation, cell survival, and immune regulation. It is involved in diverse physiological processes influenced by TNFR2 activation.
Involved in antiviral signaling pathways; the complex contributes to the activation of IRF3 and the induction of interferons, playing a crucial role in the cellular defense against viral infections and the regulation of antiviral immune responses.
Involved in MAPK signaling; the complex participates in the mitogen-activated protein kinase (MAPK) signaling pathway. It regulates cellular responses to growth factors and environmental stimuli, influencing cell proliferation, differentiation, and survival.
Participates in TGF-β signaling; the complex plays a role in the transforming growth factor-beta (TGF-β) signaling pathway. It influences cellular responses to TGF-β, impacting processes such as cell differentiation, apoptosis, and immune regulation.
Involved in TGF-β signaling; the complex participates in the transforming growth factor-beta (TGF-β) signaling pathway. It modulates cellular responses to TGF-β, affecting processes like cell growth, differentiation, and the regulation of immune and inflammatory responses.
Functions in TGF-β and p53 signaling; the complex plays a role in the transforming growth factor-beta (TGF-β) signaling pathway and interacts with the p53 pathway. It influences cellular responses to TGF-β and contributes to the regulation of cell cycle and apoptosis.
Constitutes the troponin complex in muscle cells; the complex plays a critical role in muscle contraction. It regulates the calcium-dependent interaction between actin and myosin filaments, contributing to the control of muscle contraction and overall muscle function.
Essential for TSLP signaling; the complex participates in the signaling pathway activated by thymic stromal lymphopoietin (TSLP). It plays a role in regulating immune responses, particularly in the context of TSLP-mediated effects on various immune cell populations.
Involved in immune responses and hemostasis; the complex participates in the recognition of pathogens by dendritic cells. Additionally, VWF is involved in hemostasis, playing a crucial role in blood clotting. The complex contributes to immune surveillance and the regulation of coagulation processes.
Critical for hemostasis, the F8-VWF complex plays a pivotal role in the coagulation cascade. This complex facilitates platelet adhesion and aggregation at the site of vascular injury, ensuring proper blood clot formation and preventing excessive bleeding.
Central to cellular stress responses, the KEAP1-SQSTM1 complex regulates the degradation of Nrf2. This complex modulates cellular responses to oxidative stress and autophagy processes, influencing cellular adaptation to environmental challenges.
Instrumental in neurotransmission, the ACHE-NRXN1 complex modulates cholinergic signaling at the neuromuscular junction. This complex influences synaptic transmission, acetylcholine levels, and plays a crucial role in regulating neuromuscular function.
Contributing to lipid metabolism, the APOA1-BCHE complex participates in lipoprotein metabolism. This complex regulates cholesterol levels and lipid homeostasis in the bloodstream, playing a key role in lipid transport and overall cardiovascular health.
In lipoprotein metabolism, the APOB-BCHE complex plays a crucial role in the regulation of lipoprotein synthesis and processing. This complex influences lipid transport and metabolism, contributing to overall cardiovascular health and lipid homeostasis.
Essential for acetylcholine clearance, the BCHE-CLU complex participates in the hydrolysis and clearance of acetylcholine. This complex influences cholinergic signaling, contributing to neurotransmitter regulation and cellular responses to acetylcholine.
The BCHE-KRT1 complex may have roles in cellular structure and organization. While the specific functions are context-dependent, the association with keratin 1 suggests potential involvement in the structural integrity of specific cell types and tissues.
Participating in plasma protein binding and transport, the ALB-BCHE complex contributes to the binding and transport of various molecules in the bloodstream. This complex plays a role in modulating the distribution and metabolism of substances, influencing overall physiological processes.
Involved in plasma protein interactions, the AHSG-BCHE complex may modulate the functions of both AHSG and BCHE. This complex potentially influences diverse physiological processes, serving roles in plasma protein interactions and regulatory activities.
The BCHE-TF complex may have dual roles in cholinergic signaling and iron homeostasis. This complex, associating with the iron transport protein transferrin, suggests potential involvement in both neurotransmitter regulation and the modulation of cellular iron levels.
The BCHE-KRT5 complex may participate in cellular structural support or signaling events. KRT5, a type II keratin, is often associated with cytoskeletal elements, and the interaction with BCHE might influence cell adhesion or other cellular processes related to the cytoskeleton.
The BCHE-C1S complex suggests a potential interplay between the cholinergic system and the complement system. This interaction may impact immune responses and inflammatory processes, potentially modulating complement activation and contributing to the regulation of immune-related pathways.
This complex may play a role in cellular structural functions or signaling processes. KRT16, a type I keratin, is involved in maintaining cellular integrity, and BCHE may contribute to additional functions, potentially influencing cell adhesion or participating in signaling cascades.
The BCHE-VTN complex might be involved in cell adhesion, migration, or other processes associated with vitronectin. This interaction may have implications for cellular responses to the extracellular matrix, influencing cell behavior and potentially contributing to various physiological contexts.
The BCHE-HBB complex suggests a potential link between cholinergic signaling and hemoglobin-related functions. This interaction may impact oxygen transport, cellular responses to hypoxia, or other processes related to the physiological roles of hemoglobin.
This complex may be associated with cellular processes related to thrombospondin. These processes could include cell adhesion, angiogenesis, or modulation of cellular responses to the extracellular matrix. The interaction may contribute to the regulation of tissue homeostasis and physiological functions.
The BCHE-LGALS3BP complex may participate in processes influenced by galectin-3. This interaction may play a role in cell adhesion, signaling, or other cellular responses associated with galectin-3 and its diverse functions in various physiological contexts.
This complex may be associated with protease inhibition or other functions related to the activities of these proteins. A2M is known for its role in inhibiting proteases, and BCHE may contribute to this inhibitory function within the context of this complex, potentially influencing protease-related pathways.
The BCHE-HP complex may be associated with processes related to haptoglobin. This interaction could have implications for functions such as immune response modulation or the regulation of oxidative stress, as haptoglobin is involved in binding free hemoglobin and exerting protective effects in response to hemolysis.
The Spliceosome pre-B complex is involved in pre-mRNA splicing, specifically during the processing of B-cell receptor transcripts. This complex contributes to the removal of introns from pre-mRNA, enabling the production of mature mRNA that codes for functional B-cell receptors. Efficient splicing is essential for proper B-cell development and immune response regulation.
The Spliceosome B complex is a key component of the pre-mRNA splicing machinery. It participates in the removal of introns from pre-mRNA transcripts, ensuring the accurate joining of exons. The B complex is part of the dynamic spliceosome assembly process, facilitating the precise splicing of pre-mRNA to generate mature mRNA for subsequent translation into functional proteins.
The Spliceosome A complex is a crucial component of the pre-mRNA splicing machinery. It aids in the recognition of splice sites and facilitates the assembly of the spliceosome during pre-mRNA processing. The A complex is involved in the initial steps of intron removal, contributing to the formation of mature mRNA that can be translated into functional proteins.
The Spliceosome E complex is part of the splicing machinery responsible for the removal of introns from pre-mRNA transcripts. It represents an intermediate stage in the dynamic assembly of the spliceosome during pre-mRNA splicing. The E complex helps position the spliceosome for subsequent steps in the splicing process, ensuring the accurate and efficient removal of non-coding regions.
Mediates signaling in response to tumor necrosis factor-alpha (TNF-α). Plays a crucial role in various cellular processes, including inflammation, apoptosis, and immune responses. TNFR1 signaling complex activation can lead to diverse cellular outcomes depending on the cellular context and stimuli.
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